Class information for:
Level 1: BLOOD BRAIN BARRIER//BBB//TIGHT JUNCTION

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
4989 1691 51.1 76%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
8 4 CARDIAC & CARDIOVASCULAR SYSTEM//PERIPHERAL VASCULAR DISEASES//CARDIOL 1276458
258 3       STROKE//INTRACEREBRAL HEMORRHAGE//CEREBRAL ISCHEMIA 44849
2409 2             BLOOD BRAIN BARRIER//CEREBROLYSIN//TYR MIF 1 4189
4989 1                   BLOOD BRAIN BARRIER//BBB//TIGHT JUNCTION 1691

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BLOOD BRAIN BARRIER authKW 1137173 42% 9% 712
2 BBB address 281069 1% 65% 24
3 TIGHT JUNCTION authKW 189363 10% 6% 177
4 TRANSENDOTHELIAL ELECTRICAL RESISTANCE authKW 156105 1% 41% 21
5 CEREBRAL ENDOTHELIAL CELLS authKW 154028 1% 37% 23
6 BRAIN CAPILLARY ENDOTHELIAL CELLS authKW 129676 1% 29% 25
7 CLAUDIN 5 authKW 121292 2% 22% 31
8 BRAIN ENDOTHELIAL CELLS authKW 98820 2% 17% 32
9 PHARMACEUT CARE HLTH SCI address 91731 2% 20% 26
10 PBMEC C1 2 authKW 90279 0% 100% 5

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Neurosciences 10671 46% 0% 784
2 Cell Biology 1179 15% 0% 256
3 Pharmacology & Pharmacy 690 14% 0% 238
4 Pathology 588 6% 0% 100
5 Developmental Biology 562 4% 0% 68
6 Physiology 542 7% 0% 120
7 Peripheral Vascular Diseases 415 5% 0% 90
8 CYTOLOGY & HISTOLOGY 381 1% 0% 13
9 Biochemistry & Molecular Biology 298 15% 0% 260
10 Clinical Neurology 241 7% 0% 114

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BBB 281069 1% 65% 24
2 PHARMACEUT CARE HLTH SCI 91731 2% 20% 26
3 PHYSIOPATHOL BARRIERE HEMATO ENCEPHAL 81248 0% 75% 6
4 LBHE 75323 1% 38% 11
5 EA 2465 57478 1% 29% 11
6 MOL BIOPHARM GENET 50401 1% 16% 18
7 BLOOD BRAIN BARRIER 46924 1% 20% 13
8 CELLIAL TECHNOL 40624 0% 75% 3
9 SHIONOGI DISCOVERY S 2 FUKUSHIMA KU 36112 0% 100% 2
10 OPTOMETRY VISUAL SCI PL VIS 32498 0% 60% 3

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 8067 3% 1% 49
2 CELLULAR AND MOLECULAR NEUROBIOLOGY 6990 2% 1% 31
3 MICROVASCULAR RESEARCH 6499 2% 1% 31
4 BRAIN RESEARCH 6313 8% 0% 130
5 JOURNAL OF NEUROCHEMISTRY 4401 4% 0% 72
6 ACTA NEUROPATHOLOGICA 2743 2% 1% 30
7 IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL 1902 1% 1% 15
8 JOURNAL OF SUBMICROSCOPIC CYTOLOGY AND PATHOLOGY 1498 1% 1% 11
9 JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 1444 1% 1% 16
10 ENDOTHELIUM-JOURNAL OF ENDOTHELIAL CELL RESEARCH 1362 0% 2% 5

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 BLOOD BRAIN BARRIER 1137173 42% 9% 712 Search BLOOD+BRAIN+BARRIER Search BLOOD+BRAIN+BARRIER
2 TIGHT JUNCTION 189363 10% 6% 177 Search TIGHT+JUNCTION Search TIGHT+JUNCTION
3 TRANSENDOTHELIAL ELECTRICAL RESISTANCE 156105 1% 41% 21 Search TRANSENDOTHELIAL+ELECTRICAL+RESISTANCE Search TRANSENDOTHELIAL+ELECTRICAL+RESISTANCE
4 CEREBRAL ENDOTHELIAL CELLS 154028 1% 37% 23 Search CEREBRAL+ENDOTHELIAL+CELLS Search CEREBRAL+ENDOTHELIAL+CELLS
5 BRAIN CAPILLARY ENDOTHELIAL CELLS 129676 1% 29% 25 Search BRAIN+CAPILLARY+ENDOTHELIAL+CELLS Search BRAIN+CAPILLARY+ENDOTHELIAL+CELLS
6 CLAUDIN 5 121292 2% 22% 31 Search CLAUDIN+5 Search CLAUDIN+5
7 BRAIN ENDOTHELIAL CELLS 98820 2% 17% 32 Search BRAIN+ENDOTHELIAL+CELLS Search BRAIN+ENDOTHELIAL+CELLS
8 PBMEC C1 2 90279 0% 100% 5 Search PBMEC+C1+2 Search PBMEC+C1+2
9 ENDOTHELIAL BARRIER ANTIGEN 85970 1% 48% 10 Search ENDOTHELIAL+BARRIER+ANTIGEN Search ENDOTHELIAL+BARRIER+ANTIGEN
10 OCCLUDIN 85108 3% 9% 55 Search OCCLUDIN Search OCCLUDIN

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 DELI, MA , ABRAHAM, CS , KATAOKA, Y , NIWA, M , (2005) PERMEABILITY STUDIES ON IN VITRO BLOOD-BRAIN BARRIER MODELS: PHYSIOLOGY, PATHOLOGY, AND PHARMACOLOGY.CELLULAR AND MOLECULAR NEUROBIOLOGY. VOL. 25. ISSUE 1. P. 59-127 123 66% 283
2 HELMS, HC , ABBOTT, NJ , BUREK, M , CECCHELLI, R , COURAUD, PO , DELI, MA , FORSTER, C , GALLA, HJ , ROMERO, IA , SHUSTA, EV , ET AL (2016) IN VITRO MODELS OF THE BLOOD-BRAIN BARRIER: AN OVERVIEW OF COMMONLY USED BRAIN ENDOTHELIAL CELL CULTURE MODELS AND GUIDELINES FOR THEIR USE.JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. VOL. 36. ISSUE 5. P. 862 -890 127 48% 6
3 WOLFF, A , ANTFOLK, M , BRODIN, B , TENJE, M , (2015) IN VITRO BLOOD-BRAIN BARRIER MODELS-AN OVERVIEW OF ESTABLISHED MODELS AND NEW MICROFLUIDIC APPROACHES.JOURNAL OF PHARMACEUTICAL SCIENCES. VOL. 104. ISSUE 9. P. 2727 -2746 93 80% 9
4 BICKER, J , ALVES, G , FORTUNA, A , FALCAO, A , (2014) BLOOD-BRAIN BARRIER MODELS AND THEIR RELEVANCE FOR A SUCCESSFUL DEVELOPMENT OF CNS DRUG DELIVERY SYSTEMS: A REVIEW.EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. VOL. 87. ISSUE 3. P. 409 -432 111 47% 36
5 WILHELM, I , KRIZBAI, IA , (2014) IN VITRO MODELS OF THE BLOOD-BRAIN BARRIER FOR THE STUDY OF DRUG DELIVERY TO THE BRAIN.MOLECULAR PHARMACEUTICS. VOL. 11. ISSUE 7. P. 1949 -1963 79 68% 21
6 HE, YR , YAO, Y , TSIRKA, SE , CAO, Y , (2014) CELL-CULTURE MODELS OF THE BLOOD-BRAIN BARRIER.STROKE. VOL. 45. ISSUE 8. P. 2514 -2526 103 53% 13
7 APARICIO-BLANCO, J , MARTIN-SABROSO, C , TORRES-SUAREZ, AI , (2016) IN VITRO SCREENING OF NANOMEDICINES THROUGH THE BLOOD BRAIN BARRIER: A CRITICAL REVIEW.BIOMATERIALS. VOL. 103. ISSUE . P. 229 -255 134 39% 1
8 WATSON, PMD , PATERSON, JC , THOM, G , GINMAN, U , LUNDQUIST, S , WEBSTER, CI , (2013) MODELLING THE ENDOTHELIAL BLOOD-CNS BARRIERS: A METHOD FOR THE PRODUCTION OF ROBUST IN VITRO MODELS OF THE RAT BLOOD-BRAIN BARRIER AND BLOOD-SPINAL CORD BARRIER.BMC NEUROSCIENCE. VOL. 14. ISSUE . P. - 67 78% 22
9 PATABENDIGE, A , SKINNER, RA , ABBOTT, NJ , (2013) ESTABLISHMENT OF A SIMPLIFIED IN VITRO PORCINE BLOOD-BRAIN BARRIER MODEL WITH HIGH TRANSENDOTHELIAL ELECTRICAL RESISTANCE.BRAIN RESEARCH. VOL. 1521. ISSUE . P. 1-15 54 81% 20
10 WILHELM, I , FAZAKAS, C , KRIZBAI, IA , (2011) IN VITRO MODELS OF THE BLOOD-BRAIN BARRIER.ACTA NEUROBIOLOGIAE EXPERIMENTALIS. VOL. 71. ISSUE 1. P. 113-128 65 57% 102

Classes with closest relation at Level 1


Rank Class id link
1 27403 EVANS BLUE//1 DEOXY 1 NITRO D MANNITOL//ADENYLATE CYSLASE
2 18203 TRANSENDOTHELIAL CHANNELS//ALBUMIN BINDING PROTEINS//PLVAP
3 9862 P GLYCOPROTEIN//PHARMACORESISTANCE//TARIQUIDAR
4 20325 LOGBB//BLOOD BRAIN PARTITIONING//PAMPA BBB
5 6821 BLOOD BRAIN BARRIER//BRAIN TARGETING//SMART DRUG DELIVERY
6 35725 GLUTAMATE PYRUVATE TRANSAMINASE GPT//BLOOD GLUTAMATE SCAVENGING//GLUTAMATE OXALOACETATE TRANSAMINASE GOT
7 35142 THRP//AGING BLOOD BRAIN BARRIER//ANTIOXIDANTS HYPERGLYCEMIA
8 30937 INNER BLOOD RETINAL BARRIER//PROTON COUPLED ORGANIC CATION ANTIPORTER//RETINAL CAPILLARY ENDOTHELIAL CELLS
9 12368 PERICYTES//ADVENTITIAL CELL//LARGE SCALE FUNCT BIOL LLSFBIO
10 12145 RMP 7//INTRACAROTID CHEMOTHERAPY//BLOOD TUMOR BARRIER

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