Class information for:
Level 1: MINOR GROOVE BINDER//DISTAMYCIN//PYRROLE IMIDAZOLE POLYAMIDE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
3208 2039 36.4 73%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
5 4 CHEMISTRY, ORGANIC//CHEMISTRY, INORGANIC & NUCLEAR//CHEMISTRY, MULTIDISCIPLINARY 1745167
346 3       CARDIOTOXICITY//ANTHRACYCLINES//CAMPTOTHECIN 36072
1654 2             DISTAMYCIN//MINOR GROOVE BINDER//PYRROLE IMIDAZOLE POLYAMIDE 6885
3208 1                   MINOR GROOVE BINDER//DISTAMYCIN//PYRROLE IMIDAZOLE POLYAMIDE 2039

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MINOR GROOVE BINDER authKW 579222 4% 54% 72
2 DISTAMYCIN authKW 558988 3% 67% 56
3 PYRROLE IMIDAZOLE POLYAMIDE authKW 485147 2% 90% 36
4 NETROPSIN authKW 355833 2% 61% 39
5 MINOR GROOVE authKW 197976 2% 37% 36
6 BIS NETROPSIN authKW 179687 1% 100% 12
7 HOECHST 33258 authKW 177412 2% 30% 40
8 LEXITROPSIN authKW 172635 1% 82% 14
9 TALLIMUSTINE authKW 150985 1% 92% 11
10 SEQUENCE SPECIFICITY authKW 122233 2% 23% 35

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Chemistry, Medicinal 6642 17% 0% 354
2 Biochemistry & Molecular Biology 6166 46% 0% 945
3 Chemistry, Organic 2634 17% 0% 355
4 Biophysics 2553 14% 0% 278
5 Chemistry, Multidisciplinary 1281 19% 0% 378
6 Pharmacology & Pharmacy 342 10% 0% 206
7 Biochemical Research Methods 177 4% 0% 83
8 Oncology 107 6% 0% 122
9 Cell Biology 30 4% 0% 86
10 Biology 8 1% 0% 27

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MED CHEM DRUG TECHNOL 98271 1% 41% 16
2 CANC UK DRUG DNA INTERACT GRP 66551 1% 26% 17
3 THER EUT AREA ONCOL IMMUNOL 44922 0% 100% 3
4 ADV SCI HUMANITIES 33426 1% 11% 20
5 CHIM MACROMOLEC CHIM PHYS 29948 0% 100% 2
6 NIHON UNIV MED SCI 29948 0% 100% 2
7 UK DRUG DNA INTERACT GRP 29948 0% 100% 2
8 CENT XRAY RADIOL 19964 0% 67% 2
9 CHEM BIOL BIOORGAN CHEM MOL ENGN 19964 0% 67% 2
10 MOL RADIAT 19964 0% 67% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ANTI-CANCER DRUG DESIGN 48277 2% 7% 45
2 JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS 34432 4% 3% 85
3 BIOORGANIC & MEDICINAL CHEMISTRY 6385 4% 1% 75
4 NUCLEIC ACIDS RESEARCH 4608 5% 0% 112
5 STUDIA BIOPHYSICA 3445 1% 1% 21
6 BIOCHEMISTRY 3251 5% 0% 110
7 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2694 7% 0% 133
8 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 2338 3% 0% 64
9 MOLECULAR BIOLOGY 2113 1% 1% 26
10 HETEROCYCLIC COMMUNICATIONS 1830 1% 1% 14

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 MINOR GROOVE BINDER 579222 4% 54% 72 Search MINOR+GROOVE+BINDER Search MINOR+GROOVE+BINDER
2 DISTAMYCIN 558988 3% 67% 56 Search DISTAMYCIN Search DISTAMYCIN
3 PYRROLE IMIDAZOLE POLYAMIDE 485147 2% 90% 36 Search PYRROLE+IMIDAZOLE+POLYAMIDE Search PYRROLE+IMIDAZOLE+POLYAMIDE
4 NETROPSIN 355833 2% 61% 39 Search NETROPSIN Search NETROPSIN
5 MINOR GROOVE 197976 2% 37% 36 Search MINOR+GROOVE Search MINOR+GROOVE
6 BIS NETROPSIN 179687 1% 100% 12 Search BIS+NETROPSIN Search BIS+NETROPSIN
7 HOECHST 33258 177412 2% 30% 40 Search HOECHST+33258 Search HOECHST+33258
8 LEXITROPSIN 172635 1% 82% 14 Search LEXITROPSIN Search LEXITROPSIN
9 TALLIMUSTINE 150985 1% 92% 11 Search TALLIMUSTINE Search TALLIMUSTINE
10 SEQUENCE SPECIFICITY 122233 2% 23% 35 Search SEQUENCE+SPECIFICITY Search SEQUENCE+SPECIFICITY

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 BAILLY, C , CHAIRES, JB , (1998) SEQUENCE-SPECIFIC DNA MINOR GROOVE BINDERS. DESIGN AND SYNTHESIS OF NETROPSIN AND DISTAMYCIN ANALOGUES.BIOCONJUGATE CHEMISTRY. VOL. 9. ISSUE 5. P. 513 -538 189 74% 231
2 NEIDLE, S , (2001) DNA MINOR-GROOVE RECOGNITION BY SMALL MOLECULES.NATURAL PRODUCT REPORTS. VOL. 18. ISSUE 3. P. 291 -309 164 71% 299
3 GALLMEIER, HC , KONIG, B , (2003) HETEROAROMATIC OLIGOAMIDES WITH DDNA AFFINITY.EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. VOL. . ISSUE 18. P. 3473 -3483 126 91% 15
4 BLACKLEDGE, MS , MELANDER, C , (2013) PROGRAMMABLE DNA-BINDING SMALL MOLECULES.BIOORGANIC & MEDICINAL CHEMISTRY. VOL. 21. ISSUE 20. P. 6101-6114 84 91% 26
5 JIANG, SK , WANG, P , WU, YL , ZHANG, W , (2011) THE ROLE OF ALIPHATIC CHAINS IN PYRROLE-IMIDAZOLE POLYAMIDES AND THEIR CONJUGATES BINDING TO DNA.PROGRESS IN CHEMISTRY. VOL. 23. ISSUE 11. P. 2339 -2352 84 92% 0
6 REDDY, BSP , SONDHI, SM , LOWN, JW , (1999) SYNTHETIC DNA MINOR GROOVE-BINDING DRUGS.PHARMACOLOGY & THERAPEUTICS. VOL. 84. ISSUE 1. P. 1 -111 168 51% 155
7 DERVAN, PB , EDELSON, BS , (2003) RECOGNITION OF THE DNA MINOR GROOVE BY PYRROLE-IMIDAZOLE POLYAMIDES.CURRENT OPINION IN STRUCTURAL BIOLOGY. VOL. 13. ISSUE 3. P. 284-299 64 90% 400
8 KASHIWAZAKI, G , CHANDRAN, A , ASAMITSU, S , KAWASE, T , KAWAMOTO, Y , SAWATANI, Y , HASHIYA, K , BANDO, T , SUGIYAMA, H , (2016) COMPARATIVE ANALYSIS OF DNA-BINDING SELECTIVITY OF HAIRPIN AND CYCLIC PYRROLE-IMIDAZOLE POLYAMIDES BASED ON NEXT-GENERATION SEQUENCING.CHEMBIOCHEM. VOL. 17. ISSUE 18. P. 1752 -1758 67 94% 0
9 DERVAN, PB , POULIN-KERSTIEN, AT , FECHTER, EJ , EDELSON, BS , (2005) REGULATION OF GENE EXPRESSION BY SYNTHETIC DNA-BINDING LIGANDS.DNA BINDERS AND RELATED SUBJECTS. VOL. 253. ISSUE . P. 1 -31 84 87% 68
10 HE, GF , VASILIEVA, E , HARRIS, GD , KOELLER, KJ , DUPUREUR, CM , BASHKIN, JK , (2014) BINDING STUDIES OF A LARGE ANTIVIRAL POLYAMIDE TO A NATURAL HPV SEQUENCE.BIOCHIMIE. VOL. 102. ISSUE . P. 83 -91 55 93% 9

Classes with closest relation at Level 1


Rank Class id link
1 17114 DUOCARMYCIN//CC 1065//ADOZELESIN
2 15591 DIAMIDINES//PENTAMIDINE//AROMATIC DIAMIDINES
3 36153 ACTINOCIN//A2780 HUMAN OVARIAN CANCER//ACTINOCINE MONOAMIDES
4 9157 SABARUBICIN//BARMINOMYCIN//ACTINOMYCIN
5 27495 UM SYLVESTER BRAMAN FAMILY BREAST CANC//GCN4P//DNA PROMOTER ELEMENTS TRE AND CRE
6 19395 ECHINOMYCIN//STREPTOMYCES ALBOFLAVUS 313//PIPERAZIC ACID
7 2425 DNA CURVATURE//A TRACT//JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
8 28228 METAL COMPLEXES OF NUCLEIC ACIDS//ISING PROBLEM//INTERACTION OF LIGANDS WITH DNA
9 12831 PYRROLOBENZODIAZEPINE//PYRROLO2 1 C1 4BENZODIAZEPINES//CANC UK GENE TARGETED DRUG DESIGN GRP
10 14080 CALF THYMUS DNA//GROOVE BINDING//HERRING SPERM DNA

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