Class information for:
Level 1: FLAVOPIRIDOL//CYCLIN DEPENDENT KINASE//ROSCOVITINE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
7118 1403 49.6 89%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
304 3       P53//RETINOBLASTOMA//MDM2 40663
483 2             CYCLIN DEPENDENT KINASE//CELL CYCLE//CDK5 15640
7118 1                   FLAVOPIRIDOL//CYCLIN DEPENDENT KINASE//ROSCOVITINE 1403

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 FLAVOPIRIDOL authKW 1411787 8% 55% 117
2 CYCLIN DEPENDENT KINASE authKW 534291 12% 15% 168
3 ROSCOVITINE authKW 533080 5% 32% 77
4 PALBOCICLIB authKW 445126 2% 68% 30
5 CELL CYCLE REGULAT GRP address 402166 2% 60% 31
6 CDK INHIBITOR authKW 310803 5% 20% 73
7 DINACICLIB authKW 272028 1% 83% 15
8 CYC202 authKW 236965 1% 78% 14
9 PD 0332991 authKW 198959 1% 57% 16
10 SELICICLIB authKW 195852 1% 60% 15

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Oncology 7258 38% 0% 530
2 Chemistry, Medicinal 5240 19% 0% 260
3 Cell Biology 974 15% 0% 212
4 Pharmacology & Pharmacy 882 17% 0% 235
5 Biochemistry & Molecular Biology 422 18% 0% 258
6 Chemistry, Organic 307 8% 0% 116
7 Hematology 304 5% 0% 74
8 Computer Science, Interdisciplinary Applications 42 2% 0% 30
9 Biophysics 33 3% 0% 41
10 Medicine, Research & Experimental 23 3% 0% 39

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CELL CYCLE REGULAT GRP 402166 2% 60% 31
2 DTP CLIN TRIALS UNIT 133295 0% 88% 7
3 MOL THER EUT UNIT 94032 1% 39% 11
4 GROWTH REGULATORS 74034 3% 8% 42
5 PROT PHOSPHORYLAT HUMAN DIS GRP 58015 1% 22% 12
6 CELL CYCLE REGULAT GRP CANC 48964 0% 75% 3
7 MED 1COMPREHENS CANC 43525 0% 100% 2
8 HOTEL RECH 43521 0% 50% 4
9 BUSINESS UNIT ONCOL 31329 0% 24% 6
10 GASTROINTESTINAL ONCOL SECT 29016 0% 67% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MOLECULAR CANCER THERAPEUTICS 13859 4% 1% 51
2 CLINICAL CANCER RESEARCH 5564 4% 0% 62
3 COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY SERIES 5357 2% 1% 35
4 JOURNAL OF MEDICINAL CHEMISTRY 3817 4% 0% 62
5 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 3455 5% 0% 64
6 INVESTIGATIONAL NEW DRUGS 2156 1% 1% 16
7 EXPERT OPINION ON INVESTIGATIONAL DRUGS 1439 1% 1% 12
8 CANCER CHEMOTHERAPY AND PHARMACOLOGY 1399 2% 0% 22
9 CANCER RESEARCH 1375 4% 0% 51
10 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 1198 2% 0% 23

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 FLAVOPIRIDOL 1411787 8% 55% 117 Search FLAVOPIRIDOL Search FLAVOPIRIDOL
2 CYCLIN DEPENDENT KINASE 534291 12% 15% 168 Search CYCLIN+DEPENDENT+KINASE Search CYCLIN+DEPENDENT+KINASE
3 ROSCOVITINE 533080 5% 32% 77 Search ROSCOVITINE Search ROSCOVITINE
4 PALBOCICLIB 445126 2% 68% 30 Search PALBOCICLIB Search PALBOCICLIB
5 CDK INHIBITOR 310803 5% 20% 73 Search CDK+INHIBITOR Search CDK+INHIBITOR
6 DINACICLIB 272028 1% 83% 15 Search DINACICLIB Search DINACICLIB
7 CYC202 236965 1% 78% 14 Search CYC202 Search CYC202
8 PD 0332991 198959 1% 57% 16 Search PD+0332991 Search PD+0332991
9 SELICICLIB 195852 1% 60% 15 Search SELICICLIB Search SELICICLIB
10 CDK4 6 193565 1% 68% 13 Search CDK4+6 Search CDK4+6

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 CHOHAN, TA , QIAN, HY , PAN, YL , CHEN, JZ , (2015) CYCLIN-DEPENDENT KINASE-2 AS A TARGET FOR CANCER THERAPY: PROGRESS IN THE DEVELOPMENT OF CDK2 INHIBITORS AS ANTI-CANCER AGENTS.CURRENT MEDICINAL CHEMISTRY. VOL. 22. ISSUE 2. P. 237 -263 99 71% 9
2 LI, TH , WENG, TW , ZUO, MZ , WEI, ZH , CHEN, M , LI, ZY , (2016) RECENT PROGRESS OF CYCLIN-DEPENDENT KINASE INHIBITORS AS POTENTIAL ANTICANCER AGENTS.FUTURE MEDICINAL CHEMISTRY. VOL. 8. ISSUE 17. P. 2047 -2076 89 71% 0
3 BOSE, P , SIMMONS, GL , GRANT, S , (2013) CYCLIN-DEPENDENT KINASE INHIBITOR THERAPY FOR HEMATOLOGIC MALIGNANCIES.EXPERT OPINION ON INVESTIGATIONAL DRUGS. VOL. 22. ISSUE 6. P. 723 -738 75 69% 35
4 WANG, LM , REN, DM , (2010) FLAVOPIRIDOL, THE FIRST CYCLIN-DEPENDENT KINASE INHIBITOR: RECENT ADVANCES IN COMBINATION CHEMOTHERAPY.MINI-REVIEWS IN MEDICINAL CHEMISTRY. VOL. 10. ISSUE 11. P. 1058-1070 77 74% 31
5 ASGHAR, U , WITKIEWICZ, AK , TURNER, NC , KNUDSEN, ES , (2015) THE HISTORY AND FUTURE OF TARGETING CYCLIN-DEPENDENT KINASES IN CANCER THERAPY.NATURE REVIEWS DRUG DISCOVERY. VOL. 14. ISSUE 2. P. 130 -146 65 37% 97
6 JORDA, R , PARUCH, K , KRYSTOF, V , (2012) CYCLIN-DEPENDENT KINASE INHIBITORS INSPIRED BY ROSCOVITINE: PURINE BIOISOSTERES.CURRENT PHARMACEUTICAL DESIGN. VOL. 18. ISSUE 20. P. 2974-2980 51 94% 15
7 JAIN, SK , BHARATE, SB , VISHWAKARMA, RA , (2012) CYCLIN-DEPENDENT KINASE INHIBITION BY FLAVOALKALOIDS.MINI-REVIEWS IN MEDICINAL CHEMISTRY. VOL. 12. ISSUE 7. P. 632-649 64 65% 23
8 WESIERSKA-GADEK, J , CHAMRAD, I , KRYSTOF, V , (2009) NOVEL POTENT PHARMACOLOGICAL CYCLIN-DEPENDENT KINASE INHIBITORS.FUTURE MEDICINAL CHEMISTRY. VOL. 1. ISSUE 9. P. 1561-1581 79 62% 3
9 BLACHLY, JS , BYRD, JC , (2013) EMERGING DRUG PROFILE: CYCLIN-DEPENDENT KINASE INHIBITORS.LEUKEMIA & LYMPHOMA. VOL. 54. ISSUE 10. P. 2133 -2143 57 66% 23
10 SANCHEZ-MARTINEZ, C , GELBERT, LM , LALLENA, MJ , DE DIOS, A , (2015) CYCLIN DEPENDENT KINASE (CDK) INHIBITORS AS ANTICANCER DRUGS.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. VOL. 25. ISSUE 17. P. 3420 -3435 42 74% 18

Classes with closest relation at Level 1


Rank Class id link
1 23606 CAK//SPY1//CDK ACTIVATING KINASE
2 37724 CHROMONE ALKALOIDS//ROHITUKINE//DYSOXYLUM BINECTARIFERUM
3 25613 UCN 01//7 HYDROXYSTAUROSPORINE//CGP41251
4 16686 CYCLIN E//CYCLIN A1//CYCLIN B1
5 36779 CDK11P58//PITSLRE//CDK11
6 5472 CYCLIN D1//CCND1//CYCLIN D3
7 11551 CDK5//P35//CYCLIN DEPENDENT KINASE 5
8 35523 APOPTOTIC INDUCTION//IN VIVO ANTIFUNGAL ACTIVITIES//ARALIA CONTINENTALIS
9 5889 P TEFB//CDK9//RNA POLYMERASE II
10 2300 E2F//P107//E2F1

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