Class information for:
Level 1: PI3K GAMMA//PHOSPHOINOSITIDE 3 KINASE//P110 DELTA

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
5678 1590 49.1 94%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
269 3       CELL BIOLOGY//CAVEOLIN 1//CAVEOLAE 44007
536 2             X LINKED AGAMMAGLOBULINEMIA//BTK//SH2 DOMAIN 14793
5678 1                   PI3K GAMMA//PHOSPHOINOSITIDE 3 KINASE//P110 DELTA 1590

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PI3K GAMMA authKW 470451 2% 70% 35
2 PHOSPHOINOSITIDE 3 KINASE authKW 219503 6% 13% 88
3 P110 DELTA authKW 196626 1% 64% 16
4 PI3K DELTA INHIBITOR authKW 193628 1% 92% 11
5 LYMPHOCYTE SIGNALLING DEV address 169021 2% 23% 38
6 PHOSPHOINOSITIDE 3 KINASE GAMMA authKW 129078 1% 61% 11
7 PHOSPHOINOSITIDE 3 KINASE PI3K authKW 119123 2% 19% 32
8 PHOSPHATIDYLINOSITOL 3 KINASE authKW 112614 6% 6% 98
9 P55PIK authKW 96015 0% 100% 5
10 WORTMANNIN authKW 92940 3% 10% 47

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Biochemistry & Molecular Biology 5110 48% 0% 757
2 Cell Biology 3682 26% 0% 408
3 Immunology 1359 15% 0% 246
4 Biophysics 315 6% 0% 98
5 Chemistry, Medicinal 295 5% 0% 76
6 Hematology 229 4% 0% 71
7 Oncology 133 7% 0% 110
8 Pharmacology & Pharmacy 79 7% 0% 109
9 Peripheral Vascular Diseases 55 3% 0% 40
10 Medicine, Research & Experimental 53 3% 0% 54

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 LYMPHOCYTE SIGNALLING DEV 169021 2% 23% 38
2 LYMPHOCYTE SIGNALING DEV 57932 1% 23% 13
3 BIOL CHEMBUNKYO KU 57609 0% 100% 3
4 GENET BIOL BIOCHEM 45646 3% 6% 40
5 INOSITIDE SIGNALLING GRP 43199 0% 38% 6
6 INOSITIDE 42991 1% 13% 17
7 MAX PLANCK UNIT GROWTH TOR SIGNAL TRANSDUC 38406 0% 100% 2
8 MAX PLANCK UNIT MOL CELL BIOL 34563 0% 60% 3
9 PHARMACOL EXPT THER Y 29078 1% 15% 10
10 SERONO PHARMACEUT 27664 0% 21% 7

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF BIOLOGICAL CHEMISTRY 3696 11% 0% 175
2 BIOCHEMICAL SOCIETY TRANSACTIONS 2989 3% 0% 41
3 MOLECULAR AND CELLULAR BIOLOGY 2438 3% 0% 54
4 BIOCHEMICAL JOURNAL 2056 4% 0% 57
5 SCIENCE SIGNALING 1770 1% 1% 12
6 CELLULAR SIGNALLING 1245 1% 0% 17
7 JOURNAL OF IMMUNOLOGY 926 3% 0% 53
8 EXPERT OPINION ON THERAPEUTIC PATENTS 845 1% 0% 10
9 CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY 787 1% 0% 12
10 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 660 3% 0% 51

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 PI3K GAMMA 470451 2% 70% 35 Search PI3K+GAMMA Search PI3K+GAMMA
2 PHOSPHOINOSITIDE 3 KINASE 219503 6% 13% 88 Search PHOSPHOINOSITIDE+3+KINASE Search PHOSPHOINOSITIDE+3+KINASE
3 P110 DELTA 196626 1% 64% 16 Search P110+DELTA Search P110+DELTA
4 PI3K DELTA INHIBITOR 193628 1% 92% 11 Search PI3K+DELTA+INHIBITOR Search PI3K+DELTA+INHIBITOR
5 PHOSPHOINOSITIDE 3 KINASE GAMMA 129078 1% 61% 11 Search PHOSPHOINOSITIDE+3+KINASE+GAMMA Search PHOSPHOINOSITIDE+3+KINASE+GAMMA
6 PHOSPHOINOSITIDE 3 KINASE PI3K 119123 2% 19% 32 Search PHOSPHOINOSITIDE+3+KINASE+PI3K Search PHOSPHOINOSITIDE+3+KINASE+PI3K
7 PHOSPHATIDYLINOSITOL 3 KINASE 112614 6% 6% 98 Search PHOSPHATIDYLINOSITOL+3+KINASE Search PHOSPHATIDYLINOSITOL+3+KINASE
8 P55PIK 96015 0% 100% 5 Search P55PIK Search P55PIK
9 WORTMANNIN 92940 3% 10% 47 Search WORTMANNIN Search WORTMANNIN
10 PI3K DELTA 92160 1% 40% 12 Search PI3K+DELTA Search PI3K+DELTA

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 HAWKINS, PT , STEPHENS, LR , (2015) PI3K SIGNALLING IN INFLAMMATION.BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS. VOL. 1851. ISSUE 6. P. 882 -897 104 47% 27
2 VANHAESEBROECK, B , GUILLERMET-GUIBERT, J , GRAUPERA, M , BILANGES, B , (2010) THE EMERGING MECHANISMS OF ISOFORM-SPECIFIC PI3K SIGNALLING.NATURE REVIEWS MOLECULAR CELL BIOLOGY. VOL. 11. ISSUE 5. P. 329 -341 69 42% 501
3 VANHAESEBROECK, B , ALI, K , BILANCIO, A , GEERING, B , FOUKAS, LC , (2005) SIGNALLING BY PI3K ISOFORMS: INSIGHTS FROM GENE-TARGETED MICE.TRENDS IN BIOCHEMICAL SCIENCES. VOL. 30. ISSUE 4. P. 194 -204 62 74% 288
4 KOK, K , GEERING, B , VANHAESEBROECK, B , (2009) REGULATION OF PHOSPHOINOSITIDE 3-KINASE EXPRESSION IN HEALTH AND DISEASE.TRENDS IN BIOCHEMICAL SCIENCES. VOL. 34. ISSUE 3. P. 115 -127 74 59% 116
5 WYMANN, MP , PIROLA, L , (1998) STRUCTURE AND FUNCTION OF PHOSPHOINOSITIDE 3-KINASES.BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS. VOL. 1436. ISSUE 1-2. P. 127 -150 114 39% 494
6 VANHAESEBROECK, B , STEPHENS, L , HAWKINS, P , (2012) PI3K SIGNALLING: THE PATH TO DISCOVERY AND UNDERSTANDING.NATURE REVIEWS MOLECULAR CELL BIOLOGY. VOL. 13. ISSUE 3. P. 195 -203 67 40% 229
7 GHIGO, A , HIRSCH, E , BRACCINI, L , DAMILANO, F , (2010) PI3K INHIBITION IN INFLAMMATION: TOWARD TAILORED THERAPIES FOR SPECIFIC DISEASES.BIOESSAYS. VOL. 32. ISSUE 3. P. 185-196 61 69% 57
8 STARK, AK , SRISKANTHARAJAH, S , HESSEL, EM , OKKENHAUG, K , (2015) PI3K INHIBITORS IN INFLAMMATION, AUTOIMMUNITY AND CANCER.CURRENT OPINION IN PHARMACOLOGY. VOL. 23. ISSUE . P. 82 -91 49 68% 18
9 BLAJECKA, K , BORGSTROM, A , ARCARO, A , (2011) PHOSPHATIDYLINOSITOL 3-KINASE ISOFORMS AS NOVEL DRUG TARGETS.CURRENT DRUG TARGETS. VOL. 12. ISSUE 7. P. 1056 -1081 112 39% 22
10 MARONE, R , CMIJANOVIC, V , GIESE, B , WYMANN, MP , (2008) TARGETING PHOSPHOINOSITIDE 3-KINASE - MOVING TOWARDS THERAPY.BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS. VOL. 1784. ISSUE 1. P. 159 -185 84 34% 377

Classes with closest relation at Level 1


Rank Class id link
1 1300 MTOR//PIK3CA//PI3K INHIBITOR
2 14683 SHIP2//SHIP1//DOK
3 7540 PHOSPHOINOSITIDE//PIKFYVE//SECT MOL SIGNAL TRANSDUCT
4 9406 INSULIN RECEPTOR SUBSTRATE//INSULIN RECEPTOR SUBSTRATE 1//IRS 1
5 6528 PDK1//AKT//AKT2
6 12290 SH3 DOMAIN//SH2 DOMAIN//GRB2
7 22654 VAV//VAV1//VAV PROTO ONCOGENE
8 16564 CELLULAR SIGNALLING//DNA BOUND LIPIDS//PI PLCBETA1
9 16746 T CELL METABOLISM//IMMUNOMETABOLISM//VANDERBILT IMMUNOBIOL
10 14515 S6K2//P70 S6 KINASE//RIBOSOMAL S6 KINASE 2 S6K2

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