Class information for:
Level 2: TIRAPAZAMINE//DT DIAPHORASE//BIOREDUCTIVE DRUGS

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
1363 8244 36.0 70%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
408 3       CHIM BIOINORGAN//POLO SCI//CARBONIC ANHYDRASE 29468
1363 2             TIRAPAZAMINE//DT DIAPHORASE//BIOREDUCTIVE DRUGS 8244
2109 1                   CARBOGEN//TUMOR HYPOXIA//TUMOR OXYGENATION 2354
7463 1                   NQO1//DT DIAPHORASE//EO9 1364
9841 1                   ETANIDAZOLE//HYPOXIC CELL SENSITIZER//HYPOXIC CELL RADIOSENSITIZER 1115
12399 1                   KW 2149//MITOSENE//FR900482 908
14540 1                   ADEPT//NITROREDUCTASE//CB1954 764
14991 1                   MULTICELLULAR SPHEROIDS//MULTICELLULAR TUMOR SPHEROIDS//SPHEROID 737
15678 1                   TIRAPAZAMINE//BIOREDUCTIVE DRUGS//SR 4233 698
28175 1                   CANC UK MRC//REPLICON INITIATION//HYPOXIA REOXYGENATION H R 212
35768 1                   QUIESCENT CELL//BORON TRACEDRUG//MILD TEMPERATURE HYPERTHERMIA 92

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 TIRAPAZAMINE authKW 360816 1% 86% 113
2 DT DIAPHORASE authKW 283371 2% 58% 133
3 BIOREDUCTIVE DRUGS authKW 276609 1% 84% 89
4 TUMOR HYPOXIA authKW 272880 2% 50% 147
5 CARBOGEN authKW 246825 1% 65% 102
6 NQO1 authKW 217802 2% 40% 148
7 2 NITROIMIDAZOLE authKW 170573 1% 79% 58
8 CB1954 authKW 164020 1% 92% 48
9 ADEPT authKW 154685 1% 56% 74
10 NITROREDUCTASE authKW 153335 1% 43% 97

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Oncology 49354 40% 0% 3335
2 Radiology, Nuclear Medicine & Medical Imaging 30535 24% 0% 1995
3 Chemistry, Medicinal 3704 7% 0% 575
4 Pharmacology & Pharmacy 2113 12% 0% 971
5 Biology 1722 5% 0% 393
6 Biophysics 1112 5% 0% 437
7 Chemistry, Organic 831 6% 0% 512
8 Biochemistry & Molecular Biology 767 13% 0% 1045
9 Toxicology 404 3% 0% 239
10 CYTOLOGY & HISTOLOGY 283 0% 0% 26

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 AUCKLAND CANC SOC 81847 1% 19% 119
2 EXPT CLIN ONCOL 37804 1% 14% 72
3 MED CHEM RADIOPHARM 23631 0% 30% 21
4 GRP RADIAT BIOL TUMOR PHYSIOL 23478 0% 32% 20
5 RADIAT ONCOL 20658 7% 1% 616
6 SIEMENS OXFORD MOL IMAGING 19037 0% 86% 6
7 MOL IMAGING EXPT RADIOTHER Y 18422 0% 29% 17
8 PARTICLE RADIAT ONCOL 18251 0% 25% 20
9 GRAY CANC TRUST 16692 0% 27% 17
10 MED BIOL PROD PROGRAM 16486 0% 64% 7

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 89626 8% 4% 648
2 BRITISH JOURNAL OF CANCER 32479 5% 2% 399
3 RADIOTHERAPY AND ONCOLOGY 27169 3% 4% 210
4 RADIATION RESEARCH 19433 2% 3% 187
5 CANCER CLINICAL TRIALS 18036 0% 20% 25
6 ANTI-CANCER DRUG DESIGN 14669 1% 8% 50
7 INTERNATIONAL JOURNAL OF RADIATION BIOLOGY 11067 2% 2% 124
8 CANCER RESEARCH 9618 4% 1% 326
9 BIOCHEMICAL PHARMACOLOGY 8185 2% 1% 206
10 ACTA ONCOLOGICA 6676 1% 2% 88

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 TIRAPAZAMINE 360816 1% 86% 113 Search TIRAPAZAMINE Search TIRAPAZAMINE
2 DT DIAPHORASE 283371 2% 58% 133 Search DT+DIAPHORASE Search DT+DIAPHORASE
3 BIOREDUCTIVE DRUGS 276609 1% 84% 89 Search BIOREDUCTIVE+DRUGS Search BIOREDUCTIVE+DRUGS
4 TUMOR HYPOXIA 272880 2% 50% 147 Search TUMOR+HYPOXIA Search TUMOR+HYPOXIA
5 CARBOGEN 246825 1% 65% 102 Search CARBOGEN Search CARBOGEN
6 NQO1 217802 2% 40% 148 Search NQO1 Search NQO1
7 2 NITROIMIDAZOLE 170573 1% 79% 58 Search 2+NITROIMIDAZOLE Search 2+NITROIMIDAZOLE
8 CB1954 164020 1% 92% 48 Search CB1954 Search CB1954
9 ADEPT 154685 1% 56% 74 Search ADEPT Search ADEPT
10 NITROREDUCTASE 153335 1% 43% 97 Search NITROREDUCTASE Search NITROREDUCTASE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 BASS, PD , GUBLER, DA , JUDD, TC , WILLIAMS, RM , (2013) MITOMYCINOID ALKALOIDS: MECHANISM OF ACTION, BIOSYNTHESIS, TOTAL SYNTHESES, AND SYNTHETIC APPROACHES.CHEMICAL REVIEWS. VOL. 113. ISSUE 8. P. 6816-6863 184 72% 33
2 MEES, G , DIERCKX, R , VANGESTEL, C , VAN DE WIELE, C , (2009) MOLECULAR IMAGING OF HYPOXIA WITH RADIOLABELLED AGENTS.EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. VOL. 36. ISSUE 10. P. 1674-1686 125 96% 103
3 MEES, G , SATHEKGE, M , MAES, A , VAN DE WIELE, C , (2014) RADIOLABELLED PROBES TARGETING TUMOR HYPOXIA FOR PERSONALIZED MEDICINE.CURRENT PHARMACEUTICAL DESIGN. VOL. 20. ISSUE 14. P. 2308-2318 130 96% 2
4 CHEN, Y , HU, LQ , (2009) DESIGN OF ANTICANCER PRODRUGS FOR REDUCTIVE ACTIVATION.MEDICINAL RESEARCH REVIEWS. VOL. 29. ISSUE 1. P. 29 -64 143 72% 154
5 WALSH, JC , LEBEDEV, A , ATEN, E , MADSEN, K , MARCIANO, L , KOLB, HC , (2014) THE CLINICAL IMPORTANCE OF ASSESSING TUMOR HYPOXIA: RELATIONSHIP OF TUMOR HYPOXIA TO PROGNOSIS AND THERAPEUTIC OPPORTUNITIES.ANTIOXIDANTS & REDOX SIGNALING. VOL. 21. ISSUE 10. P. 1516 -1554 172 61% 20
6 KELADA, OJ , CARLSON, DJ , (2014) MOLECULAR IMAGING OF TUMOR HYPOXIA WITH POSITRON EMISSION TOMOGRAPHY.RADIATION RESEARCH. VOL. 181. ISSUE 4. P. 335 -349 120 89% 10
7 PEETERS, SGJA , ZEGERS, CML , YAROMINA, A , VAN ELMPT, W , DUBOIS, L , LAMBIN, P , (2015) CURRENT PRECLINICAL AND CLINICAL APPLICATIONS OF HYPOXIA PET IMAGING USING 2-NITROIMIDAZOLES.QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. VOL. 59. ISSUE 1. P. 39 -57 102 94% 10
8 LJUNGKVIST, ASE , BUSSINK, J , KAANDERS, JHAM , VAN DER KOGEL, AJ , (2007) DYNAMICS OF TUMOR HYPOXIA MEASURED WITH BIOREDUCTIVE HYPOXIC CELL MARKERS.RADIATION RESEARCH. VOL. 167. ISSUE 2. P. 127-145 151 77% 77
9 FLEMING, IN , MANAVAKI, R , BLOWER, PJ , WEST, C , WILLIAMS, KJ , HARRIS, AL , DOMARKAS, J , LORD, S , BALDRY, C , GILBERT, FJ , (2015) IMAGING TUMOUR HYPOXIA WITH POSITRON EMISSION TOMOGRAPHY.BRITISH JOURNAL OF CANCER. VOL. 112. ISSUE 2. P. 238 -250 84 97% 21
10 KROHN, KA , LINK, JM , MASON, RP , (2008) MOLECULAR IMAGING OF HYPOXIA.JOURNAL OF NUCLEAR MEDICINE. VOL. 49. ISSUE . P. 129S -148S 133 69% 179

Classes with closest relation at Level 2


Rank Class id link
1 2150 HIF 1 ALPHA//HYPOXIA INDUCIBLE FACTOR//HIF 1
2 3402 METRONIDAZOLE//NITRO RADICAL ANION//DIMETRIDAZOLE
3 1816 INTERNATIONAL JOURNAL OF HYPERTHERMIA//HYPERTHERMIA//ISOLATED LIMB PERFUSION
4 2221 DCE MRI//DIFFUSION WEIGHTED IMAGING//INTRAVOXEL INCOHERENT MOTION
5 2260 ACTIVE PARTICLES//BRANCHING PROCESS//TUMOR GROWTH
6 2994 NRF2//KEAP1//ANTIOXIDANT RESPONSE ELEMENT
7 2496 IFOSFAMIDE//CHEMOSENSITIVITY TEST//MESNA
8 957 PET CT//NUCL MED//PET
9 2612 WARBURG EFFECT//PKM2//PYRUVATE KINASE
10 2593 BLOOD SUBSTITUTES//ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY//HEMOGLOBIN BASED OXYGEN CARRIER

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