Class information for:
Level 1: HISTONE DEACETYLASE INHIBITOR//HISTONE DEACETYLASE//HDAC INHIBITOR

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
185 4003 49.0 91%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
262 3       AUTOPHAGY//RESVERATROL//HISTONE DEACETYLASE INHIBITOR 44558
1531 2             HISTONE DEACETYLASE INHIBITOR//HISTONE DEACETYLASE//HDAC INHIBITOR 7464
185 1                   HISTONE DEACETYLASE INHIBITOR//HISTONE DEACETYLASE//HDAC INHIBITOR 4003

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 HISTONE DEACETYLASE INHIBITOR authKW 2359572 17% 47% 662
2 HISTONE DEACETYLASE authKW 1252312 13% 31% 535
3 HDAC INHIBITOR authKW 1034973 8% 41% 331
4 HDAC authKW 523970 6% 29% 237
5 VORINOSTAT authKW 486117 3% 51% 126
6 SAHA authKW 394632 3% 49% 105
7 PANOBINOSTAT authKW 306585 2% 59% 68
8 SUBEROYLANILIDE HYDROXAMIC ACID authKW 244460 2% 48% 67
9 BELINOSTAT authKW 240205 1% 75% 42
10 TRICHOSTATIN A authKW 207477 3% 22% 126

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Oncology 21294 38% 0% 1532
2 Chemistry, Medicinal 11847 17% 0% 664
3 Cell Biology 2108 13% 0% 539
4 Biochemistry & Molecular Biology 1892 22% 0% 867
5 Pharmacology & Pharmacy 1465 13% 0% 540
6 Hematology 956 5% 0% 220
7 Chemistry, Organic 810 8% 0% 321
8 Medicine, Research & Experimental 358 5% 0% 189
9 Genetics & Heredity 138 4% 0% 158
10 Biophysics 88 3% 0% 115

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DIPARTIMENTO PATOL GEN 33594 1% 15% 30
2 MOL GENET PREPARAT MOL BIOL 31764 0% 42% 10
3 GENEXTRA GRP 24394 0% 40% 8
4 INTER PROGRAM CHEM BIOL 23828 0% 63% 5
5 CCU PEDIAT ONCOL G340 22879 0% 100% 3
6 MOL GENET PRAEPARAT MOL BIOL 22879 0% 100% 3
7 CHEM GENET 20232 1% 12% 23
8 HEMATOL NEOPLASIA 18675 0% 35% 7
9 SYNTHET MED CHEM 17693 0% 19% 12
10 DRUG DESIGN OPTIMIZAT MED CHEM 17158 0% 75% 3

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MOLECULAR CANCER THERAPEUTICS 10432 2% 2% 75
2 CLINICAL CANCER RESEARCH 7107 3% 1% 119
3 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 6963 4% 1% 154
4 JOURNAL OF MEDICINAL CHEMISTRY 5724 3% 1% 129
5 INVESTIGATIONAL NEW DRUGS 4953 1% 2% 41
6 CHEMMEDCHEM 4251 1% 2% 36
7 INTERNATIONAL JOURNAL OF ONCOLOGY 3175 2% 1% 64
8 ACS MEDICINAL CHEMISTRY LETTERS 2410 1% 2% 21
9 CANCER BIOLOGY & THERAPY 2393 1% 1% 30
10 CANCER CHEMOTHERAPY AND PHARMACOLOGY 2312 1% 1% 48

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 HISTONE DEACETYLASE INHIBITOR 2359572 17% 47% 662 Search HISTONE+DEACETYLASE+INHIBITOR Search HISTONE+DEACETYLASE+INHIBITOR
2 HISTONE DEACETYLASE 1252312 13% 31% 535 Search HISTONE+DEACETYLASE Search HISTONE+DEACETYLASE
3 HDAC INHIBITOR 1034973 8% 41% 331 Search HDAC+INHIBITOR Search HDAC+INHIBITOR
4 HDAC 523970 6% 29% 237 Search HDAC Search HDAC
5 VORINOSTAT 486117 3% 51% 126 Search VORINOSTAT Search VORINOSTAT
6 SAHA 394632 3% 49% 105 Search SAHA Search SAHA
7 PANOBINOSTAT 306585 2% 59% 68 Search PANOBINOSTAT Search PANOBINOSTAT
8 SUBEROYLANILIDE HYDROXAMIC ACID 244460 2% 48% 67 Search SUBEROYLANILIDE+HYDROXAMIC+ACID Search SUBEROYLANILIDE+HYDROXAMIC+ACID
9 BELINOSTAT 240205 1% 75% 42 Search BELINOSTAT Search BELINOSTAT
10 TRICHOSTATIN A 207477 3% 22% 126 Search TRICHOSTATIN+A Search TRICHOSTATIN+A

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 BOLDEN, JE , PEART, MJ , JOHNSTONE, RW , (2006) ANTICANCER ACTIVITIES OF HISTONE DEACETYLASE INHIBITORS.NATURE REVIEWS DRUG DISCOVERY. VOL. 5. ISSUE 9. P. 769-784 139 70% 1602
2 MOTTAMAL, M , ZHENG, SL , HUANG, TL , WANG, GD , (2015) HISTONE DEACETYLASE INHIBITORS IN CLINICAL STUDIES AS TEMPLATES FOR NEW ANTICANCER AGENTS.MOLECULES. VOL. 20. ISSUE 3. P. 3898 -3941 134 71% 77
3 WEST, AC , JOHNSTONE, RW , (2014) NEW AND EMERGING HDAC INHIBITORS FOR CANCER TREATMENT.JOURNAL OF CLINICAL INVESTIGATION. VOL. 124. ISSUE 1. P. 30-39 91 74% 256
4 MANAL, M , CHANDRASEKAR, MJN , PRIYA, JG , NANJAN, MJ , (2016) INHIBITORS OF HISTONE DEACETYLASE AS ANTITUMOR AGENTS: A CRITICAL REVIEW.BIOORGANIC CHEMISTRY. VOL. 67. ISSUE . P. 18 -42 140 77% 6
5 KOLLAR, J , FRECER, V , (2015) SELECTIVE INHIBITORS OF ZINC-DEPENDENT HISTONE DEACETYLASES. THERAPEUTIC TARGETS RELEVANT TO CANCER.CURRENT PHARMACEUTICAL DESIGN. VOL. 21. ISSUE 11. P. 1472 -1502 199 76% 0
6 LEE, JH , CHOY, ML , MARKS, PA , (2012) MECHANISMS OF RESISTANCE TO HISTONE DEACETYLASE INHIBITORS.HISTONE DEACETYLASE INHIBITORS AS CANCER THERAPEUTICS. VOL. 116. ISSUE . P. 39-86 180 75% 26
7 THALER, F , MERCURIO, C , (2014) TOWARDS SELECTIVE INHIBITION OF HISTONE DEACETYLASE ISOFORMS: WHAT HAS BEEN ACHIEVED, WHERE WE ARE AND WHAT WILL BE NEXT.CHEMMEDCHEM. VOL. 9. ISSUE 3. P. 523-536 142 82% 27
8 ROCHE, J , BERTRAND, P , (2016) INSIDE HDACS WITH MORE SELECTIVE HDAC INHIBITORS.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. VOL. 121. ISSUE . P. 451 -483 140 76% 3
9 FALKENBERG, KJ , JOHNSTONE, RW , (2014) HISTONE DEACETYLASES AND THEIR INHIBITORS IN CANCER, NEUROLOGICAL DISEASES AND IMMUNE DISORDERS.NATURE REVIEWS DRUG DISCOVERY. VOL. 13. ISSUE 9. P. 673 -691 119 45% 254
10 MARKS, PA , (2010) THE CLINICAL DEVELOPMENT OF HISTONE DEACETYLASE INHIBITORS AS TARGETED ANTICANCER DRUGS.EXPERT OPINION ON INVESTIGATIONAL DRUGS. VOL. 19. ISSUE 9. P. 1049-1066 122 79% 143

Classes with closest relation at Level 1


Rank Class id link
1 17566 TRAUMA EMERGENCY SURG SURG CRIT CAREMASSAC//HISTONE DEACETYLASE//SURG TRAUMA EMERGENCY SURG SURG CRIT C
2 16802 MEF2C//MEF2//MEF2D
3 27711 PHENYLACETATE//ANTINEOPLASTON AS2 1//PHENYLBUTYRATE
4 5355 DECITABINE//5 AZA 2 DEOXYCYTIDINE//ZEBULARINE
5 8607 HISTONE ACETYLTRANSFERASE//GCN5//MOZ
6 34665 DINALINE//ACETYLDINALINE//SEMI ALLOGENEIC
7 35590 ANTICANC MOL ONCOL//PRO APOPTOTIC H RAS//BUPRENORPHINE HYDROCHLORIDE
8 7109 BUTYRATE//SODIUM BUTYRATE//DIVERSION COLITIS
9 12023 SET8//HISTONE//PR SET7
10 19781 HELMINTHOSPORIUM CARBONUM//BIPOLARIS ZEICOLA//HC TOXIN

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