Class information for:
Level 1: TAS 106//DUPLEX DRUG//3 C ETHYNYLCYTIDINE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
26418 255 27.2 79%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
236 3       ADENOSINE//NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS//ADENOSINE RECEPTORS 48331
793 2             NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS//NUCLEOSIDES//CARBOCYCLIC NUCLEOSIDES 12112
26418 1                   TAS 106//DUPLEX DRUG//3 C ETHYNYLCYTIDINE 255

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 TAS 106 authKW 1317210 4% 100% 11
2 DUPLEX DRUG authKW 851528 3% 89% 8
3 3 C ETHYNYLCYTIDINE authKW 538856 2% 75% 6
4 ECYD authKW 538856 2% 75% 6
5 ORGANOSILICON REAGENT authKW 498941 2% 83% 5
6 ORGANOALUMINUM REAGENT authKW 478985 2% 100% 4
7 3 ETHYNYLCYTIDINE authKW 359239 1% 100% 3
8 4 C SUBSTITUTED 2 DEOXYNUCLEOSIDE authKW 359239 1% 100% 3
9 CS 682 authKW 359239 1% 100% 3
10 DIDEHYDRO 3 DEOXYTHYMIDINE authKW 359239 1% 100% 3

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Chemistry, Organic 1418 34% 0% 87
2 Chemistry, Medicinal 266 10% 0% 26
3 Oncology 232 17% 0% 44
4 Biochemistry & Molecular Biology 215 27% 0% 69
5 Pharmacology & Pharmacy 182 18% 0% 45
6 Microbiology 34 6% 0% 16
7 Chemistry, Applied 11 3% 0% 7
8 Chemistry, Inorganic & Nuclear 8 3% 0% 8
9 Biophysics 5 3% 0% 7
10 Virology 5 2% 0% 4

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 EXPT RETROVIROL SECT 227046 6% 12% 16
2 ANTIVIRAL CHEMOTHER Y 122272 5% 9% 12
3 11 TSUTSUMIDORI AMAMIYA 119746 0% 100% 1
4 CANC DESIGNATED COMPREHENS CANC 119746 0% 100% 1
5 CHEM PHARM FOOD SCI 119746 0% 100% 1
6 IMMUNOPATHOL INTERNAL MED 2 119746 0% 100% 1
7 LICENSE DEV 119746 0% 100% 1
8 PHARMACOL EXPT CLINIQUE 119746 0% 100% 1
9 STATE ONCOL SO CHINASIR YK PAO CANC 119746 0% 100% 1
10 U716 IGM 119746 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS 37126 15% 1% 38
2 INVESTIGATIONAL NEW DRUGS 2290 3% 0% 7
3 LANCET HIV 1149 0% 1% 1
4 ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 1122 6% 0% 15
5 TETRAHEDRON-ASYMMETRY 731 3% 0% 8
6 BIOORGANIC & MEDICINAL CHEMISTRY 441 3% 0% 7
7 JOURNAL OF MEDICINAL CHEMISTRY 439 4% 0% 9
8 HOSPITAL FORMULARY 350 0% 0% 1
9 JOURNAL OF ORGANIC CHEMISTRY 320 5% 0% 12
10 CHINESE JOURNAL OF CANCER 301 0% 0% 1

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 TAS 106 1317210 4% 100% 11 Search TAS+106 Search TAS+106
2 DUPLEX DRUG 851528 3% 89% 8 Search DUPLEX+DRUG Search DUPLEX+DRUG
3 3 C ETHYNYLCYTIDINE 538856 2% 75% 6 Search 3+C+ETHYNYLCYTIDINE Search 3+C+ETHYNYLCYTIDINE
4 ECYD 538856 2% 75% 6 Search ECYD Search ECYD
5 ORGANOSILICON REAGENT 498941 2% 83% 5 Search ORGANOSILICON+REAGENT Search ORGANOSILICON+REAGENT
6 ORGANOALUMINUM REAGENT 478985 2% 100% 4 Search ORGANOALUMINUM+REAGENT Search ORGANOALUMINUM+REAGENT
7 3 ETHYNYLCYTIDINE 359239 1% 100% 3 Search 3+ETHYNYLCYTIDINE Search 3+ETHYNYLCYTIDINE
8 4 C SUBSTITUTED 2 DEOXYNUCLEOSIDE 359239 1% 100% 3 Search 4+C+SUBSTITUTED+2+DEOXYNUCLEOSIDE Search 4+C+SUBSTITUTED+2+DEOXYNUCLEOSIDE
9 CS 682 359239 1% 100% 3 Search CS+682 Search CS+682
10 DIDEHYDRO 3 DEOXYTHYMIDINE 359239 1% 100% 3 Search DIDEHYDRO+3+DEOXYTHYMIDINE Search DIDEHYDRO+3+DEOXYTHYMIDINE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 ABDELRAHIM, M , MATSUDA, A , NAING, A , (2013) TAS-106: PRECLINICAL, CLINICAL AND BEYOND.ONCOLOGY. VOL. 85. ISSUE 6. P. 356-363 29 76% 4
2 OHRUI, H , (2011) DEVELOPMENT OF MODIFIED NUCLEOSIDES THAT HAVE SUPREMELY HIGH ANTI-HIV ACTIVITY AND LOW TOXICITY AND PREVENT THE EMERGENCE OF RESISTANT HIV MUTANTS.PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES. VOL. 87. ISSUE 3. P. 53 -65 20 77% 5
3 OHRUI, H , HAYAKAWA, H , KOHGO, S , MATSUOKA, M , KODAMA, E , MITSUYA, H , (2006) CREATION OF LOW TOXIC REVERSE-TRANSCRIPTASE INHIBITORY NUCLEOSIDES THAT PREVENT THE EMERGENCE OF DRUG-RESISTANT HIV VARIANTS.JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN. VOL. 64. ISSUE 7. P. 716 -723 13 93% 3
4 OHRUI, H , (2006) 2 '-DEOXY-4 '-C-ETHYNYL-2-FLUOROADENOSINE, A NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR, IS HIGHLY POTENT AGAINST ALL HUMAN IMMUNODEFICIENCY VIRUSES TYPE 1 AND HAS LOW TOXICITY.CHEMICAL RECORD. VOL. 6. ISSUE 3. P. 133 -143 15 75% 15
5 ICHIKAWA, S , MINAKAWA, N , SHUTO, S , TANAKA, M , SASAKI, T , MATSUDA, A , (2006) SYNTHESIS OF 3 '-BETA-CARBAMOYLMETHYLCYTIDINE (CAMC) AND ITS DERIVATIVES AS POTENTIAL ANTITUMOR AGENTS.ORGANIC & BIOMOLECULAR CHEMISTRY. VOL. 4. ISSUE 7. P. 1284 -1296 24 45% 8
6 BETSON, M , ALLANSON, N , WAINWRIGHT, P , (2014) A REVIEW OF METHODS TO SYNTHESISE 4 '-SUBSTITUTED NUCLEOSIDES.ORGANIC & BIOMOLECULAR CHEMISTRY. VOL. 12. ISSUE 46. P. 9291 -9306 20 43% 3
7 HARAGUCHI, K , TAKEDA, S , KUBOTA, Y , KUMAMOTO, H , TANAKA, H , HAMASAKI, T , BABA, M , PAINTSIL, E , CHENG, YC , (2013) FROM THE CHEMISTRY OF EPOXY-SUGAR NUCLEOSIDES TO THE DISCOVERY OF ANTI-HIV AGENT 4 '-ETHYNYLSTAVUDINE-FESTINAVIR.CURRENT PHARMACEUTICAL DESIGN. VOL. 19. ISSUE 10. P. 1880-1897 21 39% 7
8 SCHOTT, H , SCHOTT, S , SCHWENDENER, RA , (2009) SYNTHESIS AND IN VITRO ACTIVITIES OF NEW ANTICANCER DUPLEX DRUGS LINKING 2 '-DEOXY-5-FLUOROURIDINE (5-FDU) WITH 3 '-C-ETHYNYLCYTIDINE (ECYD) VIA A PHOSPHODIESTER BONDING.BIOORGANIC & MEDICINAL CHEMISTRY. VOL. 17. ISSUE 19. P. 6824 -6831 13 68% 7
9 TSAO, A , HUI, EP , JUERGENS, R , MARUR, S , HUAT, TE , CHER, GB , HONG, RL , HONG, WK , CHAN, ATC , (2013) PHASE II STUDY OF TAS-106 IN PATIENTS WITH PLATINUM-FAILURE RECURRENT OR METASTATIC HEAD AND NECK CANCER AND NASOPHARYNGEAL CANCER.CANCER MEDICINE. VOL. 2. ISSUE 3. P. 351-359 13 62% 3
10 LIU, P , SHARON, A , CHU, CK , (2006) ENANTIOMERIC SYNTHESIS OF CARBOCYCLIC D-4 '-C-METHYL-RIBONUCLEOSIDES AS POTENTIAL ANTIVIRAL AGENTS.TETRAHEDRON-ASYMMETRY. VOL. 17. ISSUE 23. P. 3304 -3314 18 53% 3

Classes with closest relation at Level 1


Rank Class id link
1 5118 NUCLEOSIDES & NUCLEOTIDES//NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS//KETONUCLEOSIDES
2 5617 CARBOCYCLIC NUCLEOSIDES//CARBANUCLEOSIDES//MOLETTE DRUG DISCOVERY
3 22219 PHARMACEUT SCI KITA 12 NISHI 6 KITA KU//1 2 UNSATURATED NUCLEOSIDE//ANOMERIC RADICAL
4 14958 ISONUCLEOSIDES//TROXACITABINE//L NUCLEOSIDES
5 32446 A MASKED CAGED ION TAG//ACYCLIC BETA DIKETONES//AMIDES GLYCOSYL AZIDES
6 35665 TORREYA TAXIFOLIA//2 ETHYLHEXYLPROPANEDIOIC ACID//2 FUNCTIONALIZED ANILINES
7 8385 GEMCITABINE//DEOXYCYTIDINE KINASE//HENT1
8 32652 TRICHLOROETHYLIDENE ACETALS//MM2 PARAMETERS//ABINITIO COMPUTATIONS
9 4600 NUCLE ACID//SYNTHET BIOORGAN CHEM//NUCL ACID
10 24160 ODCASE//OROTIDINE 5 MONOPHOSPHATE DECARBOXYLASE//MOL DESIGN PREFORMULAT

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