Class information for:
Level 1: ENZASTAURIN//LY317615//INTRATUMORAL VESSELS

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
32191 142 39.1 81%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
328 3       PHOSPHOLIPASE D//STIM1//REGUCALCIN 38118
1486 2             PROTEIN KINASE C//BRYOSTATIN//BRYOSTATIN 1 7631
32191 1                   ENZASTAURIN//LY317615//INTRATUMORAL VESSELS 142

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ENZASTAURIN authKW 6519043 34% 63% 48
2 LY317615 authKW 1075195 4% 100% 5
3 INTRATUMORAL VESSELS authKW 774136 4% 60% 6
4 PROTEIN KINASE C BETA PKC BETA authKW 767994 4% 71% 5
5 PROTEIN KINASE C BETA INHIBITOR authKW 387068 2% 60% 3
6 PROTEIN KINASE C BETA authKW 355458 6% 18% 9
7 CAKI1 RENAL CELL CARCINOMA authKW 215039 1% 100% 1
8 CALU 6 NSCLC XENOGRAFT authKW 215039 1% 100% 1
9 CANCBRAIN TUMOR address 215039 1% 100% 1
10 CENTER PL CANC SCI address 215039 1% 100% 1

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Oncology 1892 59% 0% 84
2 Pharmacology & Pharmacy 168 22% 0% 31
3 Hematology 150 11% 0% 15
4 Chemistry, Organic 48 10% 0% 14
5 Chemistry, Medicinal 39 6% 0% 8
6 Respiratory System 28 4% 0% 6
7 Cell Biology 10 6% 0% 9
8 Dermatology 2 1% 0% 2
9 Clinical Neurology 1 3% 0% 4
10 Pathology 1 1% 0% 2

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CANCBRAIN TUMOR 215039 1% 100% 1
2 CENTER PL CANC SCI 215039 1% 100% 1
3 COMPREHENS CANC NV 215039 1% 100% 1
4 CTMOLEUKEMIA STUDY HEMATOL 1 215039 1% 100% 1
5 EARLY PHASE CLIN ONCOL DEV 215039 1% 100% 1
6 INTEGRAT BIOL INFORMAT 215039 1% 100% 1
7 ISREC NCCR MOL ONCOL 215039 1% 100% 1
8 LILLY FOR 215039 1% 100% 1
9 MULTIPLE MYELOMA WALDENSTROMS MACROGLOBULINEMIA P 215039 1% 100% 1
10 NO INDIANA CANC CONSORTIUM 215039 1% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 INVESTIGATIONAL NEW DRUGS 5387 6% 0% 8
2 TRANSLATIONAL ONCOLOGY 1566 1% 0% 2
3 DEVELOPMENTS IN ONCOLOGY 1541 2% 0% 3
4 MOLECULAR CANCER THERAPEUTICS 1316 4% 0% 5
5 CLINICAL LUNG CANCER 1129 1% 0% 2
6 HEMATOLOGICAL ONCOLOGY 1003 1% 0% 2
7 EXPERT OPINION ON INVESTIGATIONAL DRUGS 897 2% 0% 3
8 CANCER CHEMOTHERAPY AND PHARMACOLOGY 726 4% 0% 5
9 JOURNAL OF THORACIC ONCOLOGY 719 2% 0% 3
10 LEUKEMIA & LYMPHOMA 702 4% 0% 5

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 ENZASTAURIN 6519043 34% 63% 48 Search ENZASTAURIN Search ENZASTAURIN
2 LY317615 1075195 4% 100% 5 Search LY317615 Search LY317615
3 INTRATUMORAL VESSELS 774136 4% 60% 6 Search INTRATUMORAL+VESSELS Search INTRATUMORAL+VESSELS
4 PROTEIN KINASE C BETA PKC BETA 767994 4% 71% 5 Search PROTEIN+KINASE+C+BETA+PKC+BETA Search PROTEIN+KINASE+C+BETA+PKC+BETA
5 PROTEIN KINASE C BETA INHIBITOR 387068 2% 60% 3 Search PROTEIN+KINASE+C+BETA+INHIBITOR Search PROTEIN+KINASE+C+BETA+INHIBITOR
6 PROTEIN KINASE C BETA 355458 6% 18% 9 Search PROTEIN+KINASE+C+BETA Search PROTEIN+KINASE+C+BETA
7 CAKI1 RENAL CELL CARCINOMA 215039 1% 100% 1 Search CAKI1+RENAL+CELL+CARCINOMA Search CAKI1+RENAL+CELL+CARCINOMA
8 CALU 6 NSCLC XENOGRAFT 215039 1% 100% 1 Search CALU+6+NSCLC+XENOGRAFT Search CALU+6+NSCLC+XENOGRAFT
9 CONCENTRATION QT RELATIONSHIPS 215039 1% 100% 1 Search CONCENTRATION+QT+RELATIONSHIPS Search CONCENTRATION+QT+RELATIONSHIPS
10 ENZASTAURIN LY317615 215039 1% 100% 1 Search ENZASTAURIN+LY317615 Search ENZASTAURIN+LY317615

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 KILBURN, LB , KOCAK, M , DECKER, RL , WETMORE, C , CHINTAGUMPALA, M , SU, J , GOLDMAN, S , BANERJEE, A , GILBERTSON, R , FOULADI, M , ET AL (2015) A PHASE 1 AND PHARMACOKINETIC STUDY OF ENZASTAURIN IN PEDIATRIC PATIENTS WITH REFRACTORY PRIMARY CENTRAL NERVOUS SYSTEM TUMORS: A PEDIATRIC BRAIN TUMOR CONSORTIUM STUDY.NEURO-ONCOLOGY. VOL. 17. ISSUE 2. P. 303 -311 25 69% 1
2 LI, XY , FANG, XJ , LI, S , ZHANG, WJ , YANG, N , CUI, YM , HUANG, H , CAI, RQ , LIN, XT , FU, XH , ET AL (2016) A PHARMACOKINETIC AND SAFETY STUDY OF A FIXED ORAL DOSE OF ENZASTAURIN HCL IN NATIVE CHINESE PATIENTS WITH REFRACTORY SOLID TUMORS AND LYMPHOMA.ONCOTARGET. VOL. 7. ISSUE 14. P. 18585 -18593 21 60% 0
3 CLEMENT-DUCHENE, C , NATALE, RB , JAHAN, T , KRUPITSKAYA, Y , OSAROGIAGBON, R , SANBORN, RE , BERNSTEIN, ED , DUDEK, AZ , LATZ, JE , SHI, PP , ET AL (2012) A PHASE II STUDY OF ENZASTAURIN IN COMBINATION WITH ERLOTINIB IN PATIENTS WITH PREVIOUSLY TREATED ADVANCED NON-SMALL CELL LUNG CANCER.LUNG CANCER. VOL. 78. ISSUE 1. P. 57-62 20 43% 6
4 SABA, NS , LEVY, LS , (2012) PROTEIN KINASE C-BETA INHIBITION INDUCES APOPTOSIS AND INHIBITS CELL CYCLE PROGRESSION IN ACQUIRED IMMUNODEFICIENCY SYNDROME-RELATED NON-HODGKIN LYMPHOMA CELLS.JOURNAL OF INVESTIGATIVE MEDICINE. VOL. 60. ISSUE 1. P. 29-38 21 38% 3
5 SORBERA, LA , SERRADELL, N , BOLOS, J , ROSA, E , (2007) ENZASTAURIN HYDROCHLORIDE. PROTEIN KINASE C BETA INHIBITOR, ANTIANGIOGENIC AGENT.DRUGS OF THE FUTURE. VOL. 32. ISSUE 4. P. 297-309 16 55% 8
6 SHIMOKAWA, T , SEIKE, M , SOENO, C , UESAKA, H , MIYANAGA, A , MIZUTANI, H , KITAMURA, K , MINEGISHI, Y , NORO, R , OKANO, T , ET AL (2012) ENZASTAURIN HAS ANTI-TUMOUR EFFECTS IN LUNG CANCERS WITH OVEREXPRESSED JAK PATHWAY MOLECULES.BRITISH JOURNAL OF CANCER. VOL. 106. ISSUE 5. P. 867-875 16 42% 11
7 MA, S , ROSEN, ST , (2007) ENZASTAURIN.CURRENT OPINION IN ONCOLOGY. VOL. 19. ISSUE 6. P. 590-595 13 57% 32
8 MICHAELIS, M , ROTHWEILER, F , LOSCHMANN, N , SHARIFI, M , GHAFOURIAN, T , CINATL, J , (2015) ENZASTAURIN INHIBITS ABCB1-MEDIATED DRUG EFFLUX INDEPENDENTLY OF EFFECTS ON PROTEIN KINASE C SIGNALLING AND THE CELLULAR P53 STATUS.ONCOTARGET. VOL. 6. ISSUE 19. P. 17605 -17620 20 31% 1
9 WILLEY, CD , XIAO, DK , TU, TX , KIM, KW , MORETTI, L , NIERMANN, KJ , TAWTAWY, MN , QUARLES, CC , LU, B , (2010) ENZASTAURIN (LY317615), A PROTEIN KINASE C BETA SELECTIVE INHIBITOR, ENHANCES ANTIANGIOGENIC EFFECT OF RADIATION.INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS. VOL. 77. ISSUE 5. P. 1518-1526 13 52% 9
10 YSEBAERT, L , MORSCHHAUSER, F , (2011) ENZASTAURIN HYDROCHLORIDE FOR LYMPHOMA: REASSESSING THE RESULTS OF CLINICAL TRIALS IN LIGHT OF RECENT ADVANCES IN THE BIOLOGY OF B-CELL MALIGNANCIES.EXPERT OPINION ON INVESTIGATIONAL DRUGS. VOL. 20. ISSUE 8. P. 1167 -1174 15 39% 13

Classes with closest relation at Level 1


Rank Class id link
1 1767 PROTEIN KINASE C//PKC DELTA//CELLULAR CARCINOGENESIS TUMOR PROMOT
2 25613 UCN 01//7 HYDROXYSTAUROSPORINE//CGP41251
3 22701 PEMETREXED//MULTITARGETED ANTIFOLATE//AFFILIATED JIANGSU CANC HOSP
4 11787 GLIOBLASTOMA//TUMOR TREATING FIELDS//BEVACIZUMAB
5 35447 1 OXOINDANES//2 2 DIHYDROXY BIARYLS//2 ACETOXYPYRROLES
6 18494 RUBOXISTAURIN//LY333531//PKC BETA II INHIBITORS
7 15482 BCL10//PKC THETA//CARMA3
8 19822 PAR 4//ATYPICAL PROTEIN KINASE C//PROTEIN KINASE C IOTA
9 12530 INDOLOCARBAZOLE//REBECCAMYCIN//GRANULATIMIDE
10 17826 BRYOSTATIN//BRYOSTATIN 1//APLYSIATOXIN

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