Class information for:
Level 1: CHLOROFLUOROCARBON SUBSTITUTE//HALOTHANE//CARDIAC SENSITIZATION

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
11878 947 31.0 47%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
547 3       ACETAMINOPHEN//CARBON MONOXIDE POISONING//POISONING 18371
1613 2             ACETAMINOPHEN//DRUG INDUCED LIVER INJURY//HEPATOTOXICITY 7077
11878 1                   CHLOROFLUOROCARBON SUBSTITUTE//HALOTHANE//CARDIAC SENSITIZATION 947

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CHLOROFLUOROCARBON SUBSTITUTE authKW 161214 1% 100% 5
2 HALOTHANE authKW 132815 6% 7% 58
3 CARDIAC SENSITIZATION authKW 115150 1% 71% 5
4 TRIFLUOROACETYLATED PROTEINS authKW 96728 0% 100% 3
5 W HARVEY FE ONE MOL MICROBIOL IMMUNOL address 96728 0% 100% 3
6 HCFC 123 authKW 90045 1% 31% 9
7 HALOTHANE HEPATITIS authKW 85978 0% 67% 4
8 2 2 DICHLORO 1 1 1 TRIFLUOROETHANE authKW 73274 1% 45% 5
9 COMPLICATIONS HEPATOTOXICITY authKW 72545 0% 75% 3
10 LOW GLOBAL WARMING authKW 72545 0% 75% 3

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Anesthesiology 20630 28% 0% 266
2 Toxicology 4227 20% 0% 193
3 Pharmacology & Pharmacy 1836 27% 0% 257
4 Gastroenterology & Hepatology 231 5% 0% 52
5 Medicine, General & Internal 39 5% 0% 45
6 Pathology 39 3% 0% 24
7 Biophysics 32 3% 0% 31
8 Critical Care Medicine 31 1% 0% 14
9 Medicine, Legal 23 1% 0% 6
10 Chemistry, Medicinal 21 2% 0% 21

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 W HARVEY FE ONE MOL MICROBIOL IMMUNOL 96728 0% 100% 3
2 IST FARMACOL TER IA SPERIMENTALE 64486 0% 100% 2
3 ANESTHESIOL CRIT CARE MED PEDIAT PATHOL 32243 0% 100% 1
4 BAGHIYATALLAH GASTROENTEROL LIVER DIS 32243 0% 100% 1
5 HEART LUNG BLOOD MOL IMMUNOL NIH 32243 0% 100% 1
6 HLTH RISK SCI 32243 0% 100% 1
7 IST FARMACOL TER IA SPER 32243 0% 100% 1
8 MOL CELLULAR TOXICOL SECT MOL IMMUNOL 32243 0% 100% 1
9 PATHOL MOL CELLULAR TOXICOL SECT 32243 0% 100% 1
10 TOXICOL DRUG SAFETY EVALUAT 32243 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ANESTHESIOLOGY 14013 7% 1% 70
2 ANESTHESIA AND ANALGESIA 11725 8% 1% 73
3 DRUG METABOLISM AND DISPOSITION 4635 3% 0% 33
4 CHEMICAL & ENGINEERING NEWS 4249 2% 1% 23
5 BRITISH JOURNAL OF ANAESTHESIA 3846 3% 0% 33
6 ACTA ANAESTHESIOLOGICA SCANDINAVICA 3704 3% 0% 28
7 FUNDAMENTAL AND APPLIED TOXICOLOGY 2970 1% 1% 14
8 DRUG AND CHEMICAL TOXICOLOGY 1931 1% 1% 9
9 BIOCHEMICAL PHARMACOLOGY 1854 3% 0% 33
10 XENOBIOTICA 1609 1% 0% 14

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 CHLOROFLUOROCARBON SUBSTITUTE 161214 1% 100% 5 Search CHLOROFLUOROCARBON+SUBSTITUTE Search CHLOROFLUOROCARBON+SUBSTITUTE
2 HALOTHANE 132815 6% 7% 58 Search HALOTHANE Search HALOTHANE
3 CARDIAC SENSITIZATION 115150 1% 71% 5 Search CARDIAC+SENSITIZATION Search CARDIAC+SENSITIZATION
4 TRIFLUOROACETYLATED PROTEINS 96728 0% 100% 3 Search TRIFLUOROACETYLATED+PROTEINS Search TRIFLUOROACETYLATED+PROTEINS
5 HCFC 123 90045 1% 31% 9 Search HCFC+123 Search HCFC+123
6 HALOTHANE HEPATITIS 85978 0% 67% 4 Search HALOTHANE+HEPATITIS Search HALOTHANE+HEPATITIS
7 2 2 DICHLORO 1 1 1 TRIFLUOROETHANE 73274 1% 45% 5 Search 2+2+DICHLORO+1+1+1+TRIFLUOROETHANE Search 2+2+DICHLORO+1+1+1+TRIFLUOROETHANE
8 COMPLICATIONS HEPATOTOXICITY 72545 0% 75% 3 Search COMPLICATIONS+HEPATOTOXICITY Search COMPLICATIONS+HEPATOTOXICITY
9 LOW GLOBAL WARMING 72545 0% 75% 3 Search LOW+GLOBAL+WARMING Search LOW+GLOBAL+WARMING
10 2 2 DICHLORO 1 1 1 TRIFLUOROETHANE HCFC 123 64486 0% 100% 2 Search 2+2+DICHLORO+1+1+1+TRIFLUOROETHANE+HCFC+123 Search 2+2+DICHLORO+1+1+1+TRIFLUOROETHANE+HCFC+123

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 KENNA, JG , NEUBERGER, JM , (1995) IMMUNOPATHOGENESIS AND TREATMENT OF HALOTHANE HEPATITIS.CLINICAL IMMUNOTHERAPEUTICS. VOL. 3. ISSUE 2. P. 108-124 65 88% 11
2 HABIBOLLAHI, P , MAHBOOBI, N , ESMAEILI, S , SAFARI, S , DABBAGH, A , ALAVIAN, SM , (2011) HALOTHANE-INDUCED HEPATITIS: A FORGOTTEN ISSUE IN DEVELOPING COUNTRIES.HEPATITIS MONTHLY. VOL. 11. ISSUE 1. P. 3-6 38 86% 3
3 RAY, DC , DRUMMOND, GB , (1991) HALOTHANE HEPATITIS.BRITISH JOURNAL OF ANAESTHESIA. VOL. 67. ISSUE 1. P. 84-99 71 76% 102
4 KENNA, JG , JONES, RM , (1995) THE ORGAN TOXICITY OF INHALED ANESTHETICS.ANESTHESIA AND ANALGESIA. VOL. 81. ISSUE 6. P. S51-S66 50 60% 68
5 SPRACKLIN, DK , EMERY, ME , THUMMEL, KE , KHARASCH, ED , (2003) CONCORDANCE BETWEEN TRIFLUOROACETIC ACID AND HEPATIC PROTEIN TRIFLUOROACETYLATION AFTER DISULFIRAM INHIBITION OF HALOTHANE METABOLISM IN RATS.ACTA ANAESTHESIOLOGICA SCANDINAVICA. VOL. 47. ISSUE 6. P. 765-770 29 83% 2
6 BOURDI, M , AMOUZADEH, HR , RUSHMORE, TH , MARTIN, JL , POHL, LR , (2001) HALOTHANE-INDUCED LIVER INJURY IN OUTBRED GUINEA PIGS: ROLE OF TRIFLUOROACETYLATED PROTEIN ADDUCTS IN ANIMAL SUSCEPTIBILITY.CHEMICAL RESEARCH IN TOXICOLOGY. VOL. 14. ISSUE 4. P. 362-370 38 64% 23
7 FERRARA, R , TOLANDO, R , KING, LJ , MANNO, M , (1997) CYTOCHROME P450 INACTIVATION DURING REDUCTIVE METABOLISM OF 1,1-DICHLORO-2,2,2-TRIFLUOROETHANE (HCFC-123) BY PHENOBARBITAL- AND PYRIDINE-INDUCED RAT LIVER MICROSOMES.TOXICOLOGY AND APPLIED PHARMACOLOGY. VOL. 143. ISSUE 2. P. 420-428 32 89% 3
8 ELLIOTT, RH , STRUNIN, L , (1993) HEPATOTOXICITY OF VOLATILE ANESTHETICS.BRITISH JOURNAL OF ANAESTHESIA. VOL. 70. ISSUE 3. P. 339-348 42 74% 42
9 WHITE, INH , DE MATTEIS, F , (2001) THE ROLE OF CYP FORMS IN THE METABOLISM AND METABOLIC ACTIVATION OF HCFCS AND OTHER HALOCARBONS.TOXICOLOGY LETTERS. VOL. 124. ISSUE 1-3. P. 121-128 31 78% 8
10 HOET, P , BUCHET, JP , SEMPOUX, C , NOMIYAMA, T , RAHIER, J , LISON, D , (2001) INVESTIGATIONS ON THE LIVER TOXICITY OF A BLEND OF HCFC-123 (2,2-DICHLORO-1,1,1-TRIFLUOROETHANE) AND HCFC-124 (2-CHLORO-1,1,1,2-TETRAFLUOROETHANE) IN GUINEA-PIGS.ARCHIVES OF TOXICOLOGY. VOL. 75. ISSUE 5. P. 274-283 24 96% 2

Classes with closest relation at Level 1


Rank Class id link
1 29439 ALPHA GLUTATHIONE S TRANSFERASE//ENZYMES GLUTATHIONE S TRANSFERASE//ALPHA GLUTATHIONE TRANSFERASES
2 16328 CHLOROFORM//LOUISIANA TOXICOL//HEPATOCELLULAR REGENERATION
3 3417 SEVOFLURANE//EMERGENCE AGITATION//DESFLURANE
4 25846 IDIOSYNCRATIC DRUG INDUCED LIVER INJURY//PHAGOCYTOSIS BLOCKADE//ALPHA NAPHTHYLISOTHIOCYANATE
5 15943 TRICHLOROMETHYLPEROXYL//TRICHLOROMETHYL//CELL SURFACE BLEBS
6 10357 CHLORZOXAZONE//CYP2E1//6 HYDROXYCHLORZOXAZONE
7 17456 N ALKYLPROTOPORPHYRIN//N ALKYLPROTOPORPHYRIN IX//TAPE PORPHYRIN
8 18318 REGIONAL MYOCARDIAL PERFORMANCE//HEART CORONARY ARTERY DISEASE//ARTERIES CORONARY STEAL
9 5104 DRUG INDUCED LIVER INJURY//HEPATOTOXICITY//HERB INDUCED LIVER INJURY
10 10436 OPERATING ROOM PERSONNEL//ANESTHETIC GASES//WASTE ANESTHETIC GAS

Go to start page