Class information for:
Level 1: CEREBROTENDINOUS XANTHOMATOSIS//CHOLESTEROL 7 ALPHA HYDROXYLASE//STEROL 27 HYDROXYLASE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
9039 1193 33.1 63%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
6 4 GASTROENTEROLOGY & HEPATOLOGY//ONCOLOGY//SURGERY 1371034
212 3       GASTROENTEROLOGY & HEPATOLOGY//LAPAROSCOPIC CHOLECYSTECTOMY//PRIMARY BILIARY CIRRHOSIS 51420
1019 2             BILE ACIDS//FARNESOID X RECEPTOR//CHOLESTASIS 10277
9039 1                   CEREBROTENDINOUS XANTHOMATOSIS//CHOLESTEROL 7 ALPHA HYDROXYLASE//STEROL 27 HYDROXYLASE 1193

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CEREBROTENDINOUS XANTHOMATOSIS authKW 2488723 9% 87% 112
2 CHOLESTEROL 7 ALPHA HYDROXYLASE authKW 727899 7% 36% 80
3 STEROL 27 HYDROXYLASE authKW 580576 3% 65% 35
4 BILE ACID SYNTHESIS authKW 561212 4% 44% 50
5 CHOLESTANOL authKW 525163 4% 42% 49
6 CYP27A1 authKW 385379 3% 47% 32
7 27 HYDROXYCHOLESTEROL authKW 324138 3% 33% 38
8 7 ALPHA HYDROXYCHOLESTEROL authKW 182160 1% 65% 11
9 CEREBROTENDINOUS XANTHOMATOSIS CTX authKW 156760 1% 88% 7
10 27 HYDROXYLASE authKW 148905 1% 73% 8

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Biochemistry & Molecular Biology 3896 48% 0% 572
2 Biophysics 1004 11% 0% 136
3 Gastroenterology & Hepatology 735 8% 0% 98
4 Medicine, Research & Experimental 437 8% 0% 98
5 Endocrinology & Metabolism 317 7% 0% 89
6 Clinical Neurology 278 8% 0% 97
7 Medical Laboratory Technology 161 2% 0% 26
8 Nutrition & Dietetics 84 3% 0% 34
9 Medicine, General & Internal 34 4% 0% 51
10 Genetics & Heredity 32 4% 0% 44

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PREVENT TREATMENT ATHEROSCLEROSIS 49345 1% 21% 9
2 CASEY MOL DIAGNOST 34124 0% 67% 2
3 DIPARTIMENTO MED ENDOCRINOL METAB GERIATRIA 28789 0% 38% 3
4 AMBIENTALE BIOTECNOL MED DIMESAB 25594 0% 100% 1
5 AMBULANZ DIABET STOFFWECHSELKRANKHEITEN 25594 0% 100% 1
6 ARAGON CIENCIAS SALUD I CS 25594 0% 100% 1
7 BIOSCI NUTR NUTR TOXICOL 25594 0% 100% 1
8 CETR UNIV FEEVALE 25594 0% 100% 1
9 DIAG PREVENT THER Y NEURO HANDIC 25594 0% 100% 1
10 DIPARTIMENTO MED INTERNA EPATOL GASTROENTEROL 25594 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF LIPID RESEARCH 75151 13% 2% 158
2 HEPATOLOGY 4313 4% 0% 45
3 BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 3414 2% 1% 19
4 STEROIDS 2569 2% 0% 21
5 LIPIDS 2068 2% 0% 22
6 BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM 1914 1% 1% 9
7 BIOCHIMICA ET BIOPHYSICA ACTA 1439 3% 0% 41
8 JOURNAL OF BIOLOGICAL CHEMISTRY 1162 7% 0% 87
9 JOURNAL OF CLINICAL INVESTIGATION 878 2% 0% 25
10 BIOLOGICAL CHEMISTRY HOPPE-SEYLER 810 1% 0% 7

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 CEREBROTENDINOUS XANTHOMATOSIS 2488723 9% 87% 112 Search CEREBROTENDINOUS+XANTHOMATOSIS Search CEREBROTENDINOUS+XANTHOMATOSIS
2 CHOLESTEROL 7 ALPHA HYDROXYLASE 727899 7% 36% 80 Search CHOLESTEROL+7+ALPHA+HYDROXYLASE Search CHOLESTEROL+7+ALPHA+HYDROXYLASE
3 STEROL 27 HYDROXYLASE 580576 3% 65% 35 Search STEROL+27+HYDROXYLASE Search STEROL+27+HYDROXYLASE
4 BILE ACID SYNTHESIS 561212 4% 44% 50 Search BILE+ACID+SYNTHESIS Search BILE+ACID+SYNTHESIS
5 CHOLESTANOL 525163 4% 42% 49 Search CHOLESTANOL Search CHOLESTANOL
6 CYP27A1 385379 3% 47% 32 Search CYP27A1 Search CYP27A1
7 27 HYDROXYCHOLESTEROL 324138 3% 33% 38 Search 27+HYDROXYCHOLESTEROL Search 27+HYDROXYCHOLESTEROL
8 7 ALPHA HYDROXYCHOLESTEROL 182160 1% 65% 11 Search 7+ALPHA+HYDROXYCHOLESTEROL Search 7+ALPHA+HYDROXYCHOLESTEROL
9 CEREBROTENDINOUS XANTHOMATOSIS CTX 156760 1% 88% 7 Search CEREBROTENDINOUS+XANTHOMATOSIS+CTX Search CEREBROTENDINOUS+XANTHOMATOSIS+CTX
10 27 HYDROXYLASE 148905 1% 73% 8 Search 27+HYDROXYLASE Search 27+HYDROXYLASE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 PRINCEN, HMG , POST, SM , TWISK, J , (1997) REGULATION OF BILE ACID BIOSYNTHESIS.CURRENT PHARMACEUTICAL DESIGN. VOL. 3. ISSUE 1. P. 59-84 162 67% 81
2 VLAHCEVIC, ZR , PANDAK, WM , STRAVITZ, RT , (1999) REGULATION OF BILE ACID BIOSYNTHESIS.GASTROENTEROLOGY CLINICS OF NORTH AMERICA. VOL. 28. ISSUE 1. P. 1 -+ 93 82% 112
3 NORLIN, M , WIKVALL, K , (2007) ENZYMES IN THE CONVERSION OF CHOLESTEROL INTO BILE ACIDS.CURRENT MOLECULAR MEDICINE. VOL. 7. ISSUE 2. P. 199-218 100 58% 70
4 NIE, SK , CHEN, GQ , CAO, XB , ZHANG, YJ , (2014) CEREBROTENDINOUS XANTHOMATOSIS: A COMPREHENSIVE REVIEW OF PATHOGENESIS, CLINICAL MANIFESTATIONS, DIAGNOSIS, AND MANAGEMENT.ORPHANET JOURNAL OF RARE DISEASES. VOL. 9. ISSUE . P. - 63 79% 5
5 GALLUS, GN , DOTTI, MT , FEDERICO, A , (2006) CLINICAL AND MOLECULAR DIAGNOSIS OF CEREBROTENDINOUS XANTHOMATOSIS WITH A REVIEW OF THE MUTATIONS IN THE CYP27A1 GENE.NEUROLOGICAL SCIENCES. VOL. 27. ISSUE 2. P. 143-149 48 98% 61
6 MIGNARRI, A , GALLUS, GN , DOTTI, MT , FEDERICO, A , (2014) A SUSPICION INDEX FOR EARLY DIAGNOSIS AND TREATMENT OF CEREBROTENDINOUS XANTHOMATOSIS.JOURNAL OF INHERITED METABOLIC DISEASE. VOL. 37. ISSUE 3. P. 421-429 33 100% 12
7 VERRIPS, A , HOEFSLOOT, LH , STEENBERGEN, GCH , THEELEN, JP , WEVERS, RA , GABREELS, FJM , VAN ENGELEN, BGM , VAN DEN HEUVEL, LPWJ , (2000) CLINICAL AND MOLECULAR GENETIC CHARACTERISTICS OF PATIENTS WITH CEREBROTENDINOUS XANTHOMATOSIS.BRAIN. VOL. 123. ISSUE . P. 908-919 47 94% 100
8 FRAIDAKIS, MJ , (2013) PSYCHIATRIC MANIFESTATIONS IN CEREBROTENDINOUS XANTHOMATOSIS.TRANSLATIONAL PSYCHIATRY. VOL. 3. ISSUE . P. - 62 53% 11
9 VLAHCEVIC, ZR , PANDAK, WM , HEUMAN, DM , HYLEMON, PB , (1992) FUNCTION AND REGULATION OF HYDROXYLASES INVOLVED IN THE BILE-ACID BIOSYNTHESIS PATHWAYS.SEMINARS IN LIVER DISEASE. VOL. 12. ISSUE 4. P. 403-419 92 68% 29
10 BERTOLOTTI, M , CROSIGNANI, A , DEL PUPPO, M , (2012) THE USE OF STABLE AND RADIOACTIVE STEROL TRACERS AS A TOOL TO INVESTIGATE CHOLESTEROL DEGRADATION TO BILE ACIDS IN HUMANS IN VIVO.MOLECULES. VOL. 17. ISSUE 2. P. 1939 -1968 68 50% 1

Classes with closest relation at Level 1


Rank Class id link
1 5778 BILE ACIDS//SULFATED BILE ACID//TAURINE CONJUGATE
2 5462 FARNESOID X RECEPTOR//FXR//TGR5
3 5179 OXYSTEROLS//CHOLESTEROL OXIDES//CHOLESTEROL OXIDATION PRODUCTS
4 34646 DIETARY FAT AND OILS//ENDOGENOUS LIPASE ACTIVITY//ETHYL ESTRADIOL
5 15377 CYP27B1//VITAMIN D HYDROXYLASES//ENDOCRINE BONE
6 16617 BILE ACID MALABSORPTION//SEHCAT//ASBT
7 20027 APOLIPOPROTEINS A I AND B//ALIMENTARY HYPERCHOLESTEROLEMIA//CHOLESTEROL DEPRIVATION
8 13816 HMG COA REDUCTASE//APOMINE//FOOD FUS COMPLEX
9 17284 WHHL RABBIT//WHHLMI RABBIT//PATHOPHARMACOL UNIT
10 6474 24S HYDROXYCHOLESTEROL//CYP46//CYP46A1

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