Class information for:
Level 1: NANOBODY//SINGLE DOMAIN ANTIBODY//VHH

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
14481 767 44.7 87%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
478 3       PHAGE DISPLAY//CELL FREE PROTEIN SYNTHESIS//ANTIBODY ENGINEERING 23687
1834 2             PHAGE DISPLAY//ANTIBODY ENGINEERING//BISPECIFIC ANTIBODY 6173
14481 1                   NANOBODY//SINGLE DOMAIN ANTIBODY//VHH 767

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 NANOBODY authKW 3464408 20% 58% 151
2 SINGLE DOMAIN ANTIBODY authKW 2831293 14% 66% 108
3 VHH authKW 1937575 10% 62% 78
4 HEAVY CHAIN ANTIBODY authKW 1365714 5% 84% 41
5 CHRISTIAN DOPPLER ANTIBODY ENGN address 337207 2% 71% 12
6 IGNAR authKW 337207 2% 71% 12
7 CAMELID ANTIBODIES authKW 284352 1% 71% 10
8 NEW ANTIGEN RECEPTOR authKW 278670 1% 100% 7
9 SINGLE DOMAIN ANTIBODY FRAGMENT authKW 268713 1% 75% 9
10 CELLULAIRE MOL IMMUNOL address 231618 1% 73% 8

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Biochemistry & Molecular Biology 1733 41% 0% 313
2 Biotechnology & Applied Microbiology 1706 21% 0% 160
3 Biochemical Research Methods 916 12% 0% 94
4 Immunology 837 17% 0% 132
5 Biophysics 316 8% 0% 64
6 Chemistry, Analytical 129 7% 0% 54
7 Veterinary Sciences 106 5% 0% 40
8 Medicine, Research & Experimental 84 5% 0% 39
9 Radiology, Nuclear Medicine & Medical Imaging 46 4% 0% 33
10 Cell Biology 44 6% 0% 46

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CHRISTIAN DOPPLER ANTIBODY ENGN 337207 2% 71% 12
2 CELLULAIRE MOL IMMUNOL 231618 1% 73% 8
3 VIVO CELLULAR MOL IMAGING 146974 2% 31% 12
4 MOL CELLULAR INTERACT 142083 4% 11% 33
5 CELLULAR MOL IMMUNOL 125835 7% 6% 57
6 CELLULAR MOL INTERACT 117074 1% 29% 10
7 GDR2352 106157 1% 67% 4
8 GRP CELLULAR MOL IMMUNOL 90991 1% 57% 4
9 UNIT CELLULAR MOL IMMUNOL 87138 1% 24% 9
10 IN VIVO CELLULAR MOL IMAGING 82669 1% 23% 9

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PROTEIN ENGINEERING DESIGN & SELECTION 30014 4% 3% 28
2 MABS 4364 1% 1% 9
3 MOLECULAR IMMUNOLOGY 3504 3% 0% 25
4 JOURNAL OF CAMEL PRACTICE AND RESEARCH 2799 1% 1% 8
5 JOURNAL OF IMMUNOLOGICAL METHODS 1965 3% 0% 22
6 PORTLAND PRESS PROCEEDINGS 1655 0% 2% 2
7 BMC BIOTECHNOLOGY 1651 1% 1% 7
8 MOLECULAR IMAGING AND BIOLOGY 1481 1% 1% 6
9 HYBRIDOMA AND HYBRIDOMICS 1456 0% 1% 3
10 MICROBIAL CELL FACTORIES 1431 1% 1% 7

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 NANOBODY 3464408 20% 58% 151 Search NANOBODY Search NANOBODY
2 SINGLE DOMAIN ANTIBODY 2831293 14% 66% 108 Search SINGLE+DOMAIN+ANTIBODY Search SINGLE+DOMAIN+ANTIBODY
3 VHH 1937575 10% 62% 78 Search VHH Search VHH
4 HEAVY CHAIN ANTIBODY 1365714 5% 84% 41 Search HEAVY+CHAIN+ANTIBODY Search HEAVY+CHAIN+ANTIBODY
5 IGNAR 337207 2% 71% 12 Search IGNAR Search IGNAR
6 CAMELID ANTIBODIES 284352 1% 71% 10 Search CAMELID+ANTIBODIES Search CAMELID+ANTIBODIES
7 NEW ANTIGEN RECEPTOR 278670 1% 100% 7 Search NEW+ANTIGEN+RECEPTOR Search NEW+ANTIGEN+RECEPTOR
8 SINGLE DOMAIN ANTIBODY FRAGMENT 268713 1% 75% 9 Search SINGLE+DOMAIN+ANTIBODY+FRAGMENT Search SINGLE+DOMAIN+ANTIBODY+FRAGMENT
9 V H 184909 2% 39% 12 Search V+H Search V+H
10 FCAB 159240 1% 100% 4 Search FCAB Search FCAB

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 MUYLDERMANS, S , (2013) NANOBODIES: NATURAL SINGLE-DOMAIN ANTIBODIES.ANNUAL REVIEW OF BIOCHEMISTRY, VOL 82. VOL. 82. ISSUE . P. 775-797 105 71% 222
2 ROMAO, E , MORALES-YANEZ, F , HU, YZ , CRAUWELS, M , DE PAUW, P , HASSANZADEH, GG , DEVOOGDT, N , ACKAERT, C , VINCKE, C , MUYLDERMANS, S , (2016) IDENTIFICATION OF USEFUL NANOBODIES BY PHAGE DISPLAY OF IMMUNE SINGLE DOMAIN LIBRARIES DERIVED FROM CAMELID HEAVY CHAIN ANTIBODIES.CURRENT PHARMACEUTICAL DESIGN. VOL. 22. ISSUE 43. P. 6500 -6518 183 62% 1
3 STEELAND, S , VANDENBROUCKE, RE , LIBERT, C , (2016) NANOBODIES AS THERAPEUTICS: BIG OPPORTUNITIES FOR SMALL ANTIBODIES.DRUG DISCOVERY TODAY. VOL. 21. ISSUE 7. P. 1076 -1113 146 48% 3
4 EYER, L , HRUSKA, K , (2012) SINGLE-DOMAIN ANTIBODY FRAGMENTS DERIVED FROM HEAVY-CHAIN ANTIBODIES: A REVIEW.VETERINARNI MEDICINA. VOL. 57. ISSUE 9. P. 439 -513 109 78% 20
5 RAHBARIZADEH, F , AHMADVAND, D , SHARIFZADEH, Z , (2011) NANOBODY; AN OLD CONCEPT AND NEW VEHICLE FOR IMMUNOTARGETING.IMMUNOLOGICAL INVESTIGATIONS. VOL. 40. ISSUE 3. P. 299 -338 128 61% 31
6 VAN BOCKSTAELE, F , HOLZ, JB , REVETS, H , (2009) THE DEVELOPMENT OF NANOBODIES FOR THERAPEUTIC APPLICATIONS.CURRENT OPINION IN INVESTIGATIONAL DRUGS. VOL. 10. ISSUE 11. P. 1212 -1224 99 76% 72
7 DE MARCO, A , (2011) BIOTECHNOLOGICAL APPLICATIONS OF RECOMBINANT SINGLE-DOMAIN ANTIBODY FRAGMENTS.MICROBIAL CELL FACTORIES. VOL. 10. ISSUE . P. - 110 60% 49
8 DE MEYER, T , MUYLDERMANS, S , DEPICKER, A , (2014) NANOBODY-BASED PRODUCTS AS RESEARCH AND DIAGNOSTIC TOOLS.TRENDS IN BIOTECHNOLOGY. VOL. 32. ISSUE 5. P. 263-270 59 72% 63
9 WANG, YZ , FAN, Z , SHAO, L , KONG, XW , HOU, XJ , TIAN, DR , SUN, Y , XIAO, YZ , YU, L , (2016) NANOBODY-DERIVED NANOBIOTECHNOLOGY TOOL KITS FOR DIVERSE BIOMEDICAL AND BIOTECHNOLOGY APPLICATIONS.INTERNATIONAL JOURNAL OF NANOMEDICINE. VOL. 11. ISSUE . P. 3287 -3302 75 72% 1
10 HARMSEN, MM , DE HAARD, HJ , (2007) PROPERTIES, PRODUCTION, AND APPLICATIONS OF CAMELID SINGLE-DOMAIN ANTIBODY FRAGMENTS.APPLIED MICROBIOLOGY AND BIOTECHNOLOGY. VOL. 77. ISSUE 1. P. 13 -22 65 76% 252

Classes with closest relation at Level 1


Rank Class id link
1 2141 PHAGE DISPLAY//SCFV//ANTIBODY LIBRARY
2 18905 REPEAT PROTEIN//FN3//ANKYRIN REPEAT
3 13646 AFFIBODY MOLECULE//AFFIBODY//BIOMED RADIAT SCI
4 8251 CANONICAL STRUCTURES//ANTIBODY MODELING//HUMANIZATION
5 9947 BISPECIFIC ANTIBODY//BISPECIFIC ANTIBODIES//CATUMAXOMAB
6 10569 FCRN//NEONATAL FC RECEPTOR//TARGET MEDIATED DRUG DISPOSITION
7 33873 MASS SPECTROMETRIC EPITOPE MAPPING//RA33 AUTOANTIGEN//PEPTIDE CHIP ANALYSIS
8 8514 PROTEIN FORMULATION//PROTEIN AGGREGATION//SUBVISIBLE PARTICLES
9 28336 RADIOIODINATION//PROSTHETIC RADIOIODINATION//ELED COMPOUND
10 13476 CLUSTER OF DIFFERENTIATION CD ANTIGENS//VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY//MONOCLONAL ANTIBODIES MAB

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