Class information for:
Level 1: TIAZOFURIN//IMPDH//BENZAMIDE RIBOSIDE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
10938 1022 31.6 67%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
236 3       ADENOSINE//NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS//ADENOSINE RECEPTORS 48331
2798 2             LEFLUNOMIDE//MIZORIBINE//DIHYDROOROTATE DEHYDROGENASE 3097
10938 1                   TIAZOFURIN//IMPDH//BENZAMIDE RIBOSIDE 1022

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 TIAZOFURIN authKW 1378888 6% 77% 60
2 IMPDH authKW 582915 4% 49% 40
3 BENZAMIDE RIBOSIDE authKW 468925 2% 83% 19
4 IMP DEHYDROGENASE authKW 410904 3% 49% 28
5 IMPDH INHIBITORS authKW 392461 2% 77% 17
6 INOSINE MONOPHOSPHATE DEHYDROGENASE authKW 262965 2% 35% 25
7 TIAZOFURIN ANALOGUES authKW 149382 0% 100% 5
8 INOSINE 5 MONOPHOSPHATE DEHYDROGENASE authKW 148488 1% 38% 13
9 IMP DEHYDROGENASE INHIBITOR authKW 124484 0% 83% 5
10 NAD ANALOGUES authKW 97589 1% 47% 7

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Chemistry, Medicinal 2538 15% 0% 156
2 Biochemistry & Molecular Biology 1615 35% 0% 358
3 Oncology 1080 18% 0% 188
4 Chemistry, Organic 621 13% 0% 128
5 Pharmacology & Pharmacy 471 15% 0% 151
6 Biophysics 203 6% 0% 63
7 Medicine, Research & Experimental 49 4% 0% 39
8 Genetics & Heredity 29 4% 0% 38
9 Hematology 28 2% 0% 25
10 Cell Biology 26 5% 0% 49

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MED EXPTL ONCOL 44812 0% 50% 3
2 237 HIRANOMACHI CHUO KU 29876 0% 100% 1
3 AFMBUMR 6098 29876 0% 100% 1
4 CANC TREATMENT CLIN PHARMACOL BRANCH 29876 0% 100% 1
5 CANC TREATMENTPEDIAT BRANCHBLDG 10 29876 0% 100% 1
6 CHEM VRILLY RECH 29876 0% 100% 1
7 CLIN NUESTRA SENORA CONCEPT 29876 0% 100% 1
8 CNRSERT 5ENSCM 29876 0% 100% 1
9 EA267 29876 0% 100% 1
10 ERT 5 29876 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ADVANCES IN ENZYME REGULATION 61341 3% 6% 35
2 NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS 8726 4% 1% 37
3 NUCLEOSIDES & NUCLEOTIDES 4473 1% 2% 10
4 CURRENT MEDICINAL CHEMISTRY 3556 2% 1% 23
5 JOURNAL OF MEDICINAL CHEMISTRY 3147 5% 0% 48
6 CANCER BIOCHEMISTRY BIOPHYSICS 2919 1% 2% 6
7 CANCER COMMUNICATIONS 2630 0% 3% 3
8 CANCER RESEARCH 2003 5% 0% 52
9 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 1749 4% 0% 39
10 BIOCHEMICAL PHARMACOLOGY 1137 3% 0% 27

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 TIAZOFURIN 1378888 6% 77% 60 Search TIAZOFURIN Search TIAZOFURIN
2 IMPDH 582915 4% 49% 40 Search IMPDH Search IMPDH
3 BENZAMIDE RIBOSIDE 468925 2% 83% 19 Search BENZAMIDE+RIBOSIDE Search BENZAMIDE+RIBOSIDE
4 IMP DEHYDROGENASE 410904 3% 49% 28 Search IMP+DEHYDROGENASE Search IMP+DEHYDROGENASE
5 IMPDH INHIBITORS 392461 2% 77% 17 Search IMPDH+INHIBITORS Search IMPDH+INHIBITORS
6 INOSINE MONOPHOSPHATE DEHYDROGENASE 262965 2% 35% 25 Search INOSINE+MONOPHOSPHATE+DEHYDROGENASE Search INOSINE+MONOPHOSPHATE+DEHYDROGENASE
7 TIAZOFURIN ANALOGUES 149382 0% 100% 5 Search TIAZOFURIN+ANALOGUES Search TIAZOFURIN+ANALOGUES
8 INOSINE 5 MONOPHOSPHATE DEHYDROGENASE 148488 1% 38% 13 Search INOSINE+5+MONOPHOSPHATE+DEHYDROGENASE Search INOSINE+5+MONOPHOSPHATE+DEHYDROGENASE
9 IMP DEHYDROGENASE INHIBITOR 124484 0% 83% 5 Search IMP+DEHYDROGENASE+INHIBITOR Search IMP+DEHYDROGENASE+INHIBITOR
10 NAD ANALOGUES 97589 1% 47% 7 Search NAD+ANALOGUES Search NAD+ANALOGUES

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 HEDSTROM, L , (2009) IMP DEHYDROGENASE: STRUCTURE, MECHANISM, AND INHIBITION.CHEMICAL REVIEWS. VOL. 109. ISSUE 7. P. 2903 -2928 163 71% 107
2 CHEN, LQ , PANKIEWICZ, KW , (2007) RECENT DEVELOPMENT OF IMP DEHYDROGENASE INHIBITORS FOR THE TREATMENT OF CANCER.CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT. VOL. 10. ISSUE 4. P. 403-412 72 88% 61
3 PETRELLI, R , VITA, P , TORQUATI, I , FELCZAK, K , WILSON, DJ , FRANCHETTI, P , CAPPELLACCI, L , (2013) NOVEL INHIBITORS OF INOSINE MONOPHOSPHATE DEHYDROGENASE IN PATENT LITERATURE OF THE LAST DECADE.RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY. VOL. 8. ISSUE 2. P. 103-125 68 77% 9
4 MERINO, P , GHIRARDELLO, M , TEJERO, T , DELSO, I , MATUTE, R , (2014) RECENT ADVANCES ON THE ENANTIOSELECTIVE SYNTHESIS OF C-NUCLEOSIDES INHIBITORS OF INOSINE MONOPHOSPHATE DEHYDROGENASE (IMPDH).CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 14. ISSUE 10. P. 1212-1224 62 78% 4
5 BRAUN-SAND, SB , PEETZ, M , (2010) INOSINE MONOPHOSPHATE DEHYDROGENASE AS A TARGET FOR ANTIVIRAL, ANTICANCER, ANTIMICROBIAL AND IMMUNOSUPPRESSIVE THERAPEUTICS.FUTURE MEDICINAL CHEMISTRY. VOL. 2. ISSUE 1. P. 81 -92 61 70% 13
6 FRANCHETTI, P , GRIFANTINI, M , (1999) NUCLEOSIDE AND NON-NUCLEOSIDE IMP DEHYDROGENASE INHIBITORS AS ANTITUMOR AND ANTIVIRAL AGENTS.CURRENT MEDICINAL CHEMISTRY. VOL. 6. ISSUE 7. P. 599 -614 66 81% 84
7 PANKIEWICZ, KW , PATTERSON, SE , BLACK, PL , JAYARAM, HN , RISAL, D , GOLDSTEIN, BM , STUYVER, LJ , SCHINAZI, RF , (2004) COFACTOR MIMICS AS SELECTIVE INHIBITORS OF NAD-DEPENDENT INOSINE MONOPHOSPATE DEHYDROGENASE (IMPDH) - THE MAJOR THERAPEUTIC TARGET.CURRENT MEDICINAL CHEMISTRY. VOL. 11. ISSUE 7. P. 887-900 60 75% 52
8 GOLDSTEIN, BM , COLBY, TD , (1999) IMP DEHYDROGENASE: STRUCTURAL ASPECTS OF INHIBITOR BINDING.CURRENT MEDICINAL CHEMISTRY. VOL. 6. ISSUE 7. P. 519 -536 72 72% 37
9 BENTLEY, R , (2000) MYCOPHENOLIC ACID: A ONE HUNDRED YEAR ODYSSEY FROM ANTIBIOTIC TO IMMUNOSUPPRESSANT.CHEMICAL REVIEWS. VOL. 100. ISSUE 10. P. 3801 -3825 73 60% 126
10 CHOLEWINSKI, G , IWASZKIEWICZ-GRZES, D , PREJS, M , GLOWACKA, A , DZIERZBICKA, K , (2015) SYNTHESIS OF THE INOSINE 5 '-MONOPHOSPHATE DEHYDROGENASE (IMPDH) INHIBITORS.JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY. VOL. 30. ISSUE 4. P. 550 -563 42 79% 2

Classes with closest relation at Level 1


Rank Class id link
1 23401 CYCLOPENTENYL CYTOSINE//CTP SYNTHASE//CTP SYNTHETASE
2 26970 MIZORIBINE//ORAL MIZORIBINE PULSE THERAPY//LS180 CELL
3 4284 MYCOPHENOLIC ACID//MYCOPHENOLATE MOFETIL//MYCOPHENOLIC ACID GLUCURONIDE
4 27444 SP 303//8 HYDROXY 2 DEOXYGUANOSINE CONCENTRATION//AEDES ALBOPICTUS MOSQUITO CELLS
5 15693 PHOSPHORIBOSYLTRANSFERASE//MOL PARASITOL DRUG DESIGN//PURINE SALVAGE
6 33919 4 PYRIDONE 3 CARBOXAMIDE 1 BETA D RIBONUCLEOSIDE 4PYR//PCNR//4PYR
7 14372 PURINE BIOSYNTHESIS//ADENYLOSUCCINATE LYASE//ADENYLOSUCCINATE LYASE DEFICIENCY
8 31866 EHU MED FISIOL POB 699//RABBIT PARIETAL CELLS//ATP ATP ANALOGS
9 33865 IMMORTAL DNA//ADULT STEM CELL TECHNOL//IMMORTAL STRAND HYPOTHESIS
10 15453 WLDS//NAD BIOSYNTHESIS//WALLERIAN DEGENERATION

Go to start page