Class information for:
Level 1: IDIOSYNCRATIC DRUG INDUCED LIVER INJURY//PHAGOCYTOSIS BLOCKADE//ALPHA NAPHTHYLISOTHIOCYANATE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
25846 270 38.3 69%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
547 3       ACETAMINOPHEN//CARBON MONOXIDE POISONING//POISONING 18371
1613 2             ACETAMINOPHEN//DRUG INDUCED LIVER INJURY//HEPATOTOXICITY 7077
25846 1                   IDIOSYNCRATIC DRUG INDUCED LIVER INJURY//PHAGOCYTOSIS BLOCKADE//ALPHA NAPHTHYLISOTHIOCYANATE 270

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 IDIOSYNCRATIC DRUG INDUCED LIVER INJURY authKW 452367 3% 50% 8
2 PHAGOCYTOSIS BLOCKADE authKW 339281 1% 100% 3
3 ALPHA NAPHTHYLISOTHIOCYANATE authKW 323926 5% 22% 13
4 IDIOSYNCRATIC ADVERSE DRUG REACTIONS authKW 301580 1% 67% 4
5 MIDZONAL NECROSIS authKW 226187 1% 100% 2
6 SENSITIVITY TO INTOXICATION authKW 226187 1% 100% 2
7 FOOD SAFETY TOXICOL 221 address 150790 1% 67% 2
8 NAPHTHYLISOTHIOCYANATE authKW 150790 1% 67% 2
9 YIN ZHI HUANG authKW 150790 1% 67% 2
10 MED MIYAMAE KU address 150786 1% 33% 4

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Toxicology 5217 41% 0% 112
2 Pharmacology & Pharmacy 1110 38% 0% 103
3 Gastroenterology & Hepatology 163 8% 0% 22
4 Pathology 108 6% 0% 17
5 Integrative & Complementary Medicine 80 2% 0% 6
6 Chemistry, Medicinal 42 4% 0% 12
7 Medicine, Research & Experimental 16 4% 0% 11
8 Hematology 13 3% 0% 8
9 Surgery 12 6% 0% 16
10 Physiology 12 3% 0% 9

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 FOOD SAFETY TOXICOL 221 150790 1% 67% 2
2 MED MIYAMAE KU 150786 1% 33% 4
3 INTEGRAT TOXICOL 143618 11% 4% 29
4 ASTRA SAFETY ASSESSMENT 113094 0% 100% 1
5 BIOPOTENCY TOXICOL 113094 0% 100% 1
6 DISCOVERY SAFETY METAB PHARMACOKINET 113094 0% 100% 1
7 DRUG SAFETY SCISHOWA KU 113094 0% 100% 1
8 FOOD SAFETY TOXICOL 218H 113094 0% 100% 1
9 INNOVAT THER EUTFMTS 113094 0% 100% 1
10 PHARMACEUT 2441 EBARA SHINAGAWA KU 113094 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 TOXICOLOGICAL SCIENCES 22301 11% 1% 31
2 TOXICOLOGY AND APPLIED PHARMACOLOGY 6085 9% 0% 23
3 TOXICOLOGY 4678 6% 0% 17
4 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 2132 7% 0% 20
5 DEVELOPMENTAL PHARMACOLOGY AND THERAPEUTICS 1444 1% 0% 3
6 JOURNAL OF TOXICOLOGICAL SCIENCES 1131 1% 0% 3
7 TOXICOLOGIC PATHOLOGY 1104 2% 0% 5
8 JOURNAL OF APPLIED TOXICOLOGY 998 2% 0% 5
9 HEPATOLOGY 941 4% 0% 10
10 TOXICOLOGY LETTERS 654 3% 0% 7

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 IDIOSYNCRATIC DRUG INDUCED LIVER INJURY 452367 3% 50% 8 Search IDIOSYNCRATIC+DRUG+INDUCED+LIVER+INJURY Search IDIOSYNCRATIC+DRUG+INDUCED+LIVER+INJURY
2 PHAGOCYTOSIS BLOCKADE 339281 1% 100% 3 Search PHAGOCYTOSIS+BLOCKADE Search PHAGOCYTOSIS+BLOCKADE
3 ALPHA NAPHTHYLISOTHIOCYANATE 323926 5% 22% 13 Search ALPHA+NAPHTHYLISOTHIOCYANATE Search ALPHA+NAPHTHYLISOTHIOCYANATE
4 IDIOSYNCRATIC ADVERSE DRUG REACTIONS 301580 1% 67% 4 Search IDIOSYNCRATIC+ADVERSE+DRUG+REACTIONS Search IDIOSYNCRATIC+ADVERSE+DRUG+REACTIONS
5 MIDZONAL NECROSIS 226187 1% 100% 2 Search MIDZONAL+NECROSIS Search MIDZONAL+NECROSIS
6 SENSITIVITY TO INTOXICATION 226187 1% 100% 2 Search SENSITIVITY+TO+INTOXICATION Search SENSITIVITY+TO+INTOXICATION
7 NAPHTHYLISOTHIOCYANATE 150790 1% 67% 2 Search NAPHTHYLISOTHIOCYANATE Search NAPHTHYLISOTHIOCYANATE
8 YIN ZHI HUANG 150790 1% 67% 2 Search YIN+ZHI+HUANG Search YIN+ZHI+HUANG
9 13 14 DIHYDRO 15 KETO PROSTAGLANDIN D 2 113094 0% 100% 1 Search 13+14+DIHYDRO+15+KETO+PROSTAGLANDIN+D+2 Search 13+14+DIHYDRO+15+KETO+PROSTAGLANDIN+D+2
10 ACUTE LIVERY INJURY 113094 0% 100% 1 Search ACUTE+LIVERY+INJURY Search ACUTE+LIVERY+INJURY

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 ROTH, RA , DAHM, LJ , (1997) NEUTROPHIL- AND GLUTATHIONE-MEDIATED HEPATOTOXICITY OF ALPHA-NAPHTHYLISOTHIOCYANATE.DRUG METABOLISM REVIEWS. VOL. 29. ISSUE 1-2. P. 153-165 19 70% 37
2 LU, JT , ROTH, RA , MALLE, E , GANEY, PE , (2013) ROLES OF THE HEMOSTATIC SYSTEM AND NEUTROPHILS IN LIVER INJURY FROM CO-EXPOSURE TO AMIODARONE AND LIPOPOLYSACCHARIDE.TOXICOLOGICAL SCIENCES. VOL. 136. ISSUE 1. P. 51-62 21 38% 1
3 LUYENDYK, JP , MADDOX, JF , GREEN, CD , GANEY, PE , ROTH, RA , (2004) ROLE OF HEPATIC FIBRIN IN IDIOSYNCRASY-LIKE LIVER INJURY FROM LIPOPOLYSACCHARIDE-RANITIDINE COEXPOSURE IN RATS.HEPATOLOGY. VOL. 40. ISSUE 6. P. 1342-1351 18 49% 25
4 DENG, XM , LUYENDYK, JP , GANEY, PE , ROTH, RA , (2009) INFLAMMATORY STRESS AND IDIOSYNCRATIC HEPATOTOXICITY: HINTS FROM ANIMAL MODELS.PHARMACOLOGICAL REVIEWS. VOL. 61. ISSUE 3. P. 262 -282 40 18% 39
5 ZOU, W , ROTH, RA , YOUNIS, HS , MALLE, E , GANEY, PE , (2011) NEUTROPHIL-CYTOKINE INTERACTIONS IN A RAT MODEL OF SULINDAC-INDUCED IDIOSYNCRATIC LIVER INJURY.TOXICOLOGY. VOL. 290. ISSUE 2-3. P. 278-285 17 41% 5
6 LUYENDYK, JP , MADDOX, JF , COSMA, GN , GANEY, PE , COCKERELL, GL , ROTH, RA , (2003) RANITIDINE TREATMENT DURING A MODEST INFLAMMATORY RESPONSE PRECIPITATES IDIOSYNCRASY-LIKE LIVER INJURY IN RATS.JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. VOL. 307. ISSUE 1. P. 9-16 14 58% 58
7 LUYENDYK, JP , SHAW, PJ , GREEN, CD , MADDOX, JF , GANEY, PE , ROTH, RA , (2005) COAGULATION-MEDIATED HYPOXIA AND NEUTROPHIL-DEPENDENT HEPATIC INJURY IN RATS GIVEN LIPOPOLYSACCHARIDE AND RANITIDINE.JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. VOL. 314. ISSUE 3. P. 1023-1031 17 44% 32
8 HADI, M , WESTRA, IM , STAROKOZHKO, V , DRAGOVIC, S , MEREMA, MT , GROOTHUIS, GMM , (2013) HUMAN PRECISION-CUT LIVER SLICES AS AN EX VIVO MODEL TO STUDY IDIOSYNCRATIC DRUG-INDUCED LIVER INJURY.CHEMICAL RESEARCH IN TOXICOLOGY. VOL. 26. ISSUE 5. P. 710-720 19 30% 13
9 ZOU, W , DEVI, SS , SPARKENBAUGH, E , YOUNIS, HS , ROTH, RA , GANEY, PE , (2009) HEPATOTOXIC INTERACTION OF SULINDAC WITH LIPOPOLYSACCHARIDE: ROLE OF THE HEMOSTATIC SYSTEM.TOXICOLOGICAL SCIENCES. VOL. 108. ISSUE 1. P. 184 -193 15 42% 17
10 CULLEN, JM , FALLS, JG , BROWN, HR , YOON, LW , CARIELLO, NF , FAIOLA, B , KIMBROUGH, CL , JORDAN, HL , MILLER, RT , (2010) TIME COURSE GENE EXPRESSION USING LASER CAPTURE MICROSCOPY-EXTRACTED BILE DUCTS, BUT NOT HEPATIC PARENCHYMA, REVEALS ACUTE ALPHA-NAPHTHYLISOTHIOCYANATE TOXICITY.TOXICOLOGIC PATHOLOGY. VOL. 38. ISSUE 5. P. 715-729 13 48% 5

Classes with closest relation at Level 1


Rank Class id link
1 5104 DRUG INDUCED LIVER INJURY//HEPATOTOXICITY//HERB INDUCED LIVER INJURY
2 17059 CONCANAVALIN A//D GALACTOSAMINE//D GALN LPS
3 28818 HEPARG CELLS//HEPARG//NEOHEPATOCYTES
4 4423 HEPATIC ISCHEMIA REPERFUSION INJURY//HEPATIC ISCHEMIA REPERFUSION//ISCHEMIA REPERFUSION INJURY
5 14478 ACYL GLUCURONIDE//ZOMEPIRAC//DRUG PROTEIN ADDUCTS
6 20418 D GALACTOSAMINE//PROSTAGLANDIN E1//CORN BRAN HEMICELLULOSE
7 36803 DEVELOPMENTAL DAMAGE//ENVIRONM ECO TECHNOL//MERCURIC CHLORIDE EXPOSURE
8 11878 CHLOROFLUOROCARBON SUBSTITUTE//HALOTHANE//CARDIAC SENSITIZATION
9 14486 TOXICOGENOMICS//CELLULAR MOL TOXICOL//TOXICOGENOM INFORMAT PROJECT
10 11861 THERAPEUTIC PROTEIN DRUG INTERACTION//ROLLINS 5119//9000 X G SUPERNATANT

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