Class information for:
Level 1: ODCASE//OROTIDINE 5 MONOPHOSPHATE DECARBOXYLASE//MOL DESIGN PREFORMULAT

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
24160 321 33.8 65%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
278 3       CORYNEBACTERIUM GLUTAMICUM//ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY//BIOCHEMISTRY & MOLECULAR BIOLOGY 43163
2622 2             TRIOSEPHOSPHATE ISOMERASE//HISTIDINE BIOSYNTHESIS//KETOSTEROID ISOMERASE 3550
24160 1                   ODCASE//OROTIDINE 5 MONOPHOSPHATE DECARBOXYLASE//MOL DESIGN PREFORMULAT 321

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ODCASE authKW 1046377 3% 100% 11
2 OROTIDINE 5 MONOPHOSPHATE DECARBOXYLASE authKW 765521 4% 62% 13
3 MOL DESIGN PREFORMULAT address 365854 3% 38% 10
4 OROTIDINE MONOPHOSPHATE DECARBOXYLASE authKW 285376 1% 100% 3
5 OROTIDINE authKW 216188 2% 45% 5
6 DE NOVO NUCLEOTIDE SYNTHESIS authKW 190250 1% 100% 2
7 MCLAUGHLIN ROTMAN UHN address 190250 1% 100% 2
8 PROTEIN ENGN NETWORK address 190250 1% 100% 2
9 OMP DECARBOXYLASE authKW 142685 1% 50% 3
10 1 SUBSTITUTED OROTIC ACID authKW 95125 0% 100% 1

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Biochemistry & Molecular Biology 1380 54% 0% 174
2 Biophysics 135 8% 0% 27
3 Chemistry, Organic 131 11% 0% 34
4 Chemistry, Multidisciplinary 117 15% 0% 48
5 Chemistry, Medicinal 87 6% 0% 18
6 Biochemical Research Methods 27 4% 0% 13
7 Genetics & Heredity 27 5% 0% 17
8 Mycology 23 1% 0% 4
9 Parasitiology 13 2% 0% 5
10 Biotechnology & Applied Microbiology 11 4% 0% 13

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MOL DESIGN PREFORMULAT 365854 3% 38% 10
2 MCLAUGHLIN ROTMAN UHN 190250 1% 100% 2
3 PROTEIN ENGN NETWORK 190250 1% 100% 2
4 MED BIOPHYS MOL MED GENET 95125 0% 100% 1
5 MOL DESIGN INFORM TECHNOL 95125 0% 100% 1
6 UHN TORONTO GEN HOSP 95125 0% 100% 1
7 VERNA MARRS MCLEAN BIOCHEM MOL 95125 0% 100% 1
8 THEORET PHYS CHEM GRP 95123 1% 50% 2
9 MCLAUGHLIN MOL MED 70970 3% 7% 10
10 CANC GENOM PROTEOM 41712 2% 9% 5

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BIOORGANIC CHEMISTRY 9288 4% 1% 12
2 BIOCHEMISTRY 4633 16% 0% 51
3 TOPICS IN CURRENT CHEMISTRY 2047 2% 0% 6
4 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 835 9% 0% 29
5 ADVANCES IN PHYSICAL ORGANIC CHEMISTRY 804 0% 1% 1
6 JOURNAL OF FERMENTATION AND BIOENGINEERING 683 1% 0% 4
7 INTERNATIONAL JOURNAL OF BIOCHEMISTRY 496 1% 0% 4
8 SOMATIC CELL AND MOLECULAR GENETICS 416 1% 0% 2
9 CURRENT TOPICS IN CELLULAR REGULATION 386 0% 0% 1
10 HAKKOKOGAKU KAISHI-JOURNAL OF THE SOCIETY OF FERMENTATION TECHNOLOGY 310 0% 0% 1

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 ODCASE 1046377 3% 100% 11 Search ODCASE Search ODCASE
2 OROTIDINE 5 MONOPHOSPHATE DECARBOXYLASE 765521 4% 62% 13 Search OROTIDINE+5+MONOPHOSPHATE+DECARBOXYLASE Search OROTIDINE+5+MONOPHOSPHATE+DECARBOXYLASE
3 OROTIDINE MONOPHOSPHATE DECARBOXYLASE 285376 1% 100% 3 Search OROTIDINE+MONOPHOSPHATE+DECARBOXYLASE Search OROTIDINE+MONOPHOSPHATE+DECARBOXYLASE
4 OROTIDINE 216188 2% 45% 5 Search OROTIDINE Search OROTIDINE
5 DE NOVO NUCLEOTIDE SYNTHESIS 190250 1% 100% 2 Search DE+NOVO+NUCLEOTIDE+SYNTHESIS Search DE+NOVO+NUCLEOTIDE+SYNTHESIS
6 OMP DECARBOXYLASE 142685 1% 50% 3 Search OMP+DECARBOXYLASE Search OMP+DECARBOXYLASE
7 1 SUBSTITUTED OROTIC ACID 95125 0% 100% 1 Search 1+SUBSTITUTED+OROTIC+ACID Search 1+SUBSTITUTED+OROTIC+ACID
8 1 SUBSTITUTED URACIL 95125 0% 100% 1 Search 1+SUBSTITUTED+URACIL Search 1+SUBSTITUTED+URACIL
9 3 KETO L GULONATE 6 PHOSPHATE DECARBOXYLASE 95125 0% 100% 1 Search 3+KETO+L+GULONATE+6+PHOSPHATE+DECARBOXYLASE Search 3+KETO+L+GULONATE+6+PHOSPHATE+DECARBOXYLASE
10 5 AMINO OROTIC ACID 95125 0% 100% 1 Search 5+AMINO+OROTIC+ACID Search 5+AMINO+OROTIC+ACID

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 FUJIHASHI, M , MNPOTRA, JS , MISHRA, RK , PAI, EF , KOTRA, LP , (2015) OROTIDINE MONOPHOSPHATE DECARBOXYLASE - A FASCINATING WORKHORSE ENZYME WITH THERAPEUTIC POTENTIAL.JOURNAL OF GENETICS AND GENOMICS. VOL. 42. ISSUE 5. P. 221 -234 68 89% 0
2 FUJIHASHI, M , ISHIDA, T , KURODA, S , KOTRA, LP , PAI, EF , MIKI, K , (2013) SUBSTRATE DISTORTION CONTRIBUTES TO THE CATALYSIS OF OROTIDINE 5 '-MONOPHOSPHATE DECARBOXYLASE.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. VOL. 135. ISSUE 46. P. 17432 -17443 56 71% 7
3 TSANG, WY , WOOD, BM , WONG, FM , WU, WM , GERLT, JA , AMYES, TL , RICHARD, JP , (2012) PROTON TRANSFER FROM C-6 OF URIDINE 5 '-MONOPHOSPHATE CATALYZED BY OROTIDINE 5 '-MONOPHOSPHATE DECARBOXYLASE: FORMATION AND STABILITY OF A VINYL CARBANION INTERMEDIATE AND THE EFFECT OF A 5-FLUORO SUBSTITUENT.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. VOL. 134. ISSUE 35. P. 14580 -14594 46 75% 10
4 MUNDRA, S , KOTRA, LP , (2014) DESIGN OF INHIBITORS OF ODCASE.FUTURE MEDICINAL CHEMISTRY. VOL. 6. ISSUE 2. P. 165-177 50 67% 1
5 VARDI-KILSHTAIN, A , DORON, D , MAJOR, DT , (2013) QUANTUM AND CLASSICAL SIMULATIONS OF OROTIDINE MONOPHOSPHATE DECARBOXYLASE: SUPPORT FOR A DIRECT DECARBOXYLATION MECHANISM.BIOCHEMISTRY. VOL. 52. ISSUE 25. P. 4382 -4390 45 58% 9
6 FUJIHASHI, M , MITO, K , PAI, EF , MIKI, K , (2013) ATOMIC RESOLUTION STRUCTURE OF THE OROTIDINE 5 '-MONOPHOSPHATE DECARBOXYLASE PRODUCT COMPLEX COMBINED WITH SURFACE PLASMON RESONANCE ANALYSIS IMPLICATIONS FOR THE CATALYTIC MECHANISM.JOURNAL OF BIOLOGICAL CHEMISTRY. VOL. 288. ISSUE 13. P. 9011 -9016 31 79% 5
7 SENGER, NA , BLISS, CE , KEEFFE, JR , GRONERT, S , WU, WM , (2013) STABILITIES OF URACIL AND PYRIDONE-BASED CARBANIONS: A SYSTEMATIC STUDY IN THE GAS PHASE AND SOLUTION AND IMPLICATIONS FOR THE MECHANISM OF OROTIDINE-5 '-MONOPHOSPHATE DECARBOXYLASE.TETRAHEDRON. VOL. 69. ISSUE 26. P. 5287-5292 28 88% 1
8 CHAN, KK , WOOD, BM , FEDOROV, AA , FEDOROV, EV , IMKER, HJ , AMYES, TL , RICHARD, JP , ALMO, SC , GERLT, JA , (2009) MECHANISM OF THE OROTIDINE 5 '-MONOPHOSPHATE DECARBOXYLASE-CATALYZED REACTION: EVIDENCE FOR SUBSTRATE DESTABILIZATION.BIOCHEMISTRY. VOL. 48. ISSUE 24. P. 5518-5531 29 85% 24
9 WU, YJ , LIAO, CC , JEN, CH , SHIH, YC , CHIEN, TC , (2010) CHEMICAL MODELS AND THEIR MECHANISTIC IMPLICATIONS FOR THE TRANSFORMATION OF 6-CYANOURIDINE 5 '-MONOPHOSPHATE CATALYZED BY OROTIDINE 5 '-MONOPHOSPHATE DECARBOXYLASE.CHEMICAL COMMUNICATIONS. VOL. 46. ISSUE 26. P. 4821 -4823 25 100% 0
10 MEZA-AVINA, ME , WEI, L , BUHENDWA, MG , PODUCH, E , BELLO, AM , PAI, EF , KOTRA, LP , (2008) INHIBITION OF OROTIDINE 5 '-MONOPHOSPHATE DECARBOXYLASE AND ITS THERAPEUTIC POTENTIAL.MINI-REVIEWS IN MEDICINAL CHEMISTRY. VOL. 8. ISSUE 3. P. 239-247 32 74% 10

Classes with closest relation at Level 1


Rank Class id link
1 17636 TRIOSEPHOSPHATE ISOMERASE//TRIOSEPHOSPHATE ISOMERASE DEFICIENCY//BIOQUIM BIOL ESTRUCT
2 15693 PHOSPHORIBOSYLTRANSFERASE//MOL PARASITOL DRUG DESIGN//PURINE SALVAGE
3 8448 PYRIMIDINE BIOSYNTHESIS//DIHYDROOROTASE//CARBAMOYL PHOSPHATE SYNTHETASE
4 17105 HYDROGEN TUNNELLING//PROMOTING VIBRATION//HYDROGEN TUNNELING
5 22219 PHARMACEUT SCI KITA 12 NISHI 6 KITA KU//1 2 UNSATURATED NUCLEOSIDE//ANOMERIC RADICAL
6 24744 MANDELATE RACEMASE//MANDELATE RACEMASE EC 5122//ENOLASE SUPERFAMILY
7 23401 CYCLOPENTENYL CYTOSINE//CTP SYNTHASE//CTP SYNTHETASE
8 26418 TAS 106//DUPLEX DRUG//3 C ETHYNYLCYTIDINE
9 34318 CIZ1//ENHANCER OF RUDIMENTARY//CW DOMAIN
10 22175 HISTIDINE BIOSYNTHESIS//BETA ALPHA8 BARREL//INDOLE 3 GLYCEROL PHOSPHATE SYNTHASE

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