Class information for:
Level 1: LEFLUNOMIDE//DIHYDROOROTATE DEHYDROGENASE//TERIFLUNOMIDE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
10582 1051 29.1 77%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
236 3       ADENOSINE//NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS//ADENOSINE RECEPTORS 48331
2798 2             LEFLUNOMIDE//MIZORIBINE//DIHYDROOROTATE DEHYDROGENASE 3097
10582 1                   LEFLUNOMIDE//DIHYDROOROTATE DEHYDROGENASE//TERIFLUNOMIDE 1051

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 LEFLUNOMIDE authKW 3784480 24% 51% 257
2 DIHYDROOROTATE DEHYDROGENASE authKW 1519933 7% 76% 69
3 TERIFLUNOMIDE authKW 575774 4% 47% 42
4 DG RHEUMATOL address 484194 2% 83% 20
5 A77 1726 authKW 474508 2% 78% 21
6 BREQUINAR authKW 354151 2% 76% 16
7 FK778 authKW 299688 1% 74% 14
8 DIHYDROOROTATE DEHYDROGENASE DHODH authKW 292940 1% 92% 11
9 DG RHEUMATOL IMMUNOL address 264108 1% 91% 10
10 MALONONITRILAMIDES authKW 203364 1% 100% 7

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Transplantation 8275 19% 0% 196
2 Rheumatology 3731 11% 0% 116
3 Immunology 2660 25% 0% 264
4 Surgery 1062 19% 0% 196
5 Pharmacology & Pharmacy 975 20% 0% 207
6 Chemistry, Medicinal 659 8% 0% 85
7 Biochemistry & Molecular Biology 128 14% 0% 144
8 Biochemical Research Methods 40 3% 0% 32
9 Cell Biology 30 5% 0% 52
10 Toxicology 29 2% 0% 25

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DG RHEUMATOL 484194 2% 83% 20
2 DG RHEUMATOL IMMUNOL 264108 1% 91% 10
3 BEHRINGWERKE AG 145260 0% 100% 5
4 IMMUNOL DOMAIN 116208 0% 100% 4
5 PHARMA WERK KALLE ALBERT 87156 0% 100% 3
6 CHEM GLOBAL HLTH 77470 0% 67% 4
7 CRISTALOG PROT 67779 1% 33% 7
8 CHEM PATHOBIOL 58104 0% 100% 2
9 ONCOL POB 80026 58104 0% 100% 2
10 SUB SOCIAL PHARM PHARMACOEPIDEMIOL PHARMACOT 58104 0% 100% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 TRANSPLANTATION PROCEEDINGS 10900 12% 0% 123
2 TRANSPLANTATION 4045 5% 0% 51
3 INTERNATIONAL JOURNAL OF IMMUNOTHERAPY 3932 1% 2% 8
4 AGENTS AND ACTIONS 3590 2% 1% 20
5 INFLAMMATION RESEARCH 2013 1% 1% 14
6 ANNALS OF THE RHEUMATIC DISEASES 810 2% 0% 16
7 ROMATIZMA-RHEUMATISM 783 0% 3% 1
8 RHEUMATOLOGY 731 1% 0% 11
9 JOURNAL OF RHEUMATOLOGY 709 2% 0% 18
10 JOURNAL OF MEDICINAL CHEMISTRY 679 2% 0% 23

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 LEFLUNOMIDE 3784480 24% 51% 257 Search LEFLUNOMIDE Search LEFLUNOMIDE
2 DIHYDROOROTATE DEHYDROGENASE 1519933 7% 76% 69 Search DIHYDROOROTATE+DEHYDROGENASE Search DIHYDROOROTATE+DEHYDROGENASE
3 TERIFLUNOMIDE 575774 4% 47% 42 Search TERIFLUNOMIDE Search TERIFLUNOMIDE
4 A77 1726 474508 2% 78% 21 Search A77+1726 Search A77+1726
5 BREQUINAR 354151 2% 76% 16 Search BREQUINAR Search BREQUINAR
6 FK778 299688 1% 74% 14 Search FK778 Search FK778
7 DIHYDROOROTATE DEHYDROGENASE DHODH 292940 1% 92% 11 Search DIHYDROOROTATE+DEHYDROGENASE+DHODH Search DIHYDROOROTATE+DEHYDROGENASE+DHODH
8 MALONONITRILAMIDES 203364 1% 100% 7 Search MALONONITRILAMIDES Search MALONONITRILAMIDES
9 DHODH 193674 1% 67% 10 Search DHODH Search DHODH
10 DIHYDROOROTATE DEHYDROGENASE INHIBITORS 174312 1% 100% 6 Search DIHYDROOROTATE+DEHYDROGENASE+INHIBITORS Search DIHYDROOROTATE+DEHYDROGENASE+INHIBITORS

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 MUNIER-LEHMANN, H , VIDALAIN, PO , TANGY, F , JANIN, YL , (2013) ON DIHYDROOROTATE DEHYDROGENASES AND THEIR INHIBITORS AND USES.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 56. ISSUE 8. P. 3148-3167 166 72% 28
2 VYAS, VK , GHATE, M , (2011) RECENT DEVELOPMENTS IN THE MEDICINAL CHEMISTRY AND THERAPEUTIC POTENTIAL OF DIHYDROOROTATE DEHYDROGENASE (DHODH) INHIBITORS.MINI-REVIEWS IN MEDICINAL CHEMISTRY. VOL. 11. ISSUE 12. P. 1039 -1055 53 93% 26
3 CLAUSSEN, MC , KORN, T , (2012) IMMUNE MECHANISMS OF NEW THERAPEUTIC STRATEGIES IN MS - TERIFLUNOMIDE.CLINICAL IMMUNOLOGY. VOL. 142. ISSUE 1. P. 49-56 40 82% 45
4 SILVA, HT , MORRIS, RE , (1997) LEFLUNOMIDE AND MALONONITRILAMIDES.AMERICAN JOURNAL OF THE MEDICAL SCIENCES. VOL. 313. ISSUE 5. P. 289-301 64 73% 65
5 CULLELL-YOUNG, M , CASTANER, RM , LEESON, PA , (2002) FK-778. TREATMENT OF TRANSPLANT REJECTION, DIHYDROOROTATE DEHYDROGENASE INHIBITOR.DRUGS OF THE FUTURE. VOL. 27. ISSUE 8. P. 733-739 44 98% 1
6 BREEDVELD, FC , DAYER, JM , (2000) LEFLUNOMIDE: MODE OF ACTION IN THE TREATMENT OF RHEUMATOID ARTHRITIS.ANNALS OF THE RHEUMATIC DISEASES. VOL. 59. ISSUE 11. P. 841 -849 49 73% 191
7 ZHU, JS , HAN, L , DIAO, YY , REN, XL , XU, MH , XU, LX , LI, SL , LI, Q , DONG, D , HUANG, J , ET AL (2015) DESIGN, SYNTHESIS, X-RAY CRYSTALLOGRAPHIC ANALYSIS, AND BIOLOGICAL EVALUATION OF THIAZOLE DERIVATIVES AS POTENT AND SELECTIVE INHIBITORS OF HUMAN DIHYDROOROTATE DEHYDROGENASE.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 58. ISSUE 3. P. 1123 -1139 37 73% 5
8 WALSE, B , DUFE, VT , SVENSSON, B , FRITZSON, I , DAHLBERG, L , KHAIROULLINA, A , WELLMAR, U , AL-KARADAGHI, S , (2008) THE STRUCTURES OF HUMAN DIHYDROOROTATE DEHYDROGENASE WITH AND WITHOUT INHIBITOR REVEAL CONFORMATIONAL FLEXIBILITY IN THE INHIBITOR AND SUBSTRATE BINDING SITES.BIOCHEMISTRY. VOL. 47. ISSUE 34. P. 8929 -8936 39 83% 23
9 LI, EK , TAM, LS , TOMLINSON, B , (2004) LEFLUNOMIDE IN THE TREATMENT OF RHEUMATOID ARTHRITIS.CLINICAL THERAPEUTICS. VOL. 26. ISSUE 4. P. 447-459 39 91% 48
10 REIS, RAG , FERREIRA, P , MEDINA, M , NONATO, MC , (2016) THE MECHANISTIC STUDY OF LEISHMANIA MAJOR DIHYDRO-OROTATE DEHYDROGENASE BASED ON STEADY- AND PRE-STEADY-STATE KINETIC ANALYSIS.BIOCHEMICAL JOURNAL. VOL. 473. ISSUE . P. 651 -660 31 89% 0

Classes with closest relation at Level 1


Rank Class id link
1 33973 MDR I//RHEUMATOLOTA KU//BIOLOGIC AGENT THERAPY
2 3319 METHOTREXATE//RHEUMATOID ARTHRITIS//METHOTREXATE POLYGLUTAMATES
3 31961 COMPARAT TRANSPLANTAT//ANIM OURCES PROJECT//CLIN TRANSPLANAT SURG
4 24160 ODCASE//OROTIDINE 5 MONOPHOSPHATE DECARBOXYLASE//MOL DESIGN PREFORMULAT
5 12529 APICOPLAST//MED MALARIA VENTURE//DIS DEV WORLD
6 8448 PYRIMIDINE BIOSYNTHESIS//DIHYDROOROTASE//CARBAMOYL PHOSPHATE SYNTHETASE
7 22413 ALEMTUZUMAB//DACLIZUMAB//MS CLIN CENT TEXAS
8 20983 DEOXYSPERGUALIN//15 DEOXYSPERGUALIN//AXE IMMUNOL
9 34693 RHEUMATOL CONNECT TISSUE//HANS WILSDORF//COMMON RECEPTOR CHAIN
10 15771 UL97//GANCICLOVIR RESISTANCE//MARIBAVIR

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