Class information for:
Level 1: PHOSPHOLIPIDOSIS//CATIONIC AMPHIPHILIC DRUGS//DRUG INDUCED PHOSPHOLIPIDOSIS

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
16805 635 37.0 54%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
537 3       BIOARTIFICIAL LIVER//HEPATOCYTES//HEPATOCYTE TRANSPLANTATION 19236
908 2             BIOARTIFICIAL LIVER//HEPATOCYTES//HEPATOCYTE TRANSPLANTATION 11255
16805 1                   PHOSPHOLIPIDOSIS//CATIONIC AMPHIPHILIC DRUGS//DRUG INDUCED PHOSPHOLIPIDOSIS 635

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PHOSPHOLIPIDOSIS authKW 2317840 12% 63% 77
2 CATIONIC AMPHIPHILIC DRUGS authKW 876710 4% 65% 28
3 DRUG INDUCED PHOSPHOLIPIDOSIS authKW 769375 3% 100% 16
4 DICATIONIC AMPHIPHILIC DRUGS authKW 240430 1% 100% 5
5 TILORONE authKW 176300 2% 33% 11
6 LYSOSOMAL TRAPPING authKW 171733 1% 71% 5
7 BISMONOACYLGLYCEROPHOSPHATE authKW 170963 1% 44% 8
8 GLYCOSAMINOGLYCANS SULFATED authKW 144258 0% 100% 3
9 LIPIDTOX authKW 144258 0% 100% 3
10 DRUG INDUCED STEATOHEPATITIS authKW 108192 0% 75% 3

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Toxicology 4636 26% 0% 164
2 Pharmacology & Pharmacy 1641 31% 0% 196
3 Biochemistry & Molecular Biology 592 28% 0% 179
4 Pathology 519 9% 0% 55
5 Biophysics 349 9% 0% 60
6 Chemistry, Medicinal 134 5% 0% 32
7 Biochemical Research Methods 62 4% 0% 27
8 Cell Biology 57 7% 0% 44
9 Medicine, Research & Experimental 38 4% 0% 26
10 Chemistry, Analytical 16 4% 0% 24

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PS ADM 96172 0% 100% 2
2 BIOTECHNOL BIOENGN UNIT 64113 0% 67% 2
3 A 110 48086 0% 100% 1
4 ANALYT SCI STEVENAGE 48086 0% 100% 1
5 BIO MOL S 48086 0% 100% 1
6 CELLECTIS AB CELLARTIS AB 48086 0% 100% 1
7 CIBEREHDFIS 48086 0% 100% 1
8 CLIN SAFETY LICENSING EARLY DEV 48086 0% 100% 1
9 CLUSTER BIOASSAYS TOXICOL 48086 0% 100% 1
10 DIS DEV WORLD DDW 48086 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE 6006 2% 1% 10
2 TOXICOLOGY IN VITRO 5355 3% 1% 22
3 TOXICOLOGY AND APPLIED PHARMACOLOGY 3808 4% 0% 28
4 TOXICOLOGIC PATHOLOGY 2706 2% 0% 12
5 EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY 2106 1% 0% 9
6 BIOCHEMICAL PHARMACOLOGY 1725 4% 0% 26
7 EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY 1379 1% 0% 6
8 TOXICOLOGY 1331 2% 0% 14
9 BIOCHIMICA ET BIOPHYSICA ACTA 1276 4% 0% 28
10 JOURNAL OF LIPID RESEARCH 1248 2% 0% 15

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 PHOSPHOLIPIDOSIS 2317840 12% 63% 77 Search PHOSPHOLIPIDOSIS Search PHOSPHOLIPIDOSIS
2 CATIONIC AMPHIPHILIC DRUGS 876710 4% 65% 28 Search CATIONIC+AMPHIPHILIC+DRUGS Search CATIONIC+AMPHIPHILIC+DRUGS
3 DRUG INDUCED PHOSPHOLIPIDOSIS 769375 3% 100% 16 Search DRUG+INDUCED+PHOSPHOLIPIDOSIS Search DRUG+INDUCED+PHOSPHOLIPIDOSIS
4 DICATIONIC AMPHIPHILIC DRUGS 240430 1% 100% 5 Search DICATIONIC+AMPHIPHILIC+DRUGS Search DICATIONIC+AMPHIPHILIC+DRUGS
5 TILORONE 176300 2% 33% 11 Search TILORONE Search TILORONE
6 LYSOSOMAL TRAPPING 171733 1% 71% 5 Search LYSOSOMAL+TRAPPING Search LYSOSOMAL+TRAPPING
7 BISMONOACYLGLYCEROPHOSPHATE 170963 1% 44% 8 Search BISMONOACYLGLYCEROPHOSPHATE Search BISMONOACYLGLYCEROPHOSPHATE
8 GLYCOSAMINOGLYCANS SULFATED 144258 0% 100% 3 Search GLYCOSAMINOGLYCANS+SULFATED Search GLYCOSAMINOGLYCANS+SULFATED
9 LIPIDTOX 144258 0% 100% 3 Search LIPIDTOX Search LIPIDTOX
10 DRUG INDUCED STEATOHEPATITIS 108192 0% 75% 3 Search DRUG+INDUCED+STEATOHEPATITIS Search DRUG+INDUCED+STEATOHEPATITIS

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 SHAYMAN, JA , ABE, A , (2013) DRUG INDUCED PHOSPHOLIPIDOSIS: AN ACQUIRED LYSOSOMAL STORAGE DISORDER.BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS. VOL. 1831. ISSUE 3. P. 602-611 42 64% 19
2 PRZYBYLAK, KR , ALZAHRANI, AR , CRONIN, MTD , (2014) HOW DOES THE QUALITY OF PHOSPHOLIPIDOSIS DATA INFLUENCE THE PREDICTIVITY OF STRUCTURAL ALERTS?.JOURNAL OF CHEMICAL INFORMATION AND MODELING. VOL. 54. ISSUE 8. P. 2224 -2232 34 79% 2
3 MUEHLBACHER, M , TRIPAL, P , ROAS, F , KORNHUBER, J , (2012) IDENTIFICATION OF DRUGS INDUCING PHOSPHOLIPIDOSIS BY NOVEL IN VITRO DATA.CHEMMEDCHEM. VOL. 7. ISSUE 11. P. 1925 -1934 49 56% 6
4 VAN DE WATER, FM , HAVINGA, J , RAVESLOOT, WT , HORBACH, GJMJ , SCHOONEN, WGEJ , (2011) HIGH CONTENT SCREENING ANALYSIS OF PHOSPHOLIPIDOSIS: VALIDATION OF A 96-WELL ASSAY WITH CHO-K1 AND HEPG2 CELLS FOR THE PREDICTION OF IN VIVO BASED PHOSPHOLIPIDOSIS.TOXICOLOGY IN VITRO. VOL. 25. ISSUE 8. P. 1870-1882 41 61% 14
5 GORACCI, L , BURATTA, S , URBANELLI, L , FERRARA, G , DI GUIDA, R , EMILIANI, C , CROSS, S , (2015) EVALUATING THE RISK OF PHOSPHOLIPIDOSIS USING A NEW MULTIDISCIPLINARY PIPELINE APPROACH.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. VOL. 92. ISSUE . P. 49 -63 30 70% 8
6 MONTEITH, DK , MORGAN, RE , HALSTEAD, B , (2006) IN VITRO ASSAYS AND BIOMARKERS FOR DRUG-INDUCED PHOSPHOLIPIDOSIS.EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY. VOL. 2. ISSUE 5. P. 687-696 33 75% 27
7 NONOYAMA, T , FUKUDA, R , (2008) DRUG-INDUCED PHOSPHOLIPIDOSIS-PATHOLOGICAL ASPECTS AND ITS PREDICTION.JOURNAL OF TOXICOLOGIC PATHOLOGY. VOL. 21. ISSUE 1. P. 9 -24 40 56% 39
8 REASOR, MJ , HASTINGS, KL , ULRICH, RG , (2006) DRUG-INDUCED PHOSPHOLIPIDOSIS: ISSUES AND FUTURE DIRECTIONS.EXPERT OPINION ON DRUG SAFETY. VOL. 5. ISSUE 4. P. 567-583 42 46% 115
9 RUBEN, Z , RORIG, KJ , KACEW, S , (1993) PERSPECTIVES ON INTRACELLULAR STORAGE AND TRANSPORT OF CATIONIC-LIPOPHILIC DRUGS.PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE. VOL. 203. ISSUE 2. P. 140-149 49 72% 6
10 TAKAGI, M , SANOH, S , SANTOH, M , EJIRI, Y , KOTAKE, Y , OHTA, S , (2016) DETECTION OF METABOLIC ACTIVATION LEADING TO DRUG-INDUCED PHOSPHOLIPIDOSIS IN RAT HEPATOCYTE SPHEROIDS.JOURNAL OF TOXICOLOGICAL SCIENCES. VOL. 41. ISSUE 1. P. 155 -164 23 77% 0

Classes with closest relation at Level 1


Rank Class id link
1 28818 HEPARG CELLS//HEPARG//NEOHEPATOCYTES
2 37065 FIT MUTATIONS//SPECTINAMIDE//TROSPECTOMYCIN
3 3886 AMIODARONE//DESETHYLAMIODARONE//INTRAVENOUS AMIODARONE
4 26055 EXTRACELLULAR AND INTRACELLULAR CHEMILUMINESCENCE//DITHIADEN//THROMBOXANE B 2 FORMATION
5 7614 GENTAMICIN//NEPHROTOXICITY//GENTAMICIN INDUCED NEPHROTOXICITY
6 16038 LUNG METABOLIC FUNCTION//LUNG DRUG UPTAKE//PULMONARY CAPILLARY ENDOTHELIUM
7 6069 NIEMANN PICK DISEASE TYPE C//NIEMANN PICK TYPE C//NIEMANN PICK DISEASE
8 17857 PROSAPOSIN//SPHINGOLIPID ACTIVATOR PROTEINS//SAPOSIN
9 29519 EXTRACELLULAR FLUX//COMPOUND SAFETY PREDICT//UAB MITOCHONDRIAL MED
10 36204 STIMULATOR PROTEIN//ALPHA2 ADRENERGIC RECEPTOR ACTIVATION//BONE MARROW FACTOR

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