Class information for:
Level 1: GENOME EDITING//CRISPR//CRISPR CAS9

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
915 2962 51.0 93%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
7 4 INFECTIOUS DISEASES//MICROBIOLOGY//VIROLOGY 1353914
33 3       JOURNAL OF BACTERIOLOGY//MICROBIOLOGY//MOLECULAR MICROBIOLOGY 107033
1115 2             GENOME EDITING//CRISPR CAS9//CRISPR 9706
915 1                   GENOME EDITING//CRISPR//CRISPR CAS9 2962

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 GENOME EDITING authKW 1842553 9% 65% 275
2 CRISPR authKW 1703633 9% 61% 270
3 CRISPR CAS9 authKW 1696592 9% 65% 255
4 CAS9 authKW 1307140 5% 82% 154
5 TALEN authKW 1073031 5% 69% 151
6 ZINC FINGER NUCLEASE authKW 716124 4% 59% 117
7 CRISPR CAS authKW 700126 3% 77% 88
8 GENE EDITING authKW 533022 3% 60% 86
9 GENOME ENGINEERING authKW 487036 3% 49% 96
10 TRANSCRIPTION ACTIVATOR LIKE EFFECTOR NUCLEASES authKW 350871 1% 85% 40

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Biotechnology & Applied Microbiology 11117 27% 0% 788
2 Biochemistry & Molecular Biology 7594 43% 0% 1277
3 Genetics & Heredity 6413 20% 0% 599
4 Cell Biology 3866 20% 0% 588
5 Cell & Tissue Engineering 3010 3% 0% 90
6 Biochemical Research Methods 2773 11% 0% 325
7 Developmental Biology 825 4% 0% 110
8 Microbiology 761 8% 0% 239
9 Medicine, Research & Experimental 691 7% 0% 202
10 Plant Sciences 384 7% 0% 195

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 GENOME ENGN 313497 3% 37% 82
2 INNOVAT GENOM INITIAT 164899 1% 67% 24
3 REGULAT INFECT BIOL 118831 0% 82% 14
4 CREAT INITIAT GENOME ENGN 116124 0% 87% 13
5 MOL PATHOL UNIT 71982 2% 13% 54
6 RNA SYST BIOL 59949 1% 36% 16
7 COMPUTAT INTEGRAT BIOL 58730 2% 10% 55
8 OURCE MUTANT MICE 49460 0% 40% 12
9 COMBINED PROGRAM MICROBIOL IMMUNOL 48370 0% 36% 13
10 ARCHAEA 46828 1% 22% 21

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 NATURE BIOTECHNOLOGY 25071 3% 3% 80
2 NATURE METHODS 17680 2% 3% 54
3 RNA BIOLOGY 13702 1% 4% 35
4 JOURNAL OF GENETICS AND GENOMICS 10852 1% 4% 25
5 MOLECULAR THERAPY-NUCLEIC ACIDS 9831 1% 6% 17
6 NUCLEIC ACIDS RESEARCH 7590 6% 0% 173
7 SCIENTIFIC REPORTS 7095 6% 0% 175
8 ACS SYNTHETIC BIOLOGY 6644 1% 3% 19
9 G3-GENES GENOMES GENETICS 5940 1% 2% 28
10 MOLECULAR THERAPY 5814 2% 1% 45

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 GENOME EDITING 1842553 9% 65% 275 Search GENOME+EDITING Search GENOME+EDITING
2 CRISPR 1703633 9% 61% 270 Search CRISPR Search CRISPR
3 CRISPR CAS9 1696592 9% 65% 255 Search CRISPR+CAS9 Search CRISPR+CAS9
4 CAS9 1307140 5% 82% 154 Search CAS9 Search CAS9
5 TALEN 1073031 5% 69% 151 Search TALEN Search TALEN
6 ZINC FINGER NUCLEASE 716124 4% 59% 117 Search ZINC+FINGER+NUCLEASE Search ZINC+FINGER+NUCLEASE
7 CRISPR CAS 700126 3% 77% 88 Search CRISPR+CAS Search CRISPR+CAS
8 GENE EDITING 533022 3% 60% 86 Search GENE+EDITING Search GENE+EDITING
9 GENOME ENGINEERING 487036 3% 49% 96 Search GENOME+ENGINEERING Search GENOME+ENGINEERING
10 TRANSCRIPTION ACTIVATOR LIKE EFFECTOR NUCLEASES 350871 1% 85% 40 Search TRANSCRIPTION+ACTIVATOR+LIKE+EFFECTOR+NUCLEASES Search TRANSCRIPTION+ACTIVATOR+LIKE+EFFECTOR+NUCLEASES

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 WRIGHT, AV , NUNEZ, JK , DOUDNA, JA , (2016) BIOLOGY AND APPLICATIONS OF CRISPR SYSTEMS: HARNESSING NATURE'S TOOLBOX FOR GENOME ENGINEERING.CELL. VOL. 164. ISSUE 1-2. P. 29 -44 137 93% 74
2 DOUDNA, JA , CHARPENTIER, E , (2014) THE NEW FRONTIER OF GENOME ENGINEERING WITH CRISPR-CAS9.SCIENCE. VOL. 346. ISSUE 6213. P. 1077 -+ 119 82% 552
3 MAEDER, ML , GERSBACH, CA , (2016) GENOME-EDITING TECHNOLOGIES FOR GENE AND CELL THERAPY.MOLECULAR THERAPY. VOL. 24. ISSUE 3. P. 430 -446 185 65% 35
4 KIM, H , KIM, JS , (2014) A GUIDE TO GENOME ENGINEERING WITH PROGRAMMABLE NUCLEASES.NATURE REVIEWS GENETICS. VOL. 15. ISSUE 5. P. 321 -334 150 88% 246
5 CARROLL, D , (2014) GENOME ENGINEERING WITH TARGETABLE NUCLEASES.ANNUAL REVIEW OF BIOCHEMISTRY, VOL 83. VOL. 83. ISSUE . P. 409 -439 200 78% 121
6 HSU, PD , LANDER, ES , ZHANG, F , (2014) DEVELOPMENT AND APPLICATIONS OF CRISPR-CAS9 FOR GENOME ENGINEERING.CELL. VOL. 157. ISSUE 6. P. 1262 -1278 78 86% 758
7 MOHANRAJU, P , MAKAROVA, KS , ZETSCHE, B , ZHANG, F , KOONIN, EV , VAN DER OOST, J , (2016) DIVERSE EVOLUTIONARY ROOTS AND MECHANISTIC VARIATIONS OF THE CRISPR-CAS SYSTEMS.SCIENCE. VOL. 353. ISSUE 6299. P. - 153 96% 8
8 GAJ, T , GERSBACH, CA , BARBAS, CF , (2013) ZFN, TALEN, AND CRISPR/CAS-BASED METHODS FOR GENOME ENGINEERING.TRENDS IN BIOTECHNOLOGY. VOL. 31. ISSUE 7. P. 397-405 89 77% 805
9 SANDER, JD , JOUNG, JK , (2014) CRISPR-CAS SYSTEMS FOR EDITING, REGULATING AND TARGETING GENOMES.NATURE BIOTECHNOLOGY. VOL. 32. ISSUE 4. P. 347 -355 86 95% 337
10 MAKAROVA, KS , WOLF, YI , ALKHNBASHI, OS , COSTA, F , SHAH, SA , SAUNDERS, SJ , BARRANGOU, R , BROUNS, SJJ , CHARPENTIER, E , HAFT, DH , ET AL (2015) AN UPDATED EVOLUTIONARY CLASSIFICATION OF CRISPR-CAS SYSTEMS.NATURE REVIEWS MICROBIOLOGY. VOL. 13. ISSUE 11. P. 722 -736 103 91% 112

Classes with closest relation at Level 1


Rank Class id link
1 14197 ARTIFICIAL TRANSCRIPTION FACTOR//ZINC FINGER//RECOGNITION CODE
2 25066 SINGLE STRANDED OLIGONUCLEOTIDES//GENE REPAIR//CHIMERAPLASTY
3 15145 MARKER FREE//MARKER FREE TRANSGENIC PLANTS//SITE SPECIFIC RECOMBINATION
4 11925 INTEIN//PROTEIN SPLICING//HOMING ENDONUCLEASE
5 9628 MARINER//SLEEPING BEAUTY//TRANSPOSON
6 12267 PIGGYBAC//GERM LINE TRANSFORMATION//RIDL
7 7960 SYNTHETIC BIOLOGY//ACS SYNTHETIC BIOLOGY//GENETIC CIRCUITS
8 19925 VASA//NANAE F H WATER//PRIMORDIAL GERM CELLS
9 12753 T VECTOR//TA CLONING//GENE SYNTHESIS
10 24039 TILLING//SHOREMAPPING//MAPPING BY SEQUENCING

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