Class information for:
Level 1: LIVER X RECEPTOR//LXR//T0901317

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
10090 1093 46.6 93%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
66 3       LEPTIN//ADIPONECTIN//ENDOCRINOLOGY & METABOLISM 84415
2141 2             FATTY ACID SYNTHASE//LIVER X RECEPTOR//LXR 5046
10090 1                   LIVER X RECEPTOR//LXR//T0901317 1093

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 LIVER X RECEPTOR authKW 3578347 23% 51% 249
2 LXR authKW 1470976 12% 41% 129
3 T0901317 authKW 624311 3% 72% 31
4 GW3965 authKW 363163 1% 100% 13
5 LXR AGONIST authKW 310503 2% 65% 17
6 LXR ALPHA authKW 292473 3% 32% 33
7 NUCL RECEPTORS CELL SIGNALING address 269293 4% 20% 49
8 UMR 1103 address 201127 1% 60% 12
9 LIVER X RECEPTOR LXR authKW 174408 1% 39% 16
10 LXR BETA authKW 160952 1% 52% 11

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Biochemistry & Molecular Biology 1686 35% 0% 379
2 Endocrinology & Metabolism 1306 14% 0% 156
3 Cell Biology 801 15% 0% 169
4 Chemistry, Medicinal 563 7% 0% 81
5 Peripheral Vascular Diseases 312 6% 0% 62
6 Biophysics 176 6% 0% 62
7 Pharmacology & Pharmacy 168 10% 0% 107
8 Hematology 167 5% 0% 50
9 Medicine, Research & Experimental 160 6% 0% 62
10 Immunology 89 6% 0% 68

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 NUCL RECEPTORS CELL SIGNALING 269293 4% 20% 49
2 UMR 1103 201127 1% 60% 12
3 UMR 6293 102614 1% 28% 13
4 PROGRAM IMMUNOL BIO IMMUNO GENE THER Y CANC 83807 0% 100% 3
5 BIOSCI NUTR 74580 6% 4% 68
6 BIO TRANSFORMAT DISPOSIT 55871 0% 100% 2
7 ENDOCRINOL PL 55871 0% 100% 2
8 GRP MUERTE CELULAR 55871 0% 100% 2
9 AREA NEUROBIOL CELULAR MOL 50282 0% 60% 3
10 GRED 48430 1% 12% 14

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF LIPID RESEARCH 4689 3% 0% 38
2 MOLECULAR ENDOCRINOLOGY 2593 2% 0% 23
3 ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2301 2% 0% 25
4 CELL METABOLISM 1539 1% 1% 9
5 BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 1024 1% 0% 10
6 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 825 3% 0% 28
7 MOLECULAR NEURODEGENERATION 793 0% 1% 4
8 FUTURE LIPIDOLOGY 708 0% 1% 2
9 JOURNAL OF BIOLOGICAL CHEMISTRY 663 6% 0% 64
10 CLINICAL LIPIDOLOGY 652 0% 1% 3

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 LIVER X RECEPTOR 3578347 23% 51% 249 Search LIVER+X+RECEPTOR Search LIVER+X+RECEPTOR
2 LXR 1470976 12% 41% 129 Search LXR Search LXR
3 T0901317 624311 3% 72% 31 Search T0901317 Search T0901317
4 GW3965 363163 1% 100% 13 Search GW3965 Search GW3965
5 LXR AGONIST 310503 2% 65% 17 Search LXR+AGONIST Search LXR+AGONIST
6 LXR ALPHA 292473 3% 32% 33 Search LXR+ALPHA Search LXR+ALPHA
7 LIVER X RECEPTOR LXR 174408 1% 39% 16 Search LIVER+X+RECEPTOR+LXR Search LIVER+X+RECEPTOR+LXR
8 LXR BETA 160952 1% 52% 11 Search LXR+BETA Search LXR+BETA
9 OXYSTEROLS 146844 6% 8% 66 Search OXYSTEROLS Search OXYSTEROLS
10 LIVER X RECEPTOR ALPHA 144905 2% 25% 21 Search LIVER+X+RECEPTOR+ALPHA Search LIVER+X+RECEPTOR+ALPHA

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 TICE, CM , NOTO, PB , FAN, KY , ZHUANG, LH , LALA, DS , SINGH, SB , (2014) THE MEDICINAL CHEMISTRY OF LIVER X RECEPTOR (LXR) MODULATORS.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 57. ISSUE 17. P. 7182 -7205 118 77% 8
2 JAKOBSSON, T , TREUTER, E , GUSTAFSSON, JA , STEFFENSEN, KR , (2012) LIVER X RECEPTOR BIOLOGY AND PHARMACOLOGY: NEW PATHWAYS, CHALLENGES AND OPPORTUNITIES.TRENDS IN PHARMACOLOGICAL SCIENCES. VOL. 33. ISSUE 7. P. 394 -404 93 74% 92
3 VIENNOIS, E , MOUZAT, K , DUFOUR, J , MOREL, L , LOBACCARO, JM , BARON, S , (2012) SELECTIVE LIVER X RECEPTOR MODULATORS (SLIMS): WHAT USE IN HUMAN HEALTH?.MOLECULAR AND CELLULAR ENDOCRINOLOGY. VOL. 351. ISSUE 2. P. 129-141 90 74% 45
4 VAN GILST, WH , DE BOER, RA , CANNON, MV , (2016) EMERGING ROLE OF LIVER X RECEPTORS IN CARDIAC PATHOPHYSIOLOGY AND HEART FAILURE.BASIC RESEARCH IN CARDIOLOGY. VOL. 111. ISSUE 1. P. - 101 71% 0
5 STEFFENSEN, KR , JAKOBSSON, T , GUSTAFSSON, JA , (2013) TARGETING LIVER X RECEPTORS IN INFLAMMATION.EXPERT OPINION ON THERAPEUTIC TARGETS. VOL. 17. ISSUE 8. P. 977 -990 92 74% 16
6 BARANOWSKI, M , (2008) BIOLOGICAL ROLE OF LIVER X RECEPTORS.JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY. VOL. 59. ISSUE 4. P. 31-55 87 70% 119
7 LIN, CY , GUSTAFSSON, JA , (2015) TARGETING LIVER X RECEPTORS IN CANCER THERAPEUTICS.NATURE REVIEWS CANCER. VOL. 15. ISSUE 4. P. 216 -224 68 72% 16
8 LIN, CY , VEDIN, LL , STEFFENSEN, KR , (2016) THE EMERGING ROLES OF LIVER X RECEPTORS AND THEIR LIGANDS IN CANCER.EXPERT OPINION ON THERAPEUTIC TARGETS. VOL. 20. ISSUE 1. P. 61 -71 77 78% 0
9 HONG, C , TONTONOZ, P , (2014) LIVER X RECEPTORS IN LIPID METABOLISM: OPPORTUNITIES FOR DRUG DISCOVERY.NATURE REVIEWS DRUG DISCOVERY. VOL. 13. ISSUE 6. P. 433 -444 76 52% 74
10 VIENNOIS, E , POMMIER, AJC , MOUZAT, K , OUMEDDOUR, A , EL HAJJAJI, FZ , DUFOUR, J , CAIRA, F , VOLLE, DH , BARON, S , LOBACCARO, JMA , (2011) TARGETING LIVER X RECEPTORS IN HUMAN HEALTH: DEADLOCK OR PROMISING TRAIL?.EXPERT OPINION ON THERAPEUTIC TARGETS. VOL. 15. ISSUE 2. P. 219-232 77 74% 32

Classes with closest relation at Level 1


Rank Class id link
1 7504 ABCA1//TANGIER DISEASE//ATP BINDING CASSETTE TRANSPORTER A1
2 8938 SREBP//SCAP//STEROL REGULATORY ELEMENT BINDING PROTEIN
3 23794 ROR GAMMA//ROR ALPHA//RORC
4 5462 FARNESOID X RECEPTOR//FXR//TGR5
5 6474 24S HYDROXYCHOLESTEROL//CYP46//CYP46A1
6 9039 CEREBROTENDINOUS XANTHOMATOSIS//CHOLESTEROL 7 ALPHA HYDROXYLASE//STEROL 27 HYDROXYLASE
7 5179 OXYSTEROLS//CHOLESTEROL OXIDES//CHOLESTEROL OXIDATION PRODUCTS
8 29356 REPROD METAB//ADIPQ//AIB3
9 32560 APOLIPOPROTEIN M//APOM//COMPREHENS
10 13608 EZETIMIBE//NPC1L1//CHOLESTEROL ABSORPTION INHIBITOR

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