Class information for:
Level 1: PHOSPHORIBOSYLTRANSFERASE//MOL PARASITOL DRUG DESIGN//PURINE SALVAGE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
15693 697 31.8 55%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
236 3       ADENOSINE//NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS//ADENOSINE RECEPTORS 48331
1752 2             LESCH NYHAN SYNDROME//AMP DEAMINASE//LESCH NYHAN DISEASE 6485
15693 1                   PHOSPHORIBOSYLTRANSFERASE//MOL PARASITOL DRUG DESIGN//PURINE SALVAGE 697

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PHOSPHORIBOSYLTRANSFERASE authKW 887088 5% 56% 36
2 MOL PARASITOL DRUG DESIGN address 528828 2% 93% 13
3 PURINE SALVAGE authKW 162511 2% 23% 16
4 PYRAZOLO3 4 CPYRIDINE authKW 140185 1% 80% 4
5 HYPOXANTHINE GUANINE PHOSPHORIBOSYLTRANSFERASE authKW 129672 2% 20% 15
6 ARTHUR F SCOTT CHEM address 116820 1% 67% 4
7 PFHGXPRT authKW 98567 0% 75% 3
8 ADENINE PHOSPHORIBOSYLTRANSFERASE authKW 93194 1% 21% 10
9 5 PHOSPHORIBOSYL ALPHA 1 PYROPHOSPHATE authKW 87617 0% 100% 2
10 STETIZ STRUCT BIOL address 87617 0% 100% 2

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Parasitiology 4902 16% 0% 113
2 Biochemistry & Molecular Biology 3458 58% 0% 403
3 Biophysics 718 12% 0% 87
4 Chemistry, Organic 184 9% 0% 62
5 Tropical Medicine 118 2% 0% 15
6 Microbiology 101 6% 0% 45
7 Chemistry, Medicinal 100 4% 0% 30
8 Pharmacology & Pharmacy 73 9% 0% 60
9 Biochemical Research Methods 34 3% 0% 23
10 Crystallography 25 2% 0% 16

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MOL PARASITOL DRUG DESIGN 528828 2% 93% 13
2 ARTHUR F SCOTT CHEM 116820 1% 67% 4
3 STETIZ STRUCT BIOL 87617 0% 100% 2
4 FELS 75485 1% 19% 9
5 BIOL 100 WASHINGTON SQ 43808 0% 100% 1
6 DIPARTIMENTO FARMACO CHIM TENOL 43808 0% 100% 1
7 DRUG DSICOVERY 43808 0% 100% 1
8 DYNAM MOL BIOL STRUCTURALE JEAN PIERRE E 43808 0% 100% 1
9 EA 3741 PARASITOL 43808 0% 100% 1
10 EA PHARMACOCHIM BIOMOL CHIM ORGAN PHARMACEU 43808 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MOLECULAR AND BIOCHEMICAL PARASITOLOGY 25918 8% 1% 58
2 NUCLEOSIDES & NUCLEOTIDES 3214 1% 1% 7
3 BIOCHEMISTRY 2899 9% 0% 60
4 EXPERIMENTAL PARASITOLOGY 2525 2% 0% 17
5 NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS 1333 2% 0% 12
6 INTERNATIONAL JOURNAL FOR PARASITOLOGY 839 1% 0% 10
7 BIOCHEMICAL PHARMACOLOGY 827 3% 0% 19
8 AUSTRALIAN JOURNAL OF EXPERIMENTAL BIOLOGY AND MEDICAL SCIENCE 824 0% 1% 3
9 JOURNAL OF PROTOZOOLOGY 708 1% 0% 5
10 BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS 671 1% 0% 7

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 PHOSPHORIBOSYLTRANSFERASE 887088 5% 56% 36 Search PHOSPHORIBOSYLTRANSFERASE Search PHOSPHORIBOSYLTRANSFERASE
2 PURINE SALVAGE 162511 2% 23% 16 Search PURINE+SALVAGE Search PURINE+SALVAGE
3 PYRAZOLO3 4 CPYRIDINE 140185 1% 80% 4 Search PYRAZOLO3+4+CPYRIDINE Search PYRAZOLO3+4+CPYRIDINE
4 HYPOXANTHINE GUANINE PHOSPHORIBOSYLTRANSFERASE 129672 2% 20% 15 Search HYPOXANTHINE+GUANINE+PHOSPHORIBOSYLTRANSFERASE Search HYPOXANTHINE+GUANINE+PHOSPHORIBOSYLTRANSFERASE
5 PFHGXPRT 98567 0% 75% 3 Search PFHGXPRT Search PFHGXPRT
6 ADENINE PHOSPHORIBOSYLTRANSFERASE 93194 1% 21% 10 Search ADENINE+PHOSPHORIBOSYLTRANSFERASE Search ADENINE+PHOSPHORIBOSYLTRANSFERASE
7 5 PHOSPHORIBOSYL ALPHA 1 PYROPHOSPHATE 87617 0% 100% 2 Search 5+PHOSPHORIBOSYL+ALPHA+1+PYROPHOSPHATE Search 5+PHOSPHORIBOSYL+ALPHA+1+PYROPHOSPHATE
8 ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE 78853 0% 60% 3 Search ANTHRANILATE+PHOSPHORIBOSYLTRANSFERASE Search ANTHRANILATE+PHOSPHORIBOSYLTRANSFERASE
9 GTP ACTIVATION 78853 0% 60% 3 Search GTP+ACTIVATION Search GTP+ACTIVATION
10 PYRAZOLO4 3 BPYRIDINE 78853 0% 60% 3 Search PYRAZOLO4+3+BPYRIDINE Search PYRAZOLO4+3+BPYRIDINE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 EL KOUNI, MH , (2003) POTENTIAL CHEMOTHERAPEUTIC TARGETS IN THE PURINE METABOLISM OF PARASITES.PHARMACOLOGY & THERAPEUTICS. VOL. 99. ISSUE 3. P. 283-309 89 46% 79
2 SCHRAMM, VL , GRUBMEYER, C , (2004) PHOSPHORIBOSYLTRANSFEROSE MECHANISMS AND ROLES IN NUCLEIC ACID METABOLISM.PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY, VOL 78. VOL. 78. ISSUE . P. 261-+ 60 65% 24
3 HASSAN, HF , COOMBS, GH , (1988) PURINE AND PYRIMIDINE METABOLISM IN PARASITIC PROTOZOA.FEMS MICROBIOLOGY LETTERS. VOL. 54. ISSUE 1. P. 47 -84 94 59% 55
4 DANTAS, DD , DOS SANTOS, CR , GUIMARAES PEREIRA, GA , MEDRANO, FJ , (2008) BIOCHEMICAL AND STRUCTURAL CHARACTERIZATION OF THE HYPOXANTHINE-GUANINE-XANTHINE PHOSPHORIBOSYLTRANSFERASE FROM PYROCOCCUS HORIKOSHII.BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS. VOL. 1784. ISSUE 6. P. 953 -960 32 84% 1
5 ROY, S , NAGAPPA, LK , PRAHLADARAO, VS , BALARAM, H , (2015) KINETIC MECHANISM OF PLASMODIUM FALCIPARUM HYPOXANTHINE-GUANINE-XANTHINE PHOSPHORIBOSYLTRANSFERASE.MOLECULAR AND BIOCHEMICAL PARASITOLOGY. VOL. 204. ISSUE 2. P. 111 -120 27 84% 0
6 ULLMAN, B , CYR, N , CHOI, K , JARDIM, A , (2010) ACIDIC RESIDUES IN THE PURINE BINDING SITE GOVERN THE 6-OXOPURINE SPECIFICITY OF THE LEISHMANIA DONOVANI XANTHINE PHOSPHORIBOSYLTRANSFERASE.INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. VOL. 42. ISSUE 2. P. 253-262 35 71% 2
7 ROY, S , KARMAKAR, T , RAO, VSP , NAGAPPA, LK , BALASUBRAMANIAN, S , BALARAM, H , (2015) SLOW LIGAND-INDUCED CONFORMATIONAL SWITCH INCREASES THE CATALYTIC RATE IN PLASMODIUM FALCIPARUM HYPOXANTHINE GUANINE XANTHINE PHOSPHORIBOSYLTRANSFERASE.MOLECULAR BIOSYSTEMS. VOL. 11. ISSUE 5. P. 1410 -1424 40 56% 0
8 CHEN, Q , LIANG, YH , SU, XD , GU, XC , ZHENG, XF , LUO, M , (2005) ALTERNATIVE IMP BINDING IN FEEDBACK INHIBITION OF HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE FROM THERMOANAEROBACTER TENGCONGENSIS.JOURNAL OF MOLECULAR BIOLOGY. VOL. 348. ISSUE 5. P. 1199-1210 35 74% 12
9 SARVER, AE , WANG, CC , (2002) THE ADENINE PHOSPHORIBOSYLTRANSFERASE FROM GIARDIA LAMBLIA HAS A UNIQUE REACTION MECHANISM AND UNUSUAL SUBSTRATE BINDING PROPERTIES.JOURNAL OF BIOLOGICAL CHEMISTRY. VOL. 277. ISSUE 42. P. 39973-39980 31 91% 6
10 CANYUK, B , MEDRANO, FJ , WENCK, MA , FOCIA, PJ , EAKIN, AE , CRAIG, SP , (2004) INTERACTIONS AT THE DIMER INTERFACE INFLUENCE THE RELATIVE EFFICIENCIES FOR PURINE NUCLEOTIDE SYNTHESIS AND PYROPHOSPHOROLYSIS IN A PHOSPHORIBOSYLTRANSFERASE.JOURNAL OF MOLECULAR BIOLOGY. VOL. 335. ISSUE 4. P. 905-921 31 84% 17

Classes with closest relation at Level 1


Rank Class id link
1 9868 PURINE NUCLEOSIDE PHOSPHORYLASE//CARBOHYDRATE CHEM TEAM//NUCLEOSIDE HYDROLASE
2 24160 ODCASE//OROTIDINE 5 MONOPHOSPHATE DECARBOXYLASE//MOL DESIGN PREFORMULAT
3 15139 LESCH NYHAN SYNDROME//LESCH NYHAN DISEASE//LESCH NYHAN
4 32029 APRT DEFICIENCY//ADENINE PHOSPHORIBOSYLTRANSFERASE DEFICIENCY//2 8 DIHYDROXYADENINE
5 24376 PHOSPHORIBOSYLPYROPHOSPHATE SYNTHETASE//NUCLEOTIDE SYNTHESIS//PRPP SYNTHETASE
6 20226 RIBOKINASE//ADENOSINE KINASE//D GLUCOSE DEHYDROGENASE
7 17554 7H 1 2 4 TRIAZOLO1 5 DTETRAZOL 6 YLSULFANYL ACETIC ACID HYDRAZIDE//APIOSHOWDOMYCIN//CYCLIC AMIDRAZONES
8 14372 PURINE BIOSYNTHESIS//ADENYLOSUCCINATE LYASE//ADENYLOSUCCINATE LYASE DEFICIENCY
9 13361 GLYCOSOME//UNIDAD BIOQUIM PARASITOS//TROP DIS UNIT
10 6949 NUCLEOSIDE TRANSPORT//NUCLEOSIDE TRANSPORTER//NITROBENZYLTHIOINOSINE

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