Class information for:
Level 2: LEFLUNOMIDE//MIZORIBINE//DIHYDROOROTATE DEHYDROGENASE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
2798 3097 28.6 71%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
236 3       ADENOSINE//NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS//ADENOSINE RECEPTORS 48331
2798 2             LEFLUNOMIDE//MIZORIBINE//DIHYDROOROTATE DEHYDROGENASE 3097
10582 1                   LEFLUNOMIDE//DIHYDROOROTATE DEHYDROGENASE//TERIFLUNOMIDE 1051
10938 1                   TIAZOFURIN//IMPDH//BENZAMIDE RIBOSIDE 1022
20983 1                   DEOXYSPERGUALIN//15 DEOXYSPERGUALIN//AXE IMMUNOL 437
23401 1                   CYCLOPENTENYL CYTOSINE//CTP SYNTHASE//CTP SYNTHETASE 347
26970 1                   MIZORIBINE//ORAL MIZORIBINE PULSE THERAPY//LS180 CELL 240

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 LEFLUNOMIDE authKW 1283964 8% 51% 257
2 MIZORIBINE authKW 586053 3% 62% 96
3 DIHYDROOROTATE DEHYDROGENASE authKW 515714 2% 76% 69
4 TIAZOFURIN authKW 454948 2% 77% 60
5 CYCLOPENTENYL CYTOSINE authKW 228186 1% 93% 25
6 CTP SYNTHASE authKW 218385 1% 92% 24
7 IMPDH authKW 212022 1% 51% 42
8 TERIFLUNOMIDE authKW 195340 1% 47% 42
9 IMP DEHYDROGENASE authKW 177067 1% 56% 32
10 DG RHEUMATOL address 164290 1% 83% 20

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Transplantation 17922 16% 0% 497
2 Immunology 5553 21% 0% 665
3 Pharmacology & Pharmacy 2215 18% 0% 547
4 Chemistry, Medicinal 2201 9% 0% 265
5 Surgery 2106 16% 0% 488
6 Rheumatology 1560 4% 0% 135
7 Biochemistry & Molecular Biology 1339 21% 0% 649
8 Oncology 1012 11% 0% 350
9 Chemistry, Organic 233 6% 0% 174
10 Biophysics 181 4% 0% 121

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DG RHEUMATOL 164290 1% 83% 20
2 DG RHEUMATOL IMMUNOL 89615 0% 91% 10
3 BEHRINGWERKE AG 49289 0% 100% 5
4 IMMUNOL DOMAIN 39431 0% 100% 4
5 AXE IMMUNOL 31543 0% 80% 4
6 PHARMA WERK KALLE ALBERT 29573 0% 100% 3
7 CHEM GLOBAL HLTH 26285 0% 67% 4
8 CRISTALOG PROT 22992 0% 33% 7
9 CHEM PATHOBIOL 19716 0% 100% 2
10 KIDNEY PEDIAT 19716 0% 100% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ADVANCES IN ENZYME REGULATION 27727 1% 7% 41
2 TRANSPLANTATION PROCEEDINGS 27555 11% 1% 336
3 TRANSPLANTATION 4594 3% 1% 94
4 NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS 3658 1% 1% 42
5 CANCER TREATMENT REPORTS 2978 1% 1% 26
6 JOURNAL OF MEDICINAL CHEMISTRY 2532 2% 0% 76
7 JOURNAL OF ANTIBIOTICS 2421 1% 1% 41
8 INVESTIGATIONAL NEW DRUGS 2370 1% 1% 25
9 BIOCHEMICAL PHARMACOLOGY 2358 2% 0% 68
10 INTERNATIONAL JOURNAL OF IMMUNOTHERAPY 2073 0% 2% 10

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 LEFLUNOMIDE 1283964 8% 51% 257 Search LEFLUNOMIDE Search LEFLUNOMIDE
2 MIZORIBINE 586053 3% 62% 96 Search MIZORIBINE Search MIZORIBINE
3 DIHYDROOROTATE DEHYDROGENASE 515714 2% 76% 69 Search DIHYDROOROTATE+DEHYDROGENASE Search DIHYDROOROTATE+DEHYDROGENASE
4 TIAZOFURIN 454948 2% 77% 60 Search TIAZOFURIN Search TIAZOFURIN
5 CYCLOPENTENYL CYTOSINE 228186 1% 93% 25 Search CYCLOPENTENYL+CYTOSINE Search CYCLOPENTENYL+CYTOSINE
6 CTP SYNTHASE 218385 1% 92% 24 Search CTP+SYNTHASE Search CTP+SYNTHASE
7 IMPDH 212022 1% 51% 42 Search IMPDH Search IMPDH
8 TERIFLUNOMIDE 195340 1% 47% 42 Search TERIFLUNOMIDE Search TERIFLUNOMIDE
9 IMP DEHYDROGENASE 177067 1% 56% 32 Search IMP+DEHYDROGENASE Search IMP+DEHYDROGENASE
10 CTP SYNTHETASE 162216 1% 69% 24 Search CTP+SYNTHETASE Search CTP+SYNTHETASE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 MUNIER-LEHMANN, H , VIDALAIN, PO , TANGY, F , JANIN, YL , (2013) ON DIHYDROOROTATE DEHYDROGENASES AND THEIR INHIBITORS AND USES.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 56. ISSUE 8. P. 3148-3167 166 72% 28
2 HEDSTROM, L , (2009) IMP DEHYDROGENASE: STRUCTURE, MECHANISM, AND INHIBITION.CHEMICAL REVIEWS. VOL. 109. ISSUE 7. P. 2903 -2928 164 72% 107
3 CHEN, LQ , PANKIEWICZ, KW , (2007) RECENT DEVELOPMENT OF IMP DEHYDROGENASE INHIBITORS FOR THE TREATMENT OF CANCER.CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT. VOL. 10. ISSUE 4. P. 403-412 72 88% 61
4 PETRELLI, R , VITA, P , TORQUATI, I , FELCZAK, K , WILSON, DJ , FRANCHETTI, P , CAPPELLACCI, L , (2013) NOVEL INHIBITORS OF INOSINE MONOPHOSPHATE DEHYDROGENASE IN PATENT LITERATURE OF THE LAST DECADE.RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY. VOL. 8. ISSUE 2. P. 103-125 69 78% 9
5 MERINO, P , GHIRARDELLO, M , TEJERO, T , DELSO, I , MATUTE, R , (2014) RECENT ADVANCES ON THE ENANTIOSELECTIVE SYNTHESIS OF C-NUCLEOSIDES INHIBITORS OF INOSINE MONOPHOSPHATE DEHYDROGENASE (IMPDH).CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 14. ISSUE 10. P. 1212-1224 62 78% 4
6 VYAS, VK , GHATE, M , (2011) RECENT DEVELOPMENTS IN THE MEDICINAL CHEMISTRY AND THERAPEUTIC POTENTIAL OF DIHYDROOROTATE DEHYDROGENASE (DHODH) INHIBITORS.MINI-REVIEWS IN MEDICINAL CHEMISTRY. VOL. 11. ISSUE 12. P. 1039 -1055 53 93% 26
7 LIU, JL , (2016) THE CYTOOPHIDIUM AND ITS KIND: FILAMENTATION AND COMPARTMENTATION OF METABOLIC ENZYMES.ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 32. VOL. 32. ISSUE . P. 349 -372 63 72% 0
8 TUFVESON, G , GANNEDAHL, G , (1994) DEOXYSPERGUALIN - A DIFFERENT AND INTRIGUING IMMUNOSUPPRESSANT.TRANSPLANTATION PROCEEDINGS. VOL. 26. ISSUE 5. P. 3029-3039 100 79% 13
9 ZIMMERMANN, AG , GU, JJ , LALIBERTE, J , MITCHELL, BS , (1998) INOSINE-5 '-MONOPHOSPHATE DEHYDROGENASE: REGULATION OF EXPRESSION AND ROLE IN CELLULAR PROLIFERATION AND T LYMPHOCYTE ACTIVATION.PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY, VOL 61. VOL. 61. ISSUE . P. 181 -209 89 71% 49
10 PERENYEI, M , JAYNE, DRW , FLOSSMANN, O , (2014) GUSPERIMUS: IMMUNOLOGICAL MECHANISM AND CLINICAL APPLICATIONS.RHEUMATOLOGY. VOL. 53. ISSUE 10. P. 1732 -1741 53 74% 4

Classes with closest relation at Level 2


Rank Class id link
1 1752 LESCH NYHAN SYNDROME//AMP DEAMINASE//LESCH NYHAN DISEASE
2 3150 ADENOSINE DEAMINASE//PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY//CECR1
3 1684 METHOTREXATE//FOLATE RECEPTOR//REDUCED FOLATE CARRIER
4 93 TRANSPLANTATION//TRANSPLANTATION PROCEEDINGS//KIDNEY TRANSPLANTATION
5 2341 RIBONUCLEOTIDE REDUCTASE//POLG//HYDROXYUREA
6 681 XENOTRANSPLANTATION//ISLET TRANSPLANTATION//TRANSPLANTATION
7 793 NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS//NUCLEOSIDES//CARBOCYCLIC NUCLEOSIDES
8 1445 HEPATIC ENCEPHALOPATHY//HYPERAMMONEMIA//MINIMAL HEPATIC ENCEPHALOPATHY
9 3271 6 MERCAPTOPURINE//THIOPURINE METHYLTRANSFERASE//AZATHIOPRINE
10 2762 CYCLIC ADP RIBOSE//ADP RIBOSYL CYCLASE//NAADP

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