Class information for:
Level 1: TIRAPAZAMINE//BIOREDUCTIVE DRUGS//SR 4233

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
15678 698 39.7 76%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
408 3       CHIM BIOINORGAN//POLO SCI//CARBONIC ANHYDRASE 29468
1363 2             TIRAPAZAMINE//DT DIAPHORASE//BIOREDUCTIVE DRUGS 8244
15678 1                   TIRAPAZAMINE//BIOREDUCTIVE DRUGS//SR 4233 698

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 TIRAPAZAMINE authKW 2645049 13% 68% 89
2 BIOREDUCTIVE DRUGS authKW 990826 7% 46% 49
3 SR 4233 authKW 869753 4% 76% 26
4 AQ4N authKW 789606 3% 95% 19
5 HYPOXIA ACTIVATED PRODRUG authKW 752004 3% 90% 19
6 PR 104 authKW 615171 2% 94% 15
7 NLCQ 1 authKW 524947 2% 100% 12
8 AUCKLAND CANC SOC address 506177 12% 13% 86
9 HYPOXIC CYTOTOXIN authKW 468694 2% 71% 15
10 TH 302 authKW 434877 2% 76% 13

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Oncology 5164 45% 0% 312
2 Chemistry, Medicinal 1515 14% 0% 100
3 Radiology, Nuclear Medicine & Medical Imaging 475 11% 0% 78
4 Pharmacology & Pharmacy 468 17% 0% 120
5 Chemistry, Organic 116 7% 0% 52
6 Toxicology 105 4% 0% 31
7 Chemistry, Inorganic & Nuclear 86 5% 0% 35
8 Chemistry, Multidisciplinary 78 10% 0% 69
9 Crystallography 41 3% 0% 19
10 Biology 35 3% 0% 19

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 AUCKLAND CANC SOC 506177 12% 13% 86
2 EXPT ONCOL GRP 88571 1% 23% 9
3 DCTDFAIRVIEW 87491 0% 100% 2
4 AUCKLAND CANC SOCIETY 49210 0% 38% 3
5 ANN BARBARA KARRNANOS CANC 43746 0% 100% 1
6 AUSTRALYAN SYNCHROTRON PROGRAM 43746 0% 100% 1
7 BIOMED PROTE PLATFORM 43746 0% 100% 1
8 BROMATOL FOOD TECHNOL TOXICOL 43746 0% 100% 1
9 CANC UK CLLIN 43746 0% 100% 1
10 CHIRURG GINECOL 43746 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ANTI-CANCER DRUG DESIGN 10023 2% 2% 12
2 ONCOLOGY RESEARCH 7129 2% 1% 14
3 INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 4217 6% 0% 41
4 BRITISH JOURNAL OF CANCER 3677 6% 0% 39
5 CANCER CHEMOTHERAPY AND PHARMACOLOGY 1698 2% 0% 17
6 CHEMICAL RESEARCH IN TOXICOLOGY 1627 2% 0% 14
7 JOURNAL OF MEDICINAL CHEMISTRY 1341 4% 0% 26
8 BIOCHEMICAL PHARMACOLOGY 1219 3% 0% 23
9 RADIATION ONCOLOGY INVESTIGATIONS 970 0% 2% 1
10 CLINICAL CANCER RESEARCH 928 3% 0% 18

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 TIRAPAZAMINE 2645049 13% 68% 89 Search TIRAPAZAMINE Search TIRAPAZAMINE
2 BIOREDUCTIVE DRUGS 990826 7% 46% 49 Search BIOREDUCTIVE+DRUGS Search BIOREDUCTIVE+DRUGS
3 SR 4233 869753 4% 76% 26 Search SR+4233 Search SR+4233
4 AQ4N 789606 3% 95% 19 Search AQ4N Search AQ4N
5 HYPOXIA ACTIVATED PRODRUG 752004 3% 90% 19 Search HYPOXIA+ACTIVATED+PRODRUG Search HYPOXIA+ACTIVATED+PRODRUG
6 PR 104 615171 2% 94% 15 Search PR+104 Search PR+104
7 NLCQ 1 524947 2% 100% 12 Search NLCQ+1 Search NLCQ+1
8 HYPOXIC CYTOTOXIN 468694 2% 71% 15 Search HYPOXIC+CYTOTOXIN Search HYPOXIC+CYTOTOXIN
9 TH 302 434877 2% 76% 13 Search TH+302 Search TH+302
10 BIOREDUCTIVE AGENTS 341670 2% 46% 17 Search BIOREDUCTIVE+AGENTS Search BIOREDUCTIVE+AGENTS

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 PHILLIPS, RM , (2016) TARGETING THE HYPOXIC FRACTION OF TUMOURS USING HYPOXIA-ACTIVATED PRODRUGS.CANCER CHEMOTHERAPY AND PHARMACOLOGY. VOL. 77. ISSUE 3. P. 441 -457 60 54% 8
2 DENNY, WA , WILSON, WR , (2000) TIRAPAZAMINE: A BIOREDUCTIVE ANTICANCER DRUG THAT EXPLOITS TUMOUR HYPOXIA.EXPERT OPINION ON INVESTIGATIONAL DRUGS. VOL. 9. ISSUE 12. P. 2889 -2901 67 74% 56
3 HAY, MP , HICKS, KO , WANG, JL , (2014) HYPOXIA-DIRECTED DRUG STRATEGIES TO TARGET THE TUMOR MICROENVIRONMENT.TUMOR MICROENVIRONMENT AND CELLULAR STRESS: SIGNALING, METABOLISM, IMAGING, AND THERAPEUTIC TARGETS. VOL. 772. ISSUE . P. 111-145 94 37% 6
4 SHEN, XL , RAJAPAKSE, A , GALLAZZI, F , JUNNOTULA, V , FUCHS-KNOTTS, T , GLASER, R , GATES, KS , (2014) ISOTOPIC LABELING EXPERIMENTS THAT ELUCIDATE THE MECHANISM OF DNA STRAND CLEAVAGE BY THE HYPOXIA-SELECTIVE ANTITUMOR AGENT 1,2,4-BENZOTRIAZINE 1,4-DI-N-OXIDE.CHEMICAL RESEARCH IN TOXICOLOGY. VOL. 27. ISSUE 1. P. 111 -118 44 70% 1
5 GUISE, CP , MOWDAY, AM , ASHOORZADEH, A , YUAN, R , LIN, WH , WU, DH , SMAILL, JB , PATTERSON, AV , DING, K , (2014) BIOREDUCTIVE PRODRUGS AS CANCER THERAPEUTICS: TARGETING TUMOR HYPOXIA.CHINESE JOURNAL OF CANCER. VOL. 33. ISSUE 2. P. - 41 59% 26
6 JOHNSON, KM , PARSONS, ZD , BARNES, CL , GATES, KS , (2014) TOWARD HYPOXIA-SELECTIVE DNA-ALKYLATING AGENTS BUILT BY GRAFTING NITROGEN MUSTARDS ONTO THE BIOREDUCTIVELY ACTIVATED, HYPOXIA-SELECTIVE DNA-OXIDIZING AGENT 3-AMINO-1,2,4-BENZOTRIAZINE 1,4-DIOXIDE (TIRAPAZAMINE).JOURNAL OF ORGANIC CHEMISTRY. VOL. 79. ISSUE 16. P. 7520 -7531 46 59% 6
7 MCKEOWN, SR , COWENT, RL , WILLIAMS, KJ , (2007) BIOREDUCTIVE DRUGS: FROM CONCEPT TO CLINIC.CLINICAL ONCOLOGY. VOL. 19. ISSUE 6. P. 427-442 64 41% 96
8 LEE, CI , HUANG, CM , HUANG, WH , LEE, AR , (2014) SYNTHESIS, PREFERENTIALLY HYPOXIC APOPTOSIS AND ANTI-ANGIOGENIC ACTIVITY OF 3-AMINO-1,2,4-BENZOTRIAZINE-1,4-DIOXIDE BEARING ALKYL LINKERS WITH A 3-AMINO-1,2,4-BENZOTRIAZINE-1-OXIDE MOIETY.ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY. VOL. 14. ISSUE 10. P. 1428 -1446 32 82% 0
9 HAY, MP , HICKS, KO , PCHALEK, K , LEE, HH , BLASER, A , PRUIJN, FB , ANDERSON, RF , SHINDE, SS , WILSON, WR , DENNY, WA , (2008) TRICYCLIC [1,2,4]TRIAZINE 1,4-DIOXIDES AS HYPOXIA SELECTIVE CYTOTOXINS.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 51. ISSUE 21. P. 6853 -6865 42 68% 25
10 CHEN, Y , HU, LQ , (2009) DESIGN OF ANTICANCER PRODRUGS FOR REDUCTIVE ACTIVATION.MEDICINAL RESEARCH REVIEWS. VOL. 29. ISSUE 1. P. 29 -64 65 33% 154

Classes with closest relation at Level 1


Rank Class id link
1 35768 QUIESCENT CELL//BORON TRACEDRUG//MILD TEMPERATURE HYPERTHERMIA
2 9841 ETANIDAZOLE//HYPOXIC CELL SENSITIZER//HYPOXIC CELL RADIOSENSITIZER
3 14540 ADEPT//NITROREDUCTASE//CB1954
4 2109 CARBOGEN//TUMOR HYPOXIA//TUMOR OXYGENATION
5 7463 NQO1//DT DIAPHORASE//EO9
6 12399 KW 2149//MITOSENE//FR900482
7 20086 OLAQUINDOX//QUINOCETONE//CARBADOX
8 22006 DMXAA//FLAVONE ACETIC ACID//5 6 DIMETHYLXANTHENONE 4 ACETIC ACID
9 7615 QUINOXALINE//UNIDAD INVEST DESARROLLO MEDICAMENTOS//PYRROLO1 2 AQUINOXALINE
10 7272 ACRIDINE//C 1311//PYRAZOLOACRIDINE

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