Class information for:
Level 1: ESTERASE SENSITIVE PRODRUGS//KIRBYS ENZYME MODEL//PROXIMITY ORIENTATION

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
25636 276 36.6 50%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
5 4 CHEMISTRY, ORGANIC//CHEMISTRY, INORGANIC & NUCLEAR//CHEMISTRY, MULTIDISCIPLINARY 1745167
654 3       POLYOXYMETHYLENE DIMETHYL ETHERS//CROSS INTERACTION CONSTANT//PSEUDOACID 11347
1417 2             CROSS INTERACTION CONSTANT//GRUNWALD WINSTEIN EQUATION//PYRIDINOLYSIS 7994
25636 1                   ESTERASE SENSITIVE PRODRUGS//KIRBYS ENZYME MODEL//PROXIMITY ORIENTATION 276

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ESTERASE SENSITIVE PRODRUGS authKW 995715 3% 100% 9
2 KIRBYS ENZYME MODEL authKW 774445 3% 100% 7
3 PROXIMITY ORIENTATION authKW 774445 3% 100% 7
4 CYCLIC PRODRUG authKW 568979 2% 86% 6
5 EFFECTIVE MOLARITY EM authKW 442540 1% 100% 4
6 BIOORGAN PHARMACEUT CHEM address 331905 1% 100% 3
7 CHEMICAL AND ENZYMATIC STABILITY authKW 295024 1% 67% 4
8 ACYLOXYALKOXY LINKER authKW 221270 1% 100% 2
9 AMIDASE ENZYMES authKW 221270 1% 100% 2
10 ANCHIMERIC ASSISTENCE authKW 221270 1% 100% 2

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Chemistry, Organic 1780 37% 0% 101
2 Chemistry, Multidisciplinary 826 36% 0% 100
3 Chemistry, Medicinal 407 12% 0% 33
4 Pharmacology & Pharmacy 230 19% 0% 52
5 Chemistry, Physical 136 17% 0% 48
6 Biochemistry & Molecular Biology 28 13% 0% 36
7 Computer Science, Interdisciplinary Applications 26 3% 0% 9
8 Polymer Science 19 4% 0% 12
9 Biochemical Research Methods 13 3% 0% 9
10 Biophysics 6 3% 0% 8

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BIOORGAN PHARMACEUT CHEM 331905 1% 100% 3
2 AZ BIOVENTURE HUB 110635 0% 100% 1
3 EMERITI PHARMA AB 110635 0% 100% 1
4 SIMONS S 64314 2% 12% 5
5 AGR FO TRY ENVIRONM 44251 1% 20% 2
6 RIA IMED 12291 0% 11% 1
7 EUROPEAN CULTU DICEM 11062 0% 10% 1
8 STUDIO MECCANISMI REAZIONE 11062 0% 10% 1
9 CVMD IMED DMPK 6506 0% 6% 1
10 MINIST EDUC CHEM BIOL 6506 0% 6% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2 6539 8% 0% 22
2 BIOORGANIC CHEMISTRY 6074 3% 1% 9
3 JOURNAL OF PEPTIDE RESEARCH 4336 2% 1% 6
4 PHARMACEUTICAL RESEARCH 3528 6% 0% 16
5 JOURNAL OF MOLECULAR MODELING 1099 2% 0% 6
6 JOURNAL OF ORGANIC CHEMISTRY 843 7% 0% 20
7 COMPUTATIONAL AND THEORETICAL CHEMISTRY 760 1% 0% 4
8 ACCOUNTS OF CHEMICAL RESEARCH 628 2% 0% 5
9 JOURNAL OF PHARMACEUTICAL SCIENCES 620 3% 0% 8
10 CHEMICAL BIOLOGY & DRUG DESIGN 598 1% 0% 3

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 ESTERASE SENSITIVE PRODRUGS 995715 3% 100% 9 Search ESTERASE+SENSITIVE+PRODRUGS Search ESTERASE+SENSITIVE+PRODRUGS
2 KIRBYS ENZYME MODEL 774445 3% 100% 7 Search KIRBYS+ENZYME+MODEL Search KIRBYS+ENZYME+MODEL
3 PROXIMITY ORIENTATION 774445 3% 100% 7 Search PROXIMITY+ORIENTATION Search PROXIMITY+ORIENTATION
4 CYCLIC PRODRUG 568979 2% 86% 6 Search CYCLIC+PRODRUG Search CYCLIC+PRODRUG
5 EFFECTIVE MOLARITY EM 442540 1% 100% 4 Search EFFECTIVE+MOLARITY+EM Search EFFECTIVE+MOLARITY+EM
6 CHEMICAL AND ENZYMATIC STABILITY 295024 1% 67% 4 Search CHEMICAL+AND+ENZYMATIC+STABILITY Search CHEMICAL+AND+ENZYMATIC+STABILITY
7 ACYLOXYALKOXY LINKER 221270 1% 100% 2 Search ACYLOXYALKOXY+LINKER Search ACYLOXYALKOXY+LINKER
8 AMIDASE ENZYMES 221270 1% 100% 2 Search AMIDASE+ENZYMES Search AMIDASE+ENZYMES
9 ANCHIMERIC ASSISTENCE 221270 1% 100% 2 Search ANCHIMERIC+ASSISTENCE Search ANCHIMERIC+ASSISTENCE
10 ANTIMALARIAL PRODRUGS 221270 1% 100% 2 Search ANTIMALARIAL+PRODRUGS Search ANTIMALARIAL+PRODRUGS

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 KARAMAN, R , JUMAA, S , AWWADALLAH, H , SALAH, S , KHAWAJA, Y , KARAMAN, D , (2016) INTRAMOLECULAR PROCESSES AND THEIR APPLICATIONS IN PRODRUGS APPROACHES-EXPERIMENTAL AND COMPUTATIONAL STUDIES.CURRENT ORGANIC CHEMISTRY. VOL. 20. ISSUE 3. P. 289 -315 62 56% 0
2 KARAMAN, R , (2011) ANALYZING THE EFFICIENCY OF PROTON TRANSFER TO CARBON IN KIRBY'S ENZYME MODEL-A COMPUTATIONAL APPROACH.TETRAHEDRON LETTERS. VOL. 52. ISSUE 6. P. 699 -704 37 95% 0
3 KARAMAN, R , DAJANI, K , HALLAK, H , (2012) COMPUTER-ASSISTED DESIGN FOR ATENOLOL PRODRUGS FOR THE USE IN AQUEOUS FORMULATIONS.JOURNAL OF MOLECULAR MODELING. VOL. 18. ISSUE 4. P. 1523 -1540 35 83% 1
4 KARAMAN, R , (2010) A GENERAL EQUATION CORRELATING INTRAMOLECULAR RATES WITH 'ATTACK' PARAMETERS: DISTANCE AND ANGLE.TETRAHEDRON LETTERS. VOL. 51. ISSUE 39. P. 5185-5190 32 94% 2
5 KARAMAN, R , (2010) THE EFFICIENCY OF PROTON TRANSFER IN KIRBY'S ENZYME MODEL, A COMPUTATIONAL APPROACH.TETRAHEDRON LETTERS. VOL. 51. ISSUE 16. P. 2130-2135 31 94% 2
6 KARAMAN, R , AMLY, W , SCRANO, L , MECCA, G , BUFO, SA , (2013) COMPUTATIONALLY DESIGNED PRODRUGS OF STATINS BASED ON KIRBY'S ENZYME MODEL.JOURNAL OF MOLECULAR MODELING. VOL. 19. ISSUE 9. P. 3969-3982 35 76% 0
7 KARAMAN, R , GHAREEB, H , DAJANI, KK , SCRANO, L , HALLAK, H , ABU-LAFI, S , MECCA, G , BUFO, SA , (2013) DESIGN, SYNTHESIS AND IN VITRO KINETIC STUDY OF TRANEXAMIC ACID PRODRUGS FOR THE TREATMENT OF BLEEDING CONDITIONS.JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN. VOL. 27. ISSUE 7. P. 615-635 37 70% 2
8 HEJAZ, H , KARAMAN, R , KHAMIS, M , (2012) COMPUTER-ASSISTED DESIGN FOR PARACETAMOL MASKING BITTER TASTE PRODRUGS.JOURNAL OF MOLECULAR MODELING. VOL. 18. ISSUE 1. P. 103 -114 33 80% 1
9 KARAMAN, R , FATTASH, B , MECCA, G , BADER, M , (2014) COMPUTATIONALLY DESIGNED ATOVAQUONE PRODRUGS BASED ON BRUICE'S ENZYME MODEL.CURRENT COMPUTER-AIDED DRUG DESIGN. VOL. 10. ISSUE 1. P. 15 -27 38 64% 0
10 KARAMAN, R , (2011) THE ROLE OF PROXIMITY ORIENTATION IN INTRAMOLECULAR PROTON TRANSFER REACTIONS.COMPUTATIONAL AND THEORETICAL CHEMISTRY. VOL. 966. ISSUE 1-3. P. 311-321 37 70% 3

Classes with closest relation at Level 1


Rank Class id link
1 27060 HALOCARBANIONS//2 ARYL 2 TETRAHYDROFURANYL PHOSPHONATE//ANTIHCV ACTIVITY
2 13198 PRODRUG//DIFFUSION CELL EXPERIMENTS//DERMAL PRODRUG
3 27635 COMPUTATIONAL CHEMICAL KINETICS//GEM DIMETHYL EFFECT//4 HYDROXYTHIAZOLE
4 34676 PYRITINOL DIHYDROCHLORIDE//BIOTECH DRUG DESIGN//2H PYRAZOLES
5 30450 ALPHA AMINOESTER//L ENANTIOSPECIFIC HYDROLYSIS//NITRILASIC ACTIVITY
6 6692 CROSS INTERACTION CONSTANT//PYRIDINOLYSIS//PHOSPHORYL TRANSFER REACTION
7 35944 ARENE COMPLEXES IN CCL4//ADDITIONAL SHIELDING//CARBAMOYL PHOSPHONATE
8 34121 DIMER SHIFT//MONOMER SHIFT//MONOMER DIMER SELF ASSOCIATION
9 24555 SELF IMMOLATIVE//POLYMETHYL GLYOXYLATE//POLYOLEFIN SULFONES
10 34669 ELSAMICIN A//CHARTREUSIN//N 1 NAPHTHYL SUCCINIMIDE

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