Class information for:
Level 1: ADEPT//NITROREDUCTASE//CB1954

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
14540 764 37.0 78%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
408 3       CHIM BIOINORGAN//POLO SCI//CARBONIC ANHYDRASE 29468
1363 2             TIRAPAZAMINE//DT DIAPHORASE//BIOREDUCTIVE DRUGS 8244
14540 1                   ADEPT//NITROREDUCTASE//CB1954 764

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ADEPT authKW 1494860 9% 53% 70
2 NITROREDUCTASE authKW 1490090 12% 41% 92
3 CB1954 authKW 1421097 6% 83% 43
4 ANTIBODY DIRECTED ENZYME PRODRUG THERAPY authKW 479584 2% 67% 18
5 GDEPT authKW 257885 3% 29% 22
6 VDEPT authKW 254513 1% 58% 11
7 HUMAN BETA GLUCURONIDASE authKW 199832 1% 100% 5
8 ANTIBODY ENZYME CONJUGATE authKW 195831 1% 70% 7
9 PRODRUG authKW 186208 14% 4% 106
10 NITROAROMATIC PRODRUG authKW 159865 1% 100% 4

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Chemistry, Medicinal 2914 19% 0% 143
2 Oncology 1070 21% 0% 159
3 Chemistry, Organic 970 17% 0% 132
4 Pharmacology & Pharmacy 628 19% 0% 143
5 Biochemistry & Molecular Biology 498 24% 0% 187
6 Biotechnology & Applied Microbiology 425 11% 0% 86
7 Biochemical Research Methods 199 6% 0% 48
8 Medicine, Research & Experimental 177 7% 0% 52
9 Chemistry, Multidisciplinary 118 11% 0% 84
10 Genetics & Heredity 93 6% 0% 46

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 TY MYDDFAI 89923 0% 75% 3
2 MED KLIN WERPUNKT HAMATOL ONKOL CBF 79933 0% 100% 2
3 COBRA THER EUT LTD 71047 1% 44% 4
4 SCIIFR 110 53287 0% 67% 2
5 GRP SYST MOL PROGRAMMES 51382 0% 43% 3
6 AUCKLAND CANC SOC 45544 4% 4% 27
7 BIOANALYT ASSAYS PHARMACOKINET 39966 0% 100% 1
8 BIOMED SCI ENVIROM BIOL 39966 0% 100% 1
9 BIOTECHNOL DEV TECH OPERAT 39966 0% 100% 1
10 BREAKTHROUGH TOBY TOBINS BREAST 39966 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ANTI-CANCER DRUG DESIGN 12466 2% 2% 14
2 BIOCONJUGATE CHEMISTRY 6254 4% 1% 28
3 JOURNAL OF MEDICINAL CHEMISTRY 3237 5% 0% 42
4 ADVANCED DRUG DELIVERY REVIEWS 2507 2% 0% 13
5 BRITISH JOURNAL OF CANCER 2106 4% 0% 31
6 BIOCHEMICAL PHARMACOLOGY 2038 4% 0% 31
7 CANCER GENE THERAPY 2023 1% 1% 10
8 GENE THERAPY 1979 2% 0% 14
9 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 1898 5% 0% 35
10 ANTIBODY IMMUNOCONJUGATES AND RADIOPHARMACEUTICALS 971 0% 1% 2

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 ADEPT 1494860 9% 53% 70 Search ADEPT Search ADEPT
2 NITROREDUCTASE 1490090 12% 41% 92 Search NITROREDUCTASE Search NITROREDUCTASE
3 CB1954 1421097 6% 83% 43 Search CB1954 Search CB1954
4 ANTIBODY DIRECTED ENZYME PRODRUG THERAPY 479584 2% 67% 18 Search ANTIBODY+DIRECTED+ENZYME+PRODRUG+THERAPY Search ANTIBODY+DIRECTED+ENZYME+PRODRUG+THERAPY
5 GDEPT 257885 3% 29% 22 Search GDEPT Search GDEPT
6 VDEPT 254513 1% 58% 11 Search VDEPT Search VDEPT
7 HUMAN BETA GLUCURONIDASE 199832 1% 100% 5 Search HUMAN+BETA+GLUCURONIDASE Search HUMAN+BETA+GLUCURONIDASE
8 ANTIBODY ENZYME CONJUGATE 195831 1% 70% 7 Search ANTIBODY+ENZYME+CONJUGATE Search ANTIBODY+ENZYME+CONJUGATE
9 PRODRUG 186208 14% 4% 106 Search PRODRUG Search PRODRUG
10 NITROAROMATIC PRODRUG 159865 1% 100% 4 Search NITROAROMATIC+PRODRUG Search NITROAROMATIC+PRODRUG

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 SHARMA, SK , BAGSHAWE, KD , (2017) TRANSLATING ANTIBODY DIRECTED ENZYME PRODRUG THERAPY (ADEPT) AND PROSPECTS FOR COMBINATION.EXPERT OPINION ON BIOLOGICAL THERAPY. VOL. 17. ISSUE 1. P. 1 -13 83 58% 0
2 NICULESCUDUVAZ, I , SPRINGER, CJ , (1997) ANTIBODY-DIRECTED ENZYME PRODRUG THERAPY (ADEPT): A REVIEW.ADVANCED DRUG DELIVERY REVIEWS. VOL. 26. ISSUE 2-3. P. 151-172 83 87% 66
3 SENTER, PD , SPRINGER, CJ , (2001) SELECTIVE ACTIVATION OF ANTICANCER PRODRUGS BY MONOCLONAL ANTIBODY-ENZYME CONJUGATES.ADVANCED DRUG DELIVERY REVIEWS. VOL. 53. ISSUE 3. P. 247 -264 70 78% 91
4 WILLIAMS, EM , LITTLE, RF , MOWDAY, AM , RICH, MH , CHAN-HYAMS, JVE , COPP, JN , SMAILL, JB , PATTERSON, AV , ACKERLEY, DF , (2015) NITROREDUCTASE GENE-DIRECTED ENZYME PRODRUG THERAPY: INSIGHTS AND ADVANCES TOWARD CLINICAL UTILITY.BIOCHEMICAL JOURNAL. VOL. 471. ISSUE . P. 131 -153 91 40% 6
5 BAGSHAWE, KD , SHARMA, SK , BEGENT, RHJ , (2004) ANTIBODY-DIRECTED ENZYME PRODRUG THERAPY (ADEPT) FOR CANCER.EXPERT OPINION ON BIOLOGICAL THERAPY. VOL. 4. ISSUE 11. P. 1777 -1789 59 65% 44
6 BAGSHAWE, KD , (2006) ANTIBODY-DIRECTED ENZYME PRODRUG THERAPY (ADEPT) FOR CANCER.EXPERT REVIEW OF ANTICANCER THERAPY. VOL. 6. ISSUE 10. P. 1421-1431 54 64% 56
7 NICULESCU-DUVAZ, I , FRIEDLOS, F , NICULESCU-DUVAZ, D , DAVIES, L , SPRINGER, CJ , (1999) PRODRUGS FOR ANTIBODY- AND GENE-DIRECTED ENZYME PRODRUG THERAPIES (ADEPT AND GDEPT).ANTI-CANCER DRUG DESIGN. VOL. 14. ISSUE 6. P. 517 -538 55 80% 36
8 MELTON, R , CONNORS, T , KNOX, RJ , (1999) THE USE OF PRODRUGS IN TARGETED ANTICANCER THERAPIES.STP PHARMA SCIENCES. VOL. 9. ISSUE 1. P. 13 -33 85 53% 6
9 VASS, SO , JARROM, D , WILSON, WR , HYDE, EI , SEARLE, PF , (2009) E. COLI NFSA: AN ALTERNATIVE NITROREDUCTASE FOR PRODRUG ACTIVATION GENE THERAPY IN COMBINATION WITH CB1954.BRITISH JOURNAL OF CANCER. VOL. 100. ISSUE 12. P. 1903 -1911 38 81% 20
10 SHERWOOD, RF , (1996) ADVANCED DRUG DELIVERY REVIEWS: ENZYME PRODRUG THERAPY.ADVANCED DRUG DELIVERY REVIEWS. VOL. 22. ISSUE 3. P. 269-288 62 70% 27

Classes with closest relation at Level 1


Rank Class id link
1 15678 TIRAPAZAMINE//BIOREDUCTIVE DRUGS//SR 4233
2 24555 SELF IMMOLATIVE//POLYMETHYL GLYOXYLATE//POLYOLEFIN SULFONES
3 28817 ADUBILTEM SCI TECHNOL DEV//NUCL PLICAT//BLEOMYCIN GLUCURONIDE
4 3940 SUICIDE GENE THERAPY//CYTOSINE DEAMINASE//HERPES SIMPLEX VIRUS THYMIDINE KINASE
5 17114 DUOCARMYCIN//CC 1065//ADOZELESIN
6 35662 A33 ANTIGEN//ADHESION REGULATING MOLECULE 1//ADRM1
7 7463 NQO1//DT DIAPHORASE//EO9
8 26433 6 MALEIMIDOCAPROYLHYDRAZONE DERIVATIVE OF DOXORUBICIN//METHOTREXATE ALBUMIN//256 CARCINOSARCOMA WALKER
9 25636 ESTERASE SENSITIVE PRODRUGS//KIRBYS ENZYME MODEL//PROXIMITY ORIENTATION
10 4480 TNT//RDX//2 4 6 TRINITROTOLUENE

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