Class information for:
Level 3: P53//RETINOBLASTOMA//MDM2

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
304 40663 40.5 84%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
304 3       P53//RETINOBLASTOMA//MDM2 40663
483 2             CYCLIN DEPENDENT KINASE//CELL CYCLE//CDK5 15640
936 2             P53//MDM2//P73 10991
1517 2             UVEAL MELANOMA//OCULAR ONCOL SERV//CHOROIDAL MELANOMA 7502
2606 2             FHIT//WWOX//FRAGILE SITES 3592
2853 2             RETINOBLASTOMA//OPHTHALM ONCOL SERV//CHEMOREDUCTION 2938

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 P53 authKW 505754 9% 19% 3508
2 RETINOBLASTOMA authKW 437095 2% 60% 981
3 MDM2 authKW 329450 2% 52% 841
4 UVEAL MELANOMA authKW 316892 1% 72% 585
5 P73 authKW 243313 1% 72% 453
6 OCULAR ONCOL SERV address 224182 1% 70% 430
7 CELL CYCLE authKW 201548 5% 13% 2173
8 CYCLIN DEPENDENT KINASE authKW 168974 1% 44% 510
9 ONCOLOGY WoSSC 151169 32% 2% 13171
10 P63 authKW 140453 1% 45% 421

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Oncology 151169 32% 2% 13171
2 Ophthalmology 117103 15% 3% 6052
3 Cell Biology 74640 23% 1% 9395
4 Genetics & Heredity 31370 13% 1% 5171
5 Biochemistry & Molecular Biology 24259 24% 1% 9617
6 Pathology 6659 4% 1% 1748
7 Developmental Biology 3718 2% 1% 934
8 Medicine, Research & Experimental 976 3% 0% 1250
9 Hematology 889 2% 0% 928
10 Biophysics 768 3% 0% 1119

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 OCULAR ONCOL SERV 224182 1% 70% 430
2 WILLS EYE HOSP 51602 1% 30% 233
3 OPHTHALMOL 47172 7% 3% 2680
4 OPHTHALM ONCOL SERV 41806 0% 85% 66
5 OCULAR ONCOL 33962 0% 64% 71
6 PATHOL 31382 11% 1% 4645
7 OPHTHALM ONCOL 28590 0% 67% 57
8 WILLS EYE 26326 0% 34% 105
9 ONCOL SERV 23363 0% 23% 138
10 CELL CYCLE REGULAT GRP 17621 0% 67% 35

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 ONCOGENE 123845 4% 10% 1741
2 COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY SERIES 43010 1% 11% 537
3 ARCHIVES OF OPHTHALMOLOGY 28890 1% 7% 574
4 OPHTHALMOLOGY 26239 2% 6% 628
5 CANCER RESEARCH 23765 3% 3% 1153
6 GENES CHROMOSOMES & CANCER 19957 1% 9% 294
7 BRITISH JOURNAL OF OPHTHALMOLOGY 18191 1% 5% 486
8 CANCER GENETICS AND CYTOGENETICS 17107 1% 6% 380
9 MOLECULAR AND CELLULAR BIOLOGY 15442 2% 3% 702
10 AMERICAN JOURNAL OF OPHTHALMOLOGY 13441 1% 4% 442

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class		 LCSH search Wikipedia search
1 P53 505754 9% 19% 3508 Search P53 Search P53
2 RETINOBLASTOMA 437095 2% 60% 981 Search RETINOBLASTOMA Search RETINOBLASTOMA
3 MDM2 329450 2% 52% 841 Search MDM2 Search MDM2
4 UVEAL MELANOMA 316892 1% 72% 585 Search UVEAL+MELANOMA Search UVEAL+MELANOMA
5 P73 243313 1% 72% 453 Search P73 Search P73
6 CELL CYCLE 201548 5% 13% 2173 Search CELL+CYCLE Search CELL+CYCLE
7 CYCLIN DEPENDENT KINASE 168974 1% 44% 510 Search CYCLIN+DEPENDENT+KINASE Search CYCLIN+DEPENDENT+KINASE
8 P63 140453 1% 45% 421 Search P63 Search P63
9 CDK5 120467 1% 58% 279 Search CDK5 Search CDK5
10 E2F 117458 1% 50% 315 Search E2F Search E2F

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 RUAS, M , PETERS, G , (1998) THE P16(INK4A)/CDKN2A TUMOR SUPPRESSOR AND ITS RELATIVES.BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER. VOL. 1378. ISSUE 2. P. F115 -F177 387 73% 528
2 SHERR, CJ , (1996) CANCER CELL CYCLES.SCIENCE. VOL. 274. ISSUE 5293. P. 1672 -1677 149 83% 4122
3 MOLLER, MB , (2003) MOLECULAR CONTROL OF THE CELL CYCLE IN CANCER: BIOLOGICAL AND CLINICAL ASPECTS.DANISH MEDICAL BULLETIN. VOL. 50. ISSUE 2. P. 118-138 407 78% 18
4 KO, LJ , PRIVES, C , (1996) P53: PUZZLE AND PARADIGM.GENES & DEVELOPMENT. VOL. 10. ISSUE 9. P. 1054-1072 183 78% 1985
5 DYSON, N , (1998) THE REGULATION OF E2F BY PRB-FAMILY PROTEINS.GENES & DEVELOPMENT. VOL. 12. ISSUE 15. P. 2245-2262 163 89% 1660
6 FREED-PASTOR, WA , PRIVES, C , (2012) MUTANT P53: ONE NAME, MANY PROTEINS.GENES & DEVELOPMENT. VOL. 26. ISSUE 12. P. 1268 -1286 159 82% 263
7 ASGHAR, U , WITKIEWICZ, AK , TURNER, NC , KNUDSEN, ES , (2015) THE HISTORY AND FUTURE OF TARGETING CYCLIN-DEPENDENT KINASES IN CANCER THERAPY.NATURE REVIEWS DRUG DISCOVERY. VOL. 14. ISSUE 2. P. 130 -146 131 74% 97
8 MULLER, PAJ , VOUSDEN, KH , (2014) MUTANT P53 IN CANCER: NEW FUNCTIONS AND THERAPEUTIC OPPORTUNITIES.CANCER CELL. VOL. 25. ISSUE 3. P. 304-317 124 77% 206
9 KARNI-SCHMIDT, O , LOKSHIN, M , PRIVES, C , (2016) THE ROLES OF MDM2 AND MDMX IN CANCER.ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 11. VOL. 11. ISSUE . P. 617 -644 166 84% 6
10 MEEK, DW , (2015) REGULATION OF THE P53 RESPONSE AND ITS RELATIONSHIP TO CANCER.BIOCHEMICAL JOURNAL. VOL. 469. ISSUE . P. 325 -346 182 66% 45

Classes with closest relation at Level 3


Rank Class id link
1 441 TRAIL//SURVIVIN//APOPTOSIS
2 563 DNA METHYLATION//EPIGENETICS//METHYLATION
3 204 PROTEASOME//UBIQUITIN//UNFOLDED PROTEIN RESPONSE
4 375 MELANOMA//DERMATOLOGY//DERMATOL
5 373 ENDOGENOUS RETROVIRUS//VIROLOGY//JOURNAL OF VIROLOGY
6 419 ADENOVIRUS//MERKEL CELL CARCINOMA//GENE THERAPY
7 365 MICROTUBULES//MITOSIS//KINETOCHORE
8 512 BRCA1//BRCA2//FANCONI ANEMIA
9 142 DNA REPAIR//INTERNATIONAL JOURNAL OF RADIATION BIOLOGY//RADIATION RESEARCH
10 27 DEVELOPMENTAL BIOLOGY//DEVELOPMENT//AGR2

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