Class information for:
Level 1: HPPK//DIHYDROPTEROATE SYNTHASE//PYROPHOSPHOKINASE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
31201 156 32.0 71%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
278 3       CORYNEBACTERIUM GLUTAMICUM//ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY//BIOCHEMISTRY & MOLECULAR BIOLOGY 43163
3354 2             DIHYDROFOLATE REDUCTASE//HPPK//DHFR 1711
31201 1                   HPPK//DIHYDROPTEROATE SYNTHASE//PYROPHOSPHOKINASE 156

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 HPPK authKW 1631167 6% 83% 10
2 DIHYDROPTEROATE SYNTHASE authKW 1006640 12% 29% 18
3 PYROPHOSPHOKINASE authKW 611685 3% 63% 5
4 DIHYDRONEOPTERIN ALDOLASE authKW 440415 2% 75% 3
5 6 HYDROXYMETHYL 7 8 DIHYDROPTERIN PYROPHOSPHOKINASE authKW 391481 1% 100% 2
6 7 8 DIHYDRONEOPTERIN ALDOLASE authKW 391481 1% 100% 2
7 DIHYDROFOLIC ACID authKW 391481 1% 100% 2
8 DIHYDROPTEROIC ACID authKW 391481 1% 100% 2
9 TETRAHYDROFOLATE BIOSYNTHESIS authKW 391481 1% 100% 2
10 HYDROXYMETHYLDIHYDROPTERIN PYROPHOSPHOKINASE authKW 260986 1% 67% 2

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Microbiology 681 28% 0% 44
2 Biochemistry & Molecular Biology 410 44% 0% 68
3 Chemistry, Medicinal 239 12% 0% 19
4 Pharmacology & Pharmacy 106 17% 0% 27
5 Biophysics 103 10% 0% 16
6 Infectious Diseases 45 6% 0% 9
7 Parasitiology 35 3% 0% 5
8 Chemistry, Organic 28 8% 0% 12
9 Biochemical Research Methods 18 4% 0% 7
10 Cell Biology 15 7% 0% 11

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BEYING NMR 195740 1% 100% 1
2 BIOINFORMAT PL GENOM 195740 1% 100% 1
3 BIOLMOLEC 195740 1% 100% 1
4 CNRS 7278INSERM 1095IRD 198 195740 1% 100% 1
5 PHYSIOL CELLULAIRE VEGETALE UMR 5019 195740 1% 100% 1
6 MACROMOL CRYSTALLOG 86497 10% 3% 15
7 BIOTECHNIKUM GREIFSWALD 48934 1% 25% 1
8 CHEM BIOL THER EUT 46073 6% 3% 9
9 UNIDADE CHAVES 27961 1% 14% 1
10 VECTOR VECTOR BORNE DIS 27961 1% 14% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MICROBIAL DRUG RESISTANCE 2706 3% 0% 4
2 JOURNAL OF BACTERIOLOGY 1500 10% 0% 16
3 STRUCTURE 1283 3% 0% 5
4 MICROBIAL DRUG RESISTANCE-MECHANISMS EPIDEMIOLOGY AND DISEASE 1277 1% 1% 1
5 ADVANCES IN INTERNAL MEDICINE 1007 1% 1% 1
6 JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE 864 1% 0% 1
7 JOURNAL OF THE SCIENCE SOCIETY OF THAILAND 835 1% 0% 1
8 ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 817 6% 0% 10
9 FEMS MICROBIOLOGY LETTERS 781 5% 0% 8
10 INTERDISCIPLINARY SCIENCES-COMPUTATIONAL LIFE SCIENCES 631 1% 0% 1

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 HPPK 1631167 6% 83% 10 Search HPPK Search HPPK
2 DIHYDROPTEROATE SYNTHASE 1006640 12% 29% 18 Search DIHYDROPTEROATE+SYNTHASE Search DIHYDROPTEROATE+SYNTHASE
3 PYROPHOSPHOKINASE 611685 3% 63% 5 Search PYROPHOSPHOKINASE Search PYROPHOSPHOKINASE
4 DIHYDRONEOPTERIN ALDOLASE 440415 2% 75% 3 Search DIHYDRONEOPTERIN+ALDOLASE Search DIHYDRONEOPTERIN+ALDOLASE
5 6 HYDROXYMETHYL 7 8 DIHYDROPTERIN PYROPHOSPHOKINASE 391481 1% 100% 2 Search 6+HYDROXYMETHYL+7+8+DIHYDROPTERIN+PYROPHOSPHOKINASE Search 6+HYDROXYMETHYL+7+8+DIHYDROPTERIN+PYROPHOSPHOKINASE
6 7 8 DIHYDRONEOPTERIN ALDOLASE 391481 1% 100% 2 Search 7+8+DIHYDRONEOPTERIN+ALDOLASE Search 7+8+DIHYDRONEOPTERIN+ALDOLASE
7 DIHYDROFOLIC ACID 391481 1% 100% 2 Search DIHYDROFOLIC+ACID Search DIHYDROFOLIC+ACID
8 DIHYDROPTEROIC ACID 391481 1% 100% 2 Search DIHYDROPTEROIC+ACID Search DIHYDROPTEROIC+ACID
9 TETRAHYDROFOLATE BIOSYNTHESIS 391481 1% 100% 2 Search TETRAHYDROFOLATE+BIOSYNTHESIS Search TETRAHYDROFOLATE+BIOSYNTHESIS
10 HYDROXYMETHYLDIHYDROPTERIN PYROPHOSPHOKINASE 260986 1% 67% 2 Search HYDROXYMETHYLDIHYDROPTERIN+PYROPHOSPHOKINASE Search HYDROXYMETHYLDIHYDROPTERIN+PYROPHOSPHOKINASE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 SHAW, GX , LI, Y , SHI, GB , WU, Y , CHERRY, S , NEEDLE, D , ZHANG, D , TROPEA, JE , WAUGH, DS , YAN, HG , ET AL (2014) STRUCTURAL ENZYMOLOGY AND INHIBITION OF THE BI-FUNCTIONAL FOLATE PATHWAY ENZYME HPPK-DHPS FROM THE BIOWARFARE AGENT FRANCISELLA TULARENSIS.FEBS JOURNAL. VOL. 281. ISSUE 18. P. 4123 -4137 31 70% 2
2 DERRICK, JR , (2008) THE STRUCTURE AND MECHANISM OF 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE.FOLIC ACID AND FOLATES. VOL. 79. ISSUE . P. 411-+ 32 63% 10
3 YUN, MK , HOAGLAND, D , KUMAR, G , WADDELL, MB , ROCK, CO , LEE, RE , WHITE, SW , (2014) THE IDENTIFICATION, ANALYSIS AND STRUCTURE-BASED DEVELOPMENT OF NOVEL INHIBITORS OF 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE.BIOORGANIC & MEDICINAL CHEMISTRY. VOL. 22. ISSUE 7. P. 2157 -2165 25 69% 2
4 YAN, HG , JI, XH , (2011) ROLE OF PROTEIN CONFORMATIONAL DYNAMICS IN THE CATALYSIS BY 6-HYDROXYMETHYL-7, 8-DIHYDROPTERIN PYROPHOSPHOKINASE.PROTEIN AND PEPTIDE LETTERS. VOL. 18. ISSUE 4. P. 328-335 20 87% 3
5 DENNIS, ML , PITCHER, NP , LEE, MD , DEBONO, AJ , WANG, ZC , HARJANI, JR , RAHMANI, R , CLEARY, B , PEAT, TS , BAELL, JB , ET AL (2016) STRUCTURAL BASIS FOR THE SELECTIVE BINDING OF INHIBITORS TO 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE FROM STAPHYLOCOCCUS AUREUS AND ESCHERICHIA COLI.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 59. ISSUE 11. P. 5248 -5263 30 48% 0
6 GARCON, A , LEVY, C , DERRICK, JP , (2006) CRYSTAL STRUCTURE OF THE BIFUNCTIONAL DIHYDRONEOPTERIN ALDOLASE/6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE FROM STREPTOCOCCUS PNEUMONIAE.JOURNAL OF MOLECULAR BIOLOGY. VOL. 360. ISSUE 3. P. 644 -653 25 66% 16
7 SHI, GB , SHAW, G , LI, Y , WU, Y , YAN, HG , JI, XH , (2012) BISUBSTRATE ANALOG INHIBITORS OF 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE: NEW LEAD EXHIBITS A DISTINCT BINDING MODE.BIOORGANIC & MEDICINAL CHEMISTRY. VOL. 20. ISSUE 14. P. 4303-4309 19 73% 6
8 DENNIS, ML , CHHABRA, S , WANG, ZC , DEBONO, A , DOLEZAL, O , NEWMAN, J , PITCHER, NP , RAHMANI, R , CLEARY, B , BARLOW, N , ET AL (2014) STRUCTURE-BASED DESIGN AND DEVELOPMENT OF FUNCTIONALIZED MERCAPTOGUANINE DERIVATIVES AS INHIBITORS OF THE FOLATE BIOSYNTHESIS PATHWAY ENZYME 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE FROM STAPHYLOCOCCUS AUREUS.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 57. ISSUE 22. P. 9612 -9626 25 52% 1
9 CHHABRA, S , BARLOW, N , DOLEZAL, O , HATTARKI, MK , NEWMAN, J , PEAT, TS , GRAHAM, B , SWARBRICK, JD , (2013) EXPLORING THE CHEMICAL SPACE AROUND 8-MERCAPTOGUANINE AS A ROUTE TO NEW INHIBITORS OF THE FOLATE BIOSYNTHESIS ENZYME HPPK.PLOS ONE. VOL. 8. ISSUE 4. P. - 20 63% 2
10 SHI, GB , SHAW, G , LIANG, YH , SUBBURAMAN, P , LI, Y , WU, Y , YAN, HG , JI, XH , (2012) BISUBSTRATE ANALOGUE INHIBITORS OF 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE: NEW DESIGN WITH IMPROVED PROPERTIES.BIOORGANIC & MEDICINAL CHEMISTRY. VOL. 20. ISSUE 1. P. 47 -57 19 58% 5

Classes with closest relation at Level 1


Rank Class id link
1 8575 DIHYDROFOLATE REDUCTASE//DHFR//10065 BARNES CANYON RD
2 17979 SPHEROIDAL GRANULE//AFRICAN RESISTANCE SURVEY//ANTI MICROBIAL RESISTANCE SURVEILLANCE
3 454 PNEUMOCYSTIS CARINII//PNEUMOCYSTIS JIROVECII//PNEUMOCYSTIS PNEUMONIA
4 24309 HISTIDASE//HISTIDINEMIA//HUTP
5 8151 FOLATE//FOLIC ACID//FOOD FOLATE
6 196 PLASMODIUM FALCIPARUM//PFCRT//PFMDR1
7 37689 LIRIOPE PLATYPHYLLA//NCI H716//WELLBEING PROD
8 34695 ANTIBIOTIC RESISTANT LACTIC ACID BACTERIA//MENINGOCIN//ANAEROBIOSIS BACTEROIDES FRAGILIS BACTERIOCIN
9 1814 ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY//MACROMOLECULAR CRYSTALLOGRAPHY//ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY
10 30031 CIENCIAS EXACTASCCT LA PLATACONICET//6 FORMYLPTERIN//QUIMCCT LA PLATA CONICET

Go to start page