Class information for:
Level 1: PYRROLOBENZODIAZEPINE//PYRROLO2 1 C1 4BENZODIAZEPINES//CANC UK GENE TARGETED DRUG DESIGN GRP

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
12831 878 25.9 61%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
5 4 CHEMISTRY, ORGANIC//CHEMISTRY, INORGANIC & NUCLEAR//CHEMISTRY, MULTIDISCIPLINARY 1745167
9 3       CHEMISTRY, ORGANIC//JOURNAL OF HETEROCYCLIC CHEMISTRY//KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII 135847
2105 2             QUINOXALINE//1 5 BENZODIAZEPINES//1 5 BENZOTHIAZEPINE 5138
12831 1                   PYRROLOBENZODIAZEPINE//PYRROLO2 1 C1 4BENZODIAZEPINES//CANC UK GENE TARGETED DRUG DESIGN GRP 878

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PYRROLOBENZODIAZEPINE authKW 1908190 7% 84% 65
2 PYRROLO2 1 C1 4BENZODIAZEPINES authKW 776264 3% 89% 25
3 CANC UK GENE TARGETED DRUG DESIGN GRP address 528971 2% 89% 17
4 GENE TARGETED DRUG DESIGN GRP address 445137 2% 80% 16
5 SPIROGEN LTD address 281691 1% 90% 9
6 PYRROLOBENZODIAZEPINE DIMERS authKW 278215 1% 100% 8
7 SJG 136 authKW 247300 1% 89% 8
8 GENE TARGETING DRUG DESIGN GRP address 178851 1% 86% 6
9 PYRROLO1 4BENZODIAZEPINES authKW 178851 1% 86% 6
10 CRC GENE TARGETED DRUG DESIGN GRP address 173884 1% 100% 5

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Chemistry, Organic 16700 62% 0% 540
2 Chemistry, Medicinal 3911 20% 0% 177
3 Pharmacology & Pharmacy 211 12% 0% 101
4 Chemistry, Multidisciplinary 85 9% 0% 83
5 Chemistry, Applied 12 2% 0% 17
6 Microbiology 12 3% 0% 27
7 Crystallography 10 2% 0% 14
8 Biochemistry & Molecular Biology 10 8% 0% 70
9 Biotechnology & Applied Microbiology 5 3% 0% 23
10 Oncology 4 3% 0% 30

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CANC UK GENE TARGETED DRUG DESIGN GRP 528971 2% 89% 17
2 GENE TARGETED DRUG DESIGN GRP 445137 2% 80% 16
3 SPIROGEN LTD 281691 1% 90% 9
4 GENE TARGETING DRUG DESIGN GRP 178851 1% 86% 6
5 CRC GENE TARGETED DRUG DESIGN GRP 173884 1% 100% 5
6 YORKSHIRE CANC DRUG DESIGN 134129 1% 43% 9
7 EA IMT 6306 104331 0% 100% 3
8 UATRS ANGLE ALLAL FASSI FAR 104331 0% 100% 3
9 CANC UK DRUG DNA INTERACT GRP 90399 1% 20% 13
10 CR UK DRUG DNA INTERACT GRP 86937 1% 50% 5

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF HETEROCYCLIC CHEMISTRY 27090 10% 1% 92
2 FARMACO-EDIZIONE SCIENTIFICA 10708 2% 2% 16
3 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 4911 7% 0% 60
4 FARMACO 4447 2% 1% 15
5 TETRAHEDRON LETTERS 3277 10% 0% 84
6 TETRAHEDRON 2887 6% 0% 56
7 HETEROCYCLES 2661 4% 0% 32
8 HETEROCYCLIC COMMUNICATIONS 2181 1% 1% 10
9 JOURNAL OF MEDICINAL CHEMISTRY 1937 4% 0% 35
10 JOURNAL OF ANTIBIOTICS 1665 2% 0% 18

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 PYRROLOBENZODIAZEPINE 1908190 7% 84% 65 Search PYRROLOBENZODIAZEPINE Search PYRROLOBENZODIAZEPINE
2 PYRROLO2 1 C1 4BENZODIAZEPINES 776264 3% 89% 25 Search PYRROLO2+1+C1+4BENZODIAZEPINES Search PYRROLO2+1+C1+4BENZODIAZEPINES
3 PYRROLOBENZODIAZEPINE DIMERS 278215 1% 100% 8 Search PYRROLOBENZODIAZEPINE+DIMERS Search PYRROLOBENZODIAZEPINE+DIMERS
4 SJG 136 247300 1% 89% 8 Search SJG+136 Search SJG+136
5 PYRROLO1 4BENZODIAZEPINES 178851 1% 86% 6 Search PYRROLO1+4BENZODIAZEPINES Search PYRROLO1+4BENZODIAZEPINES
6 PBDS 173884 1% 100% 5 Search PBDS Search PBDS
7 PYRROLOBENZOTHIADIAZEPINE 173884 1% 100% 5 Search PYRROLOBENZOTHIADIAZEPINE Search PYRROLOBENZOTHIADIAZEPINE
8 DNA BINDING AFFINITY 170084 2% 33% 15 Search DNA+BINDING+AFFINITY Search DNA+BINDING+AFFINITY
9 DNA BINDING ABILITY 158973 1% 57% 8 Search DNA+BINDING+ABILITY Search DNA+BINDING+ABILITY
10 1 4 BENZODIAZEPINE 151192 1% 43% 10 Search 1+4+BENZODIAZEPINE Search 1+4+BENZODIAZEPINE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 ANTONOW, D , THURSTON, DE , (2011) SYNTHESIS OF DNA-INTERACTIVE PYRROLO[2,1-C][1,4]BENZODIAZEPINES (PBDS).CHEMICAL REVIEWS. VOL. 111. ISSUE 4. P. 2815 -2864 166 87% 47
2 GERRATANA, B , (2012) BIOSYNTHESIS, SYNTHESIS, AND BIOLOGICAL ACTIVITIES OF PYRROLOBENZODIAZEPINES.MEDICINAL RESEARCH REVIEWS. VOL. 32. ISSUE 2. P. 254 -293 102 78% 24
3 VARVOUNIS, G , (2016) AN UPDATE ON THE SYNTHESIS OF PYRROLO[1,4]BENZODIAZEPINES.MOLECULES. VOL. 21. ISSUE 2. P. - 68 79% 0
4 CIPOLLA, L , ARAUJO, AC , AIROLDI, C , BINI, D , (2009) PYRROLO[2,1-C][1,4]BENZODIAZEPINE AS A SCAFFOLD FOR THE DESIGN AND SYNTHESIS OF ANTI-TUMOUR DRUGS.ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY. VOL. 9. ISSUE 1. P. 1-31 84 67% 40
5 THURSTON, DE , BOSE, DS , (1994) SYNTHESIS OF DNA-INTERACTIVE PYRROLO[2,1-C][1,4]BENZODIAZEPINES.CHEMICAL REVIEWS. VOL. 94. ISSUE 2. P. 433-465 87 85% 226
6 GILL, RK , KAUSHIK, SO , CHUGH, J , BANSAL, S , SHAH, A , BARIWAL, J , (2014) RECENT DEVELOPMENT IN [1,4]BENZODIAZEPINES AS POTENT ANTICANCER AGENTS: A REVIEW.MINI-REVIEWS IN MEDICINAL CHEMISTRY. VOL. 14. ISSUE 3. P. 229 -256 64 57% 1
7 JACKSON, PJM , JAMES, CH , JENKINS, TC , RAHMAN, KM , THURSTON, DE , (2014) COMPUTATIONAL STUDIES SUPPORT THE ROLE OF THE C7-SIBIROSAMINE SUGAR OF THE PYRROLOBENZODIAZEPINE (PBD) SIBIROMYCIN IN TRANSCRIPTION FACTOR INHIBITION.ACS CHEMICAL BIOLOGY. VOL. 9. ISSUE 10. P. 2432 -2440 41 87% 2
8 HARTLEY, JA , (2011) THE DEVELOPMENT OF PYRROLOBENZODIAZEPINES AS ANTITUMOUR AGENTS.EXPERT OPINION ON INVESTIGATIONAL DRUGS. VOL. 20. ISSUE 6. P. 733 -744 43 73% 26
9 KAMAL, A , AZEEZA, S , BHARATHI, EV , MALIK, MS , SHETTI, RVCRNC , (2010) SEARCH FOR NEW AND NOVEL CHEMOTHERAPEUTICS FOR THE TREATMENT OF HUMAN MALIGNANCIES.MINI-REVIEWS IN MEDICINAL CHEMISTRY. VOL. 10. ISSUE 5. P. 405-435 84 39% 15
10 RAHMAN, KM , JAMES, CH , BUI, TTT , DRAKE, AF , THURSTON, DE , (2011) OBSERVATION OF A SINGLE-STRANDED DNA/PYRROLOBENZODIAZEPINE ADDUCT.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. VOL. 133. ISSUE 48. P. 19376-19385 35 88% 6

Classes with closest relation at Level 1


Rank Class id link
1 27759 ARDEEMIN//ALANTRYPINONE//ASZONALENIN
2 28071 1 RUE VAUBENARD//UER SCI PHARMACEUT//TRIPENTONE
3 12300 1 5 BENZODIAZEPINES//O PHENYLENEDIAMINES//5 BENZODIAZEPINES
4 26181 NITRILIMINE CYCLOADDITION//PENTALENES DIHETERO//CONJUGATED AZOMETHINE YLIDE
5 17114 DUOCARMYCIN//CC 1065//ADOZELESIN
6 28709 HORMAOMYCIN//CLINDAMYCIN//D ERYTHRO ASCORBIC ACID
7 29228 DRUG DESIGN SYNTH//GUANINE DEAMINASE//ORGANIC SYNTHESIS AND MEDICINAL CHEMISTRY
8 3208 MINOR GROOVE BINDER//DISTAMYCIN//PYRROLE IMIDAZOLE POLYAMIDE
9 12773 ISOINDOLINONES//LENNOXAMINE//CHILENINE
10 36569 ANTIBIOTIC ASSOCIATED HEMORRHAGIC COLITIS//NONPSEUDOMEMBRANOUS COLITIS//ANTIBIOTIC ASSOCIATED AND HAEMORRHAGIC COLITIS

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