Class information for:
Level 1: DIHYDROFOLATE REDUCTASE//DHFR//10065 BARNES CANYON RD

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
8575 1239 34.7 60%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
278 3       CORYNEBACTERIUM GLUTAMICUM//ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY//BIOCHEMISTRY & MOLECULAR BIOLOGY 43163
3354 2             DIHYDROFOLATE REDUCTASE//HPPK//DHFR 1711
8575 1                   DIHYDROFOLATE REDUCTASE//DHFR//10065 BARNES CANYON RD 1239

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DIHYDROFOLATE REDUCTASE authKW 961538 12% 26% 152
2 DHFR authKW 160231 3% 17% 38
3 10065 BARNES CANYON RD address 73931 0% 100% 3
4 ROLE OF FLEXIBLE LOOP authKW 73931 0% 100% 3
5 ANTIFOLATE authKW 66952 2% 9% 30
6 COMPUTAT MOL BIOL DRUG DESIGN GRP address 56003 0% 45% 5
7 EPIROPRIM authKW 55446 0% 75% 3
8 HUMAN DIHYDROFOLATE REDUCTASE authKW 55446 0% 75% 3
9 8 ALKYLPTERINS authKW 49287 0% 100% 2
10 ELECTRON DENSITY DIFFERENCES authKW 49287 0% 100% 2

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Chemistry, Medicinal 4560 18% 0% 228
2 Biochemistry & Molecular Biology 4138 48% 0% 600
3 Biophysics 1039 11% 0% 141
4 Pharmacology & Pharmacy 532 14% 0% 178
5 Microbiology 303 8% 0% 98
6 Chemistry, Organic 199 7% 0% 91
7 Biochemical Research Methods 177 5% 0% 61
8 Crystallography 143 4% 0% 44
9 Chemistry, Multidisciplinary 86 9% 0% 106
10 Computer Science, Interdisciplinary Applications 39 2% 0% 27

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 10065 BARNES CANYON RD 73931 0% 100% 3
2 COMPUTAT MOL BIOL DRUG DESIGN GRP 56003 0% 45% 5
3 SCI TECHNOL BIOCHEM 36962 0% 50% 3
4 BACTERIOL MYCOL UNIT 32857 0% 67% 2
5 MED CHEM PROGRAMME 26281 0% 27% 4
6 BIOCHEM MOLEC BIOL POB 10008 24644 0% 100% 1
7 CEMDD 24644 0% 100% 1
8 CLIN INFECT DIS PULM DIS 24644 0% 100% 1
9 CMBDDG 24644 0% 100% 1
10 CNRS URA 464 24644 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF MEDICINAL CHEMISTRY 15927 10% 1% 118
2 BIOCHEMISTRY 12056 13% 0% 162
3 ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 3194 5% 0% 56
4 ANTI-CANCER DRUG DESIGN 3166 1% 1% 9
5 JOURNAL OF BIOCHEMISTRY 2022 2% 0% 30
6 PROTEIN ENGINEERING 1820 1% 1% 13
7 PROGRESS IN MEDICINAL CHEMISTRY 1367 0% 6% 1
8 JOURNAL OF HETEROCYCLIC CHEMISTRY 1268 2% 0% 24
9 CANCER BIOCHEMISTRY BIOPHYSICS 1066 0% 1% 4
10 ADVANCES IN ENZYME REGULATION 1024 0% 1% 5

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 DIHYDROFOLATE REDUCTASE 961538 12% 26% 152 Search DIHYDROFOLATE+REDUCTASE Search DIHYDROFOLATE+REDUCTASE
2 DHFR 160231 3% 17% 38 Search DHFR Search DHFR
3 ROLE OF FLEXIBLE LOOP 73931 0% 100% 3 Search ROLE+OF+FLEXIBLE+LOOP Search ROLE+OF+FLEXIBLE+LOOP
4 ANTIFOLATE 66952 2% 9% 30 Search ANTIFOLATE Search ANTIFOLATE
5 EPIROPRIM 55446 0% 75% 3 Search EPIROPRIM Search EPIROPRIM
6 HUMAN DIHYDROFOLATE REDUCTASE 55446 0% 75% 3 Search HUMAN+DIHYDROFOLATE+REDUCTASE Search HUMAN+DIHYDROFOLATE+REDUCTASE
7 8 ALKYLPTERINS 49287 0% 100% 2 Search 8+ALKYLPTERINS Search 8+ALKYLPTERINS
8 ELECTRON DENSITY DIFFERENCES 49287 0% 100% 2 Search ELECTRON+DENSITY+DIFFERENCES Search ELECTRON+DENSITY+DIFFERENCES
9 ESFF FORCEFIELD 49287 0% 100% 2 Search ESFF+FORCEFIELD Search ESFF+FORCEFIELD
10 FOLDING ELEMENTS 49287 0% 100% 2 Search FOLDING+ELEMENTS Search FOLDING+ELEMENTS

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 FEENEY, J , (2000) NMR STUDIES OF LIGAND BINDING TO DIHYDROFOLATE REDUCTASE.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. VOL. 39. ISSUE 2. P. 290 -312 102 76% 32
2 POLSHAKOV, VI , (2001) DIHYDROFOLATE REDUCTASE: STRUCTURAL ASPECTS OF MECHANISMS OF ENZYME CATALYSIS AND INHIBITION.RUSSIAN CHEMICAL BULLETIN. VOL. 50. ISSUE 10. P. 1733 -1751 86 87% 7
3 TAWARI, NR , BAG, S , DEGANI, MS , (2011) A REVIEW OF MOLECULAR MODELLING STUDIES OF DIHYDROFOLATE REDUCTASE INHIBITORS AGAINST OPPORTUNISTIC MICROORGANISMS AND COMPREHENSIVE EVALUATION OF NEW MODELS.CURRENT PHARMACEUTICAL DESIGN. VOL. 17. ISSUE 7. P. 712 -751 68 70% 4
4 GANGJEE, A , KURUP, S , NAMJOSHI, O , (2007) DIHYDROFOLATE REDUCTASE AS A TARGET FOR CHEMOTHERAPY IN PARASITES.CURRENT PHARMACEUTICAL DESIGN. VOL. 13. ISSUE 6. P. 609-639 87 56% 35
5 CHAN, DCM , ANDERSON, AC , (2006) TOWARDS SPECIES-SPECIFIC ANTIFOLATES.CURRENT MEDICINAL CHEMISTRY. VOL. 13. ISSUE 4. P. 377 -398 80 53% 46
6 BASRAN, J , CASAROTTO, MG , BARSUKOV, IL , ROBERTS, GCK , (1995) ROLE OF THE ACTIVE-SITE CARBOXYLATE IN DIHYDROFOLATE-REDUCTASE - KINETIC AND SPECTROSCOPIC STUDIES OF THE ASPARTATE 26-]ASPARAGINE MUTANT OF THE LACTOBACILLUS-CASEI ENZYME.BIOCHEMISTRY. VOL. 34. ISSUE 9. P. 2872-2882 58 92% 15
7 HOWELL, EE , (2005) SEARCHING SEQUENCE SPACE: TWO DIFFERENT APPROACHES TO DIHYDROFOLATE REDUCTASE CATALYSIS.CHEMBIOCHEM. VOL. 6. ISSUE 4. P. 591-600 57 62% 3
8 BOCK, RA , SOULAGES, JL , BARROW, WW , (2007) SUBSTRATE AND INHIBITOR SPECIFICITY OF MYCOBACTERIUM AVIUM DIHYDROFOLATE REDUCTASE.FEBS JOURNAL. VOL. 274. ISSUE 13. P. 3286 -3298 34 94% 4
9 NYIRI, K , VERTESSY, BG , (2017) PERTURBATION OF GENOME INTEGRITY TO FIGHT PATHOGENIC MICROORGANISMS.BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS. VOL. 1861. ISSUE 1. P. 3593 -3612 56 25% 1
10 SAWAYA, MR , KRAUT, J , (1997) LOOP AND SUBDOMAIN MOVEMENTS IN THE MECHANISM OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE: CRYSTALLOGRAPHIC EVIDENCE.BIOCHEMISTRY. VOL. 36. ISSUE 3. P. 586 -603 37 63% 458

Classes with closest relation at Level 1


Rank Class id link
1 17105 HYDROGEN TUNNELLING//PROMOTING VIBRATION//HYDROGEN TUNNELING
2 31201 HPPK//DIHYDROPTEROATE SYNTHASE//PYROPHOSPHOKINASE
3 2341 REDUCED FOLATE CARRIER//FOLYLPOLYGLUTAMATE SYNTHETASE//ANTIFOLATE
4 15011 THYMIDYLATE SYNTHASE//THYX//FLUORODEOXYURIDYLATE
5 24280 JOURNAL OF MOLECULAR GRAPHICS//SPACE FILLING MOLECULAR MODELS//DESK TOP MOLECULAR MODELING
6 26824 2 4 DIAMINOPYRIMIDINIUM//DADA ARRAY//1S 3R 3 AMINO 2 2 3 TRIMETHYL CYCLOPENTANE 1 CARBOXYLIC
7 17979 SPHEROIDAL GRANULE//AFRICAN RESISTANCE SURVEY//ANTI MICROBIAL RESISTANCE SURVEILLANCE
8 25675 PROTEIN SWITCH//CIRCULAR PERMUTATION//BIOMED ST PAU IIB SANTPAU
9 17227 ATOVAQUONE//TOXOPLASMA ENCEPHALITIS//TOXOPLASMIC ENCEPHALITIS
10 11263 PYRIDO2 3 DPYRIMIDINES//6 AMINOURACIL//6 AMINOTHIOURACIL

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