Class information for:
Level 2: LESCH NYHAN SYNDROME//AMP DEAMINASE//LESCH NYHAN DISEASE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
1752 6485 29.0 52%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
236 3       ADENOSINE//NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS//ADENOSINE RECEPTORS 48331
1752 2             LESCH NYHAN SYNDROME//AMP DEAMINASE//LESCH NYHAN DISEASE 6485
13855 1                   5 NUCLEOTIDASE//CN II//PYRIMIDINE 5 NUCLEOTIDASE 808
14372 1                   PURINE BIOSYNTHESIS//ADENYLOSUCCINATE LYASE//ADENYLOSUCCINATE LYASE DEFICIENCY 774
14850 1                   AMP DEAMINASE//MYOADENYLATE DEAMINASE DEFICIENCY//PURINE NUCLEOTIDE CYCLE 746
15139 1                   LESCH NYHAN SYNDROME//LESCH NYHAN DISEASE//LESCH NYHAN 729
15693 1                   PHOSPHORIBOSYLTRANSFERASE//MOL PARASITOL DRUG DESIGN//PURINE SALVAGE 697
16843 1                   PARTITION ADSORPTION SYSTEMS//3 4 DIMETHOXYPHENYLGLYOXAL//RAT RETICULOCYTES 632
17042 1                   NUCLEOSIDE TRANSPORT INHIBITION//DRAFLAZINE//ENDOTHELIAL CONTROL 621
19971 1                   HYPOXANTHINE//OXYPURINOL//NUCLEOTIDE METABOLITES 482
21436 1                   RAT HEART FUNCTION//D RIBOSE//AMP BREAKDOWN 419
24376 1                   PHOSPHORIBOSYLPYROPHOSPHATE SYNTHETASE//NUCLEOTIDE SYNTHESIS//PRPP SYNTHETASE 314
32029 1                   APRT DEFICIENCY//ADENINE PHOSPHORIBOSYLTRANSFERASE DEFICIENCY//2 8 DIHYDROXYADENINE 145
33919 1                   4 PYRIDONE 3 CARBOXAMIDE 1 BETA D RIBONUCLEOSIDE 4PYR//PCNR//4PYR 118

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 LESCH NYHAN SYNDROME authKW 436036 2% 88% 105
2 AMP DEAMINASE authKW 282962 1% 70% 86
3 LESCH NYHAN DISEASE authKW 216725 1% 87% 53
4 PHOSPHORIBOSYLTRANSFERASE authKW 123595 1% 64% 41
5 5 NUCLEOTIDASE authKW 114794 2% 24% 102
6 HYPOXANTHINE GUANINE PHOSPHORIBOSYLTRANSFERASE authKW 114471 1% 57% 43
7 HYPOXANTHINE authKW 110940 2% 22% 107
8 PURINE BIOSYNTHESIS authKW 104557 1% 56% 40
9 ADENYLOSUCCINATE LYASE authKW 103965 0% 82% 27
10 LESCH NYHAN authKW 83019 0% 84% 21

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Biochemistry & Molecular Biology 9197 33% 0% 2171
2 Physiology 2011 7% 0% 454
3 Chemistry, Analytical 2002 9% 0% 579
4 Medicine, Research & Experimental 1675 7% 0% 461
5 Biophysics 1394 6% 0% 413
6 Cardiac & Cardiovascular System 1124 6% 0% 418
7 Biochemical Research Methods 1021 5% 0% 332
8 Genetics & Heredity 885 6% 0% 407
9 Medical Laboratory Technology 723 2% 0% 130
10 Sport Sciences 513 3% 0% 167

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MOL PARASITOL DRUG DESIGN 56815 0% 93% 13
2 MED BIOCHEM GENET METAB 38122 0% 90% 9
3 PURINE UNIT 27364 0% 36% 16
4 BIOCHEM CLIN PHYSIOL 23820 0% 56% 9
5 METAB VASC UNIT 23165 0% 62% 8
6 DIPARTIMENTO SCI UOMO AMBIENTE CHIM BIOCHIM M 18827 0% 100% 4
7 PURINE NEUROSCI 14705 0% 63% 5
8 CLIN BIOCHEM PHYSIOL 14120 0% 100% 3
9 ARTHUR F SCOTT CHEM 12548 0% 67% 4
10 PURINE 9687 0% 15% 14

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS 14109 2% 3% 119
2 JOURNAL OF CHROMATOGRAPHY 7758 3% 1% 177
3 INTERNATIONAL JOURNAL OF BIOCHEMISTRY 3796 1% 2% 50
4 JOURNAL OF INHERITED METABOLIC DISEASE 3762 1% 1% 61
5 JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 3334 1% 1% 69
6 MOLECULAR AND BIOCHEMICAL PARASITOLOGY 3075 1% 1% 62
7 BASIC RESEARCH IN CARDIOLOGY 2866 1% 1% 42
8 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY 2802 1% 1% 77
9 ANALYTICAL BIOCHEMISTRY 2796 2% 1% 108
10 ENZYME 2712 0% 3% 21

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 LESCH NYHAN SYNDROME 436036 2% 88% 105 Search LESCH+NYHAN+SYNDROME Search LESCH+NYHAN+SYNDROME
2 AMP DEAMINASE 282962 1% 70% 86 Search AMP+DEAMINASE Search AMP+DEAMINASE
3 LESCH NYHAN DISEASE 216725 1% 87% 53 Search LESCH+NYHAN+DISEASE Search LESCH+NYHAN+DISEASE
4 PHOSPHORIBOSYLTRANSFERASE 123595 1% 64% 41 Search PHOSPHORIBOSYLTRANSFERASE Search PHOSPHORIBOSYLTRANSFERASE
5 5 NUCLEOTIDASE 114794 2% 24% 102 Search 5+NUCLEOTIDASE Search 5+NUCLEOTIDASE
6 HYPOXANTHINE GUANINE PHOSPHORIBOSYLTRANSFERASE 114471 1% 57% 43 Search HYPOXANTHINE+GUANINE+PHOSPHORIBOSYLTRANSFERASE Search HYPOXANTHINE+GUANINE+PHOSPHORIBOSYLTRANSFERASE
7 HYPOXANTHINE 110940 2% 22% 107 Search HYPOXANTHINE Search HYPOXANTHINE
8 PURINE BIOSYNTHESIS 104557 1% 56% 40 Search PURINE+BIOSYNTHESIS Search PURINE+BIOSYNTHESIS
9 ADENYLOSUCCINATE LYASE 103965 0% 82% 27 Search ADENYLOSUCCINATE+LYASE Search ADENYLOSUCCINATE+LYASE
10 LESCH NYHAN 83019 0% 84% 21 Search LESCH+NYHAN Search LESCH+NYHAN

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 FU, R , CEBALLOS-PICOT, I , TORRES, RJ , LAROVERE, LE , YAMADA, Y , NGUYEN, KV , HEGDE, M , VISSER, JE , SCHRETLEN, DJ , NYHAN, WL , ET AL (2014) GENOTYPE-PHENOTYPE CORRELATIONS IN NEUROGENETICS: LESCH-NYHAN DISEASE AS A MODEL DISORDER.BRAIN. VOL. 137. ISSUE . P. 1282 -1303 121 98% 12
2 JURECKA, A , ZIKANOVA, M , KMOCH, S , TYLKI-SZYMANSKA, A , (2015) ADENYLOSUCCINATE LYASE DEFICIENCY.JOURNAL OF INHERITED METABOLIC DISEASE. VOL. 38. ISSUE 2. P. 231 -242 59 92% 3
3 TORRES, RJ , PUIG, JG , (2007) HYPOXANTHINE-GUANINE PHOSOPHORIBOSYLTRANSFERASE (HPRT) DEFICIENCY: LESCH-NYHAN SYNDROME.ORPHANET JOURNAL OF RARE DISEASES. VOL. 2. ISSUE . P. - 61 97% 53
4 FU, R , JINNAH, HA , (2012) GENOTYPE-PHENOTYPE CORRELATIONS IN LESCH-NYHAN DISEASE MOVING BEYOND THE GENE.JOURNAL OF BIOLOGICAL CHEMISTRY. VOL. 287. ISSUE 5. P. 2997-3008 56 98% 11
5 ZHANG, Y , MORAR, M , EALICK, SE , (2008) STRUCTURAL BIOLOGY OF THE PURINE BIOSYNTHETIC PATHWAY.CELLULAR AND MOLECULAR LIFE SCIENCES. VOL. 65. ISSUE 23. P. 3699-3724 68 81% 61
6 JINNAH, HA , CEBALLOS-PICOT, I , TORRES, RJ , VISSER, JE , SCHRETLEN, DJ , VERDU, A , LAROVERE, LE , CHEN, CJ , COSSU, A , WU, CH , ET AL (2010) ATTENUATED VARIANTS OF LESCH-NYHAN DISEASE.BRAIN. VOL. 133. ISSUE . P. 671 -689 55 93% 39
7 ZIMMERMANN, H , (1992) 5'-NUCLEOTIDASE - MOLECULAR-STRUCTURE AND FUNCTIONAL-ASPECTS.BIOCHEMICAL JOURNAL. VOL. 285. ISSUE . P. 345-365 115 54% 476
8 ITOH, R , (2013) ENZYMATIC PROPERTIES AND PHYSIOLOGICAL ROLES OF CYTOSOLIC 5 '-NUCLEOTIDASE II.CURRENT MEDICINAL CHEMISTRY. VOL. 20. ISSUE 34. P. 4260-4284 71 70% 4
9 JINNAH, HA , DE GREGORIO, L , HARRIS, JC , NYHAN, WL , O'NEILL, JP , (2000) THE SPECTRUM OF INHERITED MUTATIONS CAUSING HPRT DEFICIENCY: 75 NEW CASES AND A REVIEW OF 196 PREVIOUSLY REPORTED CASES.MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH. VOL. 463. ISSUE 3. P. 309 -326 61 95% 127
10 TORRES, RJ , PUIG, JG , (2010) LESCH-NYHAN SYNDROME.DRUGS OF THE FUTURE. VOL. 35. ISSUE 5. P. 421-427 60 86% 1

Classes with closest relation at Level 2


Rank Class id link
1 3150 ADENOSINE DEAMINASE//PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY//CECR1
2 3291 PURINE NUCLEOSIDE PHOSPHORYLASE//CARBOHYDRATE CHEM TEAM//METHIONINE DEPENDENCE
3 409 ADENOSINE//ADENOSINE RECEPTORS//ATP
4 2798 LEFLUNOMIDE//MIZORIBINE//DIHYDROOROTATE DEHYDROGENASE
5 3474 DIETARY NUCLEOTIDES//URINARY NUCLEOSIDES//NUCLEOTIDES
6 1622 GOUT//HYPERURICEMIA//URIC ACID
7 1189 NICORANDIL//ISCHEMIC PRECONDITIONING//K ATP CHANNEL
8 3408 ADENYLATE KINASE//PHOSPHOGLYCERATE KINASE//CHIM STRUCT MACROMOL
9 1804 ARTERIOGENESIS//COLLATERAL CIRCULATION//TRANSMYOCARDIAL LASER REVASCULARIZATION
10 2596 ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY//ACTA CRYSTALLOGRAPHICA SECTION A//ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY

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