Class information for:
Level 1: 6 MALEIMIDOCAPROYLHYDRAZONE DERIVATIVE OF DOXORUBICIN//METHOTREXATE ALBUMIN//256 CARCINOSARCOMA WALKER

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
26433 255 33.3 65%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
12 4 POLYMER SCIENCE//MATERIALS SCIENCE, PAPER & WOOD//CHEMISTRY, PHYSICAL 1084170
41 3       INTERNATIONAL JOURNAL OF PHARMACEUTICS//DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY//PHARMACOLOGY & PHARMACY 99449
147 2             SOLID LIPID NANOPARTICLES//POLYMERIC MICELLES//LIPOSOMES 23275
26433 1                   6 MALEIMIDOCAPROYLHYDRAZONE DERIVATIVE OF DOXORUBICIN//METHOTREXATE ALBUMIN//256 CARCINOSARCOMA WALKER 255

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 6 MALEIMIDOCAPROYLHYDRAZONE DERIVATIVE OF DOXORUBICIN authKW 359239 1% 100% 3
2 METHOTREXATE ALBUMIN authKW 359239 1% 100% 3
3 256 CARCINOSARCOMA WALKER authKW 239493 1% 100% 2
4 ALBUMIN BINDING PRODRUG authKW 239493 1% 100% 2
5 CONJUGATE FRAGMENTS authKW 239493 1% 100% 2
6 GELATIN METHOTREXATE CONJUGATES authKW 239493 1% 100% 2
7 HL 60 GROWTH INHIBITION authKW 239493 1% 100% 2
8 HYDROLYTIC RELEASE FROM PROTEIN CONJUGATES authKW 239493 1% 100% 2
9 OVARIAN 342 TUMOR authKW 239493 1% 100% 2
10 PROTEIN CONJUGATE STABILITY authKW 239493 1% 100% 2

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Oncology 885 31% 0% 80
2 Pharmacology & Pharmacy 557 29% 0% 73
3 Chemistry, Medicinal 417 13% 0% 32
4 Chemistry, Organic 55 8% 0% 21
5 Chemistry, Multidisciplinary 28 10% 0% 25
6 Medicine, Research & Experimental 23 5% 0% 12
7 Materials Science, Biomaterials 16 2% 0% 4
8 Biochemical Research Methods 15 4% 0% 9
9 Biochemistry & Molecular Biology 14 11% 0% 28
10 Rheumatology 12 2% 0% 4

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 RADIOCHEM RADIOPHARMACOL E0300 239493 1% 100% 2
2 EXPT ANTICANC THER Y 179617 1% 50% 3
3 ASSOC MED ONCOL 119746 0% 100% 1
4 EXPT ANICANC THER Y 119746 0% 100% 1
5 FUJISAWA GRP 119746 0% 100% 1
6 KOPFKLINIKUM HEIDELBERG 119746 0% 100% 1
7 KOPFZENTRUM 119746 0% 100% 1
8 MEDAC GMBH 119746 0% 100% 1
9 NEOLEK 119746 0% 100% 1
10 PHASE STUDY GRP 1 119746 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 NEOPLASMA 6521 5% 0% 13
2 SBORNIK LEKARSKY 3518 1% 1% 2
3 FUNKTIONELLE BIOLOGIE & MEDIZIN 1195 0% 1% 1
4 BIOCONJUGATE CHEMISTRY 1168 3% 0% 7
5 ANTI-CANCER DRUGS 910 2% 0% 5
6 DRUG DELIVERY 826 1% 0% 3
7 THERANOSTICS 813 1% 0% 2
8 ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS 719 1% 0% 3
9 GANN 638 1% 0% 2
10 AMERICAN JOURNAL OF CANCER RESEARCH 604 1% 0% 2

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 6 MALEIMIDOCAPROYLHYDRAZONE DERIVATIVE OF DOXORUBICIN 359239 1% 100% 3 Search 6+MALEIMIDOCAPROYLHYDRAZONE+DERIVATIVE+OF+DOXORUBICIN Search 6+MALEIMIDOCAPROYLHYDRAZONE+DERIVATIVE+OF+DOXORUBICIN
2 METHOTREXATE ALBUMIN 359239 1% 100% 3 Search METHOTREXATE+ALBUMIN Search METHOTREXATE+ALBUMIN
3 256 CARCINOSARCOMA WALKER 239493 1% 100% 2 Search 256+CARCINOSARCOMA+WALKER Search 256+CARCINOSARCOMA+WALKER
4 ALBUMIN BINDING PRODRUG 239493 1% 100% 2 Search ALBUMIN+BINDING+PRODRUG Search ALBUMIN+BINDING+PRODRUG
5 CONJUGATE FRAGMENTS 239493 1% 100% 2 Search CONJUGATE+FRAGMENTS Search CONJUGATE+FRAGMENTS
6 GELATIN METHOTREXATE CONJUGATES 239493 1% 100% 2 Search GELATIN+METHOTREXATE+CONJUGATES Search GELATIN+METHOTREXATE+CONJUGATES
7 HL 60 GROWTH INHIBITION 239493 1% 100% 2 Search HL+60+GROWTH+INHIBITION Search HL+60+GROWTH+INHIBITION
8 HYDROLYTIC RELEASE FROM PROTEIN CONJUGATES 239493 1% 100% 2 Search HYDROLYTIC+RELEASE+FROM+PROTEIN+CONJUGATES Search HYDROLYTIC+RELEASE+FROM+PROTEIN+CONJUGATES
9 OVARIAN 342 TUMOR 239493 1% 100% 2 Search OVARIAN+342+TUMOR Search OVARIAN+342+TUMOR
10 PROTEIN CONJUGATE STABILITY 239493 1% 100% 2 Search PROTEIN+CONJUGATE+STABILITY Search PROTEIN+CONJUGATE+STABILITY

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 KREMER, P , HARTUNG, G , BAUDER-WUST, U , SCHRENK, HH , WUNDER, A , HECKL, S , ZILLMANN, U , SINN, H , (2002) EFFICACY AND TOLERABILITY OF AN AMINOPTERIN-ALBUMIN CONJUGATE IN TUMOR-BEARING RATS.ANTI-CANCER DRUGS. VOL. 13. ISSUE 6. P. 615 -623 17 74% 10
2 NEUMANN, E , FREI, E , FUNK, D , BECKER, MD , SCHRENK, HH , MULLER-LADNER, U , FIEHN, C , (2010) NATIVE ALBUMIN FOR TARGETED DRUG DELIVERY.EXPERT OPINION ON DRUG DELIVERY. VOL. 7. ISSUE 8. P. 915-925 19 43% 45
3 WUNDER, A , STEHLE, G , SCHRENK, HH , HARTUNG, G , HEENE, DL , MAIER-BORST, W , SINN, H , (1998) ANTITUMOR ACTIVITY OF METHOTREXATE-ALBUMIN CONJUGATES IN RATS BEARING A WALKER-256 CARCINOMA.INTERNATIONAL JOURNAL OF CANCER. VOL. 76. ISSUE 6. P. 884-890 15 79% 18
4 WARNECKE, A , FICHTNER, I , SASS, G , KRATZ, F , (2007) SYNTHESIS, CLEAVAGE PROFILE, AND ANTITUMOR EFFICACY OF AN ALBUMIN-BINDING PRODRUG OF METHOTREXATE THAT IS CLEAVED BY PLASMIN AND CATHEPSIN B.ARCHIV DER PHARMAZIE. VOL. 340. ISSUE 8. P. 389 -395 16 53% 25
5 GOU, Y , YANG, F , LIANG, H , (2016) DESIGNING PRODRUGS BASED ON SPECIAL RESIDUES OF HUMAN SERUM ALBUMIN.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 16. ISSUE 9. P. 996 -1008 30 22% 1
6 WOLFF, D , FREI, E , HOFMEISTER, N , STEINER, B , KLEINE, HD , JUNGHANSS, C , SIEVERT, K , TERPE, H , SCHRENK, HH , FREUND, M , ET AL (2006) METHOTREXATE-ALBUMIN AND AMINOPTERIN-ALBUMIN EFFECTIVELY PREVENT EXPERIMENTAL ACUTE GRAFT-VERSUS-HOST DISEASE.TRANSPLANTATION. VOL. 82. ISSUE 4. P. 527 -533 15 60% 6
7 JAGIELLO, M , KANSKA, U , NEVOZHAY, D , BORATYNSKI, J , (2010) SYNTHESIS AND BIOLOGICAL ACTIVITY OF RALTITREXED-CARRIER CONJUGATES.ACTA BIOCHIMICA POLONICA. VOL. 57. ISSUE 1. P. 83-87 13 62% 0
8 GRAESER, R , ESSER, N , UNGER, H , FICHTNER, I , ZHU, A , UNGER, C , KRATZ, F , (2010) INNO-206, THE (6-MALEIMIDOCAPROYL HYDRAZONE DERIVATIVE OF DOXORUBICIN), SHOWS SUPERIOR ANTITUMOR EFFICACY COMPARED TO DOXORUBICIN IN DIFFERENT TUMOR XENOGRAFT MODELS AND IN AN ORTHOTOPIC PANCREAS CARCINOMA MODEL.INVESTIGATIONAL NEW DRUGS. VOL. 28. ISSUE 1. P. 14 -19 12 60% 34
9 ELSADEK, B , GRAESER, R , ESSER, N , SCHAFER-OBODOZIE, C , ABU AJAJ, K , UNGER, C , WARNECKE, A , SALEEM, T , EL-MELEGY, N , MADKOR, H , ET AL (2010) DEVELOPMENT OF A NOVEL PRODRUG OF PACLITAXEL THAT IS CLEAVED BY PROSTATE-SPECIFIC ANTIGEN: AN IN VITRO AND IN VIVO EVALUATION STUDY.EUROPEAN JOURNAL OF CANCER. VOL. 46. ISSUE 18. P. 3434-3444 14 52% 20
10 BURGER, AM , HARTUNG, G , STEHLE, G , SINN, H , FIEBIG, HH , (2001) PRE-CLINICAL EVALUATION OF A METHOTREXATE-ALBUMIN CONJUGATE (MTX-HSA) IN HUMAN TUMOR XENOGRAFTS IN VIVO.INTERNATIONAL JOURNAL OF CANCER. VOL. 92. ISSUE 5. P. 718-724 14 61% 31

Classes with closest relation at Level 1


Rank Class id link
1 16519 NAB PACLITAXEL//ALBUMIN NANOPARTICLES//ABRAXANE
2 8461 HPMA COPOLYMER//POLYMER THER EUT//HPMA
3 21790 N SUCCINYL CHITOSAN//DEXTRAN PRODRUGS//BIOPHARMACEUT DRUG METAB
4 6520 IMMUNOTOXIN//GELONIN//RICIN A CHAIN
5 28336 RADIOIODINATION//PROSTHETIC RADIOIODINATION//ELED COMPOUND
6 36891 GLUTATHIONE DOXORUBICIN CONJUGATE//RAT HEPATOMA CELL//EXPT CYTOL
7 17243 ALBUMIN MICROSPHERES//ALBUMIN MICROSPHERE//LUNG TARGETING
8 37618 NBD GLUCOSAMINE//TUMOR SPECIFIC DOSE//MED HARVARD STUDY KIDNEY DIS
9 22255 GRP PEPTIDE CHEM//PEPTIDE PROT CHEM//PHYSICOCHEM UNIT
10 14540 ADEPT//NITROREDUCTASE//CB1954

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