Class information for:
Level 1: NQO1//DT DIAPHORASE//EO9

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
7463 1364 37.1 72%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
408 3       CHIM BIOINORGAN//POLO SCI//CARBONIC ANHYDRASE 29468
1363 2             TIRAPAZAMINE//DT DIAPHORASE//BIOREDUCTIVE DRUGS 8244
7463 1                   NQO1//DT DIAPHORASE//EO9 1364

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 NQO1 authKW 1264995 11% 39% 145
2 DT DIAPHORASE authKW 1259257 8% 49% 114
3 EO9 authKW 581394 2% 84% 31
4 RH1 authKW 251823 1% 75% 15
5 NQO2 authKW 248806 1% 65% 17
6 NADPH QUINONE OXIDOREDUCTASE 1 authKW 222113 2% 35% 28
7 INDOLEQUINONE authKW 182799 1% 58% 14
8 DICOUMAROL authKW 173162 2% 37% 21
9 AZIRIDINYLBENZOQUINONES authKW 164832 1% 82% 9
10 NQO1 POLYMORPHISM authKW 156695 1% 100% 7

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Oncology 3487 27% 0% 372
2 Biochemistry & Molecular Biology 1838 33% 0% 447
3 Pharmacology & Pharmacy 1371 20% 0% 278
4 Toxicology 1064 9% 0% 123
5 Chemistry, Medicinal 702 7% 0% 101
6 Biophysics 519 8% 0% 110
7 Endocrinology & Metabolism 54 4% 0% 51
8 Chemistry, Organic 32 4% 0% 54
9 Cell Biology 26 4% 0% 61
10 Biochemical Research Methods 15 2% 0% 29

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 GRP EXPT RADIAT ONCOL 44770 0% 100% 2
2 MED ONCOL CRC 29845 0% 67% 2
3 ZABLOCKI VAMC 29845 0% 67% 2
4 PHARMACEUT SCI KAGAWA 26641 0% 24% 5
5 29 39 BRUNSWICK SQ 22385 0% 100% 1
6 AFFAIRS HOSP 4 22385 0% 100% 1
7 ANHUI PROV HEPATOPANCREATOBILIARY 22385 0% 100% 1
8 BIOMED SCI BIOSCI BIOTECHNOL 22385 0% 100% 1
9 BLOOMBERG PUBL HLTH PHARMACOL MOL SCI 22385 0% 100% 1
10 BRADFORD TEACHING HOSP FDN HLTH SERV TRUST 22385 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CHEMICA SCRIPTA 6404 1% 2% 17
2 CANCER TREATMENT REPORTS 6310 2% 1% 25
3 BIOCHEMICAL PHARMACOLOGY 5523 5% 0% 68
4 CHEMICO-BIOLOGICAL INTERACTIONS 4265 2% 1% 33
5 FREE RADICAL BIOLOGY AND MEDICINE 4116 3% 0% 40
6 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 3225 4% 0% 50
7 PHARMACOGENETICS 2845 1% 1% 11
8 ANTI-CANCER DRUG DESIGN 2269 1% 1% 8
9 ADVANCES IN FREE RADICAL BIOLOGY AND MEDICINE 2033 0% 9% 1
10 CANCER RESEARCH 1982 4% 0% 60

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 NQO1 1264995 11% 39% 145 Search NQO1 Search NQO1
2 DT DIAPHORASE 1259257 8% 49% 114 Search DT+DIAPHORASE Search DT+DIAPHORASE
3 EO9 581394 2% 84% 31 Search EO9 Search EO9
4 RH1 251823 1% 75% 15 Search RH1 Search RH1
5 NQO2 248806 1% 65% 17 Search NQO2 Search NQO2
6 NADPH QUINONE OXIDOREDUCTASE 1 222113 2% 35% 28 Search NADPH+QUINONE+OXIDOREDUCTASE+1 Search NADPH+QUINONE+OXIDOREDUCTASE+1
7 INDOLEQUINONE 182799 1% 58% 14 Search INDOLEQUINONE Search INDOLEQUINONE
8 DICOUMAROL 173162 2% 37% 21 Search DICOUMAROL Search DICOUMAROL
9 AZIRIDINYLBENZOQUINONES 164832 1% 82% 9 Search AZIRIDINYLBENZOQUINONES Search AZIRIDINYLBENZOQUINONES
10 NQO1 POLYMORPHISM 156695 1% 100% 7 Search NQO1+POLYMORPHISM Search NQO1+POLYMORPHISM

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 PEY, AL , MEGARITY, CF , MEDINA-CARMONA, E , TIMSON, DJ , (2016) NATURAL SMALL MOLECULES AS STABILIZERS AND ACTIVATORS OF CANCER-ASSOCIATED NQO1 POLYMORPHISMS.CURRENT DRUG TARGETS. VOL. 17. ISSUE 13. P. 1506 -1514 66 80% 0
2 DANSON, S , WARD, TH , BUTLER, J , RANSON, M , (2004) DT-DIAPHORASE: A TARGET FOR NEW ANTICANCER DRUGS.CANCER TREATMENT REVIEWS. VOL. 30. ISSUE 5. P. 437-449 89 68% 93
3 ROSS, D , SIEGEL, D , (2004) NAD(P)H : QUINONE OXIDOREDUCTASE 1 (NQO1, DT-DIAPHORASE), FUNCTIONS AND PHARMACOGENCTICS.QUINONES AND QUINONE ENZYMES, PT B. VOL. 382. ISSUE . P. 115-144 80 62% 145
4 KEPA, JK , WINSKI, SL , BEALL, HD , ANWAR, A , SIEGEL, D , ROSS, D , (2000) NAD(P)H : QUINONE OXIDOREDUCTASE 1 (NQO1): CHEMOPROTECTION, BIOACTIVATION, GENE REGULATION AND GENETIC POLYMORPHISMS.CHEMICO-BIOLOGICAL INTERACTIONS. VOL. 129. ISSUE 1-2. P. 77 -97 73 57% 355
5 COLUCCI, MA , MOODY, CJ , COUCH, GD , (2008) NATURAL AND SYNTHETIC QUINONES AND THEIR REDUCTION BY THE QUINONE REDUCTASE ENZYME NQO1: FROM SYNTHETIC ORGANIC CHEMISTRY TO COMPOUNDS WITH ANTICANCER POTENTIAL.ORGANIC & BIOMOLECULAR CHEMISTRY. VOL. 6. ISSUE 4. P. 637 -656 59 68% 64
6 PHILLIPS, RM , HENDRIKS, HR , PETERS, GJ , (2013) EO9 (APAZIQUONE): FROM THE CLINIC TO THE LABORATORY AND BACK AGAIN.BRITISH JOURNAL OF PHARMACOLOGY. VOL. 168. ISSUE 1. P. 11-18 48 67% 18
7 GUTIERREZ, PL , (2000) THE ROLE OF NAD(P)H OXIDOREDUCTASE (DT-DIAPHORASE) IN THE BIOACTIVATION OF QUINONE-CONTAINING ANTITUMOR AGENTS: A REVIEW.FREE RADICAL BIOLOGY AND MEDICINE. VOL. 29. ISSUE 3-4. P. 263 -275 63 72% 66
8 CADENAS, E , (1995) ANTIOXIDANT AND PROOXIDANT FUNCTIONS OF DT-DIAPHORASE IN QUINONE METABOLISM.BIOCHEMICAL PHARMACOLOGY. VOL. 49. ISSUE 2. P. 127-140 73 61% 225
9 OH, ET , PARK, HJ , (2015) IMPLICATIONS OF NQO1 IN CANCER THERAPY.BMB REPORTS. VOL. 48. ISSUE 11. P. 609 -617 50 62% 4
10 ROSS, D , (2004) QUINONE REDUCTASES MULTITASKING IN THE METABOLIC WORLD.DRUG METABOLISM REVIEWS. VOL. 36. ISSUE 3-4. P. 639 -654 58 64% 111

Classes with closest relation at Level 1


Rank Class id link
1 12399 KW 2149//MITOSENE//FR900482
2 15678 TIRAPAZAMINE//BIOREDUCTIVE DRUGS//SR 4233
3 22766 ANTHRAQUINONE DISULPHONATES//NAA UNIT//SOLVENT POLARITY EFFECT
4 17875 LAVENDAMYCIN//ETNOFARMACOL IDE//QUINOLINE 5 8 DIONES
5 14540 ADEPT//NITROREDUCTASE//CB1954
6 10792 BETA LAPACHONE//LAPACHOL//NAPHTHOQUINONE
7 15937 CDC25B//CDC25 PHOSPHATASE//CDC25A
8 15943 TRICHLOROMETHYLPEROXYL//TRICHLOROMETHYL//CELL SURFACE BLEBS
9 1613 NRF2//KEAP1//ANTIOXIDANT RESPONSE ELEMENT
10 13838 PHENOXODIOL//NADH OXIDASE//PLASMA MEMBRANE REDOX SYSTEM

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