Class information for:
Level 1: CARBOXYLESTERASE//DRUG METAB BIOPHARMACEUT//CES2

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
12461 904 33.2 64%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
11 4 NEUROSCIENCES//CLINICAL NEUROLOGY//NEUROL 1112395
471 3       ACETYLCHOLINESTERASE//PARAOXONASE//SULFUR MUSTARD 23986
3716 2             CARBOXYLESTERASE//DRUG METAB BIOPHARMACEUT//CES2 1078
12461 1                   CARBOXYLESTERASE//DRUG METAB BIOPHARMACEUT//CES2 904

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CARBOXYLESTERASE authKW 1450026 19% 25% 172
2 DRUG METAB BIOPHARMACEUT address 243182 1% 60% 12
3 CES2 authKW 202659 1% 100% 6
4 HUMAN CARBOXYLESTERASE 2 authKW 202659 1% 100% 6
5 CES1 authKW 195415 1% 64% 9
6 CARBOXYLESTERASE 2 authKW 166278 1% 62% 8
7 ARYLACETAMIDE DEACETYLASE authKW 165501 1% 70% 7
8 HUMAN CARBOXYLESTERASE 1 authKW 140734 1% 83% 5
9 CES1A2 authKW 135106 0% 100% 4
10 DRUG HYDROLYSIS authKW 108083 0% 80% 4

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Pharmacology & Pharmacy 3743 38% 0% 346
2 Biochemistry & Molecular Biology 1286 34% 0% 303
3 Toxicology 604 8% 0% 76
4 Biophysics 427 9% 0% 80
5 Chemistry, Medicinal 391 7% 0% 62
6 Genetics & Heredity 191 7% 0% 67
7 Zoology 53 3% 0% 31
8 Entomology 47 2% 0% 20
9 Chemistry, Multidisciplinary 29 7% 0% 63
10 Biochemical Research Methods 29 3% 0% 26

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DRUG METAB BIOPHARMACEUT 243182 1% 60% 12
2 PHARMACOGENOM MOL THER Y 105548 1% 63% 5
3 PHARMACOGEN MOL THER Y 76759 1% 45% 5
4 DRUG METAB TOXICOL 48667 1% 21% 7
5 CIHR GRP MOL CELL BIOL LIPIDS 43418 1% 21% 6
6 BIOMED PHAMACEUT SCI 33777 0% 100% 1
7 BIOSIGNALING ENVIRONM CHEM EXPOSURE ASS 33777 0% 100% 1
8 BUSAN BRANCH FORENS CHEM 33777 0% 100% 1
9 EXPTL EMBRYOL TERATOL UNIT 33777 0% 100% 1
10 GRP PHARMCOL CLIN EXPT EA 3035 33777 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DRUG METABOLISM AND DISPOSITION 17258 7% 1% 62
2 BIOCHEMICAL GENETICS 9481 3% 1% 25
3 BIOCHEMICAL PHARMACOLOGY 5679 6% 0% 56
4 REVIEWS IN BIOCHEMICAL TOXICOLOGY 5626 0% 8% 2
5 RESEARCH COMMUNICATIONS IN ALCOHOL AND SUBSTANCES OF ABUSE 3138 0% 5% 2
6 DOKLADY BIOCHEMISTRY AND BIOPHYSICS 3049 1% 1% 9
7 XENOBIOTICA 2799 2% 0% 18
8 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS 1326 0% 1% 4
9 DRUG METABOLISM AND PHARMACOKINETICS 1161 1% 1% 5
10 KOREAN JOURNAL OF BIOCHEMISTRY 1088 0% 3% 1

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 CARBOXYLESTERASE 1450026 19% 25% 172 Search CARBOXYLESTERASE Search CARBOXYLESTERASE
2 CES2 202659 1% 100% 6 Search CES2 Search CES2
3 HUMAN CARBOXYLESTERASE 2 202659 1% 100% 6 Search HUMAN+CARBOXYLESTERASE+2 Search HUMAN+CARBOXYLESTERASE+2
4 CES1 195415 1% 64% 9 Search CES1 Search CES1
5 CARBOXYLESTERASE 2 166278 1% 62% 8 Search CARBOXYLESTERASE+2 Search CARBOXYLESTERASE+2
6 ARYLACETAMIDE DEACETYLASE 165501 1% 70% 7 Search ARYLACETAMIDE+DEACETYLASE Search ARYLACETAMIDE+DEACETYLASE
7 HUMAN CARBOXYLESTERASE 1 140734 1% 83% 5 Search HUMAN+CARBOXYLESTERASE+1 Search HUMAN+CARBOXYLESTERASE+1
8 CES1A2 135106 0% 100% 4 Search CES1A2 Search CES1A2
9 DRUG HYDROLYSIS 108083 0% 80% 4 Search DRUG+HYDROLYSIS Search DRUG+HYDROLYSIS
10 CES1A1 101330 0% 100% 3 Search CES1A1 Search CES1A1

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 HOSOKAWA, M , (2008) STRUCTURE AND CATALYTIC PROPERTIES OF CARBOXYLESTERASE ISOZYMES INVOLVED IN METABOLIC ACTIVATION OF PRODRUGS.MOLECULES. VOL. 13. ISSUE 2. P. 412-431 79 84% 103
2 SATOH, T , HOSOKAWA, M , (2009) CARBOXYLESTERASES: STRUCTURE, FUNCTION AND POLYMORPHISM.BIOMOLECULES & THERAPEUTICS. VOL. 17. ISSUE 4. P. 335-347 82 81% 2
3 SATOH, T , HOSOKAWA, M , (1998) THE MAMMALIAN CARBOXYLESTERASES: FROM MOLECULES TO FUNCTIONS.ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY. VOL. 38. ISSUE . P. 257-288 94 62% 435
4 SATOH, T , HOSOKAWA, M , (2010) CARBOXYLESTERASES: STRUCTURE, FUNCTION AND POLYMORPHISM IN MAMMALS.JOURNAL OF PESTICIDE SCIENCE. VOL. 35. ISSUE 3. P. 218-228 78 80% 10
5 SATOH, T , HOSOKAWA, M , (2006) STRUCTURE, FUNCTION AND REGULATION OF CARBOXYLESTERASES.CHEMICO-BIOLOGICAL INTERACTIONS. VOL. 162. ISSUE 3. P. 195-211 62 77% 203
6 XU, YJ , ZHANG, CL , HE, WX , LIU, D , (2016) REGULATIONS OF XENOBIOTICS AND ENDOBIOTICS ON CARBOXYLESTERASES: A COMPREHENSIVE REVIEW.EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS. VOL. 41. ISSUE 4. P. 321 -330 57 83% 0
7 HOLMES, RS , WRIGHT, MW , LAULEDERKIND, SJF , COX, LA , HOSOKAWA, M , IMAI, T , ISHIBASHI, S , LEHNER, R , MIYAZAKI, M , PERKINS, EJ , ET AL (2010) RECOMMENDED NOMENCLATURE FOR FIVE MAMMALIAN CARBOXYLESTERASE GENE FAMILIES: HUMAN, MOUSE, AND RAT GENES AND PROTEINS.MAMMALIAN GENOME. VOL. 21. ISSUE 9-10. P. 427 -441 60 74% 50
8 IMAI, T , HOSOKAWA, M , (2010) PRODRUG APPROACH USING CARBOXYLESTERASES ACTIVITY: CATALYTIC PROPERTIES AND GENE REGULATION OF CARBOXYLESTERASE IN MAMMALIAN TISSUE.JOURNAL OF PESTICIDE SCIENCE. VOL. 35. ISSUE 3. P. 229-239 49 83% 7
9 LAIZURE, SC , HERRING, V , HU, ZY , WITBRODT, K , PARKER, RB , (2013) THE ROLE OF HUMAN CARBOXYLESTERASES IN DRUG METABOLISM: HAVE WE OVERLOOKED THEIR IMPORTANCE?.PHARMACOTHERAPY. VOL. 33. ISSUE 2. P. 210-222 49 54% 46
10 HOSOKAWA, M , FURIHATA, T , YAGINUMA, Y , YAMAMOTO, N , KOYANO, N , FUJII, A , NAGAHARA, Y , SATOH, T , CHIBA, K , (2007) GENOMIC STRUCTURE AND TRANSCRIPTIONAL REGULATION OF THE RAT, MOUSE, AND HUMAN CARBOXYLESTERASE GENES.DRUG METABOLISM REVIEWS. VOL. 39. ISSUE 1. P. 1-15 44 79% 42

Classes with closest relation at Level 1


Rank Class id link
1 21999 ALPHA NAPHTHYL ACETATE ESTERASE//ANAE//ANAE ACTIVITY
2 27804 ACYL COA THIOESTERASE//ACETYL COA HYDROLASE//ACYL COA HYDROLASE
3 37218 CAMPHOR HYDRAZONE//CAMPHOR ALKYNES//CAMPHOR DERIVED LIGANDS
4 34426 MUS GENUS//ANDROGEN AND ESTROGEN ANTAGONISM//CDNA AND GENE PROFILING
5 30106 COMPARATIVE ENZYMOLOGY//REVERSIBLE INHIBITORS//INSECTOACARICIDES
6 1644 CAMPTOTHECIN//SN 38//TOPOTECAN
7 19790 BILE SALT DEPENDENT LIPASE//CARBAMATE INHIBITORS//BILE SALT STIMULATED LIPASE
8 14768 COCAETHYLENE//COCAINE//BENZOYLECGONINE
9 25735 1 2 DIKETONES//BENZILS//UNSYMMETRICAL BENZIL
10 13198 PRODRUG//DIFFUSION CELL EXPERIMENTS//DERMAL PRODRUG

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