Class information for:
Level 2: SIRT1//SIRTUINS//SIRT3

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
2649 3472 54.0 92%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
262 3       AUTOPHAGY//RESVERATROL//HISTONE DEACETYLASE INHIBITOR 44558
2649 2             SIRT1//SIRTUINS//SIRT3 3472
913 1                   SIRT1//SIRTUINS//SIRT3 2965
19394 1                   N TERMINAL ACETYLTRANSFERASE//ARD1//N TERMINAL ACETYLATION 507

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 SIRT1 authKW 2549430 18% 47% 622
2 SIRTUINS authKW 2533912 14% 58% 497
3 SIRT3 authKW 921911 4% 77% 137
4 SIRT2 authKW 543296 2% 78% 79
5 SIRT6 authKW 425568 2% 77% 63
6 SIRTUIN 1 authKW 234410 2% 34% 79
7 DEACETYLASE authKW 223636 2% 40% 63
8 SIRT5 authKW 222369 1% 90% 28
9 SIR2 authKW 208102 2% 37% 64
10 SIRT4 authKW 178896 1% 88% 23

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Cell Biology 10784 29% 0% 1019
2 Biochemistry & Molecular Biology 7133 39% 0% 1360
3 Geriatrics & Gerontology 935 3% 0% 106
4 Oncology 889 10% 0% 357
5 Biophysics 885 7% 0% 237
6 Endocrinology & Metabolism 779 7% 0% 242
7 Chemistry, Medicinal 553 4% 0% 156
8 Biochemical Research Methods 425 5% 0% 161
9 Medicine, Research & Experimental 301 5% 0% 162
10 Genetics & Heredity 244 5% 0% 172

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PAUL F GLENN 110476 0% 74% 17
2 PAUL F GLENN S BIOL MECH AGING 104252 1% 46% 26
3 GLENN S BIOL MECH AGING 46890 0% 67% 8
4 SIRTRIS 45219 0% 86% 6
5 INTEGRAT SYST PHYSIOL 43924 1% 20% 25
6 GLENN SCI AGING 43282 0% 62% 8
7 COMM CELLULAR MOL PHYSIOL 37509 0% 53% 8
8 PAUL F GLENN SCI AGING 35172 0% 100% 4
9 GLADSTONE VIROL IMMUNOL 34327 1% 11% 37
10 CELL SENESCENCE 30939 0% 27% 13

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 AGING-US 20494 1% 5% 46
2 CELL METABOLISM 8665 1% 3% 38
3 AGING CELL 4805 1% 2% 26
4 MOLECULAR CELL 2639 1% 1% 41
5 MOLECULAR & CELLULAR PROTEOMICS 2348 1% 1% 29
6 CELL REPORTS 1640 1% 1% 25
7 JOURNAL OF BIOLOGICAL CHEMISTRY 1478 5% 0% 173
8 COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY SERIES 1252 1% 1% 27
9 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 1144 3% 0% 100
10 PLOS ONE 1088 5% 0% 162

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 SIRT1 2549430 18% 47% 622 Search SIRT1 Search SIRT1
2 SIRTUINS 2533912 14% 58% 497 Search SIRTUINS Search SIRTUINS
3 SIRT3 921911 4% 77% 137 Search SIRT3 Search SIRT3
4 SIRT2 543296 2% 78% 79 Search SIRT2 Search SIRT2
5 SIRT6 425568 2% 77% 63 Search SIRT6 Search SIRT6
6 SIRTUIN 1 234410 2% 34% 79 Search SIRTUIN+1 Search SIRTUIN+1
7 DEACETYLASE 223636 2% 40% 63 Search DEACETYLASE Search DEACETYLASE
8 SIRT5 222369 1% 90% 28 Search SIRT5 Search SIRT5
9 SIR2 208102 2% 37% 64 Search SIR2 Search SIR2
10 SIRT4 178896 1% 88% 23 Search SIRT4 Search SIRT4

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 MORRIS, BJ , (2013) SEVEN SIRTUINS FOR SEVEN DEADLY DISEASES OF AGING.FREE RADICAL BIOLOGY AND MEDICINE. VOL. 56. ISSUE . P. 133 -171 353 62% 84
2 YUAN, HF , SU, LL , CHEN, WY , (2013) THE EMERGING AND DIVERSE ROLES OF SIRTUINS IN CANCER: A CLINICAL PERSPECTIVE.ONCOTARGETS AND THERAPY. VOL. 6. ISSUE . P. 1399-1416 215 87% 66
3 POULOSE, N , RAJU, R , (2015) SIRTUIN REGULATION IN AGING AND INJURY.BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE. VOL. 1852. ISSUE 11. P. 2442 -2455 213 72% 23
4 HAIGIS, MC , SINCLAIR, DA , (2010) MAMMALIAN SIRTUINS: BIOLOGICAL INSIGHTS AND DISEASE RELEVANCE.ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE. VOL. 5. ISSUE . P. 253 -295 164 59% 704
5 GERTZ, M , STEEGBORN, C , (2016) USING MITOCHONDRIAL SIRTUINS AS DRUG TARGETS: DISEASE IMPLICATIONS AND AVAILABLE COMPOUNDS.CELLULAR AND MOLECULAR LIFE SCIENCES. VOL. 73. ISSUE 15. P. 2871 -2896 204 88% 1
6 NOGUEIRAS, R , HABEGGER, KM , CHAUDHARY, N , FINAN, B , BANKS, AS , DIETRICH, MO , HORVATH, TL , SINCLAIR, DA , PFLUGER, PT , TSCHOP, MH , (2012) SIRTUIN 1 AND SIRTUIN 3: PHYSIOLOGICAL MODULATORS OF METABOLISM.PHYSIOLOGICAL REVIEWS. VOL. 92. ISSUE 3. P. 1479 -1514 226 64% 120
7 AUWERX, J , HOUTKOOPER, RH , PIRINEN, E , (2012) SIRTUINS AS REGULATORS OF METABOLISM AND HEALTHSPAN.NATURE REVIEWS MOLECULAR CELL BIOLOGY. VOL. 13. ISSUE 4. P. 225 -238 105 70% 421
8 WU, XY , CAO, N , FENECH, M , WANG, X , (2016) ROLE OF SIRTUINS IN MAINTENANCE OF GENOMIC STABILITY: RELEVANCE TO CANCER AND HEALTHY AGING.DNA AND CELL BIOLOGY. VOL. 35. ISSUE 10. P. 542 -575 231 65% 0
9 JING, H , LIN, HN , (2015) SIRTUINS IN EPIGENETIC REGULATION.CHEMICAL REVIEWS. VOL. 115. ISSUE 6. P. 2350 -2375 216 60% 11
10 STUNKEL, W , CAMPBELL, RM , (2011) SIRTUIN 1 (SIRT1): THE MISUNDERSTOOD HDAC.JOURNAL OF BIOMOLECULAR SCREENING. VOL. 16. ISSUE 10. P. 1153-1169 166 82% 59

Classes with closest relation at Level 2


Rank Class id link
1 2255 RESVERATROL//PTEROSTILBENE//TRANS RESVERATROL
2 3108 FOXM1//FOXO1//FOXO
3 1531 HISTONE DEACETYLASE INHIBITOR//HISTONE DEACETYLASE//HDAC INHIBITOR
4 2654 NURR1//NUR77//PGC 1 ALPHA
5 2762 CYCLIC ADP RIBOSE//ADP RIBOSYL CYCLASE//NAADP
6 1755 LONGEVITY//CALORIC RESTRICTION//DIETARY RESTRICTION
7 2913 CELLULAR SENESCENCE//SENESCENCE//ST PETERSBURG BIOREGULAT GERONTOL
8 2357 PEUTZ JEGHERS SYNDROME//AMPK//LKB1
9 2612 WARBURG EFFECT//PKM2//PYRUVATE KINASE
10 343 EZH2//CHROMATIN//POLYCOMB

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