Class information for:
Level 1: ACYL GLUCURONIDE//ZOMEPIRAC//DRUG PROTEIN ADDUCTS

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
14478 767 33.5 64%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
275 3       NSAIDS//CYCLOOXYGENASE//CYCLOOXYGENASE 2 43399
466 2             NSAIDS//NON STEROIDAL ANTI INFLAMMATORY DRUGS//COX 2 INHIBITORS 15930
14478 1                   ACYL GLUCURONIDE//ZOMEPIRAC//DRUG PROTEIN ADDUCTS 767

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ACYL GLUCURONIDE authKW 935893 6% 49% 48
2 ZOMEPIRAC authKW 331747 1% 83% 10
3 DRUG PROTEIN ADDUCTS authKW 159232 1% 50% 8
4 FENCLOZIC ACID authKW 119430 0% 100% 3
5 GLUCURONATES authKW 119424 1% 50% 6
6 ROMAZARIT authKW 89571 0% 75% 3
7 ACYL MIGRATION REACTIONS authKW 79620 0% 100% 2
8 ASTRAZENECA UK LTD address 79620 0% 100% 2
9 CAS 26171 23 3 authKW 79620 0% 100% 2
10 DICLOFENAC METABOLISM authKW 79620 0% 100% 2

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Pharmacology & Pharmacy 6532 54% 0% 411
2 Toxicology 2251 17% 0% 128
3 Chemistry, Medicinal 819 10% 0% 79
4 Chemistry, Analytical 345 10% 0% 80
5 Gastroenterology & Hepatology 219 6% 0% 45
6 Medicine, General & Internal 191 9% 0% 68
7 Rheumatology 138 3% 0% 21
8 Chemistry, Multidisciplinary 90 10% 0% 77
9 Biochemical Research Methods 83 4% 0% 34
10 Medicine, Research & Experimental 8 2% 0% 19

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ASTRAZENECA UK LTD 79620 0% 100% 2
2 PHARMACEUT SCI HLTH MED SCI 79620 0% 100% 2
3 ROBERT ROBINSON S 68349 2% 11% 15
4 STUDIES DRUG DISPOSIT 43264 1% 22% 5
5 ALLERGY UNITAMBULATORIO ALLERGOL 39810 0% 100% 1
6 AZM TRIPOLI 39810 0% 100% 1
7 BIOANAL METAB 39810 0% 100% 1
8 BOX EHSC 39810 0% 100% 1
9 BUNDESWEHRZENT KRANKENHAUS KOBLENZ 39810 0% 100% 1
10 CENT CHEM BIOCHEM PHARMACOL 39810 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DRUG METABOLISM AND DISPOSITION 48926 13% 1% 96
2 CHEMICAL RESEARCH IN TOXICOLOGY 14125 6% 1% 43
3 XENOBIOTICA 8030 4% 1% 28
4 PROGRESS IN DRUG METABOLISM 3617 0% 9% 1
5 DRUG METABOLISM REVIEWS 2547 1% 1% 8
6 BIOPHARMACEUTICS & DRUG DISPOSITION 2050 1% 1% 10
7 BIOCHEMICAL PHARMACOLOGY 2030 4% 0% 31
8 CURRENT DRUG METABOLISM 1769 1% 1% 7
9 ANNALES DE GASTROENTEROLOGIE ET D HEPATOLOGIE 1739 1% 1% 5
10 EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS 1257 1% 0% 7

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 ACYL GLUCURONIDE 935893 6% 49% 48 Search ACYL+GLUCURONIDE Search ACYL+GLUCURONIDE
2 ZOMEPIRAC 331747 1% 83% 10 Search ZOMEPIRAC Search ZOMEPIRAC
3 DRUG PROTEIN ADDUCTS 159232 1% 50% 8 Search DRUG+PROTEIN+ADDUCTS Search DRUG+PROTEIN+ADDUCTS
4 FENCLOZIC ACID 119430 0% 100% 3 Search FENCLOZIC+ACID Search FENCLOZIC+ACID
5 GLUCURONATES 119424 1% 50% 6 Search GLUCURONATES Search GLUCURONATES
6 ROMAZARIT 89571 0% 75% 3 Search ROMAZARIT Search ROMAZARIT
7 ACYL MIGRATION REACTIONS 79620 0% 100% 2 Search ACYL+MIGRATION+REACTIONS Search ACYL+MIGRATION+REACTIONS
8 CAS 26171 23 3 79620 0% 100% 2 Search CAS+26171+23+3 Search CAS+26171+23+3
9 DICLOFENAC METABOLISM 79620 0% 100% 2 Search DICLOFENAC+METABOLISM Search DICLOFENAC+METABOLISM
10 CLEARANCE RENAL 71656 0% 60% 3 Search CLEARANCE+RENAL Search CLEARANCE+RENAL

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 DICKINSON, RG , (2011) ISO-GLUCURONIDES.CURRENT DRUG METABOLISM. VOL. 12. ISSUE 3. P. 222-228 50 94% 5
2 SHIPKOVA, M , ARMSTRONG, VW , OELLERICH, M , WIELAND, E , (2003) ACYL GLUCURONIDE DRUG METABOLITES: TOXICOLOGICAL AND ANALYTICAL IMPLICATIONS.THERAPEUTIC DRUG MONITORING. VOL. 25. ISSUE 1. P. 1-16 81 56% 156
3 SKONBERG, C , OLSEN, J , MADSEN, KG , HANSEN, SH , GRILLO, MP , (2008) METABOLIC ACTIVATION OF CARBOXYLIC ACIDS.EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY. VOL. 4. ISSUE 4. P. 425-438 61 64% 55
4 BABA, A , YOSHIOKA, T , (2009) STRUCTURE-ACTIVITY RELATIONSHIPS FOR DEGRADATION REACTION OF 1-BETA-O-ACYL GLUCURONIDES: KINETIC DESCRIPTION AND PREDICTION OF INTRINSIC ELECTROPHILIC REACTIVITY UNDER PHYSIOLOGICAL CONDITIONS.CHEMICAL RESEARCH IN TOXICOLOGY. VOL. 22. ISSUE 1. P. 158-172 60 67% 15
5 STACHULSKI, AV , HARDING, JR , LINDON, JC , MAGGS, JL , PARK, BK , WILSON, ID , (2006) ACYL GLUCURONIDES: BIOLOGICAL ACTIVITY, CHEMICAL REACTIVITY, AND CHEMICAL SYNTHESIS.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 49. ISSUE 24. P. 6931-6945 75 53% 50
6 REGAN, SL , MAGGS, JL , HAMMOND, TG , LAMBERT, C , WILLIAMS, DP , PARK, BK , (2010) ACYL GLUCURONIDES: THE GOOD, THE BAD AND THE UGLY.BIOPHARMACEUTICS & DRUG DISPOSITION. VOL. 31. ISSUE 7. P. 367-395 74 43% 55
7 BOELSTERLI, UA , (2003) DICLOFENAC-INDUCED LIVER INJURY: A PARADIGM OF IDIOSYNCRATIC DRUG TOXICITY.TOXICOLOGY AND APPLIED PHARMACOLOGY. VOL. 192. ISSUE 3. P. 307-322 55 60% 195
8 YANG, XX , HU, ZP , BOELSTERLI, UA , ZHOU, SF , (2006) DRUG ACYL GLUCURONIDES: REACTIVITY AND ANALYTICAL IMPLICATION.CURRENT PHARMACEUTICAL ANALYSIS. VOL. 2. ISSUE 3. P. 259 -277 81 46% 10
9 SYED, M , SKONBERG, C , HANSEN, SH , (2016) MITOCHONDRIAL TOXICITY OF DICLOFENAC AND ITS METABOLITES VIA INHIBITION OF OXIDATIVE PHOSPHORYLATION (ATP SYNTHESIS) IN RAT LIVER MITOCHONDRIA: POSSIBLE ROLE IN DRUG INDUCED LIVER INJURY (DILI).TOXICOLOGY IN VITRO. VOL. 31. ISSUE . P. 93 -102 32 68% 4
10 JOHNSON, CH , WILSON, ID , HARDING, JR , STACHULSKI, AV , IDDON, L , NICHOLSON, JK , LINDON, JC , (2007) NMR SPECTROSCOPIC STUDIES ON THE IN VITRO ACYL GLUCURONIDE MIGRATION KINETICS OF LBUPROFEN ((+/-)-(R,S)-2-(4-ISOBUTYLPHENYL) PROPANOIC ACID), ITS METABOLITES, AND ANALOGUES.ANALYTICAL CHEMISTRY. VOL. 79. ISSUE 22. P. 8720-8727 41 77% 17

Classes with closest relation at Level 1


Rank Class id link
1 12542 REACTIVE METABOLITES//METABOLITE IDENTIFICATION//PHARMACOKINET DYNAM METAB
2 7453 CHIRAL INVERSION//DEXIBUPROFEN//IBUPROFEN
3 28817 ADUBILTEM SCI TECHNOL DEV//NUCL PLICAT//BLEOMYCIN GLUCURONIDE
4 5104 DRUG INDUCED LIVER INJURY//HEPATOTOXICITY//HERB INDUCED LIVER INJURY
5 35824 INO 2628 CZ//EFFICIENCY OF ENTEROHEPATIC CIRCULATION//MNP001
6 26566 DRUG INDUCED ASEPTIC MENINGITIS//ASEPTIC MENINGITIS//IBUPROFEN TOXICITY
7 34588 GLYCINE N ACYLTRANSFERASE//MEDIUM CHAIN ACYL COA SYNTHETASE//GLYCINE CONJUGATION
8 28818 HEPARG CELLS//HEPARG//NEOHEPATOCYTES
9 25846 IDIOSYNCRATIC DRUG INDUCED LIVER INJURY//PHAGOCYTOSIS BLOCKADE//ALPHA NAPHTHYLISOTHIOCYANATE
10 2545 UDP GLUCURONOSYLTRANSFERASE//GLUCURONIDATION//UDP GLUCURONOSYLTRANSFERASES UGTS

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