Class information for:
Level 1: HISTIDINE BIOSYNTHESIS//BETA ALPHA8 BARREL//INDOLE 3 GLYCEROL PHOSPHATE SYNTHASE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
22175 391 38.5 69%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
278 3       CORYNEBACTERIUM GLUTAMICUM//ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY//BIOCHEMISTRY & MOLECULAR BIOLOGY 43163
2622 2             TRIOSEPHOSPHATE ISOMERASE//HISTIDINE BIOSYNTHESIS//KETOSTEROID ISOMERASE 3550
22175 1                   HISTIDINE BIOSYNTHESIS//BETA ALPHA8 BARREL//INDOLE 3 GLYCEROL PHOSPHATE SYNTHASE 391

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 HISTIDINE BIOSYNTHESIS authKW 1530640 7% 70% 28
2 BETA ALPHA8 BARREL authKW 550453 4% 41% 17
3 INDOLE 3 GLYCEROL PHOSPHATE SYNTHASE authKW 382660 2% 70% 7
4 HISTIDINOL DEHYDROGENASE authKW 372090 2% 53% 9
5 ATP PHOSPHORIBOSYLTRANSFERASE authKW 312379 1% 100% 4
6 TRPF authKW 249902 1% 80% 4
7 TRYPTOPHAN BIOSYNTHESIS authKW 248999 3% 25% 13
8 BETA ALPHA8 BARREL PROTEINS authKW 244042 1% 63% 5
9 OPERON EVOLUTION authKW 244042 1% 63% 5
10 ALPHA BETA8 BARREL ENZYME authKW 234284 1% 100% 3

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Biochemistry & Molecular Biology 2571 66% 0% 257
2 Biophysics 611 15% 0% 59
3 Genetics & Heredity 292 13% 0% 49
4 Microbiology 224 11% 0% 44
5 Biochemical Research Methods 139 7% 0% 28
6 Cell Biology 104 10% 0% 40
7 Chemistry, Medicinal 75 5% 0% 19
8 Evolutionary Biology 52 3% 0% 11
9 Crystallography 46 4% 0% 14
10 Biotechnology & Applied Microbiology 33 5% 0% 21

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DIPARTIMENTO BIOL CELLULARE SVILUPPO VIALE SCI 156189 1% 100% 2
2 ECOLE SUPER CHIM MONTPELLIERIBMMUMR 5247 156189 1% 100% 2
3 MED 2 IST PATOL GEN CATTEDRA MICROBIOL 156189 1% 100% 2
4 EVOLUT METAB ERS 124947 1% 40% 4
5 ABT STRUKTURBIOL ABT BIOPHYS CHEM 78095 0% 100% 1
6 BACTERIAL GENET GRP 78095 0% 100% 1
7 BIOMOL MAX MOUSSERONECOLE SUPER CHIM M 78095 0% 100% 1
8 BIOZENTRUM ABT STRUKTURBIOL 78095 0% 100% 1
9 BMGE UNIT 78095 0% 100% 1
10 CAMM KANSAI 78095 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BIOMOLECULAR ENGINEERING 2092 1% 1% 3
2 PROTEIN SCIENCE 2086 3% 0% 13
3 JOURNAL OF MOLECULAR BIOLOGY 1747 6% 0% 23
4 MOLECULAR AND GENERAL GENETICS 1611 3% 0% 10
5 PROTEIN ENGINEERING 1234 2% 0% 6
6 JOURNAL OF BACTERIOLOGY 1217 6% 0% 23
7 PROTEIN ENGINEERING DESIGN & SELECTION 1196 1% 0% 4
8 ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 1124 2% 0% 8
9 STRUCTURE 997 2% 0% 7
10 JOURNAL OF MOLECULAR EVOLUTION 993 2% 0% 7

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 HISTIDINE BIOSYNTHESIS 1530640 7% 70% 28 Search HISTIDINE+BIOSYNTHESIS Search HISTIDINE+BIOSYNTHESIS
2 BETA ALPHA8 BARREL 550453 4% 41% 17 Search BETA+ALPHA8+BARREL Search BETA+ALPHA8+BARREL
3 INDOLE 3 GLYCEROL PHOSPHATE SYNTHASE 382660 2% 70% 7 Search INDOLE+3+GLYCEROL+PHOSPHATE+SYNTHASE Search INDOLE+3+GLYCEROL+PHOSPHATE+SYNTHASE
4 HISTIDINOL DEHYDROGENASE 372090 2% 53% 9 Search HISTIDINOL+DEHYDROGENASE Search HISTIDINOL+DEHYDROGENASE
5 ATP PHOSPHORIBOSYLTRANSFERASE 312379 1% 100% 4 Search ATP+PHOSPHORIBOSYLTRANSFERASE Search ATP+PHOSPHORIBOSYLTRANSFERASE
6 TRPF 249902 1% 80% 4 Search TRPF Search TRPF
7 TRYPTOPHAN BIOSYNTHESIS 248999 3% 25% 13 Search TRYPTOPHAN+BIOSYNTHESIS Search TRYPTOPHAN+BIOSYNTHESIS
8 BETA ALPHA8 BARREL PROTEINS 244042 1% 63% 5 Search BETA+ALPHA8+BARREL+PROTEINS Search BETA+ALPHA8+BARREL+PROTEINS
9 OPERON EVOLUTION 244042 1% 63% 5 Search OPERON+EVOLUTION Search OPERON+EVOLUTION
10 ALPHA BETA8 BARREL ENZYME 234284 1% 100% 3 Search ALPHA+BETA8+BARREL+ENZYME Search ALPHA+BETA8+BARREL+ENZYME

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 LUNARDI, J , NUNES, JES , BIZARRO, CV , BASSO, LA , SANTOS, DS , MACHADO, P , (2013) TARGETING THE HISTIDINE PATHWAY IN MYCOBACTERIUM TUBERCULOSIS.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 13. ISSUE 22. P. 2866-2884 54 53% 5
2 LIST, F , STERNER, R , WILMANNS, M , (2011) RELATED (BETA ALPHA)(8)-BARREL PROTEINS IN HISTIDINE AND TRYPTOPHAN BIOSYNTHESIS: A PARADIGM TO STUDY ENZYME EVOLUTION.CHEMBIOCHEM. VOL. 12. ISSUE 10. P. 1487-1494 35 76% 6
3 SPERL, JM , ROHWEDER, B , RAJENDRAN, C , STERNER, R , (2013) ESTABLISHING CATALYTIC ACTIVITY ON AN ARTIFICIAL (BETA ALPHA)(8)-BARREL PROTEIN DESIGNED FROM IDENTICAL HALF-BARRELS.FEBS LETTERS. VOL. 587. ISSUE 17. P. 2798-2805 28 57% 2
4 HOCKER, B , (2014) DESIGN OF PROTEINS FROM SMALLER FRAGMENTS - LEARNING FROM EVOLUTION.CURRENT OPINION IN STRUCTURAL BIOLOGY. VOL. 27. ISSUE . P. 56 -62 24 59% 12
5 MONTI, SM , DE SIMONE, G , D'AMBROSIO, K , (2016) L-HISTIDINOL DEHYDROGENASE AS A NEW TARGET FOR OLD DISEASES.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 16. ISSUE 21. P. 2369 -2378 21 66% 0
6 ZACCARDI, MJ , YEZDIMER, EM , BOEHR, DD , (2013) FUNCTIONAL IDENTIFICATION OF THE GENERAL ACID AND BASE IN THE DEHYDRATION STEP OF INDOLE-3-GLYCEROL PHOSPHATE SYNTHASE CATALYSIS.JOURNAL OF BIOLOGICAL CHEMISTRY. VOL. 288. ISSUE 37. P. 26350-26356 17 85% 0
7 EVRAN, S , TELEFONCU, A , STERNER, R , (2012) DIRECTED EVOLUTION OF ()(8)-BARREL ENZYMES: ESTABLISHING PHOSPHORIBOSYLANTHRANILATE ISOMERISATION ACTIVITY ON THE SCAFFOLD OF THE TRYPTOPHAN SYNTHASE -SUBUNIT.PROTEIN ENGINEERING DESIGN & SELECTION. VOL. 25. ISSUE 6. P. 285-293 26 54% 5
8 CLAREN, J , MALISI, C , HOCKER, B , STERNER, R , (2009) ESTABLISHING WILD-TYPE LEVELS OF CATALYTIC ACTIVITY ON NATURAL AND ARTIFICIAL (BETA ALPHA)(8)-BARREL PROTEIN SCAFFOLDS.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. VOL. 106. ISSUE 10. P. 3704-3709 22 65% 24
9 AHANGAR, MS , VYAS, R , NASIR, N , BISWAL, BK , (2013) STRUCTURES OF NATIVE, SUBSTRATE-BOUND AND INHIBITED FORMS OF MYCOBACTERIUM TUBERCULOSIS IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE.ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY. VOL. 69. ISSUE . P. 2461-2467 19 68% 4
10 DUE, AV , KUPER, J , GEERLOF, A , VON KRIES, JP , WILMANNS, M , (2011) BISUBSTRATE SPECIFICITY IN HISTIDINE/TRYPTOPHAN BIOSYNTHESIS ISOMERASE FROM MYCOBACTERIUM TUBERCULOSIS BY ACTIVE SITE METAMORPHOSIS.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. VOL. 108. ISSUE 9. P. 3554 -3559 15 79% 23

Classes with closest relation at Level 1


Rank Class id link
1 17636 TRIOSEPHOSPHATE ISOMERASE//TRIOSEPHOSPHATE ISOMERASE DEFICIENCY//BIOQUIM BIOL ESTRUCT
2 24744 MANDELATE RACEMASE//MANDELATE RACEMASE EC 5122//ENOLASE SUPERFAMILY
3 9861 ANTHRANILATE SYNTHASE//CHORISMATE MUTASE//CHORISMATE
4 4994 PROTEIN STRUCTURE COMPARISON//PROTEIN STRUCTURE ALIGNMENT//STRUCTURE COMPARISON
5 25675 PROTEIN SWITCH//CIRCULAR PERMUTATION//BIOMED ST PAU IIB SANTPAU
6 15558 TYROSINE PHENOL LYASE//TRYPTOPHAN SYNTHASE//TRYPTOPHANASE
7 24117 EVOLUTIONARY BIOINFORMAT//FOLD SUPERFAMILY//EVOLUTION OF DOMAIN ARCHITECTURE
8 12643 PSYCHROPHILE//COLD ADAPTATION//THERMOPHILIC PROTEIN
9 13291 COMPUTATIONAL PROTEIN DESIGN//PROTEIN DESIGN//DEAD END ELIMINATION
10 15693 PHOSPHORIBOSYLTRANSFERASE//MOL PARASITOL DRUG DESIGN//PURINE SALVAGE

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