Class information for:
Level 1: TRAUMA EMERGENCY SURG SURG CRIT CAREMASSAC//HISTONE DEACETYLASE//SURG TRAUMA EMERGENCY SURG SURG CRIT C

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
17566 593 50.7 93%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
262 3       AUTOPHAGY//RESVERATROL//HISTONE DEACETYLASE INHIBITOR 44558
1531 2             HISTONE DEACETYLASE INHIBITOR//HISTONE DEACETYLASE//HDAC INHIBITOR 7464
17566 1                   TRAUMA EMERGENCY SURG SURG CRIT CAREMASSAC//HISTONE DEACETYLASE//SURG TRAUMA EMERGENCY SURG SURG CRIT C 593

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 TRAUMA EMERGENCY SURG SURG CRIT CAREMASSAC address 205967 1% 100% 4
2 HISTONE DEACETYLASE authKW 189025 13% 5% 80
3 SURG TRAUMA EMERGENCY SURG SURG CRIT C address 173437 1% 42% 8
4 HISTONE DEACETYLASE INHIBITOR authKW 153515 11% 5% 65
5 TRAUMA EMERGENCY SURG SURG CRIT CARE address 141728 4% 11% 25
6 VALPROIC ACID authKW 141321 12% 4% 72
7 TRICHOSTATIN A authKW 114398 6% 6% 36
8 MOL NEUROBIOL SECT address 108039 3% 11% 19
9 TRAUMA TRANSLAT CLIN address 102984 0% 100% 2
10 HDAC INHIBITOR authKW 82624 6% 4% 36

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Neurosciences 752 22% 0% 133
2 Immunology 604 17% 0% 99
3 Critical Care Medicine 401 5% 0% 32
4 Cell Biology 394 15% 0% 88
5 Medicine, Research & Experimental 301 9% 0% 56
6 Surgery 198 12% 0% 70
7 Rheumatology 190 4% 0% 21
8 Hematology 157 6% 0% 34
9 Biochemistry & Molecular Biology 155 18% 0% 104
10 Pharmacology & Pharmacy 115 11% 0% 63

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 TRAUMA EMERGENCY SURG SURG CRIT CAREMASSAC 205967 1% 100% 4
2 SURG TRAUMA EMERGENCY SURG SURG CRIT C 173437 1% 42% 8
3 TRAUMA EMERGENCY SURG SURG CRIT CARE 141728 4% 11% 25
4 MOL NEUROBIOL SECT 108039 3% 11% 19
5 TRAUMA TRANSLAT CLIN 102984 0% 100% 2
6 ANIM BOSCI 51492 0% 100% 1
7 BIOSCI LN BIO 51492 0% 100% 1
8 CELL AUTOANTIBODY B 51492 0% 100% 1
9 CLIN TRANSLAT SHANGHAISHANGHAI 51492 0% 100% 1
10 ENDOCRINOL DIABET METABPERELMAN MED 51492 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF TRAUMA AND ACUTE CARE SURGERY 5530 3% 1% 15
2 MOLECULAR MEDICINE 4008 2% 1% 11
3 NEUROTHERAPEUTICS 1883 1% 1% 5
4 SURGERY 1145 3% 0% 15
5 EPIGENOMICS 997 1% 1% 3
6 JOURNAL OF SURGICAL RESEARCH 946 2% 0% 14
7 NEUROMOLECULAR MEDICINE 825 1% 1% 3
8 IMMUNOLOGY AND CELL BIOLOGY 799 1% 0% 6
9 INTERNATIONAL IMMUNOPHARMACOLOGY 749 1% 0% 8
10 IMMUNOBIOLOGY 574 1% 0% 6

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 HISTONE DEACETYLASE 189025 13% 5% 80 Search HISTONE+DEACETYLASE Search HISTONE+DEACETYLASE
2 HISTONE DEACETYLASE INHIBITOR 153515 11% 5% 65 Search HISTONE+DEACETYLASE+INHIBITOR Search HISTONE+DEACETYLASE+INHIBITOR
3 VALPROIC ACID 141321 12% 4% 72 Search VALPROIC+ACID Search VALPROIC+ACID
4 TRICHOSTATIN A 114398 6% 6% 36 Search TRICHOSTATIN+A Search TRICHOSTATIN+A
5 HDAC INHIBITOR 82624 6% 4% 36 Search HDAC+INHIBITOR Search HDAC+INHIBITOR
6 ANTI CANCER DRUG RESISTANCE 68650 1% 33% 4 Search ANTI+CANCER+DRUG+RESISTANCE Search ANTI+CANCER+DRUG+RESISTANCE
7 ACETYLHISTONE H3 51492 0% 100% 1 Search ACETYLHISTONE+H3 Search ACETYLHISTONE+H3
8 AGING ELECTRONIC SUPPLEMENTARY MATERIAL 51492 0% 100% 1 Search AGING+ELECTRONIC+SUPPLEMENTARY+MATERIAL Search AGING+ELECTRONIC+SUPPLEMENTARY+MATERIAL
9 ANIMAL MODELS MICE 51492 0% 100% 1 Search ANIMAL+MODELS+MICE Search ANIMAL+MODELS+MICE
10 ANTIGEN INDUCED SMOOTH MUSCLE CONTRACTION 51492 0% 100% 1 Search ANTIGEN+INDUCED+SMOOTH+MUSCLE+CONTRACTION Search ANTIGEN+INDUCED+SMOOTH+MUSCLE+CONTRACTION

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 DINARELLO, CA , FOSSATI, G , MASCAGNI, P , (2011) HISTONE DEACETYLASE INHIBITORS FOR TREATING A SPECTRUM OF DISEASES NOT RELATED TO CANCER.MOLECULAR MEDICINE. VOL. 17. ISSUE 5-6. P. 333 -352 60 37% 61
2 CHEN, S , WU, HJ , KLEBE, D , HONG, Y , ZHANG, JM , (2014) VALPROIC ACID: A NEW CANDIDATE OF THERAPEUTIC APPLICATION FOR THE ACUTE CENTRAL NERVOUS SYSTEM INJURIES.NEUROCHEMICAL RESEARCH. VOL. 39. ISSUE 9. P. 1621 -1633 39 41% 15
3 HANCOCK, WW , AKIMOVA, T , BEIER, UH , LIU, YJ , WANG, LQ , (2012) HDAC INHIBITOR THERAPY IN AUTOIMMUNITY AND TRANSPLANTATION.ANNALS OF THE RHEUMATIC DISEASES. VOL. 71. ISSUE . P. 46-54 47 32% 24
4 HALILI, MA , ANDREWS, MR , SWEET, MJ , FAIRLIE, DP , (2009) HISTONE DEACETYLASE INHIBITORS IN INFLAMMATORY DISEASE.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 9. ISSUE 3. P. 309-319 39 38% 77
5 HALAWEISH, I , NIKOLIAN, V , GEORGOFF, P , LI, YQ , ALAM, HB , (2015) CREATING A "PROSURVIVAL PHENOTYPE" THROUGH HISTONE DEACETYLASE INHIBITION: PAST, PRESENT, AND FUTURE.SHOCK. VOL. 44. ISSUE . P. 6 -16 37 39% 3
6 CIARLO, E , SAVVA, A , ROGER, T , (2013) EPIGENETICS IN SEPSIS: TARGETING HISTONE DEACETYLASES.INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS. VOL. 42. ISSUE . P. S8-S12 24 62% 9
7 GRABIEC, AM , TAK, PP , REEDQUIST, KA , (2011) FUNCTION OF HISTONE DEACETYLASE INHIBITORS IN INFLAMMATION.CRITICAL REVIEWS IN IMMUNOLOGY. VOL. 31. ISSUE 3. P. 233 -263 49 29% 35
8 NELSON, DW , PORTA, CR , MCVAY, DP , SALGAR, SK , MARTIN, MJ , (2013) EFFECTS OF HISTONE DEACETYLASE INHIBITION ON 24-HOUR SURVIVAL AND END-ORGAN INJURY IN A PORCINE TRAUMA MODEL: A PROSPECTIVE, RANDOMIZED TRIAL.JOURNAL OF TRAUMA AND ACUTE CARE SURGERY. VOL. 75. ISSUE 6. P. 1031-1039 18 78% 4
9 LEUS, NGJ , ZWINDERMAN, MRH , DEKKER, FJ , (2016) HISTONE DEACETYLASE 3 (HDAC 3) AS EMERGING DRUG TARGET IN NF-KAPPA B-MEDIATED INFLAMMATION.CURRENT OPINION IN CHEMICAL BIOLOGY. VOL. 33. ISSUE . P. 160 -168 31 37% 2
10 LOHMAN, RJ , IYER, A , FAIRLIE, TJ , COTTERELL, A , GUPTA, P , REID, RC , VESEY, DA , SWEET, MJ , FAIRLIE, DP , (2016) DIFFERENTIAL ANTI-INFLAMMATORY ACTIVITY OF HDAC INHIBITORS IN HUMAN MACROPHAGES AND RAT ARTHRITIS.JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. VOL. 356. ISSUE 2. P. 387 -396 23 43% 4

Classes with closest relation at Level 1


Rank Class id link
1 185 HISTONE DEACETYLASE INHIBITOR//HISTONE DEACETYLASE//HDAC INHIBITOR
2 27625 METABOLIC MEMORY//IL RISK ASSESSMENT INTERVENT STUDIES//HYPERGLYCEMIC MEMORY
3 16802 MEF2C//MEF2//MEF2D
4 16241 CELLULAR INJURY//TOLERANCE BREAKDOWN//HUNAN MED EPIGEN
5 6500 EPIGENETICS//DNA METHYLATION//HISTONE ACETYLATION
6 7109 BUTYRATE//SODIUM BUTYRATE//DIVERSION COLITIS
7 3883 GLYCOGEN SYNTHASE KINASE 3//GSK 3//GLYCOGEN SYNTHASE KINASE 3 BETA
8 3625 VALPROIC ACID//VALPROATE//VALNOCTAMIDE
9 19181 NRSF//REST NRSF//NRSF REST
10 26162 AUTOPHAGY//AUTOPHAGIC NEURON DEATH//BIOMFG BIOTECHNOL ENTERPRISE BRITE

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