Class information for:
Level 1: HPMA COPOLYMER//POLYMER THER EUT//HPMA

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
8461 1251 47.6 77%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
12 4 POLYMER SCIENCE//MATERIALS SCIENCE, PAPER & WOOD//CHEMISTRY, PHYSICAL 1084170
41 3       INTERNATIONAL JOURNAL OF PHARMACEUTICS//DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY//PHARMACOLOGY & PHARMACY 99449
147 2             SOLID LIPID NANOPARTICLES//POLYMERIC MICELLES//LIPOSOMES 23275
8461 1                   HPMA COPOLYMER//POLYMER THER EUT//HPMA 1251

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 HPMA COPOLYMER authKW 2594258 10% 85% 125
2 POLYMER THER EUT address 813990 5% 53% 63
3 HPMA authKW 633118 3% 62% 42
4 N 2 HYDROXYPROPYLMETHACRYLAMIDE COPOLYMERS authKW 513609 2% 96% 22
5 POLYMER THERAPEUTICS authKW 509522 4% 43% 49
6 N 2 HYDROXYPROPYLMETHACRYLAMIDE HPMA authKW 292886 1% 100% 12
7 PHARMACEUT PHARMACEUT CHEM address 258879 8% 10% 104
8 POLYMER DRUG CONJUGATES authKW 248473 2% 36% 28
9 EPR EFFECT authKW 225710 3% 25% 37
10 DRUG DELIVERY SCI address 187743 1% 77% 10

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Pharmacology & Pharmacy 5888 41% 0% 508
2 Materials Science, Biomaterials 5169 11% 0% 135
3 Polymer Science 3730 21% 0% 266
4 Chemistry, Multidisciplinary 1602 25% 0% 312
5 Oncology 619 13% 0% 167
6 Chemistry, Organic 336 9% 0% 112
7 Engineering, Biomedical 283 4% 0% 54
8 Chemistry, Medicinal 172 4% 0% 53
9 Biochemical Research Methods 146 5% 0% 57
10 Biochemistry & Molecular Biology 125 13% 0% 162

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 POLYMER THER EUT 813990 5% 53% 63
2 PHARMACEUT PHARMACEUT CHEM 258879 8% 10% 104
3 DRUG DELIVERY SCI 187743 1% 77% 10
4 CCCD 171362 2% 28% 25
5 MICROBIOL ONCOL 151865 2% 27% 23
6 INNOVAT CANC DIAG THER Y 149492 1% 88% 7
7 MACROMOL CHEM 134375 12% 4% 150
8 UTAH PHOTOMED 122036 0% 100% 5
9 PHARMACEUT PHARMACEUT CHEM CCCD 122026 1% 50% 10
10 CLIN COOPERAT UNIT RADIOTHER EUT ONCOL 104130 1% 53% 8

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF CONTROLLED RELEASE 70994 12% 2% 147
2 JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS 55698 4% 5% 45
3 JOURNAL OF DRUG TARGETING 26339 3% 3% 41
4 ADVANCED DRUG DELIVERY REVIEWS 11142 3% 1% 35
5 MACROMOLECULAR BIOSCIENCE 10842 2% 1% 30
6 BIOCONJUGATE CHEMISTRY 9003 3% 1% 43
7 MOLECULAR PHARMACEUTICS 8397 3% 1% 33
8 BIOMACROMOLECULES 6980 4% 1% 44
9 PHARMACEUTICAL RESEARCH 3078 3% 0% 32
10 CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS 2684 0% 2% 6

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 HPMA COPOLYMER 2594258 10% 85% 125 Search HPMA+COPOLYMER Search HPMA+COPOLYMER
2 HPMA 633118 3% 62% 42 Search HPMA Search HPMA
3 N 2 HYDROXYPROPYLMETHACRYLAMIDE COPOLYMERS 513609 2% 96% 22 Search N+2+HYDROXYPROPYLMETHACRYLAMIDE+COPOLYMERS Search N+2+HYDROXYPROPYLMETHACRYLAMIDE+COPOLYMERS
4 POLYMER THERAPEUTICS 509522 4% 43% 49 Search POLYMER+THERAPEUTICS Search POLYMER+THERAPEUTICS
5 N 2 HYDROXYPROPYLMETHACRYLAMIDE HPMA 292886 1% 100% 12 Search N+2+HYDROXYPROPYLMETHACRYLAMIDE+HPMA Search N+2+HYDROXYPROPYLMETHACRYLAMIDE+HPMA
6 POLYMER DRUG CONJUGATES 248473 2% 36% 28 Search POLYMER+DRUG+CONJUGATES Search POLYMER+DRUG+CONJUGATES
7 EPR EFFECT 225710 3% 25% 37 Search EPR+EFFECT Search EPR+EFFECT
8 N 2 HYDROXYPROPYLMETHACRYLAMIDE 175722 1% 60% 12 Search N+2+HYDROXYPROPYLMETHACRYLAMIDE Search N+2+HYDROXYPROPYLMETHACRYLAMIDE
9 MESOCHLORIN E6 149492 1% 88% 7 Search MESOCHLORIN+E6 Search MESOCHLORIN+E6
10 MACROMOLECULAR PRODRUG 136663 1% 40% 14 Search MACROMOLECULAR+PRODRUG Search MACROMOLECULAR+PRODRUG

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 ULBRICH, K , SUBR, V , (2010) STRUCTURAL AND CHEMICAL ASPECTS OF HPMA COPOLYMERS AS DRUG CARRIERS.ADVANCED DRUG DELIVERY REVIEWS. VOL. 62. ISSUE 2. P. 150-166 145 81% 85
2 ULBRICH, K , HOLA, K , SUBR, V , BAKANDRITSOS, A , TUCEK, J , ZBORIL, R , (2016) TARGETED DRUG DELIVERY WITH POLYMERS AND MAGNETIC NANOPARTICLES: COVALENT AND NONCOVALENT APPROACHES, RELEASE CONTROL, AND CLINICAL STUDIES.CHEMICAL REVIEWS. VOL. 116. ISSUE 9. P. 5338 -5431 204 28% 16
3 KOPECEK, J , KOPECKOVA, P , (2010) HPMA COPOLYMERS: ORIGINS, EARLY DEVELOPMENTS, PRESENT, AND FUTURE.ADVANCED DRUG DELIVERY REVIEWS. VOL. 62. ISSUE 2. P. 122-149 96 63% 212
4 LAMMERS, T , (2010) IMPROVING THE EFFICACY OF COMBINED MODALITY ANTICANCER THERAPY USING HPMA COPOLYMER-BASED NANOMEDICINE FORMULATIONS.ADVANCED DRUG DELIVERY REVIEWS. VOL. 62. ISSUE 2. P. 203-230 120 60% 46
5 KOPECEK, J , (2013) POLYMER-DRUG CONJUGATES: ORIGINS, PROGRESS TO DATE AND FUTURE DIRECTIONS.ADVANCED DRUG DELIVERY REVIEWS. VOL. 65. ISSUE 1. P. 49-59 83 57% 114
6 DUNCAN, R , (2009) DEVELOPMENT OF HPMA COPOLYMER-ANTICANCER CONJUGATES: CLINICAL EXPERIENCE AND LESSONS LEARNT.ADVANCED DRUG DELIVERY REVIEWS. VOL. 61. ISSUE 13. P. 1131-1148 71 89% 111
7 YANG, JY , KOPECEK, J , (2014) MACROMOLECULAR THERAPEUTICS.JOURNAL OF CONTROLLED RELEASE. VOL. 190. ISSUE . P. 288 -303 94 53% 18
8 YANG, JY , KOPECEK, J , (2016) DESIGN OF SMART HPMA COPOLYMER-BASED NANOMEDICINES.JOURNAL OF CONTROLLED RELEASE. VOL. 240. ISSUE . P. 9 -23 100 48% 2
9 KOPECEK, J , KOPECKOVA, P , MINKO, T , LU, ZR , (2000) HPMA COPOLYMER-ANTICANCER DRUG CONJUGATES: DESIGN, ACTIVITY, AND MECHANISM OF ACTION.EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. VOL. 50. ISSUE 1. P. 61 -81 77 69% 363
10 MINKO, T , (2010) HPMA COPOLYMERS FOR MODULATING CELLULAR SIGNALING AND OVERCOMING MULTIDRUG RESISTANCE.ADVANCED DRUG DELIVERY REVIEWS. VOL. 62. ISSUE 2. P. 192-202 75 66% 18

Classes with closest relation at Level 1


Rank Class id link
1 26433 6 MALEIMIDOCAPROYLHYDRAZONE DERIVATIVE OF DOXORUBICIN//METHOTREXATE ALBUMIN//256 CARCINOSARCOMA WALKER
2 21790 N SUCCINYL CHITOSAN//DEXTRAN PRODRUGS//BIOPHARMACEUT DRUG METAB
3 3262 REDOX RESPONSIVE//REDUCTION SENSITIVE//PH SENSITIVE
4 26291 IN VIVO ANTITUMOUR ACTIVITY//MOUSE LYMPHOID NEOPLASMA P 388//MOUSE MAMMARY CARCINOMA FM 3A
5 19997 HYALURONIC ACID//HYALURONIC ACID CERAMIDE//GLYCYRRHETINIC ACID
6 26796 1 3 DITHIOLIUM SALTS//DITHIOLIUM SALTS//MESOIONIC PHENOLATES
7 2648 POLYMERIC MICELLES//MICELLES//POLYMER MICELLE
8 32478 H COMPLEX RELATIVE REACTIVITY//MERCURIATION//12 DOXYL
9 7258 PEGYLATION//MONOMETHOXYPOLYETHYLENE GLYCOL//PEGYLATED PROTEINS
10 26214 BONE TARGETING//OSTEOTROPIC DRUG DELIVERY SYSTEM//ACIDIC OLIGOPEPTIDE

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