Class information for:
Level 1: DUOCARMYCIN//CC 1065//ADOZELESIN

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
17114 617 38.3 75%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
5 4 CHEMISTRY, ORGANIC//CHEMISTRY, INORGANIC & NUCLEAR//CHEMISTRY, MULTIDISCIPLINARY 1745167
9 3       CHEMISTRY, ORGANIC//JOURNAL OF HETEROCYCLIC CHEMISTRY//KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII 135847
1235 2             INDOLE//BISINDOLYLMETHANES//ELLIPTICINE 9055
17114 1                   DUOCARMYCIN//CC 1065//ADOZELESIN 617

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DUOCARMYCIN authKW 2680622 11% 83% 65
2 CC 1065 authKW 1156102 5% 81% 29
3 ADOZELESIN authKW 745241 3% 94% 16
4 BIZELESIN authKW 597399 2% 93% 13
5 DUOCARMYCIN SA authKW 445399 1% 100% 9
6 KW 2189 authKW 346422 1% 100% 7
7 CARZELESIN authKW 254512 1% 86% 6
8 DUOCARMYCIN A authKW 158363 1% 80% 4
9 AMINOCBI authKW 148466 0% 100% 3
10 CC 1065 ANTITUMOR ANTIBIOTIC authKW 148466 0% 100% 3

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Chemistry, Organic 4062 37% 0% 228
2 Chemistry, Medicinal 3463 23% 0% 139
3 Chemistry, Multidisciplinary 792 25% 0% 154
4 Pharmacology & Pharmacy 268 14% 0% 89
5 Oncology 267 13% 0% 78
6 Biochemistry & Molecular Biology 198 19% 0% 116
7 Toxicology 53 4% 0% 22
8 Microbiology 1 2% 0% 13
9 Biotechnology & Applied Microbiology 1 2% 0% 13
10 Parasitiology 0 0% 0% 3

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DNA INTERACT GRP 74230 0% 50% 3
2 CANC DRUG DNA INTERACT GRP 49489 0% 100% 1
3 CANC PHARMACOL COMPREHENS CANC 49489 0% 100% 1
4 FDN SETAGAYA KU 49489 0% 100% 1
5 ITSUU SETAGAYA KU 49489 0% 100% 1
6 NEW DRUG OFF 49489 0% 100% 1
7 ONCOL MED KLIN 49489 0% 100% 1
8 UCLA COMPREHENS CANC 49489 0% 100% 1
9 CANC UK DRUG 49487 0% 50% 2
10 ORGAN BIOMOL CHEM 36135 5% 3% 29

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BIOORGANIC & MEDICINAL CHEMISTRY 4115 5% 0% 33
2 ANTI-CANCER DRUG DESIGN 2830 1% 1% 6
3 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2642 12% 0% 71
4 JOURNAL OF ORGANIC CHEMISTRY 2567 8% 0% 52
5 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 1730 5% 0% 30
6 JOURNAL OF MEDICINAL CHEMISTRY 1188 4% 0% 23
7 HETEROCYCLIC COMMUNICATIONS 1116 1% 0% 6
8 JOURNAL OF ANTIBIOTICS 1052 2% 0% 12
9 CHEMICAL RESEARCH IN TOXICOLOGY 936 2% 0% 10
10 TETRAHEDRON LETTERS 928 6% 0% 38

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 DUOCARMYCIN 2680622 11% 83% 65 Search DUOCARMYCIN Search DUOCARMYCIN
2 CC 1065 1156102 5% 81% 29 Search CC+1065 Search CC+1065
3 ADOZELESIN 745241 3% 94% 16 Search ADOZELESIN Search ADOZELESIN
4 BIZELESIN 597399 2% 93% 13 Search BIZELESIN Search BIZELESIN
5 DUOCARMYCIN SA 445399 1% 100% 9 Search DUOCARMYCIN+SA Search DUOCARMYCIN+SA
6 KW 2189 346422 1% 100% 7 Search KW+2189 Search KW+2189
7 CARZELESIN 254512 1% 86% 6 Search CARZELESIN Search CARZELESIN
8 DUOCARMYCIN A 158363 1% 80% 4 Search DUOCARMYCIN+A Search DUOCARMYCIN+A
9 AMINOCBI 148466 0% 100% 3 Search AMINOCBI Search AMINOCBI
10 CC 1065 ANTITUMOR ANTIBIOTIC 148466 0% 100% 3 Search CC+1065+ANTITUMOR+ANTIBIOTIC Search CC+1065+ANTITUMOR+ANTIBIOTIC

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 BOGER, DL , JOHNSON, DS , (1996) CC-1065 AND THE DUOCARMYCINS: UNDERSTANDING THEIR BIOLOGICAL FUNCTION THROUGH MECHANISTIC STUDIES.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. VOL. 35. ISSUE 13-14. P. 1438 -1474 167 91% 224
2 BOGER, DL , BOYCE, CW , GARBACCIO, RM , GOLDBERG, JA , (1997) CC-1065 AND THE DUOCARMYCINS: SYNTHETIC STUDIES.CHEMICAL REVIEWS. VOL. 97. ISSUE 3. P. 787 -828 157 78% 193
3 UEMATSU, M , BRODY, DM , BOGER, DL , (2015) A FIVE-MEMBERED LACTONE PRODRUG OF CBI-BASED ANALOGS OF THE DUOCARMYCINS.TETRAHEDRON LETTERS. VOL. 56. ISSUE 23. P. 3101 -3104 77 95% 0
4 ROBERTSON, WM , KASTRINSKY, DB , HWANG, I , BOGER, DL , (2010) SYNTHESIS AND EVALUATION OF A SERIES OF C5 '-SUBSTITUTED DUOCARMYCIN SA ANALOGS.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. VOL. 20. ISSUE 9. P. 2722-2725 84 94% 3
5 GHOSH, N , SHELDRAKE, HM , SEARCEY, M , PORS, K , (2009) CHEMICAL AND BIOLOGICAL EXPLORATIONS OF THE FAMILY OF CC-1065 AND THE DUOCARMYCIN NATURAL PRODUCTS.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 9. ISSUE 16. P. 1494-1524 106 73% 15
6 MACMILLAN, KS , BOGER, DL , (2009) FUNDAMENTAL RELATIONSHIPS BETWEEN STRUCTURE, REACTIVITY, AND BIOLOGICAL ACTIVITY FOR THE DUOCARMYCINS AND CC-1065.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 52. ISSUE 19. P. 5771 -5780 77 95% 31
7 CHANDA, PB , BOYLE, KE , BRODY, DA , SHUKLA, V , BOGER, DL , (2016) SYNTHESIS AND EVALUATION OF DUOCARMYCIN SA ANALOGS INCORPORATING THE METHYL 1,2,8,8A-TETRAHYDROCYCLOPROPA[C]IMIDAZOLO[4,5-E]INDOL-4-ONE-6-CARBOXYLATE (CIMI) ALKYLATION SUBUNIT.BIOORGANIC & MEDICINAL CHEMISTRY. VOL. 24. ISSUE 20. P. 4779 -4786 71 95% 0
8 WOLFE, AL , DUNCAN, KK , PARELKAR, NK , WEIR, SJ , VIELHAUER, GA , BOGER, DL , (2012) A NOVEL, UNUSUALLY EFFICACIOUS DUOCARMYCIN CARBAMATE PRODRUG THAT RELEASES NO RESIDUAL BYPRODUCT.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 55. ISSUE 12. P. 5878 -5886 72 89% 19
9 JIN, W , TRZUPEK, JD , RAYL, TJ , BROWARD, MA , VIELHAUER, GA , WEIR, SJ , HWANG, I , BOGER, DL , (2007) A UNIQUE CLASS OF DUOCARMYCIN AND CC-1065 ANALOGUES SUBJECT TO REDUCTIVE ACTIVATION.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. VOL. 129. ISSUE 49. P. 15391 -15397 92 80% 23
10 WOLFE, AL , DUNCAN, KK , PARELKAR, NK , BROWN, D , VIELHAUER, GA , BOGER, DL , (2013) EFFICACIOUS CYCLIC N-ACYL O-AMINO PHENOL DUOCARMYCIN PRODRUGS.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 56. ISSUE 10. P. 4104 -4115 73 87% 5

Classes with closest relation at Level 1


Rank Class id link
1 36882 3H BENZOEINDOLES//CYCLOALKANE INDOLES//M PHENYLENEBISHYDRAZONE OF ETHYL PYRUVATE
2 3208 MINOR GROOVE BINDER//DISTAMYCIN//PYRROLE IMIDAZOLE POLYAMIDE
3 14540 ADEPT//NITROREDUCTASE//CB1954
4 12831 PYRROLOBENZODIAZEPINE//PYRROLO2 1 C1 4BENZODIAZEPINES//CANC UK GENE TARGETED DRUG DESIGN GRP
5 29160 PLURAMYCINS//HEDAMYCIN//ANTHRAPYRAN ANTIBIOTICS
6 29495 IROFULVEN//ILLUDINS//MGI 114
7 34581 MENOGARIL//DNA UNWINDING ACTIVITY//N O O TRIANGULAR PHARMACOPHORE
8 15678 TIRAPAZAMINE//BIOREDUCTIVE DRUGS//SR 4233
9 12399 KW 2149//MITOSENE//FR900482
10 24305 DFT B3LYP 3 21G METHOD//DFT B3LYP 6 31GD METHOD//1 2 3 4 1H TETRAZOLE

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