Class information for:
Level 2: GENOME EDITING//CRISPR CAS9//CRISPR

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
1115 9706 43.1 87%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
7 4 INFECTIOUS DISEASES//MICROBIOLOGY//VIROLOGY 1353914
33 3       JOURNAL OF BACTERIOLOGY//MICROBIOLOGY//MOLECULAR MICROBIOLOGY 107033
1115 2             GENOME EDITING//CRISPR CAS9//CRISPR 9706
915 1                   GENOME EDITING//CRISPR//CRISPR CAS9 2962
7535 1                   SITE SPECIFIC RECOMBINATION//SERINE RECOMBINASE//PHIC31 INTEGRASE 1357
8740 1                   CRE RECOMBINASE//TET SYSTEM//RTTA 1222
9628 1                   MARINER//SLEEPING BEAUTY//TRANSPOSON 1136
12165 1                   GENE TARGETING//SOMATIC CELL AND MOLECULAR GENETICS//HOMOLOGOUS RECOMBINATION 927
15145 1                   MARKER FREE//MARKER FREE TRANSGENIC PLANTS//SITE SPECIFIC RECOMBINATION 729
16858 1                   MAMMALIAN GENET UNIT//ENU MUTAGENESIS//PHENOTYPE DRIVEN SCREEN 631
25066 1                   SINGLE STRANDED OLIGONUCLEOTIDES//GENE REPAIR//CHIMERAPLASTY 292
25676 1                   GENE TRAP//GENE TRAPPING//SPLICING AROUND 275
30077 1                   2A PEPTIDE//FMDV 2A//2A 175

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 GENOME EDITING authKW 590899 3% 67% 282
2 CRISPR CAS9 authKW 533766 3% 66% 259
3 CRISPR authKW 523383 3% 61% 271
4 SITE SPECIFIC RECOMBINATION authKW 471018 3% 57% 264
5 CAS9 authKW 403885 2% 83% 155
6 TALEN authKW 349291 2% 71% 156
7 ZINC FINGER NUCLEASE authKW 253287 1% 64% 126
8 GENOME ENGINEERING authKW 232086 1% 62% 120
9 CRISPR CAS authKW 213537 1% 77% 88
10 GENE TARGETING authKW 188441 3% 18% 335

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Genetics & Heredity 36488 26% 1% 2537
2 Biochemistry & Molecular Biology 28128 45% 0% 4415
3 Biotechnology & Applied Microbiology 20722 20% 0% 1987
4 Cell Biology 11015 19% 0% 1812
5 Developmental Biology 7474 6% 0% 574
6 Biochemical Research Methods 4899 8% 0% 809
7 Medicine, Research & Experimental 2410 7% 0% 679
8 Plant Sciences 1496 7% 0% 681
9 Cell & Tissue Engineering 1418 1% 0% 117
10 Microbiology 572 5% 0% 457

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 GENOME ENGN 178348 1% 51% 112
2 ARNOLD MABEL BECKMAN TRANSPOSON 57035 0% 55% 33
3 INNOVAT GENOM INITIAT 50289 0% 67% 24
4 GENET CELL BIOL DEV 44911 1% 10% 141
5 REGULAT INFECT BIOL 36244 0% 82% 14
6 CREAT INITIAT GENOME ENGN 35420 0% 87% 13
7 PLANT GENOME ENGN UNIT 29797 0% 59% 16
8 MOL PATHOL UNIT 22712 1% 13% 55
9 COMPUTAT INTEGRAT BIOL 18503 1% 11% 56
10 RNA SYST BIOL 18272 0% 36% 16

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 GENESIS 59248 2% 11% 169
2 TRANSGENIC RESEARCH 27423 1% 7% 121
3 NUCLEIC ACIDS RESEARCH 25785 6% 1% 577
4 NATURE BIOTECHNOLOGY 17956 1% 5% 123
5 MOLECULAR THERAPY 13216 1% 3% 123
6 MAMMALIAN GENOME 12492 1% 3% 119
7 NATURE METHODS 10601 1% 4% 76
8 SOMATIC CELL AND MOLECULAR GENETICS 9659 1% 6% 53
9 MOLECULAR THERAPY-NUCLEIC ACIDS 6990 0% 9% 26
10 PLANT BIOTECHNOLOGY JOURNAL 6858 1% 4% 52

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 GENOME EDITING 590899 3% 67% 282 Search GENOME+EDITING Search GENOME+EDITING
2 CRISPR CAS9 533766 3% 66% 259 Search CRISPR+CAS9 Search CRISPR+CAS9
3 CRISPR 523383 3% 61% 271 Search CRISPR Search CRISPR
4 SITE SPECIFIC RECOMBINATION 471018 3% 57% 264 Search SITE+SPECIFIC+RECOMBINATION Search SITE+SPECIFIC+RECOMBINATION
5 CAS9 403885 2% 83% 155 Search CAS9 Search CAS9
6 TALEN 349291 2% 71% 156 Search TALEN Search TALEN
7 ZINC FINGER NUCLEASE 253287 1% 64% 126 Search ZINC+FINGER+NUCLEASE Search ZINC+FINGER+NUCLEASE
8 GENOME ENGINEERING 232086 1% 62% 120 Search GENOME+ENGINEERING Search GENOME+ENGINEERING
9 CRISPR CAS 213537 1% 77% 88 Search CRISPR+CAS Search CRISPR+CAS
10 GENE TARGETING 188441 3% 18% 335 Search GENE+TARGETING Search GENE+TARGETING

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 WRIGHT, AV , NUNEZ, JK , DOUDNA, JA , (2016) BIOLOGY AND APPLICATIONS OF CRISPR SYSTEMS: HARNESSING NATURE'S TOOLBOX FOR GENOME ENGINEERING.CELL. VOL. 164. ISSUE 1-2. P. 29 -44 137 93% 74
2 DOUDNA, JA , CHARPENTIER, E , (2014) THE NEW FRONTIER OF GENOME ENGINEERING WITH CRISPR-CAS9.SCIENCE. VOL. 346. ISSUE 6213. P. 1077 -+ 123 85% 552
3 MAEDER, ML , GERSBACH, CA , (2016) GENOME-EDITING TECHNOLOGIES FOR GENE AND CELL THERAPY.MOLECULAR THERAPY. VOL. 24. ISSUE 3. P. 430 -446 187 66% 35
4 KIM, H , KIM, JS , (2014) A GUIDE TO GENOME ENGINEERING WITH PROGRAMMABLE NUCLEASES.NATURE REVIEWS GENETICS. VOL. 15. ISSUE 5. P. 321 -334 150 88% 246
5 CARROLL, D , (2014) GENOME ENGINEERING WITH TARGETABLE NUCLEASES.ANNUAL REVIEW OF BIOCHEMISTRY, VOL 83. VOL. 83. ISSUE . P. 409 -439 206 80% 121
6 HSU, PD , LANDER, ES , ZHANG, F , (2014) DEVELOPMENT AND APPLICATIONS OF CRISPR-CAS9 FOR GENOME ENGINEERING.CELL. VOL. 157. ISSUE 6. P. 1262 -1278 79 87% 758
7 GAJ, T , GERSBACH, CA , BARBAS, CF , (2013) ZFN, TALEN, AND CRISPR/CAS-BASED METHODS FOR GENOME ENGINEERING.TRENDS IN BIOTECHNOLOGY. VOL. 31. ISSUE 7. P. 397-405 95 83% 805
8 MOHANRAJU, P , MAKAROVA, KS , ZETSCHE, B , ZHANG, F , KOONIN, EV , VAN DER OOST, J , (2016) DIVERSE EVOLUTIONARY ROOTS AND MECHANISTIC VARIATIONS OF THE CRISPR-CAS SYSTEMS.SCIENCE. VOL. 353. ISSUE 6299. P. - 153 96% 8
9 SANDER, JD , JOUNG, JK , (2014) CRISPR-CAS SYSTEMS FOR EDITING, REGULATING AND TARGETING GENOMES.NATURE BIOTECHNOLOGY. VOL. 32. ISSUE 4. P. 347 -355 86 95% 337
10 MAKAROVA, KS , WOLF, YI , ALKHNBASHI, OS , COSTA, F , SHAH, SA , SAUNDERS, SJ , BARRANGOU, R , BROUNS, SJJ , CHARPENTIER, E , HAFT, DH , ET AL (2015) AN UPDATED EVOLUTIONARY CLASSIFICATION OF CRISPR-CAS SYSTEMS.NATURE REVIEWS MICROBIOLOGY. VOL. 13. ISSUE 11. P. 722 -736 103 91% 112

Classes with closest relation at Level 2


Rank Class id link
1 3063 DNA TRANSPOSITION//PHAGE MU//TRANSPOSASE
2 1983 SOMATOLACTIN//TRANSGENIC CHICKEN//GROWTH HORMONE
3 2094 TRANSPOSABLE ELEMENTS//RETROTRANSPOSON//LTR RETROTRANSPOSON
4 3410 ZEBRAFISH//FACTOR VII ACTIVATING PROTEASE//FSAP
5 2636 COILED COIL//KRAB DOMAIN//PROTEIN DESIGN
6 2608 CROWN GALL//TI PLASMID//BACTERIAL CONJUGATION
7 1227 TRANSPOSABLE ELEMENTS//RETROTRANSPOSON//CHROMOSOMA
8 553 EMBRYONIC STEM CELLS//HUMAN EMBRYONIC STEM CELLS//INDUCED PLURIPOTENT STEM CELLS
9 1609 RESTRICTION ENDONUCLEASE//BIOTECHNIQUES//RESTRICTION MODIFICATION SYSTEM
10 3571 TRANSHYDROGENASE//NICOTINAMIDE NUCLEOTIDE//COLLABORATIVE CROSS

Go to start page