Class information for:
Level 1: PROTEIN FORMULATION//PROTEIN AGGREGATION//SUBVISIBLE PARTICLES

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
8514 1246 41.8 75%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
350 3       COMPLEMENT//MANNOSE BINDING LECTIN//IMMUNOLOGY 35656
1655 2             BIOSIMILAR//FCRN//PROTEIN FORMULATION 6878
8514 1                   PROTEIN FORMULATION//PROTEIN AGGREGATION//SUBVISIBLE PARTICLES 1246

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PROTEIN FORMULATION authKW 2059492 13% 51% 164
2 PROTEIN AGGREGATION authKW 754233 21% 12% 256
3 SUBVISIBLE PARTICLES authKW 616003 2% 93% 27
4 LATE STAGE PHARMACEUT DEV address 472102 3% 57% 34
5 FORMULAT SCI address 423744 3% 41% 42
6 MACROMOL VACCINE STABILIZAT address 374492 3% 48% 32
7 BIOPHARMACEUTICALS CHARACTERIZATION authKW 251315 2% 51% 20
8 PROT PHARMACEUT DEV address 243603 1% 76% 13
9 JOURNAL OF PHARMACEUTICAL SCIENCES journal 242016 27% 3% 332
10 PHARM PHARMACEUT TECHNOL BIOPHARMACEUT address 225185 3% 26% 36

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Pharmacology & Pharmacy 12925 59% 0% 733
2 Chemistry, Medicinal 10911 28% 0% 348
3 Chemistry, Multidisciplinary 4056 38% 0% 469
4 Biochemical Research Methods 688 9% 0% 108
5 Chemistry, Analytical 511 10% 0% 125
6 Biotechnology & Applied Microbiology 353 9% 0% 106
7 Medicine, Research & Experimental 198 6% 0% 73
8 Biochemistry & Molecular Biology 171 14% 0% 177
9 Biophysics 136 5% 0% 61
10 Chemistry, Physical 21 6% 0% 78

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 LATE STAGE PHARMACEUT DEV 472102 3% 57% 34
2 FORMULAT SCI 423744 3% 41% 42
3 MACROMOL VACCINE STABILIZAT 374492 3% 48% 32
4 PROT PHARMACEUT DEV 243603 1% 76% 13
5 PHARM PHARMACEUT TECHNOL BIOPHARMACEUT 225185 3% 26% 36
6 FORMULAT ANALYT OURCES 191386 1% 46% 17
7 PHARMACEUT DEV SUPPLIES 171522 1% 50% 14
8 PHARMA TECH DEV BIOL EUROPE 152680 1% 69% 9
9 DRUG DELIVERY TECHNOL 149723 3% 15% 41
10 DRUG PROD DEV 138517 2% 27% 21

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF PHARMACEUTICAL SCIENCES 242016 27% 3% 332
2 MABS 45511 3% 5% 37
3 PHARMACEUTICAL RESEARCH 36384 9% 1% 109
4 BIOPHARM INTERNATIONAL 9156 1% 3% 14
5 EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 8522 3% 1% 36
6 JOURNAL OF PARENTERAL SCIENCE AND TECHNOLOGY 7402 0% 5% 6
7 PDA JOURNAL OF PHARMACEUTICAL SCIENCE AND TECHNOLOGY 7389 1% 3% 9
8 MOLECULAR PHARMACEUTICS 6504 2% 1% 29
9 AAPS JOURNAL 4223 1% 1% 14
10 INTERNATIONAL JOURNAL OF PHARMACEUTICS 3209 4% 0% 46

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 PROTEIN FORMULATION 2059492 13% 51% 164 Search PROTEIN+FORMULATION Search PROTEIN+FORMULATION
2 PROTEIN AGGREGATION 754233 21% 12% 256 Search PROTEIN+AGGREGATION Search PROTEIN+AGGREGATION
3 SUBVISIBLE PARTICLES 616003 2% 93% 27 Search SUBVISIBLE+PARTICLES Search SUBVISIBLE+PARTICLES
4 BIOPHARMACEUTICALS CHARACTERIZATION 251315 2% 51% 20 Search BIOPHARMACEUTICALS+CHARACTERIZATION Search BIOPHARMACEUTICALS+CHARACTERIZATION
5 LIGHT OBSCURATION 192108 1% 56% 14 Search LIGHT+OBSCURATION Search LIGHT+OBSCURATION
6 POLYSORBATE 190710 2% 32% 24 Search POLYSORBATE Search POLYSORBATE
7 LIGHT SCATTERING DYNAMIC 125480 1% 39% 13 Search LIGHT+SCATTERING+DYNAMIC Search LIGHT+SCATTERING+DYNAMIC
8 FORMULATION 118497 8% 5% 104 Search FORMULATION Search FORMULATION
9 PROTEIN FOLDING REFOLDING 116680 1% 48% 10 Search PROTEIN+FOLDING+REFOLDING Search PROTEIN+FOLDING+REFOLDING
10 PHYSICAL STABILITY 103299 4% 9% 45 Search PHYSICAL+STABILITY Search PHYSICAL+STABILITY

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 FUNKE, S , MATILAINEN, J , NALENZ, H , BECHTOLD-PETERS, K , MAHLER, HC , FRIESS, W , (2016) SILICONE MIGRATION FROM BAKED-ON SILICONE LAYERS. PARTICLE CHARACTERIZATION IN PLACEBO AND PROTEIN SOLUTIONS.JOURNAL OF PHARMACEUTICAL SCIENCES. VOL. 105. ISSUE 12. P. 3520 -3531 62 84% 0
2 CHAUDHURI, R , CHENG, Y , MIDDAUGH, CR , VOLKIN, DB , (2014) HIGH-THROUGHPUT BIOPHYSICAL ANALYSIS OF PROTEIN THERAPEUTICS TO EXAMINE INTERRELATIONSHIPS BETWEEN AGGREGATE FORMATION AND CONFORMATIONAL STABILITY.AAPS JOURNAL. VOL. 16. ISSUE 1. P. 48-64 62 70% 16
3 BRADER, ML , ESTEY, T , BAI, SJ , ALSTON, RW , LUCAS, KK , LANTZ, S , LANDSMAN, P , MALONEY, KM , (2015) EXAMINATION OF THERMAL UNFOLDING AND AGGREGATION PROFILES OF A SERIES OF DEVELOPABLE THERAPEUTIC MONOCLONAL ANTIBODIES.MOLECULAR PHARMACEUTICS. VOL. 12. ISSUE 4. P. 1005 -1017 44 76% 10
4 SAMRA, HS , HE, F , (2012) ADVANCEMENTS IN HIGH THROUGHPUT BIOPHYSICAL TECHNOLOGIES: APPLICATIONS FOR CHARACTERIZATION AND SCREENING DURING EARLY FORMULATION DEVELOPMENT OF MONOCLONAL ANTIBODIES.MOLECULAR PHARMACEUTICS. VOL. 9. ISSUE 4. P. 696-707 60 64% 21
5 TELIKEPALLI, SN , KUMRU, OS , KALONIA, C , ESFANDIARY, R , JOSHI, SB , MIDDAUGH, CR , VOLKIN, DB , (2014) STRUCTURAL CHARACTERIZATION OF IGG1 MAB AGGREGATES AND PARTICLES GENERATED UNDER VARIOUS STRESS CONDITIONS.JOURNAL OF PHARMACEUTICAL SCIENCES. VOL. 103. ISSUE 3. P. 796 -809 45 79% 14
6 GENG, SB , CHEUNG, JK , NARASIMHAN, C , SHAMEEM, M , TESSIER, PM , (2014) IMPROVING MONOCLONAL ANTIBODY SELECTION AND ENGINEERING USING MEASUREMENTS OF COLLOIDAL PROTEIN INTERACTIONS.JOURNAL OF PHARMACEUTICAL SCIENCES. VOL. 103. ISSUE 11. P. 3356 -3363 52 70% 10
7 MOUSSA, EM , PANCHAL, JP , MOORTHY, BS , BLUM, JS , JOUBERT, MK , NARHI, LO , TOPP, EM , (2016) IMMUNOGENICITY OF THERAPEUTIC PROTEIN AGGREGATES.JOURNAL OF PHARMACEUTICAL SCIENCES. VOL. 105. ISSUE 2. P. 417 -430 48 57% 5
8 AMIN, S , BARNETT, GV , PATHAK, JA , ROBERTS, CJ , SARANGAPANI, PS , (2014) PROTEIN AGGREGATION, PARTICLE FORMATION, CHARACTERIZATION & RHEOLOGY.CURRENT OPINION IN COLLOID & INTERFACE SCIENCE. VOL. 19. ISSUE 5. P. 438 -449 54 59% 22
9 HAWE, A , WIGGENHORN, M , VAN DE WEERT, M , GARBE, JHO , MAHLER, HC , JISKOOT, W , (2012) FORCED DEGRADATION OF THERAPEUTIC PROTEINS.JOURNAL OF PHARMACEUTICAL SCIENCES. VOL. 101. ISSUE 3. P. 895 -913 67 49% 49
10 KALONIA, C , KUMRU, OS , KIM, JH , MIDDAUGH, CR , VOLKIN, DB , (2013) RADAR CHART ARRAY ANALYSIS TO VISUALIZE EFFECTS OF FORMULATION VARIABLES ON IGG1 PARTICLE FORMATION AS MEASURED BY MULTIPLE ANALYTICAL TECHNIQUES.JOURNAL OF PHARMACEUTICAL SCIENCES. VOL. 102. ISSUE 12. P. 4256-4267 41 89% 8

Classes with closest relation at Level 1


Rank Class id link
1 7069 FREEZE DRYING//LYOPHILIZATION//FREEZE DRYING LYOPHILIZATION
2 4824 AGALACTOSYL IGG//MABS//PROT ANALYT CHEM
3 21074 DYNAM MACROMOL ASSEMBLY SECT//ANALYTICAL ULTRACENTRIFUGATION//SEDIMENTATION VELOCITY
4 35000 TAYLOR DISPERSION ANALYSIS//DISPLAY SCREENING//DOUBLE UV DETECTION POINTS
5 14993 BIOSIMILAR//ANTI ERYTHROPOIETIN ANTIBODIES//CT P13
6 21401 HUMAN HYALINE CARTILAGE//PROTEIN MELTING DOMAINS//THERMAL SHIFT ASSAY
7 8183 INCLUSION BODIES//PROTEIN REFOLDING//REFOLDING
8 26378 GRIPE GRP INVESTIGADOR PROBLEMAS ENFERMEDADES INF//EFFECT OF PROCESSING FACTORS//EFFECT OF FORMULATION FACTORS
9 9378 OSMOLYTES//PREFERENTIAL INTERACTIONS//PREFERENTIAL HYDRATION
10 35198 DESHBANDHU//SURVISMETER//HUGGINS COEFFICIENT

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