Class information for:
Level 1: REDUCED FOLATE CARRIER//FOLYLPOLYGLUTAMATE SYNTHETASE//ANTIFOLATE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
2341 2275 35.2 62%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
316 3       RHEUMATOLOGY//RHEUMATOID ARTHRITIS//RHEUMATOL 39766
1684 2             METHOTREXATE//FOLATE RECEPTOR//REDUCED FOLATE CARRIER 6769
2341 1                   REDUCED FOLATE CARRIER//FOLYLPOLYGLUTAMATE SYNTHETASE//ANTIFOLATE 2275

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 REDUCED FOLATE CARRIER authKW 728976 4% 64% 85
2 FOLYLPOLYGLUTAMATE SYNTHETASE authKW 485971 2% 77% 47
3 ANTIFOLATE authKW 481567 5% 33% 109
4 PROTON COUPLED FOLATE TRANSPORTER authKW 276868 1% 74% 28
5 PCFT authKW 253540 1% 82% 23
6 HEREDITARY FOLATE MALABSORPTION authKW 228146 1% 100% 17
7 EXPT CLIN THER EUT PROGRAM address 214701 1% 57% 28
8 FOLATE TRANSPORT authKW 209674 1% 63% 25
9 EDATREXATE authKW 185096 1% 69% 20
10 POLYGLUTAMATION authKW 176287 1% 77% 17

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Oncology 8092 32% 0% 722
2 Chemistry, Medicinal 3095 12% 0% 262
3 Pharmacology & Pharmacy 2552 21% 0% 486
4 Biochemistry & Molecular Biology 1266 23% 0% 524
5 Chemistry, Organic 376 7% 0% 169
6 Biophysics 265 5% 0% 114
7 Hematology 221 4% 0% 87
8 Biochemical Research Methods 71 3% 0% 65
9 Medicine, Research & Experimental 60 3% 0% 72
10 Nutrition & Dietetics 58 2% 0% 45

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 EXPT CLIN THER EUT PROGRAM 214701 1% 57% 28
2 PROGRAM MOL PHARMACOL EXPT THER EUT 94346 1% 47% 15
3 FRED WYSZKOWSKI CANC 57862 1% 25% 17
4 PENNY COLE HEMATOL 42943 0% 80% 4
5 GRACE CANC DRUG 39397 1% 12% 24
6 ALBERT E EIN COMPREHENS CANC 30656 1% 19% 12
7 GRACE CANC DRUG EXPTL THER EUT 26841 0% 100% 2
8 MOLEC THER EUT 26841 0% 100% 2
9 TAKEDA RABICS 26841 0% 100% 2
10 MOL THER EUT PROGRAM 19058 1% 9% 16

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ADVANCES IN ENZYME REGULATION 17600 1% 5% 28
2 JOURNAL OF MEDICINAL CHEMISTRY 17508 7% 1% 168
3 CANCER CHEMOTHERAPY AND PHARMACOLOGY 15040 4% 1% 91
4 BIOCHEMICAL PHARMACOLOGY 10856 5% 1% 123
5 CANCER RESEARCH 7886 7% 0% 153
6 INVESTIGATIONAL NEW DRUGS 5333 1% 1% 32
7 MOLECULAR PHARMACOLOGY 3783 2% 1% 53
8 CLINICAL CANCER RESEARCH 3611 3% 0% 64
9 CANCER DRUG DELIVERY 2883 0% 4% 5
10 VITAMINS AND HORMONES-ADVANCES IN RESEARCH AND APPLICATIONS 2299 0% 2% 8

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 REDUCED FOLATE CARRIER 728976 4% 64% 85 Search REDUCED+FOLATE+CARRIER Search REDUCED+FOLATE+CARRIER
2 FOLYLPOLYGLUTAMATE SYNTHETASE 485971 2% 77% 47 Search FOLYLPOLYGLUTAMATE+SYNTHETASE Search FOLYLPOLYGLUTAMATE+SYNTHETASE
3 ANTIFOLATE 481567 5% 33% 109 Search ANTIFOLATE Search ANTIFOLATE
4 PROTON COUPLED FOLATE TRANSPORTER 276868 1% 74% 28 Search PROTON+COUPLED+FOLATE+TRANSPORTER Search PROTON+COUPLED+FOLATE+TRANSPORTER
5 PCFT 253540 1% 82% 23 Search PCFT Search PCFT
6 HEREDITARY FOLATE MALABSORPTION 228146 1% 100% 17 Search HEREDITARY+FOLATE+MALABSORPTION Search HEREDITARY+FOLATE+MALABSORPTION
7 FOLATE TRANSPORT 209674 1% 63% 25 Search FOLATE+TRANSPORT Search FOLATE+TRANSPORT
8 EDATREXATE 185096 1% 69% 20 Search EDATREXATE Search EDATREXATE
9 POLYGLUTAMATION 176287 1% 77% 17 Search POLYGLUTAMATION Search POLYGLUTAMATION
10 TRIMETREXATE 161276 1% 48% 25 Search TRIMETREXATE Search TRIMETREXATE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 GONEN, N , ASSARAF, YG , (2012) ANTIFOLATES IN CANCER THERAPY: STRUCTURE, ACTIVITY AND MECHANISMS OF DRUG RESISTANCE.DRUG RESISTANCE UPDATES. VOL. 15. ISSUE 4. P. 183 -210 223 62% 85
2 MATHERLY, LH , WILSON, MR , HOU, ZJ , (2014) THE MAJOR FACILITATIVE FOLATE TRANSPORTERS SOLUTE CARRIER 19A1 AND SOLUTE CARRIER 46A1: BIOLOGY AND ROLE IN ANTIFOLATE CHEMOTHERAPY OF CANCER.DRUG METABOLISM AND DISPOSITION. VOL. 42. ISSUE 4. P. 632 -649 162 78% 6
3 ZHAO, RB , GOLDMAN, ID , (2003) RESISTANCE TO ANTIFOLATES.ONCOGENE. VOL. 22. ISSUE 47. P. 7431-7457 195 64% 145
4 HOU, ZJ , MATHERLY, LH , (2014) BIOLOGY OF THE MAJOR FACILITATIVE FOLATE TRANSPORTERS SLC19A1 AND SLC46A1.EXCHANGERS. VOL. 73. ISSUE . P. 175 -204 108 87% 16
5 ASSARAF, YG , (2007) MOLECULAR BASIS OF ANTIFOLATE RESISTANCE.CANCER AND METASTASIS REVIEWS. VOL. 26. ISSUE 1. P. 153-181 143 66% 141
6 MCGUIRE, JJ , (2003) ANTICANCER ANTIFOLATES: CURRENT STATUS AND FUTURE DIRECTIONS..CURRENT PHARMACEUTICAL DESIGN. VOL. 9. ISSUE 31. P. 2593 -2613 136 78% 185
7 MATHERLY, LH , GOLDMAN, D , (2003) MEMBRANE TRANSPORT OF FOLATES.VITAMINS AND HORMONES - ADVANCES IN RESEARCH AND APPLICATIONS, VOL 66. VOL. 66. ISSUE . P. 403 -456 139 59% 227
8 MATHERLY, LH , HOU, ZJ , DENG, YJ , (2007) HUMAN REDUCED FOLATE CARRIER: TRANSLATION OF BASIC BIOLOGY TO CANCER ETIOLOGY AND THERAPY.CANCER AND METASTASIS REVIEWS. VOL. 26. ISSUE 1. P. 111 -128 104 74% 86
9 RAZ, S , STARK, M , ASSARAF, YG , (2016) FOLYLPOLY-GAMMA-GLUTAMATE SYNTHETASE: A KEY DETERMINANT OF FOLATE HOMEOSTASIS AND ANTIFOLATE RESISTANCE IN CANCER.DRUG RESISTANCE UPDATES. VOL. 28. ISSUE . P. 43 -64 122 56% 0
10 DESMOULIN, SK , HOU, ZJ , GANGJEE, A , MATHERLY, LH , (2012) THE HUMAN PROTON-COUPLED FOLATE TRANSPORTER BIOLOGY AND THERAPEUTIC APPLICATIONS TO CANCER.CANCER BIOLOGY & THERAPY. VOL. 13. ISSUE 14. P. 1355-1373 94 63% 28

Classes with closest relation at Level 1


Rank Class id link
1 22701 PEMETREXED//MULTITARGETED ANTIFOLATE//AFFILIATED JIANGSU CANC HOSP
2 15824 HIGH DOSE METHOTREXATE//7 HYDROXYMETHOTREXATE//METHOTREXATE
3 10553 FOLATE RECEPTOR//FOLATE BINDING PROTEIN//FOLATE RECEPTOR ALPHA
4 15011 THYMIDYLATE SYNTHASE//THYX//FLUORODEOXYURIDYLATE
5 8575 DIHYDROFOLATE REDUCTASE//DHFR//10065 BARNES CANYON RD
6 8151 FOLATE//FOLIC ACID//FOOD FOLATE
7 13841 SERINE HYDROXYMETHYLTRANSFERASE//THREONINE ALDOLASE//SHMT
8 14372 PURINE BIOSYNTHESIS//ADENYLOSUCCINATE LYASE//ADENYLOSUCCINATE LYASE DEFICIENCY
9 7353 URIDINE PHOSPHORYLASE//5 PHENYLTHIOACYCLOURIDINE//LEUCOVORIN
10 26370 METHOTREXATE//INTESTINAL DAMAGE//ABSORPTIVE FUNCTION OF THE INTESTINE

Go to start page