Class information for:
Level 1: GAUCHER DISEASE//GLUCOCEREBROSIDASE//GAUCHER CLIN

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
1959 2406 34.2 73%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
551 3       FABRY DISEASE//GAUCHER DISEASE//LYSOSOMAL STORAGE DISEASE 18099
491 2             GAUCHER DISEASE//LYSOSOMAL STORAGE DISEASE//MUCOPOLYSACCHARIDOSIS 15457
1959 1                   GAUCHER DISEASE//GLUCOCEREBROSIDASE//GAUCHER CLIN 2406

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 GAUCHER DISEASE authKW 8645048 35% 80% 847
2 GLUCOCEREBROSIDASE authKW 2521977 10% 84% 238
3 GAUCHER CLIN address 1307587 5% 79% 130
4 IMIGLUCERASE authKW 537014 2% 92% 46
5 ENZYME REPLACEMENT THERAPY authKW 457050 8% 20% 181
6 SECT MOL NEUROGENET address 404149 2% 56% 57
7 ALGLUCERASE authKW 279170 1% 100% 22
8 GBA authKW 242854 1% 55% 35
9 BETA GLUCOCEREBROSIDASE authKW 231249 1% 68% 27
10 VELAGLUCERASE ALFA authKW 216388 1% 95% 18

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Genetics & Heredity 5769 21% 0% 510
2 Hematology 4088 13% 0% 317
3 Medicine, Research & Experimental 2198 12% 0% 294
4 Endocrinology & Metabolism 1009 9% 0% 217
5 Pediatrics 759 7% 0% 170
6 Clinical Neurology 678 9% 0% 211
7 Medicine, General & Internal 677 9% 0% 224
8 Biochemistry & Molecular Biology 567 17% 0% 407
9 Medical Laboratory Technology 393 2% 0% 57
10 Pathology 242 4% 0% 85

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 GAUCHER CLIN 1307587 5% 79% 130
2 SECT MOL NEUROGENET 404149 2% 56% 57
3 MED GENET BRANCH 97834 3% 11% 71
4 DEV METAB NEUROL BRANCH 96454 2% 19% 41
5 ENZYMOL CELLULAR FUNCT 66275 1% 33% 16
6 LYSOSOMAL STORAGE DISORDERS UNIT 53596 1% 33% 13
7 GAUCHER DIS TREATMENT 50758 0% 100% 4
8 DIAGNOST GENET BIOCHIM MALATTIE METAB 45109 0% 44% 8
9 LYSOSOMAL DISORDERS TREATMENT PROGRAM 38069 0% 100% 3
10 NW ONCOL HEMATOL ASSOCIATES PA 38069 0% 100% 3

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BLOOD CELLS MOLECULES AND DISEASES 115266 5% 7% 127
2 JOURNAL OF INHERITED METABOLIC DISEASE 29061 4% 2% 102
3 MOLECULAR GENETICS AND METABOLISM 23397 3% 2% 76
4 BAILLIERES CLINICAL HAEMATOLOGY 6048 0% 4% 12
5 ORPHANET JOURNAL OF RARE DISEASES 4090 1% 2% 19
6 AMERICAN JOURNAL OF HEMATOLOGY 2865 2% 1% 37
7 CLINICAL GENETICS 2193 1% 1% 30
8 HUMAN MUTATION 1800 1% 1% 24
9 MOVEMENT DISORDERS 1701 1% 0% 30
10 AMERICAN JOURNAL OF HUMAN GENETICS 1664 1% 0% 33

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 GAUCHER DISEASE 8645048 35% 80% 847 Search GAUCHER+DISEASE Search GAUCHER+DISEASE
2 GLUCOCEREBROSIDASE 2521977 10% 84% 238 Search GLUCOCEREBROSIDASE Search GLUCOCEREBROSIDASE
3 IMIGLUCERASE 537014 2% 92% 46 Search IMIGLUCERASE Search IMIGLUCERASE
4 ENZYME REPLACEMENT THERAPY 457050 8% 20% 181 Search ENZYME+REPLACEMENT+THERAPY Search ENZYME+REPLACEMENT+THERAPY
5 ALGLUCERASE 279170 1% 100% 22 Search ALGLUCERASE Search ALGLUCERASE
6 GBA 242854 1% 55% 35 Search GBA Search GBA
7 BETA GLUCOCEREBROSIDASE 231249 1% 68% 27 Search BETA+GLUCOCEREBROSIDASE Search BETA+GLUCOCEREBROSIDASE
8 VELAGLUCERASE ALFA 216388 1% 95% 18 Search VELAGLUCERASE+ALFA Search VELAGLUCERASE+ALFA
9 TYPE 1 GAUCHER DISEASE 203736 1% 94% 17 Search TYPE+1+GAUCHER+DISEASE Search TYPE+1+GAUCHER+DISEASE
10 GAUCHER 182710 1% 60% 24 Search GAUCHER Search GAUCHER

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 HRUSKA, KS , LAMARCA, ME , SCOTT, CR , SIDRANSKY, E , (2008) GAUCHER DISEASE: MUTATION AND POLYMORPHISM SPECTRUM IN THE GLUCOCEREBROSIDASE GENE (GBA).HUMAN MUTATION. VOL. 29. ISSUE 5. P. 567-583 146 94% 160
2 MIGDALSKA-RICHARDS, A , SCHAPIRA, AHV , (2016) THE RELATIONSHIP BETWEEN GLUCOCEREBROSIDASE MUTATIONS AND PARKINSON DISEASE.JOURNAL OF NEUROCHEMISTRY. VOL. 139. ISSUE . P. 77 -90 91 82% 4
3 HOROWITZ, M , ELSTEIN, D , ZIMRAN, A , GOKER-ALPAN, O , (2016) NEW DIRECTIONS IN GAUCHER DISEASE.HUMAN MUTATION. VOL. 37. ISSUE 11. P. 1121 -1136 150 64% 0
4 MISTRY, PK , LOPEZ, G , SCHIFFMANN, R , BARTON, NW , WEINREB, NJ , SIDRANSKY, E , (2017) GAUCHER DISEASE: PROGRESS AND ONGOING CHALLENGES.MOLECULAR GENETICS AND METABOLISM. VOL. 120. ISSUE 1-2. P. 8 -21 107 85% 0
5 GOKER-ALPAN, O , (2011) THERAPEUTIC APPROACHES TO BONE PATHOLOGY IN GAUCHER DISEASE: PAST, PRESENT AND FUTURE.MOLECULAR GENETICS AND METABOLISM. VOL. 104. ISSUE 4. P. 438 -447 98 94% 19
6 DEEGAN, PB , COX, TM , (2012) IMIGLUCERASE IN THE TREATMENT OF GAUCHER DISEASE: A HISTORY AND PERSPECTIVE.DRUG DESIGN DEVELOPMENT AND THERAPY. VOL. 6. ISSUE . P. - 110 84% 1
7 SIEBERT, M , SIDRANSKY, E , WESTBROEK, W , (2014) GLUCOCEREBROSIDASE IS SHAKING UP THE SYNUCLEINOPATHIES.BRAIN. VOL. 137. ISSUE . P. 1304 -1322 110 56% 42
8 MARCUCCI, G , ZIMRAN, A , BEMBI, B , KANIS, J , REGINSTER, JY , RIZZOLI, R , COOPER, C , BRANDI, ML , (2014) GAUCHER DISEASE AND BONE MANIFESTATIONS.CALCIFIED TISSUE INTERNATIONAL. VOL. 95. ISSUE 6. P. 477 -494 83 95% 4
9 COX, TM , AERTS, JMFG , BELMATOUG, N , CAPPELLINI, MD , VOM DAHL, S , GOLDBLATT, J , GRABOWSKI, GA , HOLLAK, CEM , HWU, P , MAAS, M , ET AL (2008) MANAGEMENT OF NON-NEURONOPATHIC GAUCHER DISEASE WITH SPECIAL REFERENCE TO PREGNANCY, SPLENECTOMY, BISPHOSPHONATE THERAPY, USE OF BIOMARKERS AND BONE DISEASE MONITORING.JOURNAL OF INHERITED METABOLIC DISEASE. VOL. 31. ISSUE 3. P. 319 -336 102 81% 60
10 CONNOCK, M , BURLS, A , FREW, E , FRY-SMITH, A , JUAREZ-GARCIA, A , MCCABE, C , WAILOO, A , ABRAMS, K , COOPER, N , SUTTON, A , ET AL (2006) THE CLINICAL EFFECTIVENESS AND COST-EFFECTIVENESS OF ENZYME REPLACEMENT THERAPY FOR GAUCHER'S DISEASE: A SYSTEMATIC REVIEW.HEALTH TECHNOLOGY ASSESSMENT. VOL. 10. ISSUE 24. P. 1 -+ 106 88% 32

Classes with closest relation at Level 1


Rank Class id link
1 17857 PROSAPOSIN//SPHINGOLIPID ACTIVATOR PROTEINS//SAPOSIN
2 12163 SANDHOFF DISEASE//GM2 GANGLIOSIDOSIS//TAY SACHS DISEASE
3 12040 YKL 40//CHITOTRIOSIDASE//CHI3L1
4 16795 KRABBE DISEASE//GLOBOID CELL LEUKODYSTROPHY//PSYCHOSINE
5 1052 MUCOPOLYSACCHARIDOSIS//MUCOPOLYSACCHARIDOSES//HUNTER SYNDROME
6 6069 NIEMANN PICK DISEASE TYPE C//NIEMANN PICK TYPE C//NIEMANN PICK DISEASE
7 4302 FABRY DISEASE//ALPHA GALACTOSIDASE A//ANDERSON FABRY DISEASE
8 35671 CANDU//FUNCTIONAL UNITS OF PROTEINS//HOP PURPAN MED BIOCHIM MED
9 6773 LRRK2//LEUCINE RICH REPEAT KINASE 2//LEUCINE RICH REPEAT KINASE 2 LRRK2
10 1091 IMINOSUGARS//AZASUGARS//GLYCOSIDASE INHIBITORS

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