Class information for:
Level 1: MITOXANTRONE//PIXANTRONE//PIROXANTRONE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
10232 1079 25.9 61%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
5 4 CHEMISTRY, ORGANIC//CHEMISTRY, INORGANIC & NUCLEAR//CHEMISTRY, MULTIDISCIPLINARY 1745167
346 3       CARDIOTOXICITY//ANTHRACYCLINES//CAMPTOTHECIN 36072
1654 2             DISTAMYCIN//MINOR GROOVE BINDER//PYRROLE IMIDAZOLE POLYAMIDE 6885
10232 1                   MITOXANTRONE//PIXANTRONE//PIROXANTRONE 1079

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MITOXANTRONE authKW 608241 13% 15% 143
2 PIXANTRONE authKW 441803 2% 71% 22
3 PIROXANTRONE authKW 341597 1% 93% 13
4 ANTHRAPYRAZOLE authKW 166451 1% 59% 10
5 AMIDOANTHRAQUINONES authKW 141491 0% 100% 5
6 BBR 2778 authKW 141491 0% 100% 5
7 NCI 60 CELL PANEL ASSAY authKW 141491 0% 100% 5
8 BISANTRENE authKW 127339 1% 75% 6
9 1 4 DIHYDROXY 9 10 ANTHRAQUINONE authKW 113192 0% 100% 4
10 ANTHRACENEDIONE authKW 106526 1% 47% 8

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Oncology 7832 44% 0% 478
2 Pharmacology & Pharmacy 2862 31% 0% 337
3 Chemistry, Medicinal 2291 14% 0% 153
4 Chemistry, Organic 128 7% 0% 71
5 Chemistry, Analytical 66 5% 0% 53
6 Toxicology 61 3% 0% 33
7 Biochemistry & Molecular Biology 56 11% 0% 117
8 Hematology 48 3% 0% 31
9 Biophysics 36 3% 0% 35
10 Chemistry, Multidisciplinary 20 6% 0% 66

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CATTEDRA ONCOL MED LARGO A GEMELLI 8 28298 0% 100% 1
2 CHEMOTHER Y INTENS TREATMENT HAEMATOL DIS 28298 0% 100% 1
3 CIENCIAS BIOLUCBIO REQUIMTE REDE QUIM TEC 28298 0% 100% 1
4 CNRS UA 198 28298 0% 100% 1
5 CONVERGENCE PHYS SCI ONCOL PS OC 28298 0% 100% 1
6 DRUG NAT PROD SYNTHES 28298 0% 100% 1
7 ENGN SOLID PREPARAT CHINESE HERBAL M 28298 0% 100% 1
8 HAEMATOL LE A SERAGNOLI 28298 0% 100% 1
9 IBR WEST EXTENS 28298 0% 100% 1
10 MEDJOHNS HOPKINS ONCOL MED ONCOL 28298 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CANCER TREATMENT REPORTS 40229 5% 3% 56
2 INVESTIGATIONAL NEW DRUGS 28798 5% 2% 51
3 ANTI-CANCER DRUG DESIGN 19863 2% 3% 21
4 CANCER CHEMOTHERAPY AND PHARMACOLOGY 6753 4% 1% 42
5 CANCER TREATMENT REVIEWS 4184 2% 1% 17
6 AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS 4010 2% 1% 24
7 JOURNAL OF MEDICINAL CHEMISTRY 1950 4% 0% 39
8 PROGRESS IN MEDICINAL CHEMISTRY 1570 0% 6% 1
9 BIOCHEMICAL PHARMACOLOGY 1521 3% 0% 32
10 CHEMIOTERAPIA 1260 0% 1% 4

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 MITOXANTRONE 608241 13% 15% 143 Search MITOXANTRONE Search MITOXANTRONE
2 PIXANTRONE 441803 2% 71% 22 Search PIXANTRONE Search PIXANTRONE
3 PIROXANTRONE 341597 1% 93% 13 Search PIROXANTRONE Search PIROXANTRONE
4 ANTHRAPYRAZOLE 166451 1% 59% 10 Search ANTHRAPYRAZOLE Search ANTHRAPYRAZOLE
5 AMIDOANTHRAQUINONES 141491 0% 100% 5 Search AMIDOANTHRAQUINONES Search AMIDOANTHRAQUINONES
6 BBR 2778 141491 0% 100% 5 Search BBR+2778 Search BBR+2778
7 NCI 60 CELL PANEL ASSAY 141491 0% 100% 5 Search NCI+60+CELL+PANEL+ASSAY Search NCI+60+CELL+PANEL+ASSAY
8 BISANTRENE 127339 1% 75% 6 Search BISANTRENE Search BISANTRENE
9 1 4 DIHYDROXY 9 10 ANTHRAQUINONE 113192 0% 100% 4 Search 1+4+DIHYDROXY+9+10+ANTHRAQUINONE Search 1+4+DIHYDROXY+9+10+ANTHRAQUINONE
10 ANTHRACENEDIONE 106526 1% 47% 8 Search ANTHRACENEDIONE Search ANTHRACENEDIONE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 FAULDS, D , BALFOUR, JA , CHRISP, P , LANGTRY, HD , (1991) MITOXANTRONE - A REVIEW OF ITS PHARMACODYNAMIC AND PHARMACOKINETIC PROPERTIES, AND THERAPEUTIC POTENTIAL IN THE CHEMOTHERAPY OF CANCER.DRUGS. VOL. 41. ISSUE 3. P. 400-449 165 53% 235
2 KRAPCHO, AP , (2015) PIXUVRI (R) (PIXANTRONE DIMALEATE, BBR 2778): FROM LAB TO MARKET.CURRENT ORGANIC CHEMISTRY. VOL. 19. ISSUE 10. P. 886 -897 45 74% 1
3 EVISON, BJ , SLEEBS, BE , PHILLIPS, DR , CUTTS, SM , WATSON, KG , (2016) MITOXANTRONE, MORE THAN JUST ANOTHER TOPOISOMERASE II POISON.MEDICINAL RESEARCH REVIEWS. VOL. 36. ISSUE 2. P. 248 -299 86 30% 2
4 SHENKENBERG, TD , VONHOFF, DD , (1986) MITOXANTRONE - A NEW ANTICANCER DRUG WITH SIGNIFICANT CLINICAL ACTIVITY.ANNALS OF INTERNAL MEDICINE. VOL. 105. ISSUE 1. P. 67-81 82 75% 209
5 DZIERZBICKA, K , KOLODZIEJCZYK, AM , (2005) ANTHRACENEDIONE ANALOGUES - SYNTHESIS AND BIOLOGICAL ACTIVITY.POLISH JOURNAL OF CHEMISTRY. VOL. 79. ISSUE 1. P. 1-29 57 62% 5
6 MOMMSEN, J , NAGEL, JD , BODE, U , (1998) CLINICAL PHARMACOKINETICS OF MITOXANTRONE - A REVIEW.INTERNATIONAL JOURNAL OF PEDIATRIC HEMATOLOGY/ONCOLOGY. VOL. 5. ISSUE 6. P. 387 -406 58 55% 0
7 KRAPCHO, AP , MENTA, E , OLIVA, A , DI DOMENICO, R , FIOCCHI, L , MARESCH, ME , GALLAGHER, CE , HACKER, MP , BEGGIOLIN, G , GIULIANI, FC , ET AL (1998) SYNTHESIS AND ANTITUMOR EVALUATION OF 2,5-DISUBSTITUTED-INDAZOLO[4,3-GH]ISOQUINOLIN-6(2H)-ONES (9-AZA-ANTHRAPYRAZOLES).JOURNAL OF MEDICINAL CHEMISTRY. VOL. 41. ISSUE 27. P. 5429 -5444 32 91% 49
8 KEATING, GM , (2016) PIXANTRONE: A REVIEW IN RELAPSED OR REFRACTORY AGGRESSIVE NON-HODGKIN'S LYMPHOMA.DRUGS. VOL. 76. ISSUE 16. P. 1579 -1586 21 81% 0
9 KRAPCHO, AP , GETAHUN, Z , AVERY, KL , VARGAS, KJ , HACKER, MP , SPINELLI, S , PEZZONI, G , MANZOTTI, C , (1991) SYNTHESIS AND ANTITUMOR EVALUATIONS OF SYMMETRICALLY AND UNSYMMETRICALLY SUBSTITUTED 1,4-BIS[(AMINOALKYL)AMINO]ANTHRACENE-9,10-DIONES AND 1,4-BIS[(AMINOALKYL)AMINO]-5,8-DIHYDROXYANTHRACENE-9,10-DIONES.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 34. ISSUE 8. P. 2373 -2380 46 74% 46
10 MCLAUGHLIN, C , MACMILLAN, D , MCCARDLE, C , SMITH, WE , (2002) QUANTITATIVE ANALYSIS OF MITOXANTRONE BY SURFACE-ENHANCED RESONANCE RAMAN SCATTERING.ANALYTICAL CHEMISTRY. VOL. 74. ISSUE 13. P. 3160 -3167 32 67% 35

Classes with closest relation at Level 1


Rank Class id link
1 29974 CI 958//ARYLMETHYLAMINOPROPANEDIOLS//SR271425
2 34581 MENOGARIL//DNA UNWINDING ACTIVITY//N O O TRIANGULAR PHARMACOPHORE
3 37618 NBD GLUCOSAMINE//TUMOR SPECIFIC DOSE//MED HARVARD STUDY KIDNEY DIS
4 9157 SABARUBICIN//BARMINOMYCIN//ACTINOMYCIN
5 8111 IDARUBICIN//IDARUBICINOL//MODIFIED ANTIBIOT
6 7272 ACRIDINE//C 1311//PYRAZOLOACRIDINE
7 1652 DOXORUBICIN//CARDIOTOXICITY//DEXRAZOXANE
8 29125 PHOTOAMINATION//COLOURED NYLON FIBRE//1 2 HETEROCYCLIZATION
9 2966 METASTATIC BREAST CANCER//VINORELBINE//DOCETAXEL
10 22766 ANTHRAQUINONE DISULPHONATES//NAA UNIT//SOLVENT POLARITY EFFECT

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