Class information for:
Level 2: DIHYDROFOLATE REDUCTASE//HPPK//DHFR

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
3354 1711 33.9 60%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
278 3       CORYNEBACTERIUM GLUTAMICUM//ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY//BIOCHEMISTRY & MOLECULAR BIOLOGY 43163
3354 2             DIHYDROFOLATE REDUCTASE//HPPK//DHFR 1711
8575 1                   DIHYDROFOLATE REDUCTASE//DHFR//10065 BARNES CANYON RD 1239
24309 1                   HISTIDASE//HISTIDINEMIA//HUTP 316
31201 1                   HPPK//DIHYDROPTEROATE SYNTHASE//PYROPHOSPHOKINASE 156

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DIHYDROFOLATE REDUCTASE authKW 705395 9% 26% 153
2 HPPK authKW 148703 1% 83% 10
3 DHFR authKW 128545 2% 18% 40
4 HISTIDASE authKW 111712 1% 52% 12
5 DIHYDROPTEROATE SYNTHASE authKW 91747 1% 29% 18
6 ANTIFOLATE authKW 65979 2% 11% 35
7 HISTIDINEMIA authKW 55761 0% 63% 5
8 PYROPHOSPHOKINASE authKW 55761 0% 63% 5
9 10065 BARNES CANYON RD address 53534 0% 100% 3
10 HUTP authKW 53534 0% 100% 3

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Biochemistry & Molecular Biology 5612 48% 0% 822
2 Chemistry, Medicinal 3905 15% 0% 251
3 Biophysics 1473 12% 0% 197
4 Microbiology 1406 13% 0% 225
5 Pharmacology & Pharmacy 489 12% 0% 210
6 Biochemical Research Methods 280 5% 0% 89
7 Chemistry, Organic 171 6% 0% 106
8 Crystallography 127 3% 0% 51
9 Chemistry, Multidisciplinary 61 7% 0% 122
10 Genetics & Heredity 39 4% 0% 60

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 10065 BARNES CANYON RD 53534 0% 100% 3
2 COMPUTAT MOL BIOL DRUG DESIGN GRP 40551 0% 45% 5
3 SCI TECHNOL BIOCHEM 26764 0% 50% 3
4 BACTERIOL MYCOL UNIT 23792 0% 67% 2
5 HEDDLE INITIAT UNIT 19029 0% 27% 4
6 MED CHEM PROGRAMME 19029 0% 27% 4
7 ASIT 17845 0% 100% 1
8 BECKMAN B062 17845 0% 100% 1
9 BEYING NMR 17845 0% 100% 1
10 BICHEM TECHNOL BV 17845 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF MEDICINAL CHEMISTRY 12678 7% 1% 124
2 BIOCHEMISTRY 10830 11% 0% 181
3 ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 3193 4% 0% 66
4 JOURNAL OF BACTERIOLOGY 2535 4% 0% 70
5 ANTI-CANCER DRUG DESIGN 2288 1% 1% 9
6 JOURNAL OF BIOCHEMISTRY 1448 2% 0% 30
7 JOURNAL OF MOLECULAR BIOLOGY 1347 3% 0% 43
8 PROTEIN ENGINEERING 1310 1% 1% 13
9 JOURNAL OF HETEROCYCLIC CHEMISTRY 1066 2% 0% 26
10 ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 1010 1% 0% 16

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 DIHYDROFOLATE REDUCTASE 705395 9% 26% 153 Search DIHYDROFOLATE+REDUCTASE Search DIHYDROFOLATE+REDUCTASE
2 HPPK 148703 1% 83% 10 Search HPPK Search HPPK
3 DHFR 128545 2% 18% 40 Search DHFR Search DHFR
4 HISTIDASE 111712 1% 52% 12 Search HISTIDASE Search HISTIDASE
5 DIHYDROPTEROATE SYNTHASE 91747 1% 29% 18 Search DIHYDROPTEROATE+SYNTHASE Search DIHYDROPTEROATE+SYNTHASE
6 ANTIFOLATE 65979 2% 11% 35 Search ANTIFOLATE Search ANTIFOLATE
7 HISTIDINEMIA 55761 0% 63% 5 Search HISTIDINEMIA Search HISTIDINEMIA
8 PYROPHOSPHOKINASE 55761 0% 63% 5 Search PYROPHOSPHOKINASE Search PYROPHOSPHOKINASE
9 HUTP 53534 0% 100% 3 Search HUTP Search HUTP
10 MATERNAL HISTIDINEMIA 53534 0% 100% 3 Search MATERNAL+HISTIDINEMIA Search MATERNAL+HISTIDINEMIA

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 FEENEY, J , (2000) NMR STUDIES OF LIGAND BINDING TO DIHYDROFOLATE REDUCTASE.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. VOL. 39. ISSUE 2. P. 290 -312 102 76% 32
2 POLSHAKOV, VI , (2001) DIHYDROFOLATE REDUCTASE: STRUCTURAL ASPECTS OF MECHANISMS OF ENZYME CATALYSIS AND INHIBITION.RUSSIAN CHEMICAL BULLETIN. VOL. 50. ISSUE 10. P. 1733 -1751 86 87% 7
3 TAWARI, NR , BAG, S , DEGANI, MS , (2011) A REVIEW OF MOLECULAR MODELLING STUDIES OF DIHYDROFOLATE REDUCTASE INHIBITORS AGAINST OPPORTUNISTIC MICROORGANISMS AND COMPREHENSIVE EVALUATION OF NEW MODELS.CURRENT PHARMACEUTICAL DESIGN. VOL. 17. ISSUE 7. P. 712 -751 68 70% 4
4 GANGJEE, A , KURUP, S , NAMJOSHI, O , (2007) DIHYDROFOLATE REDUCTASE AS A TARGET FOR CHEMOTHERAPY IN PARASITES.CURRENT PHARMACEUTICAL DESIGN. VOL. 13. ISSUE 6. P. 609-639 87 56% 35
5 GOLLNICK, P , BABITZKE, P , ANTSON, A , YANOFSKY, C , (2005) COMPLEXITY IN REGULATION OF TRYPTOPHAN BIOSYNTHESIS IN BACILLUS SUBTILIS.ANNUAL REVIEW OF GENETICS. VOL. 39. ISSUE . P. 47 -68 52 87% 88
6 CHAN, DCM , ANDERSON, AC , (2006) TOWARDS SPECIES-SPECIFIC ANTIFOLATES.CURRENT MEDICINAL CHEMISTRY. VOL. 13. ISSUE 4. P. 377 -398 80 53% 46
7 BASRAN, J , CASAROTTO, MG , BARSUKOV, IL , ROBERTS, GCK , (1995) ROLE OF THE ACTIVE-SITE CARBOXYLATE IN DIHYDROFOLATE-REDUCTASE - KINETIC AND SPECTROSCOPIC STUDIES OF THE ASPARTATE 26-]ASPARAGINE MUTANT OF THE LACTOBACILLUS-CASEI ENZYME.BIOCHEMISTRY. VOL. 34. ISSUE 9. P. 2872-2882 58 92% 15
8 KOMPIS, IM , ISLAM, K , THEN, RL , (2005) DNA AND RNA SYNTHESIS: ANTIFOLATES.CHEMICAL REVIEWS. VOL. 105. ISSUE 2. P. 593-620 84 38% 111
9 LEVITIN, A , YANOFSKY, C , (2010) POSITIONS OF TRP CODONS IN THE LEADER PEPTIDE-CODING REGION OF THE AT OPERON INFLUENCE ANTI-TRAP SYNTHESIS AND TRP OPERON EXPRESSION IN BACILLUS LICHENIFORMIS.JOURNAL OF BACTERIOLOGY. VOL. 192. ISSUE 6. P. 1518 -1526 36 92% 0
10 BABITZKE, P , (2004) REGULATION OF TRANSCRIPTION ATTENUATION AND TRANSLATION INITIATION BY ALLOSTERIC CONTROL OF AN RNA-BINDING PROTEIN: THE BACILLUS SUBTILIS TRAP PROTEIN.CURRENT OPINION IN MICROBIOLOGY. VOL. 7. ISSUE 2. P. 132-139 38 95% 41

Classes with closest relation at Level 2


Rank Class id link
1 1684 METHOTREXATE//FOLATE RECEPTOR//REDUCED FOLATE CARRIER
2 2622 TRIOSEPHOSPHATE ISOMERASE//HISTIDINE BIOSYNTHESIS//KETOSTEROID ISOMERASE
3 1833 PNEUMOCYSTIS CARINII//PNEUMOCYSTIS JIROVECII//PNEUMOCYSTIS PNEUMONIA
4 3591 LEONARDO//JOURNAL OF MOLECULAR GRAPHICS//SRI LANKA NANOTECHNOL SLINTEC
5 2596 ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY//ACTA CRYSTALLOGRAPHICA SECTION A//ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY
6 1269 JOURNAL OF CHEMICAL INFORMATION AND MODELING//LIFE SCI INFORMAT//B IT
7 3653 BETA N ACETYL D GLUCOSAMINIDASE//RAPID EQUILIBRIUM//UNSTABLE PRODUCT
8 1067 ANGIOGENIN//RIBONUCLEASE//MOLTEN GLOBULE
9 1176 THYMIDYLATE SYNTHASE//THYMIDINE PHOSPHORYLASE//5 FLUOROURACIL
10 3021 SHIKIMATE PATHWAY//CHORISMATE MUTASE//ANTHRANILATE SYNTHASE

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