Class information for:
Level 1: REPAGLINIDE//NATEGLINIDE//MITIGLINIDE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
16225 666 31.7 78%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
176 3       DIABETES CARE//ENDOCRINOLOGY & METABOLISM//TYPE 2 DIABETES 58057
1896 2             METFORMIN//ACARBOSE//REPAGLINIDE 5944
16225 1                   REPAGLINIDE//NATEGLINIDE//MITIGLINIDE 666

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 REPAGLINIDE authKW 2526273 17% 48% 115
2 NATEGLINIDE authKW 2470098 14% 57% 94
3 MITIGLINIDE authKW 1423131 6% 80% 39
4 CYP2C8 authKW 764060 8% 33% 50
5 KAD 1229 authKW 641866 2% 100% 14
6 A 4166 authKW 416794 2% 91% 10
7 PRANDIAL GLUCOSE REGULATION authKW 309467 1% 75% 9
8 GLINIDES authKW 254700 2% 56% 10
9 MEGLITINIDE authKW 146703 1% 40% 8
10 2S 2 BENZYL 3 CIS HEXAHYDROISOINDOLIN 2 YLCARBONYLPROPIONIC ACID authKW 137543 0% 100% 3

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Pharmacology & Pharmacy 4232 47% 0% 311
2 Endocrinology & Metabolism 3532 29% 0% 190
3 Chemistry, Analytical 95 7% 0% 44
4 Toxicology 66 4% 0% 25
5 Biochemical Research Methods 57 4% 0% 27
6 Medicine, General & Internal 53 6% 0% 39
7 Chemistry, Medicinal 43 3% 0% 21
8 Medicine, Research & Experimental 39 4% 0% 27
9 Medical Laboratory Technology 6 1% 0% 5
10 Health Care Sciences & Services 3 1% 0% 6

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PHARMACEUT REGULATORY AFFAIRS QUAL ASSURANCE DE 103156 0% 75% 3
2 AFFLIATED PEOPLE HOSP 6SHANGHAI DIABET 45848 0% 100% 1
3 BIOPHARMACEUT PHARMOKINET 45848 0% 100% 1
4 BULK ACT 3 45848 0% 100% 1
5 BUNDANGHOSP 45848 0% 100% 1
6 CARDIOVASC DIS ENDOCRINOL 45848 0% 100% 1
7 CARDIOVASC METAB ENDOCRINE 45848 0% 100% 1
8 CENT S LIFE SCI S 45848 0% 100% 1
9 CLIN NURSE SPECIALIST SECT 45848 0% 100% 1
10 CNRS UMR ENDOCRINOL MET CANC 45848 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DIABETES OBESITY & METABOLISM 5308 2% 1% 16
2 JOURNAL OF DIABETES INVESTIGATION 3921 1% 1% 7
3 DRUG METABOLISM AND DISPOSITION 3786 4% 0% 25
4 DIABETES CARE 3349 4% 0% 29
5 CLINICAL PHARMACOLOGY & THERAPEUTICS 3122 3% 0% 20
6 DIABETES RESEARCH AND CLINICAL PRACTICE 2781 3% 0% 18
7 EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY 2076 3% 0% 18
8 BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY 2064 1% 1% 9
9 DIABETIC MEDICINE 2040 2% 0% 16
10 ENDOCRINE JOURNAL 1908 2% 0% 11

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 REPAGLINIDE 2526273 17% 48% 115 Search REPAGLINIDE Search REPAGLINIDE
2 NATEGLINIDE 2470098 14% 57% 94 Search NATEGLINIDE Search NATEGLINIDE
3 MITIGLINIDE 1423131 6% 80% 39 Search MITIGLINIDE Search MITIGLINIDE
4 CYP2C8 764060 8% 33% 50 Search CYP2C8 Search CYP2C8
5 KAD 1229 641866 2% 100% 14 Search KAD+1229 Search KAD+1229
6 A 4166 416794 2% 91% 10 Search A+4166 Search A+4166
7 PRANDIAL GLUCOSE REGULATION 309467 1% 75% 9 Search PRANDIAL+GLUCOSE+REGULATION Search PRANDIAL+GLUCOSE+REGULATION
8 GLINIDES 254700 2% 56% 10 Search GLINIDES Search GLINIDES
9 MEGLITINIDE 146703 1% 40% 8 Search MEGLITINIDE Search MEGLITINIDE
10 2S 2 BENZYL 3 CIS HEXAHYDROISOINDOLIN 2 YLCARBONYLPROPIONIC ACID 137543 0% 100% 3 Search 2S+2+BENZYL+3+CIS+HEXAHYDROISOINDOLIN+2+YLCARBONYLPROPIONIC+ACID Search 2S+2+BENZYL+3+CIS+HEXAHYDROISOINDOLIN+2+YLCARBONYLPROPIONIC+ACID

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 GUARDADO-MENDOZA, R , PRIOLETTA, A , JIMENEZ-CEJA, LM , SOSALE, A , FOLLI, F , (2013) THE ROLE OF NATEGLINIDE AND REPAGLINIDE, DERIVATIVES OF MEGLITINIDE, IN THE TREATMENT OF TYPE 2 DIABETES MELLITUS.ARCHIVES OF MEDICAL SCIENCE. VOL. 9. ISSUE 5. P. 936-943 49 65% 14
2 SCOTT, LJ , (2012) REPAGLINIDE A REVIEW OF ITS USE IN TYPE 2 DIABETES MELLITUS.DRUGS. VOL. 72. ISSUE 2. P. 249 -272 48 65% 28
3 PRATLEY, RE , FOLEY, JE , DUNNING, BE , (2001) RAPID ACTING INSULINOTROPIC AGENTS: RESTORATION OF EARLY INSULIN SECRETION AS A PHYSIOLOGIC APPROACH TO IMPROVE GLUCOSE CONTROL.CURRENT PHARMACEUTICAL DESIGN. VOL. 7. ISSUE 14. P. 1375 -1397 73 62% 16
4 AQUILANTE, CL , NIEMI, M , GONG, L , ALTMAN, RB , KLEIN, TE , (2013) PHARMGKB SUMMARY: VERY IMPORTANT PHARMACOGENE INFORMATION FOR CYTOCHROME P450, FAMILY 2, SUBFAMILY C, POLYPEPTIDE 8.PHARMACOGENETICS AND GENOMICS. VOL. 23. ISSUE 12. P. 721-728 66 47% 10
5 BACKMAN, JT , FILPPULA, AM , NIEMI, M , NEUVONEN, PJ , (2016) ROLE OF CYTOCHROME P450 2C8 IN DRUG METABOLISM AND INTERACTIONS.PHARMACOLOGICAL REVIEWS. VOL. 68. ISSUE 1. P. 168 -241 104 18% 6
6 BLICKLE, JF , (2006) MEGLITINIDE ANALOGUES: A REVIEW OF CLINICAL DATA FOCUSED ON RECENT TRIALS.DIABETES & METABOLISM. VOL. 32. ISSUE 2. P. 113-120 39 78% 34
7 MALAISSE, WJ , (2008) MITIGLINIDE: A RAPID- AND SHORT-ACTING NON-SULFONYLUREA INSULINOTROPIC AGENT FOR THE TREATMENT OF TYPE 2 DIABETIC PATIENTS.EXPERT OPINION ON PHARMACOTHERAPY. VOL. 9. ISSUE 15. P. 2691-2698 32 82% 15
8 JOHANSEN, OE , BIRKELAN, KL , (2007) DEFINING THE ROLE OF REPAGLINIDE IN THE MANAGEMENT OF TYPE 2 DIABETES MELLITUS - A REVIEW.AMERICAN JOURNAL OF CARDIOVASCULAR DRUGS. VOL. 7. ISSUE 5. P. 319 -335 55 48% 14
9 GRUNBERGER, G , (2011) QUO VADIS NATEGLINIDE? TEN-YEAR PERSPECTIVE.EXPERT OPINION ON PHARMACOTHERAPY. VOL. 12. ISSUE 13. P. 2097 -2106 33 72% 0
10 SCHEEN, AJ , (2007) DRUG-DRUG AND FOOD-DRUG PHARMACOKINETIC INTERACTIONS WITH NEW INSULINOTROPIC AGENTS REPAGLINIDE AND NATEGLINIDE.CLINICAL PHARMACOKINETICS. VOL. 46. ISSUE 2. P. 93-108 39 55% 36

Classes with closest relation at Level 1


Rank Class id link
1 10965 GLYCEMIC VARIABILITY//GLYCAEMIC VARIABILITY//GLUCOSE VARIABILITY
2 16766 METFORMIN HYDROCHLORIDE//GLIMEPIRIDE//GLICLAZIDE
3 6705 GLIMEPIRIDE//JTT 608//SECONDARY FAILURE
4 22786 GLICLAZIDE//ARTIFICIAL CELL MICROENCAPSULATION//BIOTECHNOL DRUG DEV
5 8357 ACARBOSE//ALPHA GLUCOSIDASE INHIBITOR//MIGLITOL
6 5456 OATP1B1//SLCO1B1//OATP
7 4852 6 BETA HYDROXYCORTISOL//COCKTAIL//CYP3A
8 37593 LOPERAMIDE//LOPERAMIDE HYDROCHLORIDE//DESMETHYLLOPERAMIDE
9 4912 D GLUCOSE METABOLISM//CHILDRENS DIABET//PANCREATIC ISLETS
10 3093 PIOGLITAZONE//THIAZOLIDINEDIONES//ROSIGLITAZONE

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