Class information for:
Level 1: CANONICAL STRUCTURES//ANTIBODY MODELING//HUMANIZATION

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
8251 1275 40.9 73%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
478 3       PHAGE DISPLAY//CELL FREE PROTEIN SYNTHESIS//ANTIBODY ENGINEERING 23687
1834 2             PHAGE DISPLAY//ANTIBODY ENGINEERING//BISPECIFIC ANTIBODY 6173
8251 1                   CANONICAL STRUCTURES//ANTIBODY MODELING//HUMANIZATION 1275

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CANONICAL STRUCTURES authKW 367902 2% 59% 26
2 ANTIBODY MODELING authKW 266176 1% 65% 17
3 HUMANIZATION authKW 249425 3% 27% 39
4 COMPLEMENTARITY DETERMINING REGION authKW 192393 2% 27% 30
5 ANTIBODY STRUCTURE authKW 166656 2% 30% 23
6 ANTIBODY ANTIGEN COMPLEX authKW 149881 1% 48% 13
7 CDR CONFORMATION authKW 119738 0% 100% 5
8 ANTIBODY HUMANIZATION authKW 107308 1% 41% 11
9 HYPERVARIABLE LOOPS authKW 106671 1% 64% 7
10 CDR H3 authKW 102169 1% 53% 8

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Biochemistry & Molecular Biology 10125 72% 0% 914
2 Immunology 2616 23% 0% 291
3 Biophysics 2216 16% 0% 202
4 Biochemical Research Methods 1292 11% 0% 145
5 Biotechnology & Applied Microbiology 148 6% 0% 77
6 Crystallography 130 3% 0% 43
7 Mathematical & Computational Biology 103 2% 0% 25
8 Biology 51 3% 0% 32
9 Cell Biology 39 5% 0% 64
10 Computer Science, Interdisciplinary Applications 6 1% 0% 16

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CRYSTALLOG PROGRAM 49244 1% 17% 12
2 HGEBIET PROT MODELLING 47895 0% 100% 2
3 148 SIDNEY ST 23948 0% 100% 1
4 1500 WALLACE BLVD 23948 0% 100% 1
5 2375 GARCIA AVE 23948 0% 100% 1
6 ABT PROTE URFOR 23948 0% 100% 1
7 ANIM PHYSIOL GENET IMMUNOL 23948 0% 100% 1
8 ANTIBODY PREPARAT 23948 0% 100% 1
9 BASIC SCISTRUCT BIOPHYS 23948 0% 100% 1
10 BECKMAN INT PHYS BIOCHEM SECT 23948 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MOLECULAR IMMUNOLOGY 41167 9% 2% 110
2 PROTEIN ENGINEERING 24352 4% 2% 48
3 JOURNAL OF MOLECULAR RECOGNITION 24017 3% 3% 35
4 JOURNAL OF MOLECULAR BIOLOGY 15225 10% 1% 122
5 PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS 12558 5% 1% 58
6 BIOTECHNOLOGY SOFTWARE & INTERNET JOURNAL 11973 0% 50% 1
7 BIOTECHNOLOGY SOFTWARE JOURNAL 11973 0% 50% 1
8 PROTEIN ENGINEERING DESIGN & SELECTION 6634 1% 2% 17
9 MABS 5473 1% 2% 13
10 PORTLAND PRESS PROCEEDINGS 3984 0% 4% 4

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 CANONICAL STRUCTURES 367902 2% 59% 26 Search CANONICAL+STRUCTURES Search CANONICAL+STRUCTURES
2 ANTIBODY MODELING 266176 1% 65% 17 Search ANTIBODY+MODELING Search ANTIBODY+MODELING
3 HUMANIZATION 249425 3% 27% 39 Search HUMANIZATION Search HUMANIZATION
4 COMPLEMENTARITY DETERMINING REGION 192393 2% 27% 30 Search COMPLEMENTARITY+DETERMINING+REGION Search COMPLEMENTARITY+DETERMINING+REGION
5 ANTIBODY STRUCTURE 166656 2% 30% 23 Search ANTIBODY+STRUCTURE Search ANTIBODY+STRUCTURE
6 ANTIBODY ANTIGEN COMPLEX 149881 1% 48% 13 Search ANTIBODY+ANTIGEN+COMPLEX Search ANTIBODY+ANTIGEN+COMPLEX
7 CDR CONFORMATION 119738 0% 100% 5 Search CDR+CONFORMATION Search CDR+CONFORMATION
8 ANTIBODY HUMANIZATION 107308 1% 41% 11 Search ANTIBODY+HUMANIZATION Search ANTIBODY+HUMANIZATION
9 HYPERVARIABLE LOOPS 106671 1% 64% 7 Search HYPERVARIABLE+LOOPS Search HYPERVARIABLE+LOOPS
10 CDR H3 102169 1% 53% 8 Search CDR+H3 Search CDR+H3

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 PADLAN, EA , (1994) ANATOMY OF THE ANTIBODY MOLECULE.MOLECULAR IMMUNOLOGY. VOL. 31. ISSUE 3. P. 169-217 77 62% 610
2 PADLAN, EA , (1996) X-RAY CRYSTALLOGRAPHY OF ANTIBODIES.ADVANCES IN PROTEIN CHEMISTRY, VOL 49. VOL. 49. ISSUE . P. 57-133 72 65% 119
3 ALLAZIKANI, B , LESK, AM , CHOTHIA, C , (1997) STANDARD CONFORMATIONS FOR THE CANONICAL STRUCTURES OF IMMUNOGLOBULINS.JOURNAL OF MOLECULAR BIOLOGY. VOL. 273. ISSUE 4. P. 927-948 40 82% 399
4 AKIBA, H , TSUMOTO, K , (2015) THERMODYNAMICS OF ANTIBODY-ANTIGEN INTERACTION REVEALED BY MUTATION ANALYSIS OF ANTIBODY VARIABLE REGIONS.JOURNAL OF BIOCHEMISTRY. VOL. 158. ISSUE 1. P. 1 -13 44 59% 4
5 KURODA, D , SHIRAI, H , JACOBSON, MP , NAKAMURA, H , (2012) COMPUTER-AIDED ANTIBODY DESIGN.PROTEIN ENGINEERING DESIGN & SELECTION. VOL. 25. ISSUE 10. P. 507-521 68 35% 57
6 MARCATILI, P , OLIMPIERI, PP , CHAILYAN, A , TRAMONTANO, A , (2014) ANTIBODY STRUCTURAL MODELING WITH PREDICTION OF IMMUNOGLOBULIN STRUCTURE (PIGS).NATURE PROTOCOLS. VOL. 9. ISSUE 12. P. 2771 -2783 43 60% 7
7 MOREA, V , TRAMONTANO, A , RUSTICI, M , CHOTHIA, C , LESK, AM , (1998) CONFORMATIONS OF THE THIRD HYPERVARIABLE REGION IN THE VH DOMAIN OF IMMUNOGLOBULINS.JOURNAL OF MOLECULAR BIOLOGY. VOL. 275. ISSUE 2. P. 269 -294 47 65% 227
8 SWINDELLS, MB , PORTER, CT , COUCH, M , HURST, J , ABHINANDAN, KR , NIELSEN, JH , MACINDOE, G , HETHERINGTON, J , MARTIN, ACR , (2017) ABYSIS: INTEGRATED ANTIBODY SEQUENCE AND STRUCTURE-MANAGEMENT, ANALYSIS, AND PREDICTION.JOURNAL OF MOLECULAR BIOLOGY. VOL. 429. ISSUE 3. P. 356 -364 28 53% 1
9 SELA-CULANG, I , KUNIK, V , OFRAN, Y , (2013) THE STRUCTURAL BASIS OF ANTIBODY-ANTIGEN RECOGNITION.FRONTIERS IN IMMUNOLOGY. VOL. 4. ISSUE . P. - 53 37% 40
10 MOHAN, S , SINHA, N , SMITH-GILL, J , (2003) MODELING THE BINDING SITES OF ANTI-HEN EGG WHITE LYSOZYME ANTIBODIES HYHEL-8 AND HYHEL-26: AN INSIGHT INTO THE MOLECULAR BASIS OF ANTIBODY CROSS-REACTIVITY AND SPECIFICITY.BIOPHYSICAL JOURNAL. VOL. 85. ISSUE 5. P. 3221 -3236 53 58% 22

Classes with closest relation at Level 1


Rank Class id link
1 2141 PHAGE DISPLAY//SCFV//ANTIBODY LIBRARY
2 6004 RIBS//MOLECULAR IMMUNOLOGY//DEXTRAN B512
3 13376 B CELL EPITOPE PREDICTION//PREDETERMINED SPECIFICITY//SYNTHETIC ANTIGENIC SITE
4 25915 LIGHT CHAIN AMYLOIDOSIS//GLYCOSYLATED IMMUNOGLOBULIN LIGHT CHAIN//IMMUNOLOGICAL SIGNAL
5 8400 CATALYTIC ANTIBODIES//ABZYME//CHEM IMMUNOL THER EUT
6 14481 NANOBODY//SINGLE DOMAIN ANTIBODY//VHH
7 24364 BETA D GALACTOSIDASE//NONCOMPETITIVE IMMUNOASSAY//GELATIN PARTICLE AGGLUTINATION
8 36836 DISTANT RECOGNITION//ANTIPROGESTERONE ANTIBODIES//ARVICOLA TERRESTRIS WATER VOLE
9 6443 PROTEIN PROTEIN DOCKING//CAPRI//PROTEIN DOCKING
10 12757 BIACORE//BIOMOL INTERACT ANAL//IASYS

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