Class information for:
Level 1: CYP2C19//OMEPRAZOLE//PANTOPRAZOLE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
6086 1533 28.0 74%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
6 4 GASTROENTEROLOGY & HEPATOLOGY//ONCOLOGY//SURGERY 1371034
192 3       GASTROESOPHAGEAL REFLUX DISEASE//GASTROESOPHAGEAL REFLUX//ESOPHAGEAL CANCER 54156
531 2             GASTROESOPHAGEAL REFLUX DISEASE//GASTROESOPHAGEAL REFLUX//PROTON PUMP INHIBITORS 14930
6086 1                   CYP2C19//OMEPRAZOLE//PANTOPRAZOLE 1533

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CYP2C19 authKW 1146021 13% 28% 203
2 OMEPRAZOLE authKW 824132 17% 16% 256
3 PANTOPRAZOLE authKW 591878 7% 28% 106
4 LANSOPRAZOLE authKW 550011 8% 23% 121
5 RABEPRAZOLE authKW 480903 5% 30% 80
6 RABEPRAZOLE SODIUM authKW 444571 2% 89% 25
7 ILAPRAZOLE authKW 268870 1% 75% 18
8 PROGUANIL authKW 225291 2% 31% 37
9 PANTOPRAZOLE SODIUM authKW 191198 1% 80% 12
10 OMEPRAZOLE SULFONE authKW 179253 1% 100% 9

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Pharmacology & Pharmacy 16133 59% 0% 908
2 Chemistry, Analytical 3237 21% 0% 316
3 Biochemical Research Methods 1096 10% 0% 149
4 Gastroenterology & Hepatology 1085 9% 0% 134
5 Chemistry, Medicinal 451 6% 0% 89
6 Toxicology 247 5% 0% 70
7 Chemistry, Multidisciplinary 159 10% 0% 148
8 Medical Laboratory Technology 69 1% 0% 21
9 Spectroscopy 13 2% 0% 23
10 Medicine, Research & Experimental 8 2% 0% 33

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 SUNNY BROOK WOMENS 26555 0% 67% 2
2 ENDOSCOP PHOTODYNAM MED 22391 1% 13% 9
3 ACT PHARMACEUT INGREDIENTS 4 19917 0% 100% 1
4 ACT PHARMACEUT PHARMACEUT INGREDIENTS 3 19917 0% 100% 1
5 AEC SPECIAL 19917 0% 100% 1
6 ANTIPOISON REG PAYS LOIRE 19917 0% 100% 1
7 ARA LIFE SCI AB 19917 0% 100% 1
8 BGFA FOR UNGS ITUT ARBEITSMED DEUT GESETZ 19917 0% 100% 1
9 BIOMED INTERNAL MED SUBSPECIALITES 19917 0% 100% 1
10 BIOMED SCI MED PHARMACOL 19917 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PHARMACOGENETICS 25751 2% 4% 35
2 EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY 15777 5% 1% 75
3 CLINICAL PHARMACOLOGY & THERAPEUTICS 13505 4% 1% 63
4 BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 11617 5% 1% 69
5 INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS 10298 3% 1% 45
6 ALIMENTARY PHARMACOLOGY & THERAPEUTICS 4907 3% 1% 40
7 JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 3956 3% 0% 47
8 JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 3601 3% 0% 47
9 CLINICAL DRUG INVESTIGATION 2926 1% 1% 18
10 EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS 2890 1% 1% 15

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 CYP2C19 1146021 13% 28% 203 Search CYP2C19 Search CYP2C19
2 OMEPRAZOLE 824132 17% 16% 256 Search OMEPRAZOLE Search OMEPRAZOLE
3 PANTOPRAZOLE 591878 7% 28% 106 Search PANTOPRAZOLE Search PANTOPRAZOLE
4 LANSOPRAZOLE 550011 8% 23% 121 Search LANSOPRAZOLE Search LANSOPRAZOLE
5 RABEPRAZOLE 480903 5% 30% 80 Search RABEPRAZOLE Search RABEPRAZOLE
6 RABEPRAZOLE SODIUM 444571 2% 89% 25 Search RABEPRAZOLE+SODIUM Search RABEPRAZOLE+SODIUM
7 ILAPRAZOLE 268870 1% 75% 18 Search ILAPRAZOLE Search ILAPRAZOLE
8 PROGUANIL 225291 2% 31% 37 Search PROGUANIL Search PROGUANIL
9 PANTOPRAZOLE SODIUM 191198 1% 80% 12 Search PANTOPRAZOLE+SODIUM Search PANTOPRAZOLE+SODIUM
10 OMEPRAZOLE SULFONE 179253 1% 100% 9 Search OMEPRAZOLE+SULFONE Search OMEPRAZOLE+SULFONE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 DESTA, Z , ZHAO, XJ , SHIN, JG , FLOCKHART, DA , (2002) CLINICAL SIGNIFICANCE OF THE CYTOCHROME P4502C19 GENETIC POLYMORPHISM.CLINICAL PHARMACOKINETICS. VOL. 41. ISSUE 12. P. 913-958 144 45% 465
2 EL-KOMMOS, ME , KHASHABA, PY , ALI, HRH , EL-WEKIL, MM , (2015) DIFFERENT CHROMATOGRAPHIC AND ELECTROPHORETIC METHODS FOR ANALYSIS OF PROTON PUMP INHIBITORS (PPIS): A REVIEW.JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES. VOL. 38. ISSUE 18. P. 1639 -1659 80 82% 1
3 FRICKE-GALINDO, I , CESPEDES-GARRO, C , RODRIGUES-SOARES, F , NARANJO, MEG , DELGADO, A , DE ANDRES, F , LOPEZ-LOPEZ, M , PENAS-LLEDO, E , LLERENA, A , (2016) INTERETHNIC VARIATION OF CYP2C19 ALLELES, 'PREDICTED' PHENOTYPES AND 'MEASURED' METABOLIC PHENOTYPES ACROSS WORLD POPULATIONS.PHARMACOGENOMICS JOURNAL. VOL. 16. ISSUE 2. P. 113 -123 70 47% 8
4 WEDEMEYER, RS , BLUME, H , (2014) PHARMACOKINETIC DRUG INTERACTION PROFILES OF PROTON PUMP INHIBITORS: AN UPDATE.DRUG SAFETY. VOL. 37. ISSUE 4. P. 201 -211 63 55% 40
5 BOSCH, ME , SANCHEZ, AJR , ROJAS, FS , OJEDA, CB , (2007) ANALYTICAL METHODOLOGIES FOR THE DETERMINATION OF OMEPRAZOLE: AN OVERVIEW.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. VOL. 44. ISSUE 4. P. 831 -844 62 82% 33
6 OGAWA, R , ECHIZEN, H , (2010) DRUG-DRUG INTERACTION PROFILES OF PROTON PUMP INHIBITORS.CLINICAL PHARMACOKINETICS. VOL. 49. ISSUE 8. P. 509 -533 90 46% 44
7 BLUME, H , DONATH, F , WARNKE, A , SCHUG, BS , (2006) PHARMACOKINETIC DRUG INTERACTION PROFILES OF PROTON PUMP INHIBITORS.DRUG SAFETY. VOL. 29. ISSUE 9. P. 769-784 65 61% 88
8 FURUTA, T , SUGIMOTO, M , SHIRAI, N , (2012) INDIVIDUALIZED THERAPY FOR GASTROESOPHAGEAL REFLUX DISEASE POTENTIAL IMPACT OF PHARMACOGENETIC TESTING BASED ON CYP2C19.MOLECULAR DIAGNOSIS & THERAPY. VOL. 16. ISSUE 4. P. 223 -234 61 60% 9
9 ALONSO-NAVARRO, H , JIMENEZ-JIMENEZ, FJ , GARCIA-AGUNDEZ, JA , (2006) THE ROLE OF CYP2C19 POLYMORPHISM IN THE DEVELOPMENT OF ADVERSE EFFECTS TO DRUGS AND THE RISK FOR DISEASES.MEDICINA CLINICA. VOL. 126. ISSUE 18. P. 697 -706 90 48% 1
10 GOUDA, AA , ABD EL-HAY, SS , HASHEM, H , (2016) UTILIZATION OF ALIZARIN DERIVATIVES FOR THE SENSITIVE SPECTROPHOTOMETRIC DETERMINATION OF TWO PROTON PUMP INHIBITORS IN PHARMACEUTICAL FORMULATIONS.MAIN GROUP CHEMISTRY. VOL. 15. ISSUE 1. P. 17 -34 36 82% 0

Classes with closest relation at Level 1


Rank Class id link
1 2663 ALIMENTARY PHARMACOLOGY & THERAPEUTICS//ESOMEPRAZOLE//OMEPRAZOLE
2 1626 CYP2D6//DEBRISOQUINE//CYP2D6 POLYMORPHISM
3 18069 PROTON PUMP INHIBITORS//OMEPRAZOLE//HYPOMAGNESEMIA
4 4852 6 BETA HYDROXYCORTISOL//COCKTAIL//CYP3A
5 4970 H K ATPASE//PARIETAL CELL//ACID SECRETION
6 582 HELICOBACTER PYLORI//CLARITHROMYCIN//TRIPLE THERAPY
7 2607 CYP2C9//VKORC1//WARFARIN
8 30562 GALACTOGOGUE//DOMPERIDONE//RELACTATION
9 33387 CARISOPRODOL//MEPROBAMATE//METAXALONE
10 32661 CRYSTAL HABIT COEFFICIENT//CRYSTAL HABIT PREDOMINANT FACE//PHARM IKUTA KU

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