Class information for:
Level 1: SKP2//P27KIP1//P27

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
5545 1608 43.5 93%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
304 3       P53//RETINOBLASTOMA//MDM2 40663
483 2             CYCLIN DEPENDENT KINASE//CELL CYCLE//CDK5 15640
5545 1                   SKP2//P27KIP1//P27 1608

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 SKP2 authKW 1667923 9% 58% 152
2 P27KIP1 authKW 1658156 18% 30% 287
3 P27 authKW 1497843 18% 28% 283
4 CKS1 authKW 321892 2% 63% 27
5 S PHASE KINASE ASSOCIATED PROTEIN 2 authKW 236608 1% 69% 18
6 P57KIP2 authKW 227353 2% 31% 39
7 CKS2 authKW 153801 1% 90% 9
8 CYCLIN DEPENDENT KINASE INHIBITOR authKW 125801 4% 12% 57
9 P27KIP1 GENE authKW 97651 0% 86% 6
10 P27KIP1 PROTEIN authKW 97651 0% 86% 6

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Oncology 8631 38% 0% 618
2 Cell Biology 6009 32% 0% 514
3 Biochemistry & Molecular Biology 1291 27% 0% 427
4 Pathology 1017 8% 0% 124
5 Genetics & Heredity 463 8% 0% 135
6 Developmental Biology 200 3% 0% 42
7 Gastroenterology & Hepatology 157 4% 0% 61
8 Medicine, Research & Experimental 144 5% 0% 76
9 Hematology 105 3% 0% 53
10 Biophysics 30 3% 0% 44

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 TRANSLAT ADV ANIM HUMAN DIS 83109 1% 24% 18
2 PROGRAM MOL BIOL CELL BIOL GENET 42721 0% 75% 3
3 MOL CELLULAR PATHOL THER Y 41555 1% 24% 9
4 BILE DUCT PANCREAT SURG 37976 0% 100% 2
5 MED BIOREGULAT 36810 4% 3% 69
6 EMBRYON GENET ENGN 27450 1% 16% 9
7 GEN SURG EMERGENCY ORGAN TRANSPLANTS 25316 0% 67% 2
8 DEV GENETAOBA KU 24410 0% 43% 3
9 MOL GENET CARDIOVASC PATHOPHYSIOL 21695 0% 29% 4
10 BRAMAN BREAST CANC 21358 0% 38% 3

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY SERIES 11163 3% 1% 54
2 ONCOGENE 6307 5% 0% 78
3 CELL DIVISION 2295 0% 2% 5
4 CLINICAL CANCER RESEARCH 1425 2% 0% 34
5 CANCER RESEARCH 1236 3% 0% 52
6 CELL GROWTH & DIFFERENTIATION 1076 1% 1% 9
7 ONCOLOGY REPORTS 1063 1% 0% 24
8 INTERNATIONAL JOURNAL OF ONCOLOGY 1016 1% 0% 23
9 MOLECULAR AND CELLULAR BIOLOGY 988 2% 0% 35
10 ORAL ONCOLOGY 886 1% 0% 12

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 SKP2 1667923 9% 58% 152 Search SKP2 Search SKP2
2 P27KIP1 1658156 18% 30% 287 Search P27KIP1 Search P27KIP1
3 P27 1497843 18% 28% 283 Search P27 Search P27
4 CKS1 321892 2% 63% 27 Search CKS1 Search CKS1
5 S PHASE KINASE ASSOCIATED PROTEIN 2 236608 1% 69% 18 Search S+PHASE+KINASE+ASSOCIATED+PROTEIN+2 Search S+PHASE+KINASE+ASSOCIATED+PROTEIN+2
6 P57KIP2 227353 2% 31% 39 Search P57KIP2 Search P57KIP2
7 CKS2 153801 1% 90% 9 Search CKS2 Search CKS2
8 CYCLIN DEPENDENT KINASE INHIBITOR 125801 4% 12% 57 Search CYCLIN+DEPENDENT+KINASE+INHIBITOR Search CYCLIN+DEPENDENT+KINASE+INHIBITOR
9 P27KIP1 GENE 97651 0% 86% 6 Search P27KIP1+GENE Search P27KIP1+GENE
10 P27KIP1 PROTEIN 97651 0% 86% 6 Search P27KIP1+PROTEIN Search P27KIP1+PROTEIN

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 CHU, IM , HENGST, L , SLINGERLAND, JM , (2008) THE CDK INHIBITOR P27 IN HUMAN CANCER: PROGNOSTIC POTENTIAL AND RELEVANCE TO ANTICANCER THERAPY.NATURE REVIEWS CANCER. VOL. 8. ISSUE 4. P. 253 -267 127 64% 472
2 HERSHKO, DD , (2010) CYCLIN-DEPENDENT KINASE INHIBITOR P27 AS A PROGNOSTIC BIOMARKER AND POTENTIAL CANCER THERAPEUTIC TARGET.FUTURE ONCOLOGY. VOL. 6. ISSUE 12. P. 1837 -1847 83 85% 11
3 HERSHKO, DD , (2008) ONCOGENIC PROPERTIES AND PROGNOSTIC IMPLICATIONS OF THE UBIQUITIN LIGASE SKP2 IN CANCER.CANCER. VOL. 112. ISSUE 7. P. 1415 -1424 72 86% 88
4 VERVOORTS, J , LUSCHER, B , (2008) POST-TRANSLATIONAL REGULATION OF THE TUMOR SUPPRESSOR P27(KIP1).CELLULAR AND MOLECULAR LIFE SCIENCES. VOL. 65. ISSUE 20. P. 3255 -3264 72 79% 91
5 BELLETTI, B , NICOLOSO, MS , SCHIAPPACASSI, M , CHIMIENTI, E , BERTON, S , LOVAT, F , COLOMBATTI, A , BALDASSARRE, G , (2005) P27(KIP1) FUNCTIONAL REGULATION IN HUMAN CANCER: A POTENTIAL TARGET FOR THERAPEUTIC DESIGNS.CURRENT MEDICINAL CHEMISTRY. VOL. 12. ISSUE 14. P. 1589-1605 120 57% 55
6 SHARMA, SS , PLEDGER, WJ , (2016) THE NON-CANONICAL FUNCTIONS OF P27(KIP1) IN NORMAL AND TUMOR BIOLOGY.CELL CYCLE. VOL. 15. ISSUE 9. P. 1189 -1201 69 66% 2
7 BORRIELLO, A , BENCIVENGA, D , CRISCUOLO, M , CALDARELLI, I , CUCCIOLLA, V , TRAMONTANO, A , BORGIA, A , SPINA, A , OLIVA, A , NAVIGLIO, S , ET AL (2011) TARGETING P27(KIP1) PROTEIN: ITS RELEVANCE IN THE THERAPY OF HUMAN CANCER.EXPERT OPINION ON THERAPEUTIC TARGETS. VOL. 15. ISSUE 6. P. 677 -693 81 65% 33
8 HAO, ZL , HUANG, S , (2015) E3 UBIQUITIN LIGASE SKP2 AS AN ATTRACTIVE TARGET IN CANCER THERAPY.FRONTIERS IN BIOSCIENCE-LANDMARK. VOL. 20. ISSUE . P. 474 -490 76 60% 10
9 ALKARAIN, A , SLINGERLAND, J , (2004) DEREGULATION OF P27 BY ONCOGENIC SIGNALING AND ITS PROGNOSTIC SIGNIFICANCE IN BREAST CANCER.BREAST CANCER RESEARCH. VOL. 6. ISSUE 1. P. 13 -21 90 70% 72
10 KUDO, Y , KITAJIMA, S , OGAWA, I , MIYAUCHI, M , TAKATA, T , (2005) DOWN-REGULATION OF CDK INHIBITOR P27 IN ORAL SQUAMOUS CELL CARCINOMA.ORAL ONCOLOGY. VOL. 41. ISSUE 2. P. 105-116 83 74% 31

Classes with closest relation at Level 1


Rank Class id link
1 9064 P21//P21WAF1 CIP1//P21WAF1
2 19492 FBXW7//FBW7//FBXO7
3 16686 CYCLIN E//CYCLIN A1//CYCLIN B1
4 5472 CYCLIN D1//CCND1//CYCLIN D3
5 9078 NEDD8//COP9 SIGNALOSOME//NEDDYLATION
6 23606 CAK//SPY1//CDK ACTIVATING KINASE
7 4549 P16//CDKN2A//P16INK4A
8 2300 E2F//P107//E2F1
9 7118 FLAVOPIRIDOL//CYCLIN DEPENDENT KINASE//ROSCOVITINE
10 35681 FKBP6//AGGREGATE OF RIBOSOME//AS MUTANT

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