Class information for:
Level 1: NIEMANN PICK DISEASE TYPE C//NIEMANN PICK TYPE C//NIEMANN PICK DISEASE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
6069 1536 39.5 76%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
551 3       FABRY DISEASE//GAUCHER DISEASE//LYSOSOMAL STORAGE DISEASE 18099
491 2             GAUCHER DISEASE//LYSOSOMAL STORAGE DISEASE//MUCOPOLYSACCHARIDOSIS 15457
6069 1                   NIEMANN PICK DISEASE TYPE C//NIEMANN PICK TYPE C//NIEMANN PICK DISEASE 1536

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 NIEMANN PICK DISEASE TYPE C authKW 1698953 7% 85% 100
2 NIEMANN PICK TYPE C authKW 1311516 5% 82% 80
3 NIEMANN PICK DISEASE authKW 1233174 7% 60% 103
4 NIEMANN PICK TYPE C DISEASE authKW 912842 4% 71% 65
5 NPC1 authKW 866137 4% 68% 64
6 NIEMANN PICK C authKW 647922 2% 88% 37
7 NIEMANN PICK authKW 442484 2% 70% 32
8 NPC2 authKW 399585 2% 72% 28
9 MIGLUSTAT authKW 341672 2% 45% 38
10 NPC1 GENE authKW 278293 1% 100% 14

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Biochemistry & Molecular Biology 2491 35% 0% 544
2 Genetics & Heredity 2291 17% 0% 262
3 Medicine, Research & Experimental 1183 11% 0% 174
4 Pathology 650 6% 0% 99
5 Clinical Neurology 640 10% 0% 158
6 Cell Biology 624 12% 0% 186
7 Endocrinology & Metabolism 564 9% 0% 131
8 Neurosciences 467 13% 0% 192
9 Pediatrics 448 7% 0% 105
10 Biophysics 402 7% 0% 106

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 FDN GILLET MERIEUX 192395 1% 44% 22
2 GILLET MERIEUX 146372 1% 82% 9
3 DIABET CARDIOVASC DIS 131411 1% 29% 23
4 REG COORDINATOR RARE DIS 84174 1% 35% 12
5 SECT LIPID CELL BIOL 82824 0% 83% 5
6 LIPID CELL BIOL SECT 81163 0% 58% 7
7 FONDAT GILLET MERIEUX 79512 0% 100% 4
8 CARDIOVASC DIS ANTISENSE DRUG DISCOVERY 63608 0% 80% 4
9 CELLULAR MOL PATHOPHYSIOL SECT 63608 0% 80% 4
10 ANGEL CHAR CHILDREN WINGS GENET 62115 0% 63% 5

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF INHERITED METABOLIC DISEASE 14201 4% 1% 57
2 MOLECULAR GENETICS AND METABOLISM 12276 3% 1% 44
3 JOURNAL OF LIPID RESEARCH 12028 5% 1% 72
4 ORPHANET JOURNAL OF RARE DISEASES 7856 1% 2% 21
5 BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 3233 1% 1% 21
6 JOURNAL OF BIOLOGICAL CHEMISTRY 1467 7% 0% 111
7 TRAFFIC 1233 1% 1% 11
8 HUMAN MOLECULAR GENETICS 1039 1% 0% 23
9 BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1010 1% 0% 13
10 JOURNAL OF APPLIED GENETICS 1000 0% 1% 6

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 NIEMANN PICK DISEASE TYPE C 1698953 7% 85% 100 Search NIEMANN+PICK+DISEASE+TYPE+C Search NIEMANN+PICK+DISEASE+TYPE+C
2 NIEMANN PICK TYPE C 1311516 5% 82% 80 Search NIEMANN+PICK+TYPE+C Search NIEMANN+PICK+TYPE+C
3 NIEMANN PICK DISEASE 1233174 7% 60% 103 Search NIEMANN+PICK+DISEASE Search NIEMANN+PICK+DISEASE
4 NIEMANN PICK TYPE C DISEASE 912842 4% 71% 65 Search NIEMANN+PICK+TYPE+C+DISEASE Search NIEMANN+PICK+TYPE+C+DISEASE
5 NPC1 866137 4% 68% 64 Search NPC1 Search NPC1
6 NIEMANN PICK C 647922 2% 88% 37 Search NIEMANN+PICK+C Search NIEMANN+PICK+C
7 NIEMANN PICK 442484 2% 70% 32 Search NIEMANN+PICK Search NIEMANN+PICK
8 NPC2 399585 2% 72% 28 Search NPC2 Search NPC2
9 MIGLUSTAT 341672 2% 45% 38 Search MIGLUSTAT Search MIGLUSTAT
10 NPC1 GENE 278293 1% 100% 14 Search NPC1+GENE Search NPC1+GENE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 VANIER, MT , (2010) NIEMANN-PICK DISEASE TYPE C.ORPHANET JOURNAL OF RARE DISEASES. VOL. 5. ISSUE . P. - 113 96% 233
2 VANCE, JE , KARTEN, B , (2014) NIEMANN-PICK C DISEASE AND MOBILIZATION OF LYSOSOMAL CHOLESTEROL BY CYCLODEXTRIN.JOURNAL OF LIPID RESEARCH. VOL. 55. ISSUE 8. P. 1609 -1621 145 80% 37
3 PATTERSON, MC , HENDRIKSZ, CJ , WALTERFANG, M , SEDEL, F , VANIER, MT , WIJBURG, F , (2012) RECOMMENDATIONS FOR THE DIAGNOSIS AND MANAGEMENT OF NIEMANN-PICK DISEASE TYPE C: AN UPDATE.MOLECULAR GENETICS AND METABOLISM. VOL. 106. ISSUE 3. P. 330 -344 104 78% 103
4 VANIER, MT , (2015) COMPLEX LIPID TRAFFICKING IN NIEMANN-PICK DISEASE TYPE C.JOURNAL OF INHERITED METABOLIC DISEASE. VOL. 38. ISSUE 1. P. 187 -199 77 89% 32
5 VANIER, MT , MILLAT, G , (2003) NIEMANN-PICK DISEASE TYPE C.CLINICAL GENETICS. VOL. 64. ISSUE 4. P. 269-281 91 94% 283
6 PEAKE, KB , VANCE, JE , (2010) DEFECTIVE CHOLESTEROL TRAFFICKING IN NIEMANN-PICK C-DEFICIENT CELLS.FEBS LETTERS. VOL. 584. ISSUE 13. P. 2731 -2739 99 86% 44
7 KARTEN, B , PEAKE, KB , VANCE, JE , (2009) MECHANISMS AND CONSEQUENCES OF IMPAIRED LIPID TRAFFICKING IN NIEMANN-PICK TYPE C1-DEFICIENT MAMMALIAN CELLS.BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS. VOL. 1791. ISSUE 7. P. 659 -670 135 63% 59
8 TANG, Y , LI, H , LIU, JP , (2010) NIEMANN-PICK DISEASE TYPE C: FROM MOLECULE TO CLINIC.CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY. VOL. 37. ISSUE 1. P. 132 -140 80 96% 14
9 LIU, B , (2012) THERAPEUTIC POTENTIAL OF CYCLODEXTRINS IN THE TREATMENT OF NIEMANN-PICK TYPE C DISEASE.CLINICAL LIPIDOLOGY. VOL. 7. ISSUE 3. P. 289 -301 79 83% 13
10 VANIER, MT , GISSEN, P , BAUER, P , COLL, MJ , BURLINA, A , HENDRIKSZ, CJ , LATOUR, P , GOIZET, C , WELFORD, RWD , MARQUARDT, T , ET AL (2016) DIAGNOSTIC TESTS FOR NIEMANN-PICK DISEASE TYPE C (NP-C): A CRITICAL REVIEW.MOLECULAR GENETICS AND METABOLISM. VOL. 118. ISSUE 4. P. 244 -254 74 70% 3

Classes with closest relation at Level 1


Rank Class id link
1 20907 OXYSTEROL BINDING PROTEIN//MEMBRANE CONTACT SITES//OSBP
2 23712 MUCOLIPIDOSIS TYPE IV//MUCOLIPIN//MUCOLIPIDOSIS IV
3 17857 PROSAPOSIN//SPHINGOLIPID ACTIVATOR PROTEINS//SAPOSIN
4 19487 LYSOSOMAL ACID LIPASE//CHOLESTERYL ESTER STORAGE DISEASE//WOLMAN DISEASE
5 6474 24S HYDROXYCHOLESTEROL//CYP46//CYP46A1
6 16805 PHOSPHOLIPIDOSIS//CATIONIC AMPHIPHILIC DRUGS//DRUG INDUCED PHOSPHOLIPIDOSIS
7 21054 ALPHA MANNOSIDOSIS//BETA MANNOSIDOSIS//MANNOSIDOSIS
8 1959 GAUCHER DISEASE//GLUCOCEREBROSIDASE//GAUCHER CLIN
9 381 CERAMIDE//SPHINGOLIPIDS//SPHINGOMYELINASE
10 12318 ACAT INHIBITOR//ACYL COA CHOLESTEROL ACYLTRANSFERASE//ACAT

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