Class information for:
Level 1: SUICIDE GENE THERAPY//CYTOSINE DEAMINASE//HERPES SIMPLEX VIRUS THYMIDINE KINASE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
3940 1877 43.6 87%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
419 3       ADENOVIRUS//MERKEL CELL CARCINOMA//GENE THERAPY 28518
564 2             GENE THERAPY//ADENOVIRUS//HUMAN GENE THERAPY 14456
3940 1                   SUICIDE GENE THERAPY//CYTOSINE DEAMINASE//HERPES SIMPLEX VIRUS THYMIDINE KINASE 1877

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 SUICIDE GENE THERAPY authKW 968103 6% 54% 111
2 CYTOSINE DEAMINASE authKW 940826 6% 52% 111
3 HERPES SIMPLEX VIRUS THYMIDINE KINASE authKW 725941 4% 55% 81
4 SUICIDE GENE authKW 636694 6% 37% 106
5 THYMIDINE KINASE authKW 540059 8% 22% 154
6 HSV TK authKW 529619 4% 48% 68
7 GANCICLOVIR authKW 436214 9% 17% 161
8 BYSTANDER EFFECT authKW 389552 6% 20% 120
9 GENE THERAPY authKW 335527 29% 4% 545
10 CANCER GENE THERAPY journal 299871 10% 10% 190

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Medicine, Research & Experimental 15525 34% 0% 641
2 Oncology 11008 40% 0% 752
3 Biotechnology & Applied Microbiology 10583 32% 0% 605
4 Genetics & Heredity 9951 31% 0% 577
5 Biochemistry & Molecular Biology 358 16% 0% 296
6 Urology & Nephrology 217 4% 0% 73
7 Gastroenterology & Hepatology 195 4% 0% 73
8 Surgery 75 6% 0% 108
9 Pharmacology & Pharmacy 40 6% 0% 104
10 Clinical Neurology 31 3% 0% 65

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 UPJOHN 4713 65066 0% 100% 4
2 SERV CHIRURG ABDOMINALE THORAC 50829 0% 63% 5
3 BIOL TUMEURS THER IE GEN 48799 0% 100% 3
4 THYROID STUDY UNIT 33917 1% 19% 11
5 BIOL GENET PATHOL IMMUNITAI 32533 0% 100% 2
6 CELL BIOL GENE THER Y 32533 0% 100% 2
7 CLIN MEDONCOL 32533 0% 100% 2
8 COOPERAT CLIN CANC 32533 0% 100% 2
9 MATSUNAGA CONTE PROSTATE CANC 26558 0% 23% 7
10 GENE THER Y UNIT 25485 1% 7% 24

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CANCER GENE THERAPY 299871 10% 10% 190
2 HUMAN GENE THERAPY 96933 8% 4% 141
3 GENE THERAPY 61780 6% 3% 122
4 JOURNAL OF GENE MEDICINE 7781 1% 2% 26
5 MOLECULAR THERAPY 5891 2% 1% 36
6 CURRENT GENE THERAPY 5791 1% 3% 14
7 CANCER RESEARCH 3879 5% 0% 98
8 CURRENT OPINION IN MOLECULAR THERAPEUTICS 3123 1% 1% 13
9 TUMOR TARGETING 2240 0% 7% 2
10 ANTICANCER RESEARCH 1654 2% 0% 45

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 SUICIDE GENE THERAPY 968103 6% 54% 111 Search SUICIDE+GENE+THERAPY Search SUICIDE+GENE+THERAPY
2 CYTOSINE DEAMINASE 940826 6% 52% 111 Search CYTOSINE+DEAMINASE Search CYTOSINE+DEAMINASE
3 HERPES SIMPLEX VIRUS THYMIDINE KINASE 725941 4% 55% 81 Search HERPES+SIMPLEX+VIRUS+THYMIDINE+KINASE Search HERPES+SIMPLEX+VIRUS+THYMIDINE+KINASE
4 SUICIDE GENE 636694 6% 37% 106 Search SUICIDE+GENE Search SUICIDE+GENE
5 THYMIDINE KINASE 540059 8% 22% 154 Search THYMIDINE+KINASE Search THYMIDINE+KINASE
6 HSV TK 529619 4% 48% 68 Search HSV+TK Search HSV+TK
7 GANCICLOVIR 436214 9% 17% 161 Search GANCICLOVIR Search GANCICLOVIR
8 BYSTANDER EFFECT 389552 6% 20% 120 Search BYSTANDER+EFFECT Search BYSTANDER+EFFECT
9 GENE THERAPY 335527 29% 4% 545 Search GENE+THERAPY Search GENE+THERAPY
10 5 FLUOROCYTOSINE 218655 2% 34% 40 Search 5+FLUOROCYTOSINE Search 5+FLUOROCYTOSINE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 GRECO, O , DACHS, GU , (2001) GENE DIRECTED ENZYME/PRODRUG THERAPY OF CANCER: HISTORICAL APPRAISAL AND FUTURE PROSPECTIVES.JOURNAL OF CELLULAR PHYSIOLOGY. VOL. 187. ISSUE 1. P. 22 -36 110 68% 171
2 ZHANG, J , KALE, V , CHEN, MN , (2015) GENE-DIRECTED ENZYME PRODRUG THERAPY.AAPS JOURNAL. VOL. 17. ISSUE 1. P. 102 -110 69 67% 8
3 DUARTE, S , CARLE, G , FANECA, H , DE LIMA, MCP , PIERREFITE-CARLE, V , (2012) SUICIDE GENE THERAPY IN CANCER: WHERE DO WE STAND NOW?.CANCER LETTERS. VOL. 324. ISSUE 2. P. 160-170 80 49% 67
4 MAATTA, AM , SAMARANAYAKE, H , PIKKARAINEN, J , WIRTH, T , YLA-HERTTUALA, S , (2009) ADENOVIRUS MEDIATED HERPES SIMPLEX VIRUS-THYMIDINE KINASE/GANCICLOVIR GENE THERAPY FOR RESECTABLE MALIGNANT GLIOMA.CURRENT GENE THERAPY. VOL. 9. ISSUE 5. P. 356-367 71 68% 26
5 NICHOLAS, TW , READ, SB , BURROWS, FJ , KRUSE, CA , (2003) SUICIDE GENE THERAPY WITH HERPES SIMPLEX VIRUS THYMIDINE KINASE AND GANCICLOVIR IS ENHANCED WITH CONNEXINS TO IMPROVE GAP JUNCTIONS AND BYSTANDER EFFECTS.HISTOLOGY AND HISTOPATHOLOGY. VOL. 18. ISSUE 2. P. 495-507 74 76% 40
6 ROBSON, T , HIRST, DG , (2003) TRANSCRIPTIONAL TARGETING IN CANCER GENE THERAPY.JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY. VOL. . ISSUE 2. P. 110 -137 116 44% 69
7 ARDIANI, A , JOHNSON, AJ , RUAN, HM , SANCHEZ-BONILLA, M , SERVE, K , BLACK, ME , (2012) ENZYMES TO DIE FOR: EXPLOITING NUCLEOTIDE METABOLIZING ENZYMES FOR CANCER GENE THERAPY.CURRENT GENE THERAPY. VOL. 12. ISSUE 2. P. 77-91 65 60% 10
8 DENNY, WA , (2003) PRODRUGS FOR GENE-DIRECTED ENZYME-PRODRUG THERAPY (SUICIDE GENE THERAPY).JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY. VOL. . ISSUE 1. P. 48 -70 83 54% 67
9 MCKEOWN, SR , WARD, C , ROBSON, T , (2004) GENE-DIRECTED ENZYME PRODRUG THERAPY: A CURRENT ASSESSMENT.CURRENT OPINION IN MOLECULAR THERAPEUTICS. VOL. 6. ISSUE 4. P. 421-435 83 55% 19
10 KARJOO, Z , CHEN, XG , HATEFI, A , (2016) PROGRESS AND PROBLEMS WITH THE USE OF SUICIDE GENES FOR TARGETED CANCER THERAPY.ADVANCED DRUG DELIVERY REVIEWS. VOL. 99. ISSUE . P. 113 -128 64 40% 5

Classes with closest relation at Level 1


Rank Class id link
1 28833 GENETIC RADIOTHERAPY//TNFERADE//CARG ELEMENTS
2 16830 RAD P53//RECOMBINANT ADENOVIRUS P53//ADENOVIRAL MEDIATED INTERFERON ALPHA
3 14540 ADEPT//NITROREDUCTASE//CB1954
4 1181 ONCOLYTIC VIRUS//ONCOLYTIC ADENOVIRUS//VIROTHERAPY
5 8124 TUMOR VACCINE//GENE THERAPY//B71
6 6997 MOL MED GENE THER Y UNIT//ADENOVIRUS//HELPER DEPENDENT ADENOVIRAL VECTOR
7 11414 HSV1 TK//FIAU//F 18FHBG
8 7696 RETROVIRAL VECTOR//HUMAN GENE THERAPY//REPLICATION COMPETENT RETROVIRUS
9 10122 TUMOR TROPISM//MESENCHYMAL STEM CELLS//VET BIOCHEM IMMUNOL
10 10483 GENE THER Y S//RD 114 VIRUS//RETROVIRAL VECTOR

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