Class information for:
Level 1: DMXAA//FLAVONE ACETIC ACID//5 6 DIMETHYLXANTHENONE 4 ACETIC ACID

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
22006 397 32.0 77%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
365 3       MICROTUBULES//MITOSIS//KINETOCHORE 34118
2644 2             COMBRETASTATIN//COMBRETASTATIN A 4//VASCULAR DISRUPTING AGENTS 3490
22006 1                   DMXAA//FLAVONE ACETIC ACID//5 6 DIMETHYLXANTHENONE 4 ACETIC ACID 397

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DMXAA authKW 2523814 11% 75% 44
2 FLAVONE ACETIC ACID authKW 2053180 8% 86% 31
3 5 6 DIMETHYLXANTHENONE 4 ACETIC ACID authKW 791117 3% 86% 12
4 AUCKLAND CANC SOC address 732175 20% 12% 78
5 FLAVONE 8 ACETIC ACID authKW 699220 3% 91% 10
6 ANTIVASCULAR authKW 467705 4% 41% 15
7 5 6 DIMETHYLXANTHENONE 4 ACETIC ACID DMXAA authKW 384572 1% 100% 5
8 COLON 38 authKW 376877 2% 70% 7
9 ASA404 authKW 351602 2% 57% 8
10 VADIMEZAN authKW 175801 1% 57% 4

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Oncology 5630 61% 0% 242
2 Pharmacology & Pharmacy 726 26% 0% 105
3 Chemistry, Medicinal 321 9% 0% 36
4 Radiology, Nuclear Medicine & Medical Imaging 75 7% 0% 26
5 Biology 12 2% 0% 9
6 Chemistry, Analytical 10 4% 0% 15
7 Biochemical Research Methods 8 3% 0% 10
8 Nuclear Science & Technology 7 2% 0% 8
9 Chemistry, Organic 6 4% 0% 14
10 Toxicology 4 2% 0% 7

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 AUCKLAND CANC SOC 732175 20% 12% 78
2 PLATFORM PEPTID METABOL DRUG MEASUREMENTS 102551 1% 67% 2
3 ANTISOMA LTD 76914 0% 100% 1
4 CANC BIOL PRECLIN MR IMAGING 76914 0% 100% 1
5 CANC CELL 164 76914 0% 100% 1
6 CHIM PARISTECHSORBONNE PARIS CITEINSERMU1022C 76914 0% 100% 1
7 CHIM PARISTECHUMR8151U1022 76914 0% 100% 1
8 CURIEUMR3666U1143 76914 0% 100% 1
9 GLYCOCONJUATE 76914 0% 100% 1
10 HOSP GINECO OBSTETICIA LUIS CASTELAZO AYALA 76914 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CANCER CHEMOTHERAPY AND PHARMACOLOGY 17625 10% 1% 41
2 BRITISH JOURNAL OF CANCER 7572 11% 0% 42
3 EUROPEAN JOURNAL OF CANCER & CLINICAL ONCOLOGY 4928 3% 1% 11
4 ONCOLOGY RESEARCH 2299 2% 1% 6
5 ANTI-CANCER DRUG DESIGN 1955 1% 1% 4
6 INVESTIGATIONAL NEW DRUGS 1466 2% 0% 7
7 CANCER RESEARCH 1304 7% 0% 26
8 NEOPLASIA 1133 1% 0% 5
9 INTERNATIONAL JOURNAL OF HYPERTHERMIA 983 1% 0% 5
10 INTERNATIONAL JOURNAL OF RADIATION BIOLOGY 962 2% 0% 8

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 DMXAA 2523814 11% 75% 44 Search DMXAA Search DMXAA
2 FLAVONE ACETIC ACID 2053180 8% 86% 31 Search FLAVONE+ACETIC+ACID Search FLAVONE+ACETIC+ACID
3 5 6 DIMETHYLXANTHENONE 4 ACETIC ACID 791117 3% 86% 12 Search 5+6+DIMETHYLXANTHENONE+4+ACETIC+ACID Search 5+6+DIMETHYLXANTHENONE+4+ACETIC+ACID
4 FLAVONE 8 ACETIC ACID 699220 3% 91% 10 Search FLAVONE+8+ACETIC+ACID Search FLAVONE+8+ACETIC+ACID
5 ANTIVASCULAR 467705 4% 41% 15 Search ANTIVASCULAR Search ANTIVASCULAR
6 5 6 DIMETHYLXANTHENONE 4 ACETIC ACID DMXAA 384572 1% 100% 5 Search 5+6+DIMETHYLXANTHENONE+4+ACETIC+ACID+DMXAA Search 5+6+DIMETHYLXANTHENONE+4+ACETIC+ACID+DMXAA
7 COLON 38 376877 2% 70% 7 Search COLON+38 Search COLON+38
8 ASA404 351602 2% 57% 8 Search ASA404 Search ASA404
9 VADIMEZAN 175801 1% 57% 4 Search VADIMEZAN Search VADIMEZAN
10 3 ARYLFLAVONE 8 ACETIC ACID 153829 1% 100% 2 Search 3+ARYLFLAVONE+8+ACETIC+ACID Search 3+ARYLFLAVONE+8+ACETIC+ACID

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 GOMES, AS , BRANDAO, P , FERNANDES, CSG , DA SILVA, MRPC , DE SOUSA, MEDP , PINTO, MMD , (2016) DRUG-LIKE PROPERTIES AND ADME OF XANTHONE DERIVATIVES: THE ANTECHAMBER OF CLINICAL TRIALS.CURRENT MEDICINAL CHEMISTRY. VOL. 23. ISSUE 32. P. 3654 -3686 90 48% 0
2 CHING, LM , (2008) ASA404 VASCULAR-DISRUPTING AGENT ONCOLYTIC.DRUGS OF THE FUTURE. VOL. 33. ISSUE 7. P. 561-569 52 85% 3
3 JAMESON, MB , HEAD, M , (2011) PHARMACOKINETIC EVALUATION OF VADIMEZAN (ASA404, 5,6-DIMETHYLXANTHENONE-4-ACETIC ACID, DMXAA).EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY. VOL. 7. ISSUE 10. P. 1315 -1326 37 82% 3
4 TIJONO, SM , GUO, K , HENARE, K , PALMER, BD , WANG, LCS , ALBELDA, SM , CHING, LM , (2013) IDENTIFICATION OF HUMAN-SELECTIVE ANALOGUES OF THE VASCULAR-DISRUPTING AGENT 5,6-DIMETHYLXANTHENONE-4-ACETIC ACID (DMXAA).BRITISH JOURNAL OF CANCER. VOL. 108. ISSUE 6. P. 1306-1315 34 77% 12
5 BAGULEY, BC , CHING, LM , (1997) IMMUNOMODULATORY ACTIONS OF XANTHENONE ANTICANCER AGENTS.BIODRUGS. VOL. 8. ISSUE 2. P. 119-127 48 86% 25
6 ZHOU, SF , KESTELL, P , BAGULEY, BC , PAXTON, JW , (2002) 5,6-DIMETHYLXANTHENONE-4-ACETIC ACID (DMXAA): A NEW BIOLOGICAL RESPONSE MODIFIER FOR CANCER THERAPY.INVESTIGATIONAL NEW DRUGS. VOL. 20. ISSUE 3. P. 281 -295 48 71% 26
7 DAUZONNE, D , MARTINEZ, L , (1995) SYNTHESIS OF THE 3-AMINOFLAVONE-8-ACETIC ACID.TETRAHEDRON LETTERS. VOL. 36. ISSUE 11. P. 1845-1848 46 90% 18
8 JAMESON, MB , BAGULEY, BC , KESTELL, P , ZHAO, L , PAXTON, JW , THOMPSON, PI , WALLER, S , (2007) PHARMACOKINETICS OF 5,6-DIMETHYLXANTHENONE-4-ACETIC ACID (AS1404), A NOVEL VASCULAR DISRUPTING AGENT, IN PHASE I CLINICAL TRIAL.CANCER CHEMOTHERAPY AND PHARMACOLOGY. VOL. 59. ISSUE 5. P. 681-687 26 100% 17
9 RUSTIN, GJS , BRADLEY, C , GALBRAITH, S , STRATFORD, M , LOADMAN, P , WALLER, S , BELLENGER, K , GUMBRELL, L , FOLKES, L , HALBERT, G , (2003) 5,6-DIMETHYLXANTHENONE-4-ACETIC ACID (DMXAA), A NOVEL ANTIVASCULAR AGENT: PHASE I CLINICAL AND PHARMACOKINETIC STUDY.BRITISH JOURNAL OF CANCER. VOL. 88. ISSUE 8. P. 1160-1167 29 91% 82
10 BIBBY, MC , DOUBLE, JA , (1993) FLAVONE ACETIC-ACID FROM LABORATORY TO CLINIC AND BACK.ANTI-CANCER DRUGS. VOL. 4. ISSUE 1. P. 3-17 44 88% 37

Classes with closest relation at Level 1


Rank Class id link
1 5476 COMBRETASTATIN//COMBRETASTATIN A 4//VASCULAR DISRUPTING AGENTS
2 12306 2 STYRYLCHROMONES//FLAVONES//3 STYRYLCHROMONES
3 15678 TIRAPAZAMINE//BIOREDUCTIVE DRUGS//SR 4233
4 10481 INTERSTITIAL FLUID PRESSURE//EDWIN L STEELE//CANCER DETECTION AND TREATMENT
5 37538 HETEROCYCLIC TRIOXIRANES//TEROXIRONE//HUMAN NON SMALL CELL LUNG CANCER CELLS
6 37263 PHENOBARBITAL HYDROCORTISONE//COLORECTAL TUMOR TISSUE//SENSITIVITY TO HORMONES
7 14478 ACYL GLUCURONIDE//ZOMEPIRAC//DRUG PROTEIN ADDUCTS
8 7173 THALIDOMIDE//CEREBLON//THALIDOMIDE ANALOGUES
9 18265 VANDETANIB//NINTEDANIB//CEDIRANIB
10 25052 1 3 THIAZOLIDIN 2 ONE//1 4 DIHYDRO PYRAZOLO4 3 DPYRIMIDINE 5 7 DIONE DERIVATIVES//1 ARYL 3 ETHOXYCARBONYLPYRAZOLE 4 CARBOXYLIC ACIDS

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